Activation of basal gluconeogenesis by coactivator p300 maintains hepatic glycogen storage

Molecular Endocrinology

Volumn 27, Issue 8, 2013, Pages 1322-1332

  He, Ling ^a   Cao, Jia ^a   Meng, Shumei ^a   Ma, Anlin ^a   Radovick, Sally ^a   Wondisford, Fredric E ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; E1A ASSOCIATED P300 PROTEIN; GLYCOGEN; INSULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLYCOGEN ANALYSIS; GLYCOGEN LIVER LEVEL; GLYCOGEN SYNTHESIS; GLYCOGENOLYSIS; HYPOGLYCEMIA; LIVER CELL; MALE; MOUSE; NONHUMAN; POSTPRANDIAL STATE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

ANIMALS; BLOOD GLUCOSE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GLUCONEOGENESIS; GLUCOSE; HYPOGLYCEMIA; LIVER; LIVER GLYCOGEN; MICE; P300-CBP TRANSCRIPTION FACTORS; POSTPRANDIAL PERIOD; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84880842199     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2012-1413     Document Type: Article

References (46)

1. Petersen KF, Laurent D, Rothman DL, Cline GW, Shulman GI. Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans. J Clin Invest. 1998;101:1203-1209.
2. Edgerton DS, Ramnanan CJ, Grueter CA, et al. Effects of insulin on the metabolic control of hepatic gluconeogenesis in vivo. Diabetes. 2009;58:2766-2775.
3. Nielsen MF, Wise S, Dinneen SF, Schwenk WF, Basu A, Rizza RA. Assessment of hepatic sensitivity to glucagon in NIDDM: Use as a tool to estimate the contribution of the indirect pathway to nocturnal glycogen synthesis. Diabetes. 1997;46:2007-2016.
4. Fischer EH, Graves DJ, Crittenden ER, Krebs EG. Structure of the site phosphorylated in the phosphorylase b to a reaction. J Biol Chem. 1959;234:1698-1704.
5. Sutherland C, Leighton IA, Cohen P. Inactivation of glycogen synthase kinase-3 by phosphorylation: new kinase connections in insulin and growth-factor signalling. Biochem J. 1993;296:15-19.
6. Roach PJ, Depaoli-Roach AA, Hurley TD, Tagliabracci VS. Glycogen and its metabolism: some new developments and old themes. Biochem J. 2012;441:763-787.
7. Cline GW, Johnson K, Regittnig W, et al. Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats. Diabetes. 2002;51:2903-2910.
8. Pederson BA, Wilson WA, Roach PJ. Glycogen synthase sensitivity to glucose-6-P is important for controlling glycogen accumulation in Saccharomyces cerevisiae. J Biol Chem. 2004;279:13764-13768.
9. Minassian C, Ajzannay A, Riou JP, Mithieux G. Investigation of the mechanism of glycogen rebound in the liver of 72-hour fasted rats. J Biol Chem. 1994;269:16585-16588.
10. Koo SH, Flechner L, Qi L, et al. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature. 2005;437: 1109-1111.
11. Guo S, Rena G, Cichy S, He X, Cohen P, Unterman T. Phosphordoi ylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factorbinding protein-1 promoter activity through a conserved insulin response sequence. J Biol Chem. 1999;274:17184-17192.
12. He L, Sabet A, Djedjos S, et al. Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein. Cell. 2009;137:635-646.
13. Nielsen MF. Contribution of defects in glucose production and uptake to carbohydrate intolerance in insulin-resistant subjects. Danish MedBull. 2008;55:89-102.
14. Katz J, McGarry JD. The glucose paradox. Is glucose a substrate for liver metabolism? J Clin Invest. 1984;74:1901-1909.
15. Hems DA, Whitton PD, Taylor EA. Glycogen synthesis in the perfused liver of the starved rat. Biochem J. 1972;129:529-538.
16. Seglen PO. Autoregulation of glycolysis, respiration, gluconeogenesis and glycogen synthesis in isolated parenchymal rat liver cells under aerobic and anaerobic conditions. Biochim Biophys Acta. 1974;338:317-336.
17. Newgard CB, Moore SV, Foster DW, McGarry JD. Efficient hepatic glycogen synthesis in refeeding rats requires continued carbon flow through the gluconeogenic pathway. J Biol Chem. 1984;259: 6958-6963.
