Enhanced migration and CXCR4 over-expression in fibroblasts with telomerase reconstitution

Molecular and Cellular Biochemistry

Volumn 313, Issue 1-2, 2008, Pages 45-52

  Qu, Yi ^a   Mao, Meng ^a   Li, Xihong ^a   Zhang, Lin ^b   Huang, Xiang ^c   Yang, Chunlei ^b   Zhao, Fengyang ^a   Xiong, Ying ^a   Mu, Dezhi ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c SICHUAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Cell migration; CXCR4; Human fibroblasts; Telomerase

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; PROTEIN CDC42; RAC PROTEIN; RHO FACTOR; TELOMERASE;

ARTICLE; CELL MIGRATION; CELL STIMULATION; CELL THERAPY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME RECONSTITUTION; ENZYME REGULATION; FIBROBLAST CULTURE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; METABOLIC ACTIVATION; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; UPREGULATION;

CDC42 GTP-BINDING PROTEIN; CELL MOVEMENT; CELL PROLIFERATION; CHEMOKINE CXCL12; COLLAGEN TYPE I; ENZYME ACTIVATION; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; MALE; NF-E2-RELATED FACTOR 1; RAC GTP-BINDING PROTEINS; RECEPTORS, CXCR4; RHO GTP-BINDING PROTEINS; RNA, MESSENGER; TELOMERASE; VIMENTIN; WOUND HEALING;

EID: 44449102571     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-008-9740-6     Document Type: Article

References (14)

1. Bodnar AG, Ouellette M, Frolkis M et al (1998) Extension of life-span by introduction of telomerase into normal human cells. Science 279:349-352
2. Shay JW, Wright WE (2005) Use of telomerase to create bioengineered tissues. Ann N Y Acad Sci 1057:479-491
3. Murasawa S, Llevadot J, Silver M et al (2002) Constitutive human telomerase reverse transcriptase expression enhances regenerative properties of endothelial progenitor cells. Circulation 106:1133-1139
4. Sato N, Maehara N, Mizumoto K et al (2001) Telomerase activity of cultured human pancreatic carcinoma cell lines correlates with their potential for migration and invasion. Cancer 91:496-504
5. Claps CM, Corcoran KE, Cho KJ et al (2005) Stromal derived growth factor-1alpha as a beacon for stem cell homing in development and injury. Curr Neurovasc Res 2:319-329
6. Busillo JM, Benovic JL (2007) Regulation of CXCR4 signaling. Biochim Biophys Acta 1768:952-963
7. Caruz A, Samsom M, Alonso JM et al (1998) Genomic organization and promoter characterization of human CXCR4 gene. FEBS Lett 426:271-278
8. Wegner SA, Ehrenberg PK, Chang G et al (1998) Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1. J Biol Chem 273:4754-4760
9. 13-Rho signaling axis is required for SDF-1-induced migration through CXCR4. J Biol Chem 28:39542-39549
10. Xie HQ, Yang ZM, Qu Y (2002) Culture of human fibroblasts transfected by human telomerase reverse transcriptase eukaryotic expression plasmid pGRN145 and their biological characteristics in vitro (in Chinese). Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 16:195-199
11. Strutz F, Okada H, Lo CW et al (1995) Identification and characterization of a fibroblast marker: FSP1. J Cell Biol 130:393-405
12. Bagheri S, Nosrati M, Li S et al (2006) Genes and pathways downstream of telomerase in melanoma metastasis. Proc Natl Acad Sci U S A 103:11306-11311
13. Ridley AJ, Schwartz MA, Burridge K et al (2003) Cell migration: integrating signals from front to back. Science 302:1704-1709
14. Nobes CD, Hall A (1995) Rho, rac and Cdc42 GTPases: Regulators of actin structures, cell adhesion and motility. Biochem Soc Trans 23:456-459