Platycodin D induces anoikis and caspase-mediated apoptosis via p38 MAPK in AGS human gastric cancer cells

Journal of Cellular Biochemistry

Volumn 114, Issue 2, 2013, Pages 456-470

  Chun, Jaemoo ^a   Joo, Eun Ji ^a   Kang, Minseok ^a   Kim, Yeong Shik ^a  

^a Seoul National University   (South Korea)

Author keywords

AGS; Anoikis; AP 1; Apoptosis; P38 Mapk; Platycodin D

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLSERINE; PLATYCODIN; PROTEIN BCL 2; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANOIKIS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL; STOMACH CANCER;

ANOIKIS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; DNA FRAGMENTATION; HUMANS; IMIDAZOLES; MITOCHONDRIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRIDINES; SAPONINS; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TRANSCRIPTION FACTOR AP-1; TRITERPENES;

EID: 84872746194     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24386     Document Type: Article

References (53)

1. Ahn KS, Hahn BS, Kwack KB, Lee EB, Kim YS. 2006. Platycodin D-induced apoptosis through nuclear factor-kB activation in immortalized keratinocytes. Eur J Pharmacol 537:1-11.
2. Ahn KS, Noh EJ, Zhao HL, Jung SH, Kang SS, Kim YS. 2005. Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grand-iflorum saponins via suppression of nuclear factor-kB activation in RAW 264.7 cells. Life Sci 76:2315-2328.
3. Ameyar M, Wisniewsk M, Weitzman JB. 2003. A role for AP-1 in apoptosis: The case for and against. Biochimie 85:747-752.
4. Arnoult D, Parone P, Martinou JC, Antonsson B, Estaquier J, Ameisen JC. 2002. Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli. J Cell Biol 159:923-929.
5. Boosani CS, Nalabothula N, Munugalavadla V, Cosgrove D, Keshamoun VG, Sheibani N, Sudhakar A. 2009. Fak and p38-MAP kinase-dependent activation of apoptosis and caspase-3 in retinal endothelial cells by a1 (IV)NC1. Invest Ophthalmol Vis Sci 50:4567-4575.
6. Bossy-Wetzel E, Bakiri L, Yaniv M. 1997. Induction of apoptosis by the transcription factor c-Jun. EMBO J 16:1695-1709.
7. Boulares AH, Yakovlev AG, Ivanova V, Stoica BA, Wang G, Iyer S, Smulson M. 1999. Role of poly (ADP-ribose) polymerase (PARP) cleavage in apoptosis. J Biol Chem 274:22932-22940.
8. Chang L, Karin M. 2001. Mammalian MAP kinase signalling cascades. Nature 410:37-40.
9. Chin YW, Balunas MJ, Chai HB, Kinghorn AD. 2006. Drug discovery from natural sources. AAPS J 8:239-253.
10. Chiu CC, Chen JYF, Lin KL, Huang CJ, Lee JC, Chen BH, Chen WY, Lo YH, Chen YL, Tseng CH, Chen YL, Lin SR. 2010. p38 MAPK and NF-κB pathways are involved in naphtho [1,2-b] furan-4,5-dione induced anti-proliferation and apoptosis of human hepatoma cells. Cancer Lett 295:92-99.
11. Cragg GM, Grothaus PG, Newman DJ. 2009. Impact of natural products on developing new anti-cancer agents. Chem Rev 109:3012-3043.
12. Frisch SM, Screaton RA. 2001. Anoikis mechanisms. Curr Opin Cell Biol 13:555-562.
13. Fulda S, Debatin K. 2006. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 25:4798-4811.
14. Fulop T, Larbi A. 2002. Putative role of 67 kDa elastin-laminin receptor in tumor invasion. Semin Cancer Biol 12:219-229.
15. Ghobrial IM, Witzig TE, Adjei AA. 2005. Targeting apoptosis pathways in cancer therapy. CA Cancer J Clin 55:178-194.
