Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation

Cell Death and Differentiation

Volumn 22, Issue 10, 2015, Pages 1676-1686

  Kaushal, V ^a,b   Dye, R ^c   Pakavathkumar, P ^a,b   Foveau, B ^a,b   Flores, J ^a,b   Hyman, B ^d   Ghetti, B ^e   Koller, B H ^c   LeBlanc, A C ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CASPASE 6; CRYOPYRIN; FLAGELLIN; GLIAL FIBRILLARY ACIDIC PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN 2; MURAMYL DIPEPTIDE; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR 1; PURINERGIC P2X7 RECEPTOR; SMALL INTERFERING RNA; TUBULIN; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; NLRP1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN CORTEX; CELL DIFFERENTIATION; CENTRAL NERVOUS SYSTEM; CEREBELLAR TISSUE; COGNITIVE DEFECT; CONJUGATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; HIPPOCAMPAL TISSUE; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MICROGLIA; MOUSE; NERVE CELL CULTURE; NERVE FIBER DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIMARY CULTURE; PRIORITY JOURNAL; PROTEIN INDUCTION; ALZHEIMER DISEASE; ANIMAL; AXON; BIOSYNTHESIS; CELL CULTURE; INFLAMMATION; MALE; METABOLISM; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS REGULATORY PROTEINS; AXONS; CASPASE 1; CASPASE 6; CELLS, CULTURED; HUMANS; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-1BETA; MALE; MICE; NEURONS; SIGNAL TRANSDUCTION;

EID: 84941189756     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2015.16     Document Type: Article

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