Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer

Journal of Hepatology

Volumn 63, Issue 6, 2015, Pages 1491-1501

  Yimlamai, Dean ^a   Fowl, Brendan H ^a   Camargo, Fernando D ^a,b,c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD STEM CELL INSTITUTE   (United States)

^c Harvard University   (United States)

Author keywords

Hippo signaling; Liver regeneration; Stem cell biology

Indexed keywords

ANTINEOPLASTIC AGENT; LIVER PROTEIN; TRANSCRIPTION FACTOR; TUMOR MARKER; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; YES KINASE ASSOCIATED PROTEIN; DROSOPHILA PROTEIN; HPO PROTEIN, DROSOPHILA; NUCLEAR PROTEIN; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; TRANSACTIVATOR PROTEIN; YORKIE PROTEIN, DROSOPHILA;

DRUG TARGETING; FUTUROLOGY; HIPPO PATHWAY; HOMEOSTASIS; HUMAN; LIVER CANCER; LIVER CARCINOGENESIS; LIVER DEVELOPMENT; LIVER FUNCTION; LIVER REGENERATION; LIVER SIZE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; ANIMAL; BIOLOGICAL MODEL; LIVER; LIVER TUMOR; ORGAN SIZE; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; DROSOPHILA PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER; LIVER NEOPLASMS; LIVER REGENERATION; MODELS, BIOLOGICAL; NUCLEAR PROTEINS; ORGAN SIZE; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

EID: 84951086299     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2015.07.008     Document Type: Review

References (112)

