Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: A sequestration mechanism in metabolic regulation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 25, 1999, Pages 14511-14516

  Farrelly, Dennis ^a   Brown, Karen S ^a   Tieman, Aaron ^a   Ren, Jianming ^a   Lira, Sergio A ^a,b   Hagan, Deborah ^a   Gregg, Richard ^a   Mookhtiar, Kasim A ^a   Hariharan, Narayanan ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GLUCOKINASE; GLUCOSE; INSULIN; MESSENGER RNA; REGULATOR PROTEIN;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME REGULATION; GENE MUTATION; GENE TARGETING; GLUCOSE METABOLISM; INTRAPERITONEAL DRUG ADMINISTRATION; KNOCKOUT MOUSE; LIVER CELL; LIVER METABOLISM; METABOLIC REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BLOOD GLUCOSE; CARRIER PROTEINS; CELL NUCLEUS; GLUCOKINASE; GLUCOSE; HOMEOSTASIS; INSULIN; LIVER; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; MICE, KNOCKOUT; PROTEINS; RNA, MESSENGER;

ANIMALIA; RODENTIA;

EID: 0033432692     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.25.14511     Document Type: Article

References (31)

1. Matschinsky, F. A. (1996) Diabetes 45, 223-241.
2. Froguel, P., Zouali, H., Vionnet, N., Velho, G., Vaxillaire, M., Sun, F., Lesage, S., Stoffel, M., Takeda, J., Passa, P., et al. (1993) N. Engl. J. Med. 328, 697-702.
3. Gidh-Jain, M., Takeda, J., Wu, L., Lange, A., Vionnet, N., Stoffel, M., Velho, G., Sun, F., Cohen, D., Froguel, P., et al. (1993) Proc. Natl. Acad. Sci. USA 90, 1932-1936.
4. Bali, D., Svetlanov, A., Lee, H.-W., Fusco-DeMane, D., Leiser, M., Li, B., Barzilai, N., Surana, M., Hou, H., Fleischer, N., et al. (1995) J. Biol. Chem. 270, 21464-21467.
5. Grupe, A., Hultgren, B., Ryan, A., Ma, Y., Bauer, M. & Stewart, T. (1995) Cell 83, 69-78.
6. Efrat, S., Leiser, M., Wu, Y.-J., Fusco-DeMane, D., Emran, O., Surana, M., Jetton, T., Magnuson, M., Weir, G. & Fleischer, N. (1994) Proc. Natl. Acad. Sci. USA 91, 2051-2055.
7. Hariharan, N., Farrelly, D., Hagan, D., Hillyer, D., Arbeeny, C., Sabrah, T., Treloar, A., Brown, K., Kalinowski, K. & Mookhtiar, K. (1997) Diabetes 46, 11-16.
8. Ferre, T., Pujol, A., Riu, E., Bosch, F. & Valera, A. (1996) Proc. Natl. Acad. Sci. USA 93, 7225-7230.
9. Postic, C., Shiota, M., Niswender, K., Jetton, T., Chen, Y., Moates, J., Shelton, K., Linder, J., Cherrington, A. & Magnuson, A. (1999) J. Biol. Chem. 274, 305-315.
10. Caro, J., Triester, S., Patel, V., Tapscott, E., Frazier, N. & Dohm, G. (1995) Horm. Metab. Res. 27, 19-22.
11. Vandercammen, A. & Van Schaftingen, E. (1993) Biochem. J. 294, 551-556.
12. Veiga-da-Cunha, M., Detheux, M., Watelet, N. & Van Schaftingen, E. (1994) Eur. J. Biochem. 225, 43-51.
13. Veiga-da-Cunha, M., Courtois, S., Michel, A., Gosselain, E. & Van Schaftingen, E. (1996) J. Biol. Chem. 271, 6292-6297.
14. Brown, K., Kalinowski, S., Megill, J., Durham, S. & Mookhtiar, K. (1996) Diabetes 46, 179-186.
15. Toyoda, Y., Miwa, I., Satake, S., Anai, M. & Oka, Y. (1995) Biochem. Biophys. Res. Commun. 215, 467-473.
16. Tybulewicz, V., Crawford, C., Jackson, P., Bronson, R. & Mulligan, R. (1991) Cell 65, 1153-1163.
17. Hogan, B., Beddington, R., Costantini, F. & Lacy, E. (1994) manipulating the Mouse Embryo: A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY).
18. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989) Molecular Cloning. A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY), 2nd Ed.
19. Hagan, D., Kienzle, B., Jamil, H. & Hariharan, N. (1994) J. Biol. Chem. 269, 28737-28744.
20. Markwell, M., Hass, S., Bieber, L. & Tolbert, N. (1978) Anal. Biochem. 87, 206-210.
21. Laemmli, U. K. (1970) Nature (London) 227, 680-685.
22. Passonneau, V. & Lauderdale, R. (1974) Anal. Biochem. 60, 405-412.
23. Iynedjian, P., Pilot, P., Nouspikel, T., Milburn, J., Quadde, C., Hughes, S., Ucla C. & Newgard, C. (1989) Proc. Natl. Acad. Sci. USA 86, 7838-7842.
24. Iynedjian, P., Gjinovci, A. & Renold, A. (1988) J. Biol. Chem. 263, 740-744.
25. Davis, S. N. & Pagliassotti, M. J. (1994) in The Role of the Liver in Maintaining Glucose Homeostasis, eds. Pagliassotti, M. J., Davis, S. N. & Cherrington, A. D. (Landes, Austin, TX), pp. 85-107.
26. Kimbal, S., Vary, T. & Jefferson, L. (1994) Annu. Rev. Physiol. 56, 321-345.
27. Warner, J., Leek, J., Intody, S., Markham, A. & Bonthron, D. (1995) Manual Genome 6, 532-536.
28. Vionnet, N., Hani, E., Lesage, S., Philippi, A., Hager, J., Varret, M., Stoffe, M., Tanizawa, Y., Chiu, K., Glaser, B., et al. (1997) Diabetes 46, 1062-1068.
29. Liang, Y., Najafi, H., Smith, R., Zimmerman, E., Magnuson, M. Tal, M. A., Matschinsky, M. (1992) Diabetes 41, 792-806.
30. Velho, G., Petersen, K., Perseghin, G., Hwang, J.-H., Rothman, D., Pueyo, M., Cline, G., Froguel, P. & Shulman, G. (1996) J. Clin. Invest. 98, 1755-1761.
31. Singh, R. & Green, M. (1993) Science 259, 365-368.