New chromene scaffolds for adenosine A2A receptors: Synthesis, pharmacology and structure-activity relationships

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 303-310

  Areias, Filipe ^a,b   Costa, Marta ^a   Castro, Marián ^b   Brea, José ^b   Gregori Puigjané, Elisabet ^c   Proença, M Fernanda ^a   Mestres, Jordi ^c   Loza, María I ^b  

^a UNIVERSITY OF MINHO   (Portugal)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

Adenosine receptors; Chromene scaffolds; G protein coupled receptors; Knoevenagel condensation; Structure activity relationship

Indexed keywords

1(2 HYDROXY 8 METHOXY 2 METHYL 2H CHROMEN 3 YL) ETHANONE; 2H CHROMENE 3 CARBOXAMIDE DERIVATIVE; 6 BROMO N (1 HYDROXYBUTAN 2 YL) 2 IMINO 2H CHROMENE 3 CARBOXAMIDE; 6 BROMO N (2 HYDROXYETHYL) 2 IMINO 2H CHROMENE 3 CARBOXAMIDE; 6 BROMO N (2,3 DIHYDROXYPROPYL) 2 IMINO 2H CHROMENE 3 CARBOXAMIDE; 6 BROMO N (3 HYDROXYPROPYL) 2 IMINO 2H CHROMENE 3 CARBOXAMIDE; 6 BROMO N (3 HYDROXYPROPYL) 2 IMINO 8 METHOXY 2H CHROMENE 3 CARBOXAMIDE; 6 BROMO N CYCLOHEXYL 2 IMINO 2H CHROMENE 3 CARBOXAMIDE; 6 BROMO N CYCLOPENTYL 2 IMINO 2H CHROMENE 3 CARBOXAMIDE; 8 HYDROXY N (3 HYDROXYPROPYL) 2 OXO 2H CHROMENE 3 CARBOXAMIDE; 8 METHOXY N (2 METHOXYETHYL) 2 OXO 2H CHROMENE 3 CARBOXAMIDE; ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; AMIDE; CHROMENE DERIVATIVE; MOLECULAR SCAFFOLD; N (2 HYDROXYETHYL) 8 METHOXY 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N (3 HYDROXYPROPYL) 2 OXO 2H CHROMENE 3 CARBOXAMIDE; N (4 CYANO 1 PHENYL 1H IMIDAZOL 5 YL) 2 IMINO 8 METHOXY 2H CHROMENE 3 CARBOXAMIDE; N [(2 OXO 2H CHROMEN 3 YL) CARBONYL] GLYCINE; N [(8 METHOXY 2 OXO 2H CHROMEN 3 YL) CARBONYL] GLYCINE; N [(8 METHOXY 2 OXO 2H CHROMEN 3 YL) CARBONYL] SERINE; N [4 CYANO 1(4 CYANOPHENYL) 1H IMIDAZOL 5 YL] 2 IMINO 8 METHOXY 2H CHROMENE 3 CARBOXAMIDE; N [4 CYANO 1(4 FLUOROPHENYL) 1H IMIDAZOL 5 YL] 2 IMINO 8 METHOXY 2H CHROMENE 3 CARBOXAMIDE; N [4 CYANO 1(4 METHOXYPHENYL) 1H IMIDAZOL 5 YL] 2 IMINO 8 METHOXY 2H CHROMENE 3 CARBOXAMIDE; N CYCLOPENTYL 2 OXO 2H CHROMENE 3 CARBOXAMIDE; RADIOLIGAND; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; DRUG SYNTHESIS; LIGAND BINDING; NONHUMAN; RADIOASSAY; STRUCTURE ACTIVITY RELATION;

BENZOPYRANS; CELL LINE; CHEMISTRY TECHNIQUES, SYNTHETIC; HUMANS; RECEPTOR, ADENOSINE A2A; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84864417097     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.05.009     Document Type: Article

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