1. S. Wu, J. Huang, J. Dong, and D. Pan Hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts Cell 114 2003 445 456
2. R.W. Justice, O. Zilian, D.F. Woods, M. Noll, and P.J. Bryant The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation Genes Dev 9 1995 534 546
3. N. Tapon, K.F. Harvey, D.W. Bell, D.C. Wahrer, T.A. Schiripo, D. Haber, and et al. Salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines Cell 110 2002 467 478
4. D. Pan The Hippo Signaling Pathway in Development and Cancer Dev Cell 19 2010 491 505
5. B. Zhao, Q.-Y. Lei, and K.-L. Guan The Hippo-YAP pathway: new connections between regulation of organ size and cancer Curr Opin Cell Biol 20 2008 638 646
6. Q. Zeng, and W. Hong The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals Cancer Cell 13 2008 188 192
7. J. Dong, G. Feldmann, J. Huang, S. Wu, N. Zhang, S.A. Comerford, and et al. Elucidation of a universal size-control mechanism in Drosophila and mammals Cell 130 2007 1120 1133
8. F. Kanai, P.A. Marignani, D. Sarbassova, R. Yagi, R.A. Hall, M. Donowitz, and et al. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins EMBO J 19 2000 6778 6791
9. R. Yagi, L.F. Chen, K. Shigesada, Y. Murakami, and Y. Ito A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator EMBO J 18 1999 2551 2562
10. C.B. Cui, L.F. Cooper, X. Yang, G. Karsenty, and I. Aukhil Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZ Mol Cell Biol 23 2003 1004 1013
11. F.D. Camargo, S. Gokhale, J.B. Johnnidis, D. Fu, G.W. Bell, R. Jaenisch, and et al. YAP1 increases organ size and expands undifferentiated progenitor cells Curr Biol 17 2007 2054 2060
12. S. Basu, N. Totty, M. Irwin, M. Sudol, and J. Downward Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis Mol Cell 11 2003 11 23
13. T. Oka, V. Mazack, and M. Sudol Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP) J Biol Chem 283 2008 27534 27546
14. B. Zhao, L. Li, K. Tumaneng, C.-Y. Wang, and K.-L. Guan A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP Genes Dev 24 2010 72 85
15. P.S. Ribeiro, F. Josué, A. Wepf, M.C. Wehr, O. Rinner, G. Kelly, and et al. Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling Mol Cell 39 2010 521 534
16. D. Zhou, C. Conrad, F. Xia, J.-S. Park, B. Payer, Y. Yin, and et al. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene Cancer Cell 16 2009 425 438
17. H. Song, K.K. Mak, L. Topol, K. Yun, J. Hu, L. Garrett, and et al. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression Proc Natl Acad Sci 107 2010 1431 1436
18. L. Lu, Y. Li, S.M. Kim, W. Bossuyt, P. Liu, Q. Qiu, and et al. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver Proc Natl Acad Sci 107 2010 1437 1442
19. N. Zhang, H. Bai, K.K. David, J. Dong, Y. Zheng, J. Cai, and et al. The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals Dev Cell 19 2010 27 38
20. S. Benhamouche, M. Curto, I. Saotome, A.B. Gladden, C.-H. Liu, M. Giovannini, and et al. Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver Genes Dev 24 2010 1718 1730
21. K.-P. Lee, J.-H. Lee, T.-S. Kim, T.-H. Kim, H.-D. Park, J.-S. Byun, and et al. The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis Proc Natl Acad Sci 107 2010 8248 8253
22. F. Yin, J. Yu, Y. Zheng, Q. Chen, N. Zhang, and D. Pan Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2 Cell 154 2013 1342 1355
23. D. Yimlamai, C. Christodoulou, G.G. Galli, K. Yanger, B. Pepe-Mooney, B. Gurung, and et al. Hippo pathway activity influences liver cell fate Cell 157 2014 1324 1338
24. J.H. Hong, E.S. Hwang, M.T. McManus, A. Amsterdam, Y. Tian, R. Kalmukova, and et al. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation Science 309 2005 1074 1078
