Induction of apoptosis and inhibition of telomerase activity by aqueous extract from Platycodon grandiflorum in human lung carcinoma cells

Pharmacological Research

Volumn 51, Issue 5, 2005, Pages 437-443

  Park, Dong Il ^a   Lee, Jae Hun ^a   Moon, Sung Kwon ^b   Kim, Cheorl Ho ^c   Lee, Yong Tae ^a   Cheong, JaeHun ^d   Choi, Byung Tae ^a   Choi, Yung Hyun ^a  

^a Dong Eui University   (South Korea)

^b Chungju National University   (South Korea)

^c Dongguk University   (South Korea)

^d Pusan National University   (South Korea)

Author keywords

Apoptosis; Bcl 2; hTERT; Platycodon grandiflorum; Telomerase

Indexed keywords

CASPASE 3; PLANT EXTRACT; PLATYCODON GRANDIFLORUM EXTRACT; PROTEIN BAX; PROTEIN BCL 2; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG;

APOPTOSIS; AQUEOUS SOLUTION; ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LUNG CARCINOMA; MEDICINAL PLANT; PLATYCODON; PLATYCODON GRANDIFLORUM; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 14644399849     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phrs.2004.11.003     Document Type: Article

References (29)

1. E.R. McDonald 3rd, and W.S. El-Deiry Cell cycle control as a basis for cancer drug development Int J Oncol 16 2000 871 886
2. D.R. Schultz, and W.J. Harrington Jr. Apoptosis: programmed cell death at a molecular level Semin Arthritis Rheu 32 2003 345 369
3. D. Decaudin, I. Marzo, C. Brenner, and G. Kroemer Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy Int J Oncol 12 1998 141 152
4. W.C. Earnshaw, L.M. Martins, and S.H. Kaufmann Mammalian caspases: structure, activation, substrates, and functions during apoptosis Annu Rev Biochem 6 1999 383 424
5. J.M. Adams, and S. Cory Life-or-death decisions by the Bcl-2 protein family Trends Biochem Sci 26 2001 61 66
6. R. Oulton, and L. Harrington Telomeres, telomerase, and cancer: life on the edge of genomic stability Curr Opin Oncol 12 2000 74 81
7. W.C. Hahn, and M. Meyerson Telomerase activation, cellular immortalization and cancer Ann Med 33 2001 123 129
8. F.O. Odago, and S.L. Gerson Telomerase inhibition and telomere erosion: a two-pronged strategy in cancer therapy Trends Pharmacol Sci 24 2003 328 331
9. C. Autexier, and C.W. Greider Telomerase and cancer: revisiting the telomere hypothesis Trends Biochem Sci 21 1996 387 391
10. C.-P. Chiu, and C.B. Harley Replicative senescence and cell immortality: the role of telomeres and telomerase P Soc Exp Biol Med 214 1997 99 106
11. M. Takakura, S. Kyo, T. Kanaya, M. Tanaka, and M. Inoue Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer Cancer Res 58 1998 1558 1561
12. S. Kyo, T. Kanaya, M. Takakura, M. Tanaka, A. Yamashita, and H. Inoue Expression of human telomerase subunits in ovarian malignant, borderline and benign tumors Int J Cancer 80 1999 804 809
13. R.A. Greenberg, R.C. Allsopp, L. Chin, G.B. Morin, and R.A. DePinho Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation Oncogene 16 1998 1723 1730
14. C. Darimont, I. Zbinden, O. Avanti, P. Leone-Vautravers, V. Giusti, and P. Burckhardt Reconstitution of telomerase activity combined with HPV-E7 expression allow human preadipocytes to preserve their differentiation capacity after immortalization Cell Death Differ 10 2003 1025 1031
15. D. Xu, A. Gruber, M. Bjorkholm, C. Peterson, and P. Pisa Suppression of telomerase reverse transcriptase (hTERT) expression in differentiated HL-60 cells: regulatory mechanisms Br J Cancer 80 1999 1156 1161
16. K. Takagi, and E.B. Lee Pharmacological studies on Platycodon grandiflorum A. DC. Activities of crude platycodin on respiratory and circulatory systems and its other pharmacological activities Yakugaku Zasshi 92 1972 969 973
17. E.B. Lee Pharmacological studies on Platycodon grandiflorum A. DC. IV. A comparison of experimental pharmacological effects of crude platycodin with clinical indications of platycodi radix Yakugaku Zasshi 93 1973 1188 1194
18. A. Tada, Y. Kaneiwa, J. Shoji, and S. Shibata Studies on the saponins of the root of Platycodon grandiflorum. A. De Candolle I: isolation and the structure of platycodin-d Chem Pharm Bull (Tokyo) 23 1975 2965 2972
19. M. Kubo, T. Nagao, H. Matsuda, and K. Namba Immune pharmacological studies on platycodi radix I: effect on the phagocytosis in mouse Shoyakugaku Zasshi 40 1986 367 374
20. T. Nagao, H. Matsuda, K. Namba, and M. Kubo Immune pharmacological studies on platycodi radix II: antitumor activity of inulin from platycodi radix Shoyakugaku Zasshi 40 1986 375 380
21. C.Y. Choi, J.Y. Kim, Y.S. Kim, Y.C. Chung, K.S. Hahm, and H.G. Jeong Augmentation of macrophage functions by an aqueous extract isolated from Platycodon grandiflorum Cancer Lett 166 2001 17 25
22. S.B. Han, S.H. Park, K.H. Lee, C.W. Lee, S.H. Lee, and H.C. Kim Polysaccharide isolated from the radix of Platycodon grandiflorum selectively activates B cells and macrophages but not T cells Int Immunopharmacol 1 2001 1969 1978
23. Y.D. Yoon, S.B. Han, J.S. Kang, C.W. Lee, S.K. Park, and H.S. Lee Toll-like receptor 4-dependent activation of macrophages by polysaccharide isolated from the radix of Platycodon grandiflorum Int Immunopharmacol 3 2003 1873 1882
24. Y.H. Choi, S.J. Lee, P. Nguyen, J.S. Jang, J. Lee, and M.L. Wu Regulation of cyclin D1 by calpain protease J Biol Chem 272 1997 28479 28484
25. J. Boklan, G. Nanjangud, K.L. MacKenzie, C. May, M. Sadelain, and M.A. Moore Limited proliferation and telomere dysfunction following telomerase inhibition in immortal murine fibroblasts Cancer Res 62 2002 2104 2114
26. J. Haendeler, J. Hoffmann, S. Rahman, A.M. Zeiher, and S. Dimmeler Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation FEBS Lett 536 2003 180 186
27. M. Mandal, and R. Kumar Bcl-2 modulates telomerase activity J Biol Chem 72 1997 14183 14187
28. W. Fu, J.G. Begley, M.W. Killen, and M.P. Mattson Anti-apoptotic role of telomerase in pheochromocytoma cells J Biol Chem 274 1999 7264 7271
29. R. Ramirez, J. Carracedo, R. Jimenez, A. Canela, E. Herrera, and P. Aljama Massive telomere loss is an early event of DNA damage-induced apoptosis J Biol Chem 278 2003 836 842