Influence of receptor number on functional responses elicited by agonists acting at the human adenosine A1 receptor: Evidence for signaling pathway-dependent changes in agonist potency and relative intrinsic activity

Molecular Pharmacology

Volumn 58, Issue 5, 2000, Pages 1075-1084

  Cordeaux, Yolande ^a   Briddon, Stephen J ^a   Megson, Anne E ^a   Mcdonnell, Jacqui ^a   Dickenson, John M ^a,b   Hill, Stephen J ^a  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

^b NOTTINGHAM TRENT UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

6 N CYCLOPENTYLADENOSINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A1 RECEPTOR; ADENYLATE CYCLASE; CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL PHOSPHATE; PERTUSSIS TOXIN; PHENYLISOPROPYLADENOSINE;

ANIMAL CELL; ARTICLE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL;

EID: 0033788831     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.58.5.1075     Document Type: Article

References (32)

1. Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: Evidence for agonist-directed trafficking of receptor stimulus
2. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
3. Differential coupling of m1, m2 and m3 muscarinic receptor subtypes to inositol 1,4,5-triphosphate and adenosine 3',5'-cyclic monophosphate accumulation in Chinese hamster ovary cells
4. Specific G-protein activation and μ-opoid receptor internalization caused by morphine, DAMGO and endomorphin I
5. Stimulation of phospholipase C by guanine-nucleotide-binding protein beta gamma subunits
6. The elusive nature of intrinsic efficacy
7. Adenosine A1 receptor stimulated increases in intracellular calcium in the smooth muscle cell line DDT1 MF-2
8. 1 receptor to phospholipase C in transfected CHO cells
9. 1 adenosine receptors in Sf9 cell membranes with recombinant G proteins of defined composition
10. 35S]guanosine-5'-O-(3-thio)triphosphate binding
11. A1 adenosine receptors expressed in CHO-cells couple to adenylyl cyclase and to phospholipase C
12. ATP and its metabolite adenosine act synergistically to mobilize intracellular calcium via the formation of inositol 1,4,5-trisphosphate in a smooth muscle cell line
13. Functional and structural complexity of signal transduction via G-protein-coupled receptors
14. Agonist receptor efficacy: I. Mechanisms of efficacy and receptor promiscuity
15. Agonist-receptor efficacy II: Agonist trafficking of receptor signals
16. Cellular expression of the carboxyl terminal of a G protein-coupled receptor kinase attenuates Gβγ-mediated signaling
17. Cloning and functional characterization of a human A1 adenosine receptor
18. Agonist regulation of adenylate cyclase activity in neuroblastoma x glioma hybrid NG 108-115 cells transfected to coexpress adenylate cyclase type II and the beta2-adrenoceptor: Evidence that adenyl cyclase is the limiting component for receptor-mediated stimulation of adenylate cyclase activity
19. Influence of receptor number on the stimulation by salmeterol of gene transcription in CHO-K1 cells transfected with the human beta2-adrenoceptor
20. 2-purinoceptors in CHO-K1 cells
21. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
22. 1 adenosine receptor in regulation of phospholipase C and adenylate cyclase in COS-7 cells transfected with their receptor genes
23. Adenosine receptor subtypes: Characterization and therapeutic regulation
24. Adenosine A1 receptor-mediated changes in basal and histamine-stimulated levels of intracellular calcium in primary rat astrocytes
25. Cross talk between G0 αi- and Gαq-coupled receptors is mediated by Gβγ exchange
26. - currents in normal and cystic fibrosis airway epithelial cells
27. Adenosine and adenosine receptors in the cardiovascular system: Biochemistry, physiology, and pharmacology
28. 1 adenosine receptors stably expressed in Chinese hamster ovary cells
29. Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D
30. 1 adenosine receptor reserve for two actions of adenosine on guinea pig atrial myocytes
31. 1 adenosine receptor agonist-induced activation of phospholipase C in collaboration with thyrotropin: A novel stimulatory mechanism through the cross talk of two types of receptors
32. Measurement of receptor-stimulated guanosine 5'-O-(γ-thio)triphosphate binding by G proteins