16. Giancotti FG, Ruoslahti E. 1999. Integrin signaling. Science 285:1028-1032.
17. Giuliano M, Calvaruso G, Pellerito O, Portanova P, Carlisi D, Vento R, Tesoriere G. 2006. Anandamide-induced apoptosis in Chang liver cells involves ceramide and JNK/AP-1 pathway. Int J Mol Med 17:811-819.
18. Gordaliza M. 2007. Natural products as leads to anticancer drugs. Clin Transl Oncol 9:767-776.
19. Ha YW, Kim YS. 2009. Preparative isolation of six major saponins from Platycodi Radix by high speed counter current chromatography. Phytochem Anal 20:207-213.
20. Jiang XH, Wong B, Lin M, Zhu GH, Kung HF, Jiang SH, Yang D, Lam SK. 2001. Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells. Oncogene 20:8009-8018.
21. Johnson GL, Lapadat R. 2002. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911-1912.
22. Kaufmann SH, Earnshaw WC. 2000. Induction of apoptosis by cancer chemotherapy. Exp Cell Res 256:42-49.
23. Kaur M. 2006. Grape seed extract induces anoikis and caspase-mediated apoptosis in human prostate carcinoma LNCaP cells: Possible role of ataxia telangiectasia mutated-p53 activation. Mol Cancer Ther 5:1265-1274.
24. Kim MO, Moon DO, Choi YH, Lee JD, Kim ND, Kim GY. 2008a. Platycodin D induces mitotic arrest in vitro, leading to endoreduplication, inhibition of proliferation and apoptosis in leukemia cells. Int J Cancer 122:2674-2681.
25. Kim MO, Moon DO, Choi YH, Shin DY, Kang HS, Choi BT, Lee JD, Li W, Kim GY. 2008. Platycodin D induces apoptosis and decreases telomerase activity in human leukemia cells. Cancer Lett 261:98-107.
26. Lauricella M, Emanuele S, D'Anneo A, Calvaruso G, Vassallo B, Carlisi D, Portanova P, Vento R, Tesoriere G. 2006. JNK and AP-1 mediate apoptosis induced by bortezomib in HepG2 cells via FasL/caspase-8 and mitochondria-dependent pathways. Apoptosis 11:607-625.
27. Lee H, Kang R, Kim YS, Chung SI, Yoon Y. 2010. Platycodin D inhibits adipogenesis of 3T3 L1 cells by modulating kruppel like factor 2 and peroxisome proliferator activated receptor gamma. Phytother Res 24:161-167.
28. Lee KW, Kim SG, Kim HP, Kwon E, You J, Choi HJ, Park JH, Kang BC, Im SA, Kim TY, Kim WH, Bang YJ. 2008. Enzastaurin, a protein kinase Cb inhibitor, suppresses signaling through the ribosomal S6 kinase and bad pathways and induces apoptosis in human gastric cancer cells. Cancer Res 68:1916-1926.
29. Li C, Xu Q. 2000. Mechanical stress-initiated signal transductions in vascular smooth muscle cells. Cell Signal 12:435-445.
30. Li H, Zhu H, Xu C, Yuan J. 1998. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94:491-501.
31. Liu MJ, Wang Z, Li HX, Wu RC, Liu YZ, Wu QY. 2004. Mitochondrial dysfunction as an early event in the process of apoptosis induced by Woodfordin I in human leukemia K562 cells. Toxicol Appl Pharmacol 194:141-155.
32. Mansouri A, Ridgway LD, Korapati AL, Zhang Q, Tian L, Wang Y, Siddik ZH, Mills GB, Claret FX. 2003. Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells. J Biol Chem 278:19245-19256.
33. Naka T, Sugamura K, Hylander BL, Widmer MB, Rustum YM, Repasky EA. 2002. Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with chemotherapeutic agents on patients' colon tumors grown in SCID mice. Cancer Res 62:5800-5806.
34. Pan M-H, Ghai G, Ho C-T. 2008. Food bioactives, apoptosis, and cancer. Mol Nutr Food Res 52:43-52.
