Structure-activity relationships of thiazole and thiadiazole derivatives as potent and selective human adenosine A3 receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 3, 2004, Pages 613-623

  Jung, Kwan Young ^a   Kim, Soo Kyung ^b   Gao, Zhan Guo ^b   Gross, Ariel S ^b   Melman, Neli ^b   Jacobson, Kenneth A ^b   Kim, Yong Chul ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

A3 receptor; Adenosine; Antagonist; Thiadiazole; Thiazole

Indexed keywords

3 (4 METHOXYPHENYL) 5 AMINOTHIADIAZOLE; 4 (4 METHOXYPHENYL) 2 AMINOTHIAZOLE; ACETAMIDE DERIVATIVE; ADENOSINE A3 RECEPTOR ANTAGONIST; ADENOSINE RECEPTOR; CYCLIC AMP; N [3 (4 METHOXYPHENYL) [1,2,4]THIADIAZOL 5 YL]ACETAMIDE; N [5 (4 METHOXYPHENYL) [1,3,4]THIADIAZOL 2 YL]ACETAMIDE; PHENYL GROUP; THIADIAZOLE DERIVATIVE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOSYNTHESIS; EXPERIMENT; MOLECULAR MODEL; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; SYNTHESIS;

EID: 1642556811     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.10.041     Document Type: Article

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