Cardiac overexpression of A1-adenosine receptor protects intact mice against myocardial infarction

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 282, Issue 3 51-3, 2002, Pages

  Yang, Zequan ^a   Cerniway, Rachae L J ^b   Byford, Anne M ^c   Berr, Stuart S ^d   French, Brent A ^a   Paul Matherne, G ^b  

^a Cardiovascular Research Center

^b Departments of Biomedical Engineering

^c Department of Pediatrics ^*

^d UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Cardioprotection; Ischemia reperfusion; Magnetic resonance imaging; Transgenic mice

Indexed keywords

ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE RECEPTOR; COMPLEMENTARY DNA; PRIMER DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRADYCARDIA; CONTROLLED STUDY; DRUG RECEPTOR BINDING; GENE OVEREXPRESSION; GENE THERAPY; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEMODYNAMICS; INFLAMMATION; ISOLATED HEART; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REPERFUSION INJURY; SIGNAL TRANSDUCTION; ANIMAL; GENETICS; HEART MUSCLE; HEART MUSCLE REPERFUSION; METABOLISM; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; POLYMERASE CHAIN REACTION; RAT; TRANSGENIC MOUSE;

ANIMALS; DNA PRIMERS; DNA, COMPLEMENTARY; MAGNETIC RESONANCE IMAGING; MICE; MICE, TRANSGENIC; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; MYOCARDIUM; POLYMERASE CHAIN REACTION; RATS; RECEPTORS, PURINERGIC P1;

EID: 0036084754     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00741.2001     Document Type: Article

References (29)

1. Mitochondrial ATP-sensitive channels inhibit apoptosis induced by oxidative stress in cardiac cells
2. Adenosine receptor involvement in a delayed phase of myocardial protection 24 hours after ischemic preconditioning
3. 1 receptor activation in the rabbit
4. Delayed cardioprotection in a human cardiomyocyte-derived cell line: The role of adenosine, p 38 MAP kinase and mitochondrial KATP
5. Extracellular superoxide dismutase transgene overexpression preserves postischemic myocardial function in isolated murine hearts
6. 1 receptor activation maintains rabbit myocardium in a preconditioned state
7. 1 receptor induced delayed preconditioning in rabbits. Induction of p38 mitogen-activated protein kinase and hsp27 phosphorylation via a tyrosine kinase- and protein kinase C-dependent mechanism
8. Protective effect of adenosine in myocardial ischemia
9. 1 receptor stimulation during reperfusion following ischemia
10. Resident cardiac mast cells degranulate and release preformed TNF-α, initiating the cytokine cascade in experimental canine myocardial ischemia/reperfusion
11. 1 adenosine receptors
12. 1 adenosine receptors in the heart
13. 1 adenosine receptor overexpression markedly improves myocardial energy state during ischemia reperfusion
14. 1-adenosine receptors
15. 1 adenosine receptors
16. Protein kinase C-ε is responsible for the protection of preconditioning in rabbit cardiomyocytes
17. 1 adenosine receptors in rabbit heart
18. Preconditioning attenuates apoptosis and necrosis: Role of protein kinase Cε and -δ isoforms
19. 1 adenosine receptor overexpression increases myocardial resistance to ischemia
20. The p38 MAPK inhibitor, SB 203580, abrogates ischaemic preconditioning in rat heart but timing of administration is critical
21. 1 adenosine receptors mimics ischemic preconditioning
22. Interaction of β-adrenoceptor and adenosine receptor agonists on phosphorylation. Identification of target proteins in mammalian ventricles
23. 1-selective adenosine analogues protects the heart against infarction
24. Protection against myocardial dysfunction after a brief ischemic period in transgenic mice expressing inducible heat shock protein 70
25. 1 selective agonist is diminished after prolonged infusion as is the cardioprotective effect of ischemic preconditioning in rabbit heart
26. Effect of genetic disruption of poly (ADP-ribose) synthetase on delayed production of inflammatory mediators and delayed necrosis during myocardial ischemia/reperfusion injury
27. The crucial role of endogenous interleukin-10 production in myocardial ischemia/reperfusion injury
28. Glutathione peroxidase knockout mice are susceptible to myocardial ischemia reperfusion injury
29. Transgenic mice overexpressing glutathione peroxidase are resistant to myocardial ischemia reperfusion injury