Fragment-Based Discovery of Subtype-Selective Adenosine Receptor Ligands from Homology Models

Journal of Medicinal Chemistry

Volumn 58, Issue 24, 2015, Pages 9578-9590

  Ranganathan, Anirudh ^a   Stoddart, Leigh A ^b   Hill, Stephen J ^b   Carlsson, Jens ^c  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A3 RECEPTOR ANTAGONIST; LIGAND; MOLECULAR LIBRARY; PYRIMIDINONE DERIVATIVE; THIAZOLE DERIVATIVE; THIOPHENE DERIVATIVE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPETITIVE BINDING ASSAY; DRUG POTENCY; FLUORESCENCE; LIGAND BINDING; MOLECULAR DOCKING; NONHUMAN; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION; ANIMAL; BINDING COMPETITION; CHEMISTRY; CHO CELL LINE; COMPUTER SIMULATION; CRICETULUS; HIGH THROUGHPUT SCREENING; HUMAN; METABOLISM; MOLECULAR LIBRARY; SEQUENCE HOMOLOGY;

ADENOSINE A1 RECEPTOR ANTAGONISTS; ADENOSINE A3 RECEPTOR ANTAGONISTS; ANIMALS; BINDING, COMPETITIVE; CHO CELLS; COMPUTER SIMULATION; CRICETULUS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIGANDS; MOLECULAR DOCKING SIMULATION; PYRIMIDINONES; RECEPTOR, ADENOSINE A1; RECEPTOR, ADENOSINE A3; SEQUENCE HOMOLOGY, AMINO ACID; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; THIOPHENES;

EID: 84953308120     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01120     Document Type: Article

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