Activation of telomerase by seminal plasma in malignant and normal cervical epithelial cells

Journal of Pathology

Volumn 225, Issue 2, 2011, Pages 203-211

  Liu, Li ^a,b,c   Liu, Cheng ^b,c   Lou, Fenglan ^a   Zhang, Guiyu ^c   Wang, Xizhi ^c   Fan, Yidong ^c   Yan, Keqiang ^c   Wang, Kun ^c   Xu, Zhonghua ^c   Hu, Sanyuan ^c   Björkholm, Magnus ^b   Xu, Dawei ^b,d  

^a SHANDONG UNIVERSITY   (China)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c SHANDONG UNIVERSITY   (China)

^d Second Hospital   (China)

Author keywords

cervical cancer; hTERT; seminal fluids; telomerase

Indexed keywords

CYCLOOXYGENASE 2; MESSENGER RNA; MYC PROTEIN; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN; PROSTAGLANDIN E2; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EPITHELIUM CELL; FEMALE; GENE ACTIVITY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HELA CELL; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; SEMINAL PLASMA; TUMOR GROWTH; UTERINE CERVIX EPITHELIUM;

ANIMALS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; CERVIX UTERI; CYCLOOXYGENASE 2; DINOPROSTONE; ENZYME ACTIVATION; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOBLOTTING; MALE; MICE; MICE, NUDE; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEMEN; SP1 TRANSCRIPTION FACTOR; TELOMERASE; UTERINE CERVICAL NEOPLASMS;

EID: 80052475039     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2914     Document Type: Article

References (57)

