Erratum: Human β-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic: Polycytidylic Acid (PLoS Genetics (2015) 11:12 (e1005673) DOI: 10.1371/journal.pgen.1005673);Human β-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid

PLoS Genetics

Volumn 11, Issue 12, 2015, Pages

  Semple, Fiona ^a,b   MacPherson, Heather ^b   Webb, Sheila ^b   Kilanowski, Fiona ^b   Lettice, Laura ^b   McGlasson, Sarah L ^b   Wheeler, Ann P ^b   Chen, Valerie ^c   Millhauser, Glenn L ^c   Melrose, Lauren ^a   Davidson, Donald J ^a   Dorin, Julia R ^a,b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN 3; BETA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERFERON INDUCED WITH HELICASE C DOMAIN; LIPOSOME; MELANOMA DIFFERENTIATION ASSOCIATED PROTEIN 5; POLYINOSINIC POLYCYTIDYLIC ACID; PROTEIN; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; BETA DEFENSIN; BETA-DEFENSIN 3, HUMAN; DEAD BOX PROTEIN; IFIH1 PROTEIN, HUMAN; INTERFERON INDUCED HELICASE C DOMAIN CONTAINING PROTEIN 1; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TICAM1 PROTEIN, HUMAN; TLR3 PROTEIN, HUMAN; VESICULAR TRANSPORT ADAPTOR PROTEIN; VISA PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CELLULAR DISTRIBUTION; CELLULAR IMMUNITY; CONTROLLED STUDY; COPY NUMBER VARIATION; CYTOKINE PRODUCTION; ENDOSOME; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MACROPHAGE; MALE; MOUSE; NONHUMAN; TRANSGENE; VIRUS INFECTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BONE MARROW; GENETICS; INNATE IMMUNITY; METABOLISM; PATHOLOGY; PSORIASIS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; BETA-DEFENSINS; BONE MARROW; CHEMOKINE CXCL10; DEAD-BOX RNA HELICASES; HUMANS; IMMUNITY, INNATE; INTERFERON-INDUCED HELICASE, IFIH1; LIPOSOMES; MACROPHAGES; MICE; MICE, KNOCKOUT; POLY I-C; PSORIASIS; TOLL-LIKE RECEPTOR 3;

EID: 84953298987     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/JOURNAL.PGEN.1005801     Document Type: Erratum

References (58)

1. Schneider T, Kruse T, Wimmer R, Wiedemann I, Sass V, Pag U, et al. Plectasin, a fungal defensin, targets the bacterial cell wall precursor Lipid II 1. Science. 2010;328(5982):1168–72. doi: 10.1126/science.1185723 20508130
2. Bauer F, Schweimer K, Kluver E, Conejo-Garcia JR, Forssmann WG, Rosch P, et al. Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity. Protein Sci. 2001;10(12):2470–9. 11714914
3. Semple F, Dorin JR, beta-Defensins: multifunctional modulators of infection, inflammation and more? JInnateImmun. 2012;4(4):337–48.
4. Zhou YS, Webb S, Lettice L, Tardif S, Kilanowski F, Tyrrell C, et al. Partial deletion of chromosome 8 β-defensin cluster confers sperm dysfunction and infertility in male mice. PLoS Genet. 2013;9(10):e1003826. doi: 10.1371/journal.pgen.1003826 24204287; PubMed Central PMCID: PMCPMC3812073.
5. Harder J, Bartels J, Christophers E, Schroder JM, A peptide antibiotic from human skin. Nature. 1997;387(6636):861. 9202117
6. Salzman NH, Hung K, Haribhai D, Chu H, Karlsson-Sjoberg J, Amir E, et al. Enteric defensins are essential regulators of intestinal microbial ecology. NatImmunol. 2010;11(1):76–83.
7. Wu Z, Hoover DM, Yang D, Boulegue C, Santamaria F, Oppenheim JJ, et al. Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3. ProcNatlAcadSciUSA. 2003;100(15):8880–5.
8. Hirsch T, Spielmann M, Zuhaili B, Fossum M, Metzig M, Koehler T, et al. Human beta-defensin-3 promotes wound healing in infected diabetic wounds. JGene Med. 2009;11(3):220–8.