25. L. Boulter, W.Y. Lu, and S.J. Forbes Differentiation of progenitors in the liver: a matter of local choice J Clin Invest 123 2013 1867 1873
26. C. Kordes, and D. Haussinger Hepatic stem cell niches J Clin Invest 123 2013 1874 1880
27. H. Li, A. Wolfe, S. Septer, G. Edwards, X. Zhong, A. Bashar Abdulkarim, and et al. Deregulation of Hippo kinase signalling in Human hepatic malignancies Liver Int 32 2012 38 47
28. H. Bai, M.F. Gayyed, D.M. Lam-Himlin, A.P. Klein, S.K. Nayar, Y. Xu, and et al. Expression of Yes-associated protein modulates Survivin expression in primary liver malignancies Hum Pathol 43 2012 1376 1385
29. H. Bai, N. Zhang, Y. Xu, Q. Chen, M. Khan, J.J. Potter, and et al. Yes-associated protein regulates the hepatic response after bile duct ligation Hepatology 56 2012 1097 1107
30. M. Oertel, and D. Shafritz Stem cells, cell transplantation and liver repopulation Biochim Biophys Acta 1782 2008 61 74
31. K. Yanger, Y. Zong, L.R. Maggs, S.N. Shapira, R. Maddipati, N.M. Aiello, and et al. Robust cellular reprogramming occurs spontaneously during liver regeneration Genes Dev 27 2013 719 724
32. B. Fan, Y. Malato, D.F. Calvisi, S. Naqvi, N. Razumilava, S. Ribback, and et al. Cholangiocarcinomas can originate from hepatocytes in mice J Clin Invest 122 2012 2911 2915
33. B.D. Tarlow, C. Pelz, W.E. Naugler, L. Wakefield, E.M. Wilson, M.J. Finegold, and et al. Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes Cell Stem Cell 15 2014 605 618
34. G.T. Gurda, Q. Zhu, H. Bai, D. Pan, K.B. Schwarz, and R.A. Anders The use of Yes-associated protein expression in the diagnosis of persistent neonatal cholestatic liver disease Hum Pathol 45 2014 1057 1064
35. C. Wang, L. Zhang, Q. He, X. Feng, J. Zhu, Z. Xu, and et al. Differences in Yes-associated protein and mRNA levels in regenerating liver and hepatocellular carcinoma Mol Med Rep 5 2012 410 414
36. H. Wu, Y. Xiao, S. Zhang, S. Ji, L. Wei, F. Fan, and et al. The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense Cell Rep 3 2013 1663 1677
37. J.L. Grijalva, M. Huizenga, K. Mueller, S. Rodriguez, J. Brazzo, F. Camargo, and et al. Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration Am J Physiol Gastrointest Liver Physiol 307 2014 G196 G204
38. Y. Sato, S. Koyama, K. Tsukada, and K. Hatakeyama Acute portal hypertension reflecting shear stress as a trigger of liver regeneration following partial hepatectomy Surg Today 27 1997 518 526
39. S. Dupont, L. Morsut, M. Aragona, E. Enzo, S. Giulitti, M. Cordenonsi, and et al. Role of YAP/TAZ in mechanotransduction Nature 474 2011 179 183
40. M. Aragona, T. Panciera, A. Manfrin, S. Giulitti, F. Michielin, N. Elvassore, and et al. A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors Cell 154 2013 1047 1059
41. S. Porazinski, H. Wang, Y. Asaoka, M. Behrndt, T. Miyamoto, H. Morita, and et al. YAP is essential for tissue tension to ensure vertebrate 3D body shape Nature 521 2015 217 221
42. K. Schlegelmilch, M. Mohseni, O. Kirak, J. Pruszak, J.R. Rodriguez, D. Zhou, and et al. Yap1 acts downstream of alpha-catenin to control epidermal proliferation Cell 144 2011 782 795
43. K.J. Herr, Y.H. Tsang, J.W. Ong, Q. Li, L.L. Yap, W. Yu, and et al. Loss of alpha-catenin elicits a cholestatic response and impairs liver regeneration Sci Rep 4 2014 1 11
44. M. Mohseni, J. Sun, A. Lau, S. Curtis, J. Goldsmith, V.L. Fox, and et al. A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway Nat Cell Biol 16 2014 108 117
45. A.F. Baas, L. Smit, and H. Clevers LKB1 tumor suppressor protein: PARtaker in cell polarity Trends Cell Biol 14 2004 312 319
46. T. Yamanaka, and S. Ohno Role of Lgl/Dlg/Scribble in the regulation of epithelial junction, polarity and growth Front Biosci 13 2008 6693 6707
