Acetylation of glucokinase regulatory protein decreases glucose metabolism by suppressing glucokinase activity

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Park, Joo Man ^a   Kim, Tae Hyun ^a   Jo, Seong Ho ^a   Kim, Mi Young ^a   Ahn, Yong Ho ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; GCKR PROTEIN, HUMAN; GCKR PROTEIN, MOUSE; GLUCOKINASE; GLUCOSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SIRT2 PROTEIN, HUMAN; SIRT2 PROTEIN, MOUSE; SIRTUIN 2;

ACETYLATION; ANIMAL; GENETICS; HELA CELL LINE; HUMAN; MALE; METABOLISM; MOUSE; MOUSE MUTANT; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN PROCESSING;

ACETYLATION; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CARRIER PROTEINS; DIABETES MELLITUS, TYPE 2; GLUCOKINASE; GLUCOSE; HELA CELLS; HUMANS; MALE; MICE; MICE, OBESE; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIRTUIN 2;

EID: 84949057909     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep17395     Document Type: Article

References (53)

1. Mokdad, A. H. et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289, 76-79 (2003).
2. Consoli, A. Role of liver in pathophysiology of NIDDM. Diabetes Care 15, 430-441 (1992).
3. Iynedjian, P. B. et al. Tissue-specific expression of glucokinase: identification of the gene product in liver and pancreatic islets. Proc Natl Acad Sci USA 83, 1998-2001 (1986).
4. Matschinsky, F. M. Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes. Diabetes 39, 647-652 (1990).
5. Nordlie, R. C., Foster, J. D. & Lange, A. J. Regulation of glucose production by the liver. Annu Rev Nutr 19, 379-406 (1999).
6. Iynedjian, P. B. et al. Transcriptional induction of glucokinase gene by insulin in cultured liver cells and its repression by the glucagon-cAMP system. J Biol Chem 264, 21824-21829 (1989).
7. Iynedjian, P. B., Gjinovci, A. & Renold, A. E. Stimulation by insulin of glucokinase gene transcription in liver of diabetic rats. J Biol Chem 263, 740-744 (1988).
8. Kim, T. H. et al. Interrelationship between liver X receptor alpha, sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor gamma, and small heterodimer partner in the transcriptional regulation of glucokinase gene expression in liver. J Biol Chem 284, 15071-15083 (2009).
9. Yoshida, K. et al. Pancreatic glucokinase is activated by insulin-like growth factor-I. Endocrinology 148, 2904-2913 (2007).
10. Beer, N. L. et al. The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver. Hum Mol Genet 18, 4081-4088 (2009).
11. Van Schaftingen, E., Detheux, M. & Veiga da Cunha, M. Short-term control of glucokinase activity: role of a regulatory protein. FASEB J 8, 414-419 (1994).
12. de la Iglesia, N. et al. Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase. FEBS Lett 456, 332-338 (1999).
13. Agius, L. & Stubbs, M. Investigation of the mechanism by which glucose analogues cause translocation of glucokinase in hepatocytes: evidence for two glucose binding sites. Biochem J 346 Pt 2, 413-421 (2000).
14. Detheux, M., Vandercammen, A. & Van Schaftingen, E. Effectors of the regulatory protein acting on liver glucokinase: a kinetic investigation. Eur J Biochem 200, 553-561 (1991).
15. Farrelly, D. et al. Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation. Proc Natl Acad Sci USA 96, 14511-14516 (1999).
16. Mukhtar, M. H. et al. Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Am J Physiol Regul Integr Comp Physiol 294, R766-774 (2008).
17. Zhao, Y., Wang, Y. & Zhu, W. G. Applications of post-translational modifications of FoxO family proteins in biological functions. J Mol Cell Biol 3, 276-282 (2011).
18. Guan, K. L. & Xiong, Y. Regulation of intermediary metabolism by protein acetylation. Trends Biochem Sci 36, 108-116 (2011).
19. Xu, W. S., Parmigiani, R. B. & Marks, P. A. Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene 26, 5541-5552 (2007).
20. Bowers, E. M. et al. Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol 17, 471-482 (2010).
21. Li, A. et al. Prediction of Nepsilon-acetylation on internal lysines implemented in Bayesian Discriminant Method. Biochem Biophys Res Commun 350, 818-824 (2006).
22. Shiota, C. et al. Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase. J Biol Chem 274, 37125-37130 (1999).