9. Tewary P, de la Rosa G, Sharma N, Rodriguez LG, Tarasov SG, Howard OM, et al. β-Defensin 2 and 3 Promote the Uptake of Self or CpG DNA, Enhance IFN-α Production by Human Plasmacytoid Dendritic Cells, and Promote Inflammation. J Immunol. 2013. doi: 10.4049/jimmunol.1201648 23776172.
10. Semple F, MacPherson H, Webb S, Cox SL, Mallin LJ, Tyrrell C, et al. Human beta-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF. EurJImmunol. 2011;41(11):3291–300.
11. Semple F, Webb S, Li HN, Patel HB, Perretti M, Jackson IJ, et al. Human beta-defensin 3 has immunosuppressive activity in vitro and in vivo. EurJImmunol. 2010;40:1073–8.
12. Rohrl J, Yang D, Oppenheim JJ, Hehlgans T, Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2. JImmunol. 2010;184(12):6688–94.
13. Feng Z, Dubyak GR, Lederman MM, Weinberg A, Cutting edge: human beta defensin 3—a novel antagonist of the HIV-1 coreceptor CXCR4. JImmunol. 2006;177(2):782–6.
14. Candille SI, Kaelin CB, Cattanach BM, Yu B, Thompson DA, Nix MA, et al. A {beta}-Defensin Mutation Causes Black Coat Color in Domestic Dogs. Science. 2007;318:1418–23. 17947548
15. Anderson TM, vonHoldt BM, Candille SI, Musiani M, Greco C, Stahler DR, et al. Molecular and evolutionary history of melanism in North American gray wolves. Science. 2009;323(5919):1339–43. doi: 10.1126/science.1165448 19197024
16. Hollox EJ, Huffmeier U, Zeeuwen PL, Palla R, Lascorz J, Rodijk-Olthuis D, et al. Psoriasis is associated with increased beta-defensin genomic copy number. NatGenet. 2008;40(1):23–5.
17. Stuart PE, Hüffmeier U, Nair RP, Palla R, Tejasvi T, Schalkwijk J, et al. Association of β-defensin copy number and psoriasis in three cohorts of European origin. J Invest Dermatol. 2012;132(10):2407–13. doi: 10.1038/jid.2012.191 22739795; PubMed Central PMCID: PMCPMC3447111.
18. Cho JH, Feldman M, Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies. Nat Med. 2015;21(7):730–8. doi: 10.1038/nm.3897 26121193.
19. Lande R, Chamilos G, Ganguly D, Demaria O, Frasca L, Durr S, et al. Cationic antimicrobial peptides in psoriatic skin cooperate to break innate tolerance to self-DNA. Eur J Immunol. 2015;45(1):203–13. doi: 10.1002/eji.201344277 25332209.
20. Nestle FO, Conrad C, Tun-Kyi A, Homey B, Gombert M, Boyman O, et al. Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. J Exp Med. 2005;202(1):135–43. doi: 10.1084/jem.20050500 15998792; PubMed Central PMCID: PMCPMC2212894.
21. Ganguly D, Chamilos G, Lande R, Gregorio J, Meller S, Facchinetti V, et al. Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8. J Exp Med. 2009;206(9):1983–94. doi: 10.1084/jem.20090480 19703986; PubMed Central PMCID: PMCPMC2737167.
22. Kumar H, Koyama S, Ishii KJ, Kawai T, Akira S, Cutting edge: cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses 9. JImmunol. 2008;180(2):683–7.
23. Zou J, Kawai T, Tsuchida T, Kozaki T, Tanaka H, Shin KS, et al. Poly IC triggers a cathepsin D- and IPS-1-dependent pathway to enhance cytokine production and mediate dendritic cell necroptosis. Immunity. 2013;38(4):717–28. doi: 10.1016/j.immuni.2012.12.007 23601685.
24. Kato H, Takeuchi O, Mikamo-Satoh E, Hirai R, Kawai T, Matsushita K, et al. Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med. 2008;205(7):1601–10. doi: 10.1084/jem.20080091 18591409; PubMed Central PMCID: PMCPMC2442638.
25. Funabiki M, Kato H, Miyachi Y, Toki H, Motegi H, Inoue M, et al. Autoimmune Disorders Associated with Gain of Function of the Intracellular Sensor MDA5. Immunity. 2014. doi: 10.1016/j.immuni.2013.12.014 24530055.