35. Park EK, Park MJ, Lee SH, Li YC, Kim J, Lee JS, Lee JW, Ye SK, Park JW, Kim CW. 2009. Cholesterol depletion induces anoikis like apoptosis via FAK down regulation and caveolae internalization. J Pathol 218:337-349.
36. Park IJ, Kim MJ, Park OJ, Park MG, Choe W, Kang I, Kim SS, Ha J. 2010. Cryptotanshinone sensitizes DU145 prostate cancer cells to Fas (APO1/CD95)-mediated apoptosis through Bcl-2 and MAPK regulation. Cancer Lett 298:88-98.
37. Parkin DM. 2001. Global cancer statistics in the year 2000. Lancet Oncol 2:533-543.
38. Puviani M, Marconi A, Cozzani E, Pincelli C. 2003. Fas ligand in pemphigus sera induces keratinocyte apoptosis through the activation of caspase-8. J Invest Dermatol 120:164-167.
39. Ravindran J, Prasad S, Aggarwal BB. 2009. Curcumin and cancer cells: How many ways can curry kill tumor cells selectively? AAPS J 11:495-510.
40. Roder DM. 2002. The epidemiology of gastric cancer. Gastr Cancer 5:5-11.
41. Rosen K, Shi W, Calabretta B, Filmus J. 2002. Cell detachment triggers p38 mitogen-activated protein kinase-dependent overexpression of Fas ligand. J Biol Chem 277:46123-46130.
42. Shin DY, Kim GY, Li W, Choi BT, Kim ND, Kang HS, Choi YH. 2009. Implication of intracellular ROS formation, caspase-3 activation and Egr-1 induction in platycodon D-induced apoptosis of U937 human leukemia cells. Biomed Pharmacother 63:86-94.
43. Shin EM, Zhou HY, Xu GH, Lee SH, Merfort I, Kim YS. 2010. Anti-inflammatory activity of hispidol A 25-methyl ether, a triterpenoid isolated from Ponciri Immaturus Fructus. Eur J Pharmacol 627:318-324.
44. Silvers AL, Bachelor MA, Bowden GT. 2003. The role of JNK and p38 MAPK activities in UVA-induced signaling pathways leading to AP-1 activation and c-Fos expression. Neoplasia 5:319-329.
45. Tanos T, Marinissen MJ, Leskow FC, Hochbaum D, Martinetto H, Gutkind JS, Coso OA. 2005. Phosphorylation of c-Fos by members of the p38 MAPK family. J Biol Chem 280:18842-18852.
46. Varadhachary GR, Ajani JA. 2005. Gastric cancer. Clin Adv Hematol Oncol 3:118-124.
47. Wagner EF, Nebreda AR. 2009. Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 9:537-549.
48. Wang C, Schuller Levis, GB, Lee EB, Levis WR, Lee DW, Kim BS, Park SY, Park E. 2004. Platycodin D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF-α in activated RAW 264.7 cells. Int Immunopharmacol 4:1039-1049.
49. Windham TC, Parikh NU, Siwak DR, Summy JM, McConkey DJ, Kraker AJ, Gallick GE. 2002. Src activation regulates anoikis in human colon tumor cell lines. Oncogene 21:7797-7807.
50. Yan H, Zhu Y, Liu B, Wu H, Li Y, Wu X, Zhou Q, Xu K. 2011. Mitogen-activated protein kinase mediates the apoptosis of highly metastatic human non-small cell lung cancer cells induced by isothiocyanates. Br J Nutr 106: 1-13.
51. Yu JS, Kim AK. 2010. Platycodin D induces apoptosis in MCF-7 human breast cancer cells. J Med Food 13:298-305.
52. Zhao HL, Cho KH, Ha YW, Jeong TS, Lee WS, Kim YS. 2006. Cholesterollowering effect of platycodin D in hypercholesterolemic ICR mice. Eur J Pharmacol 537:166-173.
53. Zouq NK, Keeble JA, Lindsay J, Valentijn AJ, Zhang L, Mills D, Turner CE, Streuli CH, Gilmore AP. 2009. FAK engages multiple pathways to maintain survival of fibroblasts and epithelia-differential roles for paxillin and p130Cas. J Cell Sci 122:357-367.