Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen

Science

Volumn 349, Issue 6244, 2015, Pages 156-161

  Jardine, Joseph G ^a   Ota, Takayuki ^a   Sok, Devin ^a   Pauthner, Matthias ^a   Kulp, Daniel W ^a   Kalyuzhniy, Oleksandr ^a   Skog, Patrick D ^a   Thinnes, Theresa C ^a   Bhullar, Deepika ^a   Briney, Bryan ^a   Menis, Sergey ^a   Jones, Meaghan ^a   Kubitz, Mike ^a   Spencer, Skye ^a   Adachi, Yumiko ^a   Burton, Dennis R ^a,b   Schief, William R ^a,b   Nemazee, David ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; EPITOPE; GLYCOPROTEIN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; NEUTRALIZING ANTIBODY; COMPLEMENTARITY DETERMINING REGION; GLYCOPROTEIN GP 120; GP120 PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN; MONOCLONAL ANTIBODY; VRC01 MONOCLONAL ANTIBODY;

ANTIBODY; GENE EXPRESSION; GENETIC ENGINEERING; GERM CELL; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE SYSTEM; MATURATION; MUTATION; PROTEIN; RODENT; VACCINE;

ANTIBODY RESPONSE; ARTICLE; BINDING AFFINITY; COMPLEMENTARITY DETERMINING REGION; CROSS REACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HEAVY CHAIN; HUMAN IMMUNODEFICIENCY VIRUS 1; MOUSE; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; SOMATIC MUTATION; VIRUS ENVELOPE; ANIMAL; ANTIBODY AFFINITY; B LYMPHOCYTE; BIOSYNTHESIS; GENETICS; HIV INFECTIONS; IMMUNOLOGY; KNOCKOUT MOUSE;

HUMAN IMMUNODEFICIENCY VIRUS 1; MUS;

AIDS VACCINES; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIBODY AFFINITY; B-LYMPHOCYTES; COMPLEMENTARITY DETERMINING REGIONS; EPITOPES; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; IMMUNOGLOBULIN HEAVY CHAINS; MICE; MICE, KNOCKOUT;

EID: 84934954773     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aac5894     Document Type: Article

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