26. Todd JA, Constitutive antiviral immunity at the expense of autoimmunity. Immunity. 2014;40(2):167–9. doi: 10.1016/j.immuni.2014.01.009 24560191.
27. Oda H, Nakagawa K, Abe J, Awaya T, Funabiki M, Hijikata A, et al. Aicardi-Goutières syndrome is caused by IFIH1 mutations. Am J Hum Genet. 2014;95(1):121–5. doi: 10.1016/j.ajhg.2014.06.007 24995871; PubMed Central PMCID: PMCPMC4085581.
28. Axtell RC, Raman C, Steinman L, Interferon-β exacerbates Th17-mediated inflammatory disease. Trends Immunol. 2011;32(6):272–7. doi: 10.1016/j.it.2011.03.008 21530402.
29. Goubau D, Deddouche S, Reis e Sousa C, Cytosolic sensing of viruses. Immunity. 2013;38(5):855–69. doi: 10.1016/j.immuni.2013.05.007 23706667.
30. Blasius AL, Beutler B, Intracellular toll-like receptors. Immunity. 2010;32(3):305–15. doi: 10.1016/j.immuni.2010.03.012 20346772.
31. Chino N, Kubo S, Nishio H, Nishiuchi Y, Nakazato M, Kimura T, Chemical synthesis of human beta defenin (hBD) -1,-2,-3,-4. Optimisation of the oxidative folding reaction. International Journal of Peptide Research and Therapeutics. 2006;12(3):203–9.
32. Miller LS, Sørensen OE, Liu PT, Jalian HR, Eshtiaghpour D, Behmanesh BE, et al. TGF-alpha regulates TLR expression and function on epidermal keratinocytes. J Immunol. 2005;174(10):6137–43. 15879109.
33. Kobayashi S, Nakase I, Kawabata N, Yu HH, Pujals S, Imanishi M, et al. Cytosolic targeting of macromolecules using a pH-dependent fusogenic peptide in combination with cationic liposomes. Bioconjug Chem. 2009;20(5):953–9. doi: 10.1021/bc800530v 19388672.
34. Lande R, Gilliet M, Plasmacytoid dendritic cells: key players in the initiation and regulation of immune responses. Ann N Y Acad Sci. 2010;1183:89–103. doi: 10.1111/j.1749-6632.2009.05152.x 20146710.
35. Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature. 2006;441(7089):101–5. doi: 10.1038/nature04734 16625202.
36. Pichlmair A, Schulz O, Tan CP, Rehwinkel J, Kato H, Takeuchi O, et al. Activation of MDA5 requires higher-order RNA structures generated during virus infection. J Virol. 2009;83(20):10761–9. doi: 10.1128/JVI.00770-09 19656871; PubMed Central PMCID: PMCPMC2753146.
37. Cronican JJ, Beier KT, Davis TN, Tseng JC, Li W, Thompson DB, et al. A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo. Chem Biol. 2011;18(7):833–8. doi: 10.1016/j.chembiol.2011.07.003 21802004; PubMed Central PMCID: PMCPMC3154086.
38. Nejentsev S, Walker N, Riches D, Egholm M, Todd JA, Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science. 2009;324(5925):387–9. doi: 10.1126/science.1167728 19264985; PubMed Central PMCID: PMCPMC2707798.
39. Downes K, Pekalski M, Angus KL, Hardy M, Nutland S, Smyth DJ, et al. Reduced expression of IFIH1 is protective for type 1 diabetes. PLoS One. 2010;5(9). doi: 10.1371/journal.pone.0012646 20844740; PubMed Central PMCID: PMCPMC2936573.
40. Katakura K, Lee J, Rachmilewitz D, Li G, Eckmann L, Raz E, Toll-like receptor 9-induced type I IFN protects mice from experimental colitis. J Clin Invest. 2005;115(3):695–702. doi: 10.1172/JCI22996 15765149; PubMed Central PMCID: PMCPMC1051992.
41. Kawashima T, Kosaka A, Yan H, Guo Z, Uchiyama R, Fukui R, et al. Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-β. Immunity. 2013;38(6):1187–97. doi: 10.1016/j.immuni.2013.02.024 23791646.
