Highly potent and selective fluorescent antagonists of the human adenosine A3 receptor based on the 1,2,4-triazolo[4,3-a]quinoxalin-1-one scaffold

Journal of Medicinal Chemistry

Volumn 55, Issue 4, 2012, Pages 1771-1782

  Vernall, Andrea J ^a   Stoddart, Leigh A ^a   Briddon, Stephen J ^a   Hill, Stephen J ^a   Kellam, Barrie ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 TRIAZOLO[4,3 A]QUINOXALIN 1ONE; [4 [2 [4,4 DIFLUORO 4,4A DIHYDRO 5 (THIOPHEN 2 YL) 4 BORA 3A,4A DIAZA S INDACENE 3 YL)ETHENYL]PHENOXY]ACETAMIDO]HEXANAMIDO]ETHOXY]ETHOXY]ETHYL]SUCCINAMIDE; ADENOSINE A3 RECEPTOR; ADENOSINE RECEPTOR; MOLECULAR SCAFFOLD; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONFOCAL MICROSCOPY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; NONHUMAN;

ADENOSINE A3 RECEPTOR ANTAGONISTS; ANIMALS; BORON COMPOUNDS; CELL MEMBRANE; CHO CELLS; CRICETINAE; CRICETULUS; FLUORESCENT DYES; HEK293 CELLS; HUMANS; LIGANDS; MODELS, MOLECULAR; QUINOXALINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84857399127     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201722y     Document Type: Article

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