The orphan G protein-coupled receptor Gpr175 (Tpra40) enhances Hedgehog signaling by modulating cAMP levels

Journal of Biological Chemistry

Volumn 290, Issue 49, 2015, Pages 29663-29675

  Singh, Jaskirat ^a   Wen, Xiaohui ^a   Scales, Suzie J ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINS; TRANSCRIPTION;

ADENYLYL CYCLASE; EMBRYONIC TISSUE; G-PROTEIN COUPLED RECEPTORS; GENE TRANSCRIPTIONS; HEDGEHOG SIGNALING; HETEROTRIMERIC G PROTEINS; SIGNALING PATHWAYS; TRANS-MEMBRANE PROTEINS;

SIGNALING;

ADENYLATE CYCLASE; CELL PROTEIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; G ALPHA I 1 SUBUNIT; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 161; G PROTEIN COUPLED RECEPTOR 175; PROTEIN PATCHED 1; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; SUPPRESSOR OF FUSED PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR GLI3; UNCLASSIFIED DRUG; COMPLEMENTARY DNA; GLI3 PROTEIN, HUMAN; GPR175 PROTEIN, HUMAN; KRUPPEL LIKE FACTOR; NERVE PROTEIN; SMALL INTERFERING RNA; SMO PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CELL LEVEL; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; EUKARYOTIC FLAGELLUM; GENE; GLI1 GENE; GPR175 GENE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN SUBUNIT; SIGNAL TRANSDUCTION; 3T3 CELL LINE; AMINO ACID SEQUENCE; ANIMAL; C3H MOUSE; CELL LINE; CHLOROCEBUS AETHIOPS; COS CELL LINE; FLUORESCENCE MICROSCOPY; METABOLISM; MOLECULAR GENETICS; SEQUENCE HOMOLOGY; ZEBRA FISH;

3T3 CELLS; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; CILIA; COS CELLS; CYCLIC AMP; DNA, COMPLEMENTARY; HEDGEHOG PROTEINS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MICE, INBRED C3H; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; RECEPTORS, G-PROTEIN-COUPLED; RNA, SMALL INTERFERING; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SMOOTHENED RECEPTOR; ZEBRAFISH;

EID: 84951728154     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.665810     Document Type: Article

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