42. Trinchieri G, Type I interferon: friend or foe? J Exp Med. 2010;207(10):2053–63. doi: 10.1084/jem.20101664 20837696; PubMed Central PMCID: PMCPMC2947062.
43. Rácz E, Prens EP, Kurek D, Kant M, de Ridder D, Mourits S, et al. Effective treatment of psoriasis with narrow-band UVB phototherapy is linked to suppression of the IFN and Th17 pathways. J Invest Dermatol. 2011;131(7):1547–58. doi: 10.1038/jid.2011.53 21412260.
44. Griffiths CE, Reich K, Lebwohl M, van de Kerkhof P, Paul C, Menter A, et al. Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials. Lancet. 2015. doi: 10.1016/S0140-6736(15)60125-8 26072109.
45. Afshar M, Martinez AD, Gallo RL, Hata TR, Induction and exacerbation of psoriasis with Interferon-alpha therapy for hepatitis C: a review and analysis of 36 cases. J Eur Acad Dermatol Venereol. 2013;27(6):771–8. doi: 10.1111/j.1468-3083.2012.04582.x 22671985; PubMed Central PMCID: PMCPMC3443510.
46. La Mantia L, Capsoni F, Psoriasis during interferon beta treatment for multiple sclerosis. Neurol Sci. 2010;31(3):337–9. doi: 10.1007/s10072-009-0184-x 19924503.
47. Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, et al. Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet. 2012;44(12):1341–8. doi: 10.1038/ng.2467 23143594; PubMed Central PMCID: PMCPMC3510312.
48. Harder J, Bartels J, Christophers E, Schroder JM, Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic. JBiolChem. 2001;276(8):5707–13.
49. Wilson SS, Wiens ME, Smith JG, Antiviral mechanisms of human defensins. J Mol Biol. 2013;425(24):4965–80. doi: 10.1016/j.jmb.2013.09.038 24095897; PubMed Central PMCID: PMCPMC3842434.
50. Ryan LK, Dai J, Yin Z, Megjugorac N, Uhlhorn V, Yim S, et al. Modulation of human beta-defensin-1 (hBD-1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial cells by influenza virus, Herpes simplex virus, and Sendai virus and its possible role in innate immunity. JLeukocBiol. 2011;90(2):343–56.
51. Rohrl J, Yang D, Oppenheim JJ, Hehlgans T, Identification and biological characterization of mouse beta-defensin 14—the orthologue of human beta defensin 3. JBiolChem. 2007;283(9):5414–9.
52. Gitlin L, Benoit L, Song C, Cella M, Gilfillan S, Holtzman MJ, et al. Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo. PLoS Pathog. 2010;6(1):e1000734. doi: 10.1371/journal.ppat.1000734 20107606; PubMed Central PMCID: PMCPMC2809771.
53. McCartney SA, Thackray LB, Gitlin L, Gilfillan S, Virgin HW, Virgin Iv HW, et al. MDA-5 recognition of a murine norovirus. PLoS Pathog. 2008;4(7):e1000108. doi: 10.1371/journal.ppat.1000108 18636103; PubMed Central PMCID: PMCPMC2443291.
54. Gitlin L, Barchet W, Gilfillan S, Cella M, Beutler B, Flavell RA, et al. Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci U S A. 2006;103(22):8459–64. doi: 10.1073/pnas.0603082103 16714379; PubMed Central PMCID: PMCPMC1464000.
55. Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, et al. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol. 2003;4(11):1144–50. doi: 10.1038/ni986 14556004.
56. Barlow PG, Li Y, Wilkinson TS, Bowdish DM, Lau YE, Cosseau C, et al. The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system. JLeukocBiol. 2006;80(3):509–20.
57. Bolte S, Cordelières FP, A guided tour into subcellular colocalization analysis in light microscopy. J Microsc. 2006;224(Pt 3):213–32. doi: 10.1111/j.1365-2818.2006.01706.x 17210054.
58. Vintersten K, Monetti C, Gertsenstein M, Zhang P, Laszlo L, Biechele S, et al. Mouse in red: red fluorescent protein expression in mouse ES cells, embryos, and adult animals. Genesis. 2004;40(4):241–6. doi: 10.1002/gene.20095 15593332.