Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers

Biochemistry

Volumn 54, Issue 49, 2015, Pages 7212-7221

  Najumudeen, Arafath K ^a   Posada, Itziar M D ^a   Lectez, Benoit ^a   Zhou, Yong ^b   Landor, Sebastian K J ^a,c   Fallarero, Adyary ^d   Vuorela, Pia ^d   Hancock, John ^b   Abankwa, Daniel ^a  

^a ÅBO AKADEMI UNIVERSITY   (Finland)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CELL MEMBRANES; CELLS; CYTOLOGY; DIAGNOSIS; DISEASES; NANOCLUSTERS; PROTEINS; STEM CELLS; SYNTHESIS (CHEMICAL); TUMORS;

BREAST CANCER CELLS; CANCER STEM CELLS; CYCLOHEXIMIDES; FARNESYL TRANSFERASE INHIBITORS; NATURAL PRODUCT LIBRARIES; PHENOTYPIC SCREENING; PROTEIN SYNTHESIS; REPRESENTATIVE COMPOUND;

CELL SIGNALING;

CYCLOHEXIMIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NATURAL PRODUCT; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN KINASE B; PROTEIN SYNTHESIS INHIBITOR; HRAS PROTEIN, HUMAN; HRAS PROTEIN, RAT; MITOGEN ACTIVATED PROTEIN KINASE; ONCOPROTEIN; PROTEIN P21; RAS PROTEIN;

ANIMAL CELL; ARTICLE; BREAST CANCER; CANCER CELL; CANCER GROWTH; CANCER STEM CELL; CONTROLLED STUDY; DRUG SCREENING; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; ONCOGENE H RAS; PEPTIDE LIBRARY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; AMINO ACID SUBSTITUTION; ANIMAL; CELL MEMBRANE; CELL TRANSFORMATION; CHEMICALLY INDUCED; DRUG EFFECTS; GENETICS; HAMSTER; HEK293 CELL LINE; KNOCKOUT MOUSE; METABOLISM; MISSENSE MUTATION; NEOPLASM; PATHOLOGY; PC12 CELL LINE; RAT; SIGNAL TRANSDUCTION;

AMINO ACID SUBSTITUTION; ANIMALS; CELL MEMBRANE; CELL TRANSFORMATION, NEOPLASTIC; CRICETINAE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEK293 CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; MUTATION, MISSENSE; NEOPLASMS; ONCOGENE PROTEINS; PC12 CELLS; PROTEIN SYNTHESIS INHIBITORS; PROTO-ONCOGENE PROTEINS P21(RAS); RAS PROTEINS; RATS;

EID: 84950148630     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b00724     Document Type: Article

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