23. Rees, M. G. et al. Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk. Diabetologia 55, 114-122 (2012).
24. Kobayashi, K. et al. The db/db mouse, a model for diabetic dyslipidemia: molecular characterization and effects of Western diet feeding. Metabolism 49, 22-31 (2000).
25. Avalos, J. L., Bever, K. M. & Wolberger, C. Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. Mol Cell 17, 855-868 (2005).
26. Glozak, M. A., Sengupta, N., Zhang, X. & Seto, E. Acetylation and deacetylation of non-histone proteins. Gene 363, 15-23 (2005).
27. Zhao, S. et al. Regulation of cellular metabolism by protein lysine acetylation. Science 327, 1000-1004 (2010).
28. Dai, C. & Gu, W. p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med 16, 528-536 (2010).
29. Chen, L. F., Mu, Y. & Greene, W. C. Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. EMBO J 21, 6539-6548 (2002).
30. Kemper, J. K. et al. FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states. Cell Metab 10, 392-404 (2009).
31. Li, M., Luo, J., Brooks, C. L. & Gu, W. Acetylation of p53 inhibits its ubiquitination by Mdm2. J Biol Chem 277, 50607-50611 (2002).
32. Wang, Y. H. et al. Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305. J Biol Chem 278, 25568-25576 (2003).
33. Feng, L. et al. Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol Cell Biol 25, 5389-5395 (2005).
34. Rees, M. G. et al. Correlation of rare coding variants in the gene encoding human glucokinase regulatory protein with phenotypic, cellular, and kinetic outcomes. J Clin Invest 122, 205-217 (2012).
35. Zelent, B. et al. Analysis of the co-operative interaction between the allosterically regulated proteins GK and GKRP using tryptophan fluorescence. Biochem J 459, 551-564 (2014).
36. Qiang, L., Banks, A. S. & Accili, D. Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization. J Biol Chem 285, 27396-27401 (2010).
37. Schwer, B. & Verdin, E. Conserved metabolic regulatory functions of sirtuins. Cell Metab 7, 104-112 (2008).
38. Jiang, W. et al. Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. Mol Cell 43, 33-44 (2011).
39. Chen, S. et al. Transcriptional coactivator p300 regulates glucose-induced gene expression in endothelial cells. Am J Physiol Endocrinol Metab 298, E127-137 (2010).
40. Bricambert, J. et al. Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBPdependent hepatic steatosis in mice. J Clin Invest 120, 4316-4331 (2010).
41. Brozinick, J. T., Jr. et al. GLUT4 overexpression in db/db mice dose-dependently ameliorates diabetes but is not a lifelong cure. Diabetes 50, 593-600 (2001).
42. Bedford, D. C. et al. Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control. Cell Metab 14, 219-230 (2011).
43. He, L. et al. Activation of basal gluconeogenesis by coactivator p300 maintains hepatic glycogen storage. Mol Endocrinol 27, 1322-1332 (2013).
44. Hagberg, C. E. et al. Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes. Nature 490, 426-430 (2012).
45. Matschinsky, F. M. Assessing the potential of glucokinase activators in diabetes therapy. Nat Rev Drug Discov 8, 399-416 (2009).
46. Park, J. M. et al. Role of resveratrol in FOXO1-mediated gluconeogenic gene expression in the liver. Biochem Biophys Res Commun 403, 329-334 (2010).
47. Anderka, O. et al. Biophysical characterization of the interaction between hepatic glucokinase and its regulatory protein: impact of physiological and pharmacological effectors. J Biol Chem 283, 31333-31340 (2008).
48. Ullah, M. et al. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. Mol Cell Biol 28, 6828-6843 (2008).
49. Yoo, J. Y. et al. Nuclear hormone receptor corepressor promotes esophageal cancer cell invasion by transcriptional repression of interferon-gamma-inducible protein 10 in a casein kinase 2-dependent manner. Mol Biol Cell 23, 2943-2954 (2012).
50. Chrivia, J. C. et al. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365, 855-859 (1993).
51. Lerin, C. et al. GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha. Cell Metab 3, 429-438 (2006).
52. Schwer, B. et al. Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci USA 103, 10224-10229 (2006).
53. Wu, M. et al. Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol 292, C125-136 (2007).