Biological and clinical characterization of recurrent 14q deletions in CLL and other mature B-cell neoplasms

British Journal of Haematology

Volumn 151, Issue 1, 2010, Pages 25-36

  Reindl, Lena ^a   Bacher, Ulrike ^b   Dicker, Frank ^a   Alpermann, Tamara ^a   Kern, Wolfgang ^a   Schnittger, Susanne ^a   Haferlach, Torsten ^a   Haferlach, Claudia ^a  

^a MLL MUNICH LEUKEMIA LABORATORY   (Germany)

^b UNIVERSITY OF HAMBURG   (Germany)

Author keywords

14q deletion; chromosome banding analysis; chronic lymphocytic leukaemia; interphase fluorescence in situ hybridization; mature B cell neoplasms

Indexed keywords

ADULT; AGED; ARTICLE; B LYMPHOCYTE; CENTROMERE; CHROMOSOME BANDING PATTERN; CHRONIC LYMPHATIC LEUKEMIA; CYTOGENETICS; FEMALE; FLUORESCENCE; GENE DELETION; GENE PROBE; HUMAN; IMMUNOPHENOTYPING; IN SITU HYBRIDIZATION; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; TELOMERE; CHROMOSOME 14; CHROMOSOME ABERRATION; CHROMOSOME DELETION; FLUORESCENCE IN SITU HYBRIDIZATION; GENETICS; IMMUNOGLOBULIN VARIABLE REGION; MIDDLE AGED; MUTATION; PROLYMPHOCYTIC LEUKEMIA; SURVIVAL; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CHROMOSOME ABERRATIONS; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 14; FEMALE; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LEUKEMIA, PROLYMPHOCYTIC; MALE; MIDDLE AGED; MUTATION; PROGNOSIS; SURVIVAL ANALYSIS;

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN VARIABLE REGION;

EID: 77956837711     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2010.08299.x     Document Type: Article

References (29)

