The APP intracellular domain is required for normalsynaptic morphology, synaptic plasticity, and hippocampus-dependent behavior

Journal of Neuroscience

Volumn 35, Issue 49, 2015, Pages 16018-16033

  Klevanski, Maja ^a   Herrmann, Ulrike ^b   Weyer, Sascha W ^a   Fol, Romain ^c,d   Cartier, Nathalie ^c   Wolfer, Xdavid P ^e   Caldwell, John H ^f   Korte, Martin ^b,g   Müller, Ulrike C ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^c INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e UNIVERSITY OF ZURICH   (Switzerland)

^f UNIVERSITY OF COLORADO   (United States)

^g HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

Alzheimer s disease; Amyloid precursor protein; Behavior; Knockin; Signaling; Synaptogenesis

Indexed keywords

ARTICLE; AUDITORY STIMULATION; ELECTROENCEPHALOGRAPHY; EVENT RELATED POTENTIAL; EVOKED BRAIN STEM AUDITORY RESPONSE; FEMALE; HEARING; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; OSCILLATION; PERCEPTION; PRIORITY JOURNAL; PSYCHOMETRY; PSYCHOPHYSIOLOGY; RESPONSE TIME; TASK PERFORMANCE; WORKING MEMORY; ALZHEIMER DISEASE; ANIMAL; ANIMAL BEHAVIOR; C57BL MOUSE; COMPLICATION; DISEASE MODEL; EXCITATORY POSTSYNAPTIC POTENTIAL; EXPLORATORY BEHAVIOR; GENETICS; HIPPOCAMPUS; MAZE TEST; METABOLISM; MOUSE; MUSCLE STRENGTH; MUTATION; NERVE CELL PLASTICITY; NERVE CONDUCTION; PATHOLOGY; PATHOPHYSIOLOGY; PHRENIC NERVE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SYNAPSE; TRANSGENIC MOUSE;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APLP2 PROTEIN, MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; DISEASE MODELS, ANIMAL; EXCITATORY POSTSYNAPTIC POTENTIALS; EXPLORATORY BEHAVIOR; HIPPOCAMPUS; HOMING BEHAVIOR; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUSCLE STRENGTH; MUTATION; NEURAL CONDUCTION; NEURONAL PLASTICITY; PHRENIC NERVE; PROTEIN STRUCTURE, TERTIARY; SYNAPSES;

EID: 84949599741     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2009-15.2015     Document Type: Article

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