47. H.B. Nguyen, J.T. Babcock, C.D. Wells, and L.A. Quilliam LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap Oncogene 32 2013 4100 4109
48. S.W. Chan, C.J. Lim, Y.F. Chong, A.V. Pobbati, C. Huang, and W. Hong Hippo pathway-independent restriction of TAZ and YAP by angiomotin J Biol Chem 286 2011 7018 7026
49. B. Zhao, L. Li, Q. Lu, L.H. Wang, C.Y. Liu, Q. Lei, and et al. Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein Genes Dev 25 2011 51 63
50. W. Wang, J. Huang, and J. Chen Angiomotin-like proteins associate with and negatively regulate YAP1 J Biol Chem 286 2011 4364 4370
51. C. Yi, Z. Shen, A. Stemmer-Rachamimov, N. Dawany, S. Troutman, L.C. Showe, and et al. The p130 isoform of angiomotin is required for Yap-mediated hepatic epithelial cell proliferation and tumorigenesis Sci Signal 6 2013 1 12
52. N. Hohmann, W. Weiwei, U. Dahmen, O. Dirsch, A. Deutsch, and A. Voss-Bohme How does a single cell know when the liver has reached its correct size? PLoS One 9 2014 1 15
53. E. Miller, J. Yang, M. DeRan, C. Wu, A.I. Su, G.M. Bonamy, and et al. Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP Chem Biol 19 2012 955 962
54. F.X. Yu, B. Zhao, N. Panupinthu, J.L. Jewell, I. Lian, L.H. Wang, and et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling Cell 150 2012 780 791
55. J.S. Mo, F.X. Yu, R. Gong, J.H. Brown, and K.L. Guan Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs) Genes Dev 26 2012 2138 2143
56. W. Huang, K. Ma, J. Zhang, M. Qatanani, J. Cuvillier, J. Liu, and et al. Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration Science 312 2006 233 236
57. S. Anakk, M. Bhosale, V.A. Schmidt, R.L. Johnson, M.J. Finegold, and D.D. Moore Bile acids activate YAP to promote liver carcinogenesis Cell Rep 5 2013 1060 1069
58. A. Vassilev, K.J. Kaneko, H. Shu, Y. Zhao, and M.L. DePamphilis TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm Genes Dev 15 2001 1229 1241
59. M. Ota, and H. Sasaki Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling Development 135 2008 4059 4069
60. S. Wu, Y. Liu, Y. Zheng, J. Dong, and D. Pan The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway Dev Cell 14 2008 388 398
61. L. Zhang, F. Ren, Q. Zhang, Y. Chen, B. Wang, and J. Jiang The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control Dev Cell 14 2008 377 387
62. B. Zhao, X. Ye, J. Yu, L. Li, W. Li, S. Li, and et al. TEAD mediates YAP-dependent gene induction and growth control Genes Dev 22 2008 1962 1971
63. B. Zhao, J. Kim, X. Ye, Z. Lai, and K. Guan Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein Cancer Res 69 2009 1089 1098
64. N. Nishioka, K. Inoue, K. Adachi, H. Kiyonari, and M. Ota The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass Dev Cell 16 2009 398 410
65. S. Jiao, H. Wang, Z. Shi, A. Dong, W. Zhang, X. Song, and et al. A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer Cancer Cell 25 2014 166 180
66. W. Zhang, Y. Gao, P. Li, Z. Shi, T. Guo, F. Li, and et al. VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex Cell Res 24 2014 331 343
67. S. Strano, E. Munarriz, M. Rossi, and L. Castagnoli Physical interaction with Yes-associated protein enhances p73 transcriptional activity J Biol Chem 276 2001 15164 15173
68. A. Komuro, M. Nagai, N.E. Navin, and M. Sudol WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus J Biol Chem 2003 33334 33341
69. M. Imajo, M. Ebisuya, and E. Nishida Dual role of YAP and TAZ in renewal of the intestinal epithelium Nat Cell Biol 17 2015 7 19
70. A. Kapoor, W. Yao, H. Ying, S. Hua, A. Liewen, Q. Wang, and et al. Yap1 activation enables bypass of oncogenic kras addiction in pancreatic cancer Cell 158 2014 185 197
