Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining

ACS Chemical Biology

Volumn 10, Issue 12, 2015, Pages 2841-2849

  Tang, Xiaoyu ^a   Li, Jie ^a   Millán Aguiñaga, Natalie ^a   Zhang, Jia Jia ^a   O'Neill, Ellis C ^a   Ugalde, Juan A ^c   Jensen, Paul R ^a   Mantovani, Simone M ^a   Moore, Bradley S ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSIDAD MAYOR   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CYTOCHROME P450 REDUCTASE; DOUBLE STRANDED DNA; FATTY ACID SYNTHASE; GENOMIC DNA; NATURAL PRODUCT; NONRIBOSOMAL PEPTIDE SYNTHETASE; PEPTIDE SYNTHASE; POLYKETIDE SYNTHASE; SALINOSPORAMIDE A; THIOLACTOMYCIN; THIOTETRONIC ACID; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; HYDROXYBUTYRIC ACID; THIOL DERIVATIVE; THIOPHENE DERIVATIVE;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; DNA SEQUENCE; GENE CLUSTER; HETEROLOGOUS EXPRESSION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; BACTERIAL GENOME; BIOLOGY; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENE TARGETING; GENETICS; METABOLISM; MULTIGENE FAMILY; PHYSIOLOGY; STREPTOMYCES;

ANTI-BACTERIAL AGENTS; BIOSYNTHETIC PATHWAYS; COMPUTATIONAL BIOLOGY; GENE TARGETING; GENOME, BACTERIAL; HYDROXYBUTYRATES; MOLECULAR STRUCTURE; MULTIGENE FAMILY; STREPTOMYCES; SULFHYDRYL COMPOUNDS; THIOPHENES;

EID: 84952008952     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.5b00658     Document Type: Article

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