Novel monofunctional platinum (II) complex Mono-Pt induces apoptosis-independent autophagic cell death in human ovarian carcinoma cells, distinct from cisplatin

Autophagy

Volumn 9, Issue 7, 2013, Pages 996-1008

  Guo, Wen Jie ^a   Zhang, Yang Miao ^a,b   Zhang, Li ^c   Huang, Bin ^b   Tao, Fei Fei ^a   Chen, Wei ^a   Guo, Zi Jian ^b   Xu, Qiang ^a   Sun, Yang ^a  

^a NANJING UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

^c JIANGSU INSTITUTE OF NUCLEAR MEDICINE   (China)

Author keywords

AKT1; Autophagy; Cisplatin; MAPK1 3; Monofunctional platinum complex

Indexed keywords

3 METHYLADENINE; ANTINEOPLASTIC METAL COMPLEX; BAFILOMYCIN; BECLIN 1; CASPASE; CHLOROQUINE; CISPLATIN; DANSYLCADAVERINE; MICROTUBULE ASSOCIATED PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOFUNCTIONAL PLATINUM (II) COMPLEX; PLATINUM COMPLEX; RAPAMYCIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CARCINOMA CELL; CELL CYCLE ARREST; CELL DEATH; CELL VACUOLE; CHROMATIN CONDENSATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOPLASM; DNA DAMAGE; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LIPOPHILICITY; OVARY CARCINOMA; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; VIRUS ONCOGENE;

AKT1; AUTOPHAGY; CISPLATIN; MAPK1/3; MONOFUNCTIONAL PLATINUM COMPLEX;

APOPTOSIS; AUTOPHAGY; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CISPLATIN; DNA DAMAGE; FEMALE; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; OVARIAN NEOPLASMS; PLATINUM; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84879605949     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.24407     Document Type: Article

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