71. T. Rayon, S. Menchero, A. Nieto, P. Xenopoulos, M. Crespo, K. Cockburn, and et al. Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst Dev Cell 30 2014 410 422
72. D.D. Shao, W. Xue, E.B. Krall, A. Bhutkar, F. Piccioni, X. Wang, and et al. KRAS and YAP1 Converge to Regulate EMT and Tumor Survival Cell 158 2014 171 184
73. J.J. Hofmann, A.C. Zovein, H. Koh, F. Radtke, G. Weinmaster, and M.L. Iruela-Arispe Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome Development 137 2010 4061 4072
74. Y. Zong, A. Panikkar, J. Xu, A. Antoniou, P. Raynaud, F. Lemaigre, and et al. Notch signaling controls liver development by regulating biliary differentiation Development 136 2009 1727 1739
75. F. Geisler, and M. Strazzabosco Emerging roles of Notch signaling in liver disease Hepatology 61 2015 382 392
76. D.F. Tschaharganeh, X. Chen, P. Latzko, M. Malz, M.M. Gaida, K. Felix, and et al. Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma Gastroenterology 144 2013 e1512
77. H. Clevers, K.M. Loh, and R. Nusse Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control Science 346 2014 1248012
78. E.R. Barry, T. Morikawa, B.L. Butler, K. Shrestha, R. de la Rosa, K.S. Yan, and et al. Restriction of intestinal stem cell expansion and the regenerative response by YAP Nature 493 2013 106 110
79. T. Heallen, M. Zhang, J. Wang, M. Bonilla-Claudio, E. Klysik, R.L. Johnson, and et al. Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size Science 332 2011 458 461
80. J. Rosenbluh, D. Nijhawan, A.G. Cox, X. Li, J.T. Neal, E.J. Schafer, and et al. Beta-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis Cell 151 2012 1457 1473
81. L. Azzolin, T. Panciera, S. Soligo, E. Enzo, S. Bicciato, S. Dupont, and et al. YAP/TAZ incorporation in the beta-catenin destruction complex orchestrates the Wnt response Cell 158 2014 157 170
82. M. Overholtzer, J. Zhang, G.A. Smolen, B. Muir, W. Li, D.C. Sgroi, and et al. Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon Proc Natl Acad Sci USA 103 2006 12405 12410
83. L. Zender, M.S. Spector, W. Xue, P. Flemming, C. Cordon-Cardo, J. Silke, and et al. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach Cell 2006 1253 1267
84. M. Overholtzer, J. Zhang, and G. Smolen Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon Proc Natl Acad Sci USA 103 2006 12405 12410
85. A.A. Steinhardt, M.F. Gayyed, A.P. Klein, J. Dong, A. Maitra, D. Pan, and et al. Expression of Yes-associated protein in common solid tumors Hum Pathol 39 2008 1582 1589
86. J.M. Kim, D.W. Kang, L.Z. Long, S.M. Huang, M.K. Yeo, E.S. Yi, and et al. Differential expression of Yes-associated protein is correlated with expression of cell cycle markers and pathologic TNM staging in non-small-cell lung carcinoma Hum Pathol 42 2011 315 323
87. X. Zhang, J. George, S. Deb, J.L. Degoutin, E.A. Takano, S.B. Fox, and et al. The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene Oncogene 30 2011 2810 2822
88. C.A. Hall, R. Wang, J. Miao, E. Oliva, X. Shen, T. Wheeler, and et al. Hippo pathway effector Yap is an ovarian cancer oncogene Cancer Res 70 2010 8517 8525
89. A. Fernandez-L, P.A. Northcott, J. Dalton, C. Fraga, D. Ellison, S. Angers, and et al. YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation Genes Dev 2009 2729 2741
90. T. Zhang, J. Zhang, X. You, Q. Liu, Y. Du, Y. Gao, and et al. Hepatitis B virus X protein modulates oncogene Yes-associated protein by CREB to promote growth of hepatoma cells Hepatology 56 2012 2051 2059
91. M.Z. Xu, T.-J. Yao, N.P.Y. Lee, I.O.L. Ng, Y.-T. Chan, L. Zender, and et al. Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma Cancer 2009 4576 4585
92. A.A. Steinhardt, M.F. Gayyed, A.P. Klein, J. Dong, A. Maitra, D. Pan, and et al. Expression of Yes-associated protein in common solid tumors Hum Pathol 2008 1 8