1. Long HJ III, Laack NN, Gostout BS,. Prevention, diagnosis, and treatment of cervical cancer. Mayo Clin Proc 2007; 82: 1566-1574. (Pubitemid 350211707)
2. Beral V, Hermon C, Munoz N, et al., Cervical cancer. Cancer Surv 1994; 19-20: 265-285. (Pubitemid 24289389)
3. zur Hausen H,. Papillomaviruses in the causation of human cancers-a brief historical account. Virology 2009; 384: 260-265.
4. Thierry F,. Transcriptional regulation of the papillomavirus oncogenes by cellular and viral transcription factors in cervical carcinoma. Virology 2009; 384: 375-379.
5. Cheng YW, Wu TC, Chen CY, et al., Human telomerase reverse transcriptase activated by E6 oncoprotein is required for human papillomavirus-16/18-infected lung tumorigenesis. Clin Cancer Res 2008; 14: 7173-7179.
6. zur Hausen H,. Immortalization of human cells and their malignant conversion by high risk human papillomavirus genotypes. Semin Cancer Biol 1999; 9: 405-411. (Pubitemid 30184510)
7. Bailie R, Barron P, Learmonth G,. Towards a rational cervical cytology screening strategy. Case study of a peri-urban settlement. S Afr Med J 1995; 85: 30-33.
8. Muller M, Sales KJ, Katz AA, et al., Seminal plasma promotes the expression of tumorigenic and angiogenic genes in cervical adenocarcinoma cells via the E-series prostanoid 4 receptor. Endocrinology 2006; 147: 3356-3365. (Pubitemid 43901127)
9. Sales KJ, Katz AA, Millar RP, et al., Seminal plasma activates cyclooxygenase-2 and prostaglandin E2 receptor expression and signalling in cervical adenocarcinoma cells. Mol Hum Reprod 2002; 8: 1065-1070. (Pubitemid 36032843)
10. Jeremias J, Witkin SS,. Effect of human seminal fluid on production of messenger ribonucleic acid for metalloproteinase 2 and metalloproteinase 9 in cervical epithelial carcinoma cells. Am J Obstet Gynecol 1999; 181: 591-595. (Pubitemid 29453517)
11. Battersby S, Sales KJ, Williams AR, et al., Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase pathway. Hum Reprod 2007; 22: 36-44. (Pubitemid 44942664)
12. Cong YS, Wright WE, Shay JW,. Human telomerase and its regulation. Microbiol Mol Biol Rev 2002; 66: 407-425. (Pubitemid 35001137)
13. Kyo S, Inoue M,. Complex regulatory mechanisms of telomerase activity in normal and cancer cells: how can we apply them for cancer therapy? Oncogene 2002; 21: 688-697. (Pubitemid 34146272)
14. Liu JP,. Studies of the molecular mechanisms in the regulation of telomerase activity. FASEB J 1999; 13: 2091-2104.
15. Shay JW, Keith WN,. Targeting telomerase for cancer therapeutics. Br J Cancer 2008; 98: 677-683. (Pubitemid 351272604)
16. Liu L, Lai S, Andrews LG, et al., Genetic and epigenetic modulation of telomerase activity in development and disease. Gene 2004; 340: 1-10. (Pubitemid 39360227)
17. Kelland L,. Targeting the limitless replicative potential of cancer: the telomerase/telomere pathway. Clin Cancer Res 2007; 13: 4960-4963. (Pubitemid 47502059)
18. Liu X, Dakic A, Chen R, et al., Cell-restricted immortalization by human papillomavirus correlates with telomerase activation and engagement of the hTERT promoter by Myc. J Virol 2008; 82: 11568-11576.
19. Klingelhutz AJ, Foster SA, McDougall JK,. Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature 1996; 380: 79-82. (Pubitemid 26076241)
20. Kumakura S, Tsutsui TW, Yagisawa J, et al., Reversible conversion of immortal human cells from telomerase-positive to telomerase-negative cells. Cancer Res 2005; 65: 2778-2786. (Pubitemid 40490080)
21. Liu X, Disbrow GL, Yuan H, et al., Myc and human papillomavirus type 16 E7 genes cooperate to immortalize human keratinocytes. J Virol 2007; 81: 12689-12695. (Pubitemid 350085884)
22. Feng J, Funk WD, Wang SS, et al., The RNA component of human telomerase. Science 1995; 269: 1236-1241.
23. Zhang A, Wang J, Zheng B, et al., Telomere attrition predominantly occurs in precursor lesions during in vivo carcinogenic process of the uterine cervix. Oncogene 2004; 23: 7441-7447. (Pubitemid 39382147)
24. Anderson S, Shera K, Ihle J, et al., Telomerase activation in cervical cancer. Am J Pathol 1997; 151: 25-31. (Pubitemid 27283953)
25. Bravaccini S, Sanchini MA, Amadori A, et al., Potential of telomerase expression and activity in cervical specimens as a diagnostic tool. J Clin Pathol 2005; 58: 911-914. (Pubitemid 41265273)
26. Kyo S, Kanaya T, Ishikawa H, et al., Telomerase activity in gynecological tumors. Clin Cancer Res 1996; 2: 2023-2028. (Pubitemid 27006635)
27. Mutirangura A, Sriuranpong V, Termrunggraunglert W, et al., Telomerase activity and human papillomavirus in malignant, premalignant and benign cervical lesions. Br J Cancer 1998; 78: 933-939. (Pubitemid 28430024)
28. Pao CC, Tseng CJ, Lin CY, et al., Differential expression of telomerase activity in human cervical cancer and cervical intraepithelial neoplasia lesions. J Clin Oncol 1997; 15: 1932-1937. (Pubitemid 27209523)
29. Sagawa Y, Nishi H, Isaka K, et al., The correlation of TERT expression with c-myc expression in cervical cancer. Cancer Lett 2001; 168: 45-50. (Pubitemid 32463911)