1. Annunziata, C.M., Davis, R.E., Demchenko, Y., Bellamy, W., Gabrea, A., Zhan, F., Lenz, G., Hanamura, I., Wright, G., Xiao, W., Dave, S., Hurt, E.M., Tan, B., Zhao, H., Stephens, O., Santra, M., Williams, D.R., Dang, L., Barlogie, B., Shaughnessy, Jr., J.D., Kuehl, W.M. Staudt, L.M. (2007) Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell, 12, 115 130.
2. Braggio, E., Keats, J.J., Leleu, X., Van, W.S., Jimenez-Zepeda, V.H., Valdez, R., Schop, R.F., Price-Troska, T., Henderson, K., Sacco, A., Azab, F., Greipp, P., Gertz, M., Hayman, S., Rajkumar, S.V., Carpten, J., Chesi, M., Barrett, M., Stewart, A.K., Dogan, A., Bergsagel, P.L., Ghobrial, I.M. Fonseca, R. (2009) Identification of copy number abnormalities and inactivating mutations in two negative regulators of nuclear factor-kappaB signaling pathways in Waldenstrom's macroglobulinemia. Cancer Research, 69, 3579 3588.
3. Buhmann, R., Kurzeder, C., Rehklau, J., Westhaus, D., Bursch, S., Hiddemann, W., Haferlach, T., Hallek, M. Schoch, C. (2002) CD40L stimulation enhances the ability of conventional metaphase cytogenetics to detect chromosome aberrations in B-cell chronic lymphocytic leukaemia cells. British Journal of Haematology, 118, 968 975.
4. Cools, J., DeAngelo, D.J., Gotlib, J., Stover, E.H., Legare, R.D., Cortes, J., Kutok, J., Clark, J., Galinsky, I., Griffin, J.D., Cross, N.C., Tefferi, A., Malone, J., Alam, R., Schrier, S.L., Schmid, J., Rose, M., Vandenberghe, P., Verhoef, G., Boogaerts, M., Wlodarska, I., Kantarjian, H., Marynen, P., Coutre, S.E., Stone, R. Gilliland, D.G. (2003) A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. The New England Journal of Medicine, 348, 1201 1214.
5. Dicker, F., Schnittger, S., Kern, W., Haferlach, T. Schoch, C. (2005) Complex aberrant karyotypes and unbalanced translocations in CLL correlate with an unmutated IgVH status: a study on 133 patients studied with chromosome banding analysis, interphase FISH, IgVH mutation status, ZAP-70 RNA exrpession and immunophenotyping. Blood, 106, 825a.
6. Dicker, F., Schnittger, S., Haferlach, T., Kern, W. Schoch, C. (2006) Immunostimulatory oligonucleotide-induced metaphase cytogenetics detect chromosomal aberrations in 80% of CLL patients: a study of 132 CLL cases with correlation to FISH, IgVH status, and CD38 expression. Blood, 108, 3152 3160.
7. Döhner, H., Stilgenbauer, S., Benner, A., Leupolt, E., Krober, A., Bullinger, L., Dohner, K., Bentz, M. Lichter, P. (2000) Genomic aberrations and survival in chronic lymphocytic leukemia. The New England Journal of Medicine, 343, 1910 1916. (Pubitemid 32064784)
8. Fu, J.F., Hsu, J.J., Tang, T.C. Shih, L.Y. (2003) Identification of CBL, a proto-oncogene at 11q23.3, as a novel MLL fusion partner in a patient with de novo acute myeloid leukemia. Genes Chromosomes Cancer, 37, 214 219.
9. Ghia, P., Stamatopoulos, K., Belessi, C., Moreno, C., Stilgenbauer, S., Stevenson, F., Davi, F. Rosenquist, R. (2007) ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia. Leukemia, 21, 1 3.
10. Haferlach, C., Dicker, F., Schnittger, S., Kern, W. Haferlach, T. (2007) Comprehensive genetic characterization of CLL: a study on 506 cases analysed with chromosome banding analysis, interphase FISH, IgV(H) status and immunophenotyping. Leukemia, 21, 2442 2451.
11. Hiller, B., Bradtke, J., Balz, H. Rieder, H. (2005) CyDAS: a cytogenetic data analysis system. Bioinformatics, 21, 1282 1283.
12. ISCN (2009) An international system for human cytogenetic nomenclature (2009). In : Recommendations of the International Standing Committee on Human Cytogenetic Nomenclature (ed. by L.G. Shaffer, M.L. Slovak L.J. Campbell Karger, Basel, Switzerland.
13. Juliusson, G., Oscier, D.G., Fitchett, M., Ross, F.M., Stockdill, G., Mackie, M.J., Parker, A.C., Castoldi, G.L., Guneo, A. Knuutila, S. (1990) Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities. The New England Journal of Medicine, 323, 720 724.
14. Keats, J.J., Fonseca, R., Chesi, M., Schop, R., Baker, A., Chng, W.J., Van, W.S., Tiedemann, R., Shi, C.X., Sebag, M., Braggio, E., Henry, T., Zhu, Y.X., Fogle, H., Price-Troska, T., Ahmann, G., Mancini, C., Brents, L.A., Kumar, S., Greipp, P., Dispenzieri, A., Bryant, B., Mulligan, G., Bruhn, L., Barrett, M., Valdez, R., Trent, J., Stewart, A.K., Carpten, J. Bergsagel, P.L. (2007) Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma. Cancer Cell, 12, 131 144.