93. T. Pei, Y. Li, J. Wang, H. Wang, Y. Liang, H. Shi, and et al. YAP is a critical oncogene in human cholangiocarcinoma Oncotarget 2015 1 15
94. A. Perra, M.A. Kowalik, E. Ghiso, G.M. Ledda-Columbano, L. Di Tommaso, M.M. Angioni, and et al. YAP activation is an early event and a potential therapeutic target in liver cancer development J Hepatol 61 2014 1088 1096
95. U. Ehmer, A.F. Zmoos, R.K. Auerbach, D. Vaka, A.J. Butte, M.A. Kay, and et al. Organ size control is dominant over Rb family inactivation to restrict proliferation in vivo Cell Rep 8 2014 371 381
96. H. Chen, L. Mei, L. Zhou, X. Zhang, C. Guo, J. Li, and et al. Moesin-ezrin-radixin-like protein (merlin) mediates protein interacting with the carboxyl terminus-1 (PICT-1)-induced growth inhibition of glioblastoma cells in the nucleus Int J Biochem Cell Biol 43 2011 545 555
97. G. Guo, J. Chmielecki, C. Goparaju, A. Heguy, I. Dolgalev, M. Carbone, and et al. Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma Cancer Res 75 2015 264 269
98. G.L. Dalgliesh, K. Furge, C. Greenman, L. Chen, G. Bignell, A. Butler, and et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes Nature 463 2010 360 363
99. K.A. Morrow, S. Das, B.J. Metge, K. Ye, M.S. Mulekar, J.A. Tucker, and et al. Loss of tumor suppressor Merlin in advanced breast cancer is due to post-translational regulation J Biol Chem 286 2011 40376 40385
100. C. Armengol, S. Cairo, M. Fabre, and M.A. Buendia Wnt signaling and hepatocarcinogenesis: the hepatoblastoma model Int J Biochem Cell Biol 43 2011 265 270
101. K.N. Nejak-Bowen, and S.P. Monga Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad Semin Cancer Biol 21 2011 44 58
102. J. Wang, J.S. Park, Y. Wei, M. Rajurkar, J.L. Cotton, Q. Fan, and et al. TRIB2 acts downstream of Wnt/TCF in liver cancer cells to regulate YAP and C/EBPalpha function Mol Cell 51 2013 211 225
103. J. Tao, D.F. Calvisi, S. Ranganathan, A. Cigliano, L. Zhou, S. Singh, and et al. Activation of beta-catenin and Yap1 in human hepatoblastoma and induction of hepatocarcinogenesis in mice Gastroenterology 147 2014 690 701
104. D. Yamada, S. Rizvi, N. Razumilava, S.F. Bronk, J.I. Davila, M.D. Champion, and et al. IL-33 facilitates oncogene-induced cholangiocarcinoma in mice by an interleukin-6-sensitive mechanism Hepatology 61 2015 1627 1642
105. M. Nishio, K. Hamada, K. Kawahara, M. Sasaki, F. Noguchi, S. Chiba, and et al. Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice J Clin Invest 122 2012 4505 4518
106. S. Li, and M. Mao Next generation sequencing reveals genetic landscape of hepatocellular carcinomas Cancer Lett 340 2013 247 253
107. T. Shibata, and H. Aburatani Exploration of liver cancer genomes Nat Rev Gastroenterol Hepatol 11 2014 340 349
108. Y. Liu-Chittenden, B. Huang, J.S. Shim, Q. Chen, S.J. Lee, R.A. Anders, and et al. Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP Genes Dev 26 2012 1300 1305
109. J. Fitamant, F. Kottakis, S. Benhamouche, H.S. Tian, N. Chuvin, C.A. Parachoniak, and et al. YAP inhibition restores hepatocyte differentiation in advanced HCC, leading to tumor regression Cell Rep 10 2015 1692 1707
110. T. Guo, Y. Lu, P. Li, M.X. Yin, D. Lv, W. Zhang, and et al. A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity Cell Res 23 2013 1201 1214
111. L.M. Koontz, Y. Liu-Chittenden, F. Yin, Y. Zheng, J. Yu, B. Huang, and et al. The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression Dev Cell 25 2013 388 401
112. N.J. Ganem, H. Cornils, S.Y. Chiu, K.P. O'Rourke, J. Arnaud, D. Yimlamai, and et al. Cytokinesis failure triggers hippo tumor suppressor pathway activation Cell 158 2014 833 848