30. Snijders PJ, van Duin M, Walboomers JM, et al., Telomerase activity exclusively in cervical carcinomas and a subset of cervical intraepithelial neoplasia grade III lesions: strong association with elevated messenger RNA levels of its catalytic subunit and high-risk human papillomavirus DNA. Cancer Res 1998; 58: 3812-3818. (Pubitemid 28405635)
31. Wisman GB, Hollema H, de Jong S, et al., Telomerase activity as a biomarker for (pre)neoplastic cervical disease in scrapings and frozen sections from patients with abnormal cervical smear. J Clin Oncol 1998; 16: 2238-2245. (Pubitemid 28265063)
32. Wisman GB, Knol AJ, Helder MN, et al., Telomerase in relation to clinicopathologic prognostic factors and survival in cervical cancer. Int J Cancer 2001; 91: 658-664. (Pubitemid 32115261)
33. Zhang A, Zheng C, Hou M, et al., Amplification of the telomerase reverse transcriptase (hTERT) gene in cervical carcinomas. Genes Chromosomes Cancer 2002; 34: 269-275. (Pubitemid 34553305)
34. Zheng PS, Iwasaka T, Yokoyama M, et al., Telomerase activation in in vitro and in vivo cervical carcinogenesis. Gynecol Oncol 1997; 66: 222-226. (Pubitemid 27335407)
35. Li Y, Liu L, Tollefsbol TO,. Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression. FASEB J 2010; 24: 1442-1453.
36. Zeng J, Wang L, Li Q, et al., FoxM1 is up-regulated in gastric cancer and its inhibition leads to cellular senescence, partially dependent on p27 kip1. J Pathol 2009; 218: 419-427.
37. Cassar L, Li H, Pinto AR, et al., Bone morphogenetic protein-7 inhibits telomerase activity, telomere maintenance, and cervical tumor growth. Cancer Res 2008; 68: 9157-9166.
38. Veldman T, Liu X, Yuan H, et al., Human papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoter. Proc Natl Acad Sci USA 2003; 100: 8211-8216. (Pubitemid 36842524)
39. Veldman T, Horikawa I, Barrett JC, et al., Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoprotein. J Virol 2001; 75: 4467-4472. (Pubitemid 32410165)
40. McMurray HR, McCance DJ,. Human papillomavirus type 16 E6 activates TERT gene transcription through induction of c-Myc and release of USF-mediated repression. J Virol 2003; 77: 9852-9861. (Pubitemid 37122066)
41. Zhang A, Zheng C, Lindvall C, et al., Frequent amplification of the telomerase reverse transcriptase gene in human tumors. Cancer Res 2000; 60: 6230-6235.
42. Takakura M, Kyo S, Kanaya T, et al., Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res 1999; 59: 551-557. (Pubitemid 29076049)
43. Kyo S, Takakura M, Taira T, et al., Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT). Nucleic Acids Res 2000; 28: 669-677. (Pubitemid 30068249)
44. Straat K, Liu C, Rahbar A, et al., Activation of telomerase by human cytomegalovirus. J Natl Cancer Inst 2009; 101: 488-497.
45. Munkarah A, Ali-Fehmi R,. COX-2: a protein with an active role in gynecological cancers. Curr Opin Obstet Gynecol 2005; 17: 49-53. (Pubitemid 40315264)
46. Greenhough A, Smartt HJ, Moore AE, et al., The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis 2009; 30: 377-386.
47. Ge Z, Li W, Wang N, et al., Chromatin remodeling: recruitment of histone demethylase RBP2 by Mad1 for transcriptional repression of a Myc target gene, telomerase reverse transcriptase. FASEB J 2010; 24: 579-586.
48. Xu D, Popov N, Hou M, et al., Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells. Proc Natl Acad Sci USA 2001; 98: 3826-3831. (Pubitemid 32249856)
49. Kishimoto Y, Yashima K, Morisawa T, et al., Effects of cyclooxygenase-2 inhibitor NS-398 on APC and c-myc expression in rat colon carcinogenesis induced by azoxymethane. J Gastroenterol 2002; 37: 186-193. (Pubitemid 34296216)
50. Parreno M, Vaque JP, Casanova I, et al., Novel triiodophenol derivatives induce caspase-independent mitochondrial cell death in leukemia cells inhibited by Myc. Mol Cancer Ther 2006; 5: 1166-1175. (Pubitemid 43881308)
51. Singh A, Sharma H, Salhan S, et al., Evaluation of expression of apoptosis-related proteins and their correlation with HPV, telomerase activity, and apoptotic index in cervical cancer. Pathobiology 2004; 71: 314-322. (Pubitemid 40082311)
52. Baoping Y, Guoyong H, Jieping Y, et al., Cyclooxygenase-2 inhibitor nimesulide suppresses telomerase activity by blocking Akt/PKB activation in gastric cancer cell line. Dig Dis Sci 2004; 49: 948-953. (Pubitemid 39012277)
53. Park C, Jung JH, Kim ND, et al., Inhibition of cyclooxygenase-2 and telomerase activities in human leukemia cells by dideoxypetrosynol A, a polyacetylene from the marine sponge Petrosia sp. Int J Oncol 2007; 30: 291-298.
54. Salcedo R, Zhang X, Young HA, et al., Angiogenic effects of prostaglandin E2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells. Blood 2003; 102: 1966-1977. (Pubitemid 37122368)
55. Zheng Y, Ritzenthaler JD, Sun X, et al., Prostaglandin E2 stimulates human lung carcinoma cell growth through induction of integrin-linked kinase: the involvement of EP4 and Sp1. Cancer Res 2009; 69: 896-904.
56. Subbaramaiah K, Dannenberg AJ,. Cyclooxygenase-2 transcription is regulated by human papillomavirus 16 E6 and E7 oncoproteins: evidence of a corepressor/coactivator exchange. Cancer Res 2007; 67: 3976-3985. (Pubitemid 46762188)
57. Singh-Ranger G, Salhab M, Mokbel K,. The role of cyclooxygenase-2 in breast cancer: review. Breast Cancer Res Treat 2008; 109: 189-198. (Pubitemid 351644840)