15. Kern, W., Dicker, F., Schnittger, S., Haferlach, C. Haferlach, T. (2009) Correlation of flow cytometrically determined expression of ZAP-70 using the SBZAP antibody with IgVH mutation status and cytogenetics in 1,229 patients with chronic lymphocytic leukemia. Cytometry B Clinical Cytometry, 76, 385 393.
16. Kristoffersson, U., Heim, S., Johnsson, A., Mandahl, N., Olsson, H., Akerman, M. Mitelman, F. (1990) Deletion of 14q in non-Hodgkin's lymphoma. European Journal of Haematology, 44, 261 264.
17. Martin-Subero, J.I., Ibbotson, R., Klapper, W., Michaux, L., Callet-Bauchu, E., Berger, F., Calasanz, M.J., De Wolf-Peeters, C., Dyer, M.J., Felman, P., Gardiner, A., Gascoyne, R.D., Gesk, S., Harder, L., Horsman, D.E., Kneba, M., Kuppers, R., Majid, A., Parry-Jones, N., Ritgen, M., Salido, M., Sole, F., Thiel, G., Wacker, H.H., Oscier, D., Wlodarska, I. Siebert, R. (2007) A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation. Leukemia, 21, 1532 1544.
18. Mayr, C., Speicher, M.R., Kofler, D.M., Buhmann, R., Strehl, J., Busch, R., Hallek, M. Wendtner, C.M. (2006) Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia. Blood, 107, 742 751.
19. Mitelman, F., Johansson, B. Mertens, F. (Eds 2010) Mitelman Database of Chromosome Aberrations in Cancer. WW document, URL http://cgap.nci.nih.gov/ Chromosomes/Mitelman.
20. Nagel, I., Bug, S., Tonnies, H., Ammerpohl, O., Richter, J., Vater, I., Callet-Bauchu, E., Calasanz, M.J., Martinez-Climent, J.A., Bastard, C., Salido, M., Schroers, E., Martin-Subero, J.I., Gesk, S., Harder, L., Majid, A., Dyer, M.J. Siebert, R. (2009) Biallelic inactivation of TRAF3 in a subset of B-cell lymphomas with interstitial del(14)(q24.1q32.33). Leukemia, 23, 2153 2155.
21. Ouillette, P., Erba, H., Kujawski, L., Kaminski, M., Shedden, K. Malek, S.N. (2008) Integrated genomic profiling of chronic lymphocytic leukemia identifies subtypes of deletion 13q14. Cancer Research, 68, 1012 1021.
22. Pospisilova, H., Baens, M., Michaux, L., Stul, M., Van, H.P., Van, L.P., Vermeesch, J., Jarosova, M., Zemanova, Z., Michalova, K., Van, d.B.I., Alexander, H.D., Hagemeijer, A., Vandenberghe, P., Cools, J., De Wolf-Peeters, C., Marynen, P. Wlodarska, I. (2007) Interstitial del(14)(q) involving IGH: a novel recurrent aberration in B-NHL. Leukemia, 21, 2079 2083.
23. Put, N., Konings, P., Rack, K., Jamar, M., Van, R.N., Libouton, J.M., Vannuffel, P., Sartenaer, D., Ameye, G., Speleman, F., Herens, C., Poirel, H.A., Moreau, Y., Hagemeijer, A., Vandenberghe, P. Michaux, L. (2009) Improved detection of chromosomal abnormalities in chronic lymphocytic leukemia by conventional cytogenetics using CpG oligonucleotide and interleukin-2 stimulation: a Belgian multicentric study. Genes Chromosomes Cancer, 48, 843 853.
24. Quintero-Rivera, F., Nooraie, F. Rao, P.N. (2009) Frequency of 5′IGH deletions in B-cell chronic lymphocytic leukemia. Cancer Genetics and Cytogenetics, 190, 33 39.
25. Schoch, C., Schnittger, S., Bursch, S., Gerstner, D., Hochhaus, A., Berger, U., Hehlmann, R., Hiddemann, W. Haferlach, T. (2002a) Comparison of chromosome banding analysis, interphase- and hypermetaphase-FISH, qualitative and quantitative PCR for diagnosis and for follow-up in chronic myeloid leukemia: a study on 350 cases. Leukemia, 16, 53 59.
26. Schoch, C., Haferlach, T., Bursch, S., Gerstner, D., Schnittger, S., Dugas, M., Kern, W., Loffler, H. Hiddemann, W. (2002b) Loss of genetic material is more common than gain in acute myeloid leukemia with complex aberrant karyotype: a detailed analysis of 125 cases using conventional chromosome analysis and fluorescence in situ hybridization including 24-color FISH. Genes Chromosomes Cancer, 35, 20 29.
27. Swerdlow, S.H., Campo, E., Harris, N.L., Jaffe, E.S., Pileri, S.A., Stein, H., Thiele, J. Vardiman, J.W. (2008) WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edn. International Agency for Research on Cancer (IARC), Lyon, France.
28. Wlodarska, I., Matthews, C., Veyt, E., Pospisilova, H., Catherwood, M.A., Poulsen, T.S., Vanhentenrijk, V., Ibbotson, R., Vandenberghe, P., Morris, T.C. Alexander, H.D. (2007a) Telomeric IGH losses detectable by fluorescence in situ hybridization in chronic lymphocytic leukemia reflect somatic VH recombination events. The Journal of Molecular Diagnostics, 9, 47 54.
29. Wlodarska, I., Ross, F.M., Russell, L.J., Pospisilova, H., Chiecchio, L., Van Caillie, M., Dagrada, G.P., De Wolf-Peeters, C., Harrison, C.J., De Paepe, P., Vandenberghe, P. Michaux, L. (2007b) Multiple Myeloma with IGH-Involving del(14q): report of 34 Cases. Blood, 110, 991 (Abstract).