Analysis of Ig gene hypermutation in Ung-/-Polh-/- mice suggests that UNG and A:T mutagenesis pathway target different U:G lesions

Molecular Immunology

Volumn 53, Issue 3, 2013, Pages 214-217

  Li, Shuyin ^a,b   Zhao, Yaofeng ^a   Wang, Ji Yang ^b  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b RIKEN YOKOHAMA INSTITUTE   (Japan)

Author keywords

Activation induced cytidine deaminase; Cell cycle; DNA polymerase ; Immunoglobulin gene hypermutation; Uracil DNA glycosylase

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; ADENINE; DNA POLYMERASE; GUANINE; THYMINE; URACIL; URACIL DNA GLYCOSIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME DEFICIENCY; ENZYME MECHANISM; GENE MUTATION; GENETIC MODEL; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN GENE HYPERMUTATION; KNOCKOUT MOUSE; MISMATCH REPAIR; MOUSE; MUTAGENESIS; MUTATION RATE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; WILD TYPE;

ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; CYTIDINE DEAMINASE; DNA MISMATCH REPAIR; DNA PRIMERS; DNA-DIRECTED DNA POLYMERASE; G1 PHASE; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, GENETIC; MODELS, IMMUNOLOGICAL; S PHASE; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; URACIL-DNA GLYCOSIDASE;

MUS;

EID: 84865663785     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2012.08.009     Document Type: Article

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