AID induces intraclonal diversity and genomic damage in CD86+ chronic lymphocytic leukemia cells

European Journal of Immunology

Volumn 44, Issue 12, 2014, Pages 3747-3757

  Huemer, Michael ^a   Rebhandl, Stefan ^a   Zaborsky, Nadja ^a   Gassner, Franz J ^a   Hainzl, Stefan ^a   Weiss, Lukas ^a   Hebenstreit, Daniel ^b   Greil, Richard ^a   Geisberger, Roland ^a  

^a PARACELSUS MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Activation induced deaminase (AID); CD86; Chronic lymphocytic leukemia (CLL); Clonal evolution; Mutation

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; CD86 ANTIGEN; HISTONE H2AX; IMMUNOGLOBULIN M; AICDA (ACTIVATION-INDUCED CYTIDINE DEAMINASE); CD86 PROTEIN, HUMAN; CYTIDINE DEAMINASE; H2AFX PROTEIN, HUMAN; HISTONE; IMMUNOGLOBULIN MU CHAIN; TUMOR PROTEIN;

AMPLICON; ANTIGEN EXPRESSION; ARTICLE; CD86 POSITIVE CHRONIC LYMPHOCYTIC LEUKEMIA; CELL FRACTIONATION; CELL PROLIFERATION; CHRONIC LYMPHATIC LEUKEMIA; CLONAL EVOLUTION; CONTROLLED STUDY; DISEASE COURSE; DNA DAMAGE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENETIC HETEROGENEITY; HUMAN; IMMUNOGLOBULIN GENE; IN VIVO STUDY; INTRACLONAL DIVERSITY; PRIORITY JOURNAL; CLINICAL TRIAL; FEMALE; GENE EXPRESSION REGULATION; IMMUNOGLOBULIN HEAVY CHAIN GENE; IMMUNOLOGY; MALE; PATHOLOGY;

ANTIGENS, CD86; CELL PROLIFERATION; CYTIDINE DEAMINASE; DNA DAMAGE; FEMALE; GENE EXPRESSION REGULATION, LEUKEMIC; GENES, IMMUNOGLOBULIN HEAVY CHAIN; HISTONES; HUMANS; IMMUNOGLOBULIN MU-CHAINS; IMMUNOGLOBULIN SWITCH REGION; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; NEOPLASM PROTEINS;

EID: 84924302041     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201344421     Document Type: Article

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