18. Sugden MC, Watts DI, Palmer TN, Myles DD. Direction of carbon flux in starvation and after refeeding: in vitro and in vivo effects of 3-mercaptopicolinate. Biochem Int. 1983;7:329-337.
19. Shulman GI, Rothman DL, Smith D, et al. Mechanism of liver glycogen repletion in vivo by nuclear magnetic resonance spectroscopy. J Clin Invest. 1985;76:1229-1236.
20. Cline GW, Greenawalt K, Shulman GI. Enhancement of the gluconeogenic flux of hepatic glycogen repletion by a phenacyl imidazolium compound in vivo. Acta Diabetol. 1993;30:70-72.
21. Lang CH, Bagby GJ, Blakesley HL, Johnson JL, Spitzer JJ. Plasma glucose concentration determines direct versus indirect liver glycogen synthesis. Am J Physiol. 1986;251:E584-E590.
22. Moore MC, Cherrington AD, Cline G, et al. Sources of carbon for hepatic glycogen synthesis in the conscious dog. J Clin Invest. 1991; 88:578-587.
23. Radziuk J. Sources of carbon in hepatic glycogen synthesis during absorption of an oral glucose load in humans. Fed Proc. 1982;41: 110-116.
24. Cline GW, Rothman DL, Magnusson I, Katz LD, Shulman GI. 13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulindependent diabetes mellitus. J Clin Invest. 1994;94:2369-2376.
25. Radziuk J. Hepatic glycogen in humans. I. Direct formation after oral and intravenous glucose or after a 24-h fast. Am J Physiol. 1989;257:E147-E157.
26. Radziuk J, Pye S. Hepatic glucose uptake, gluconeogenesis and the regulation of glycogen synthesis. Diabetes Metab Res Rev. 2001; 17:250-272.
27. Ramnanan CJ, Edgerton DS, Rivera N, et al. Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo. Diabetes. 2010;59:1302-1311.
28. Kelley D, Mitrakou A, Marsh H, et al. Skeletal muscle glycolysis, oxidation, and storage of an oral glucose load. J Clin Invest. 1988; 81:1563-1571.
29. He L, Naik K, Meng S, et al. Transcriptional co-activator p300 maintains basal hepatic gluconeogenesis. J Biol Chem. 2012;287: 32069-32077.
30. Arrizabalaga O, Lacerda HM, Zubiaga AM, Zugaza JL. Rac1 protein regulates glycogen phosphorylase activation and controls interleukin (IL)-2-dependent T cell proliferation. J Biol Chem. 2012; 287:11878-11890.
31. Andersen B, Westergaard N. The effect of glucose on the potency of two distinct glycogen phosphorylase inhibitors. Biochem J. 2002; 367(Pt 2):443-450.
32. Thomas JA, Schlender KK, Larner J. A rapid filter paper assay for UDPglucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucose. Anal Biochem. 1968;25:486-499.
33. Liu Y, Dentin R, Chen D, et al. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature. 2008; 456:269-273.
34. Davis MA, Williams PE, Cherrington AD. Effect of a mixed meal on hepatic lactate and gluconeogenic precursor metabolism in dogs. Am J Physiol. 1984;247:E362-E369.
35. Wang J, Gallagher D, DeVito LM, et al. Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. Cell Stem Cell. 2012;11:23-35.
36. Zhou XY, Shibusawa N, Naik K, et al. Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein. Nat Med. 2004;10:633-637.
37. Boyd ME, Albright EB, Foster DW, McGarry JD. In vitro reversal of the fasting state of liver metabolism in the rat. Reevaluation of the roles of insulin and glucose. J Clin Invest. 1981;68:142-152.
38. Katz J, Golden S, Wals PA. Stimulation of hepatic glycogen synthesis by amino acids. Proc Natl Acad Sci USA. 1976;73:3433-3437.
39. Boden G, Cheung P, Stein TP, Kresge K, Mozzoli M. FFA cause hepatic insulin resistance by inhibiting insulin suppression of glycogenolysis. Am J Physiol Endocrinol Metab. 2002;283:E12-E19.
40. Adkins A, Basu R, Persson M, et al. Higher insulin concentrations are required to suppress gluconeogenesis than glycogenolysis in nondiabetic humans. Diabetes. 2003;52:2213-2220.
41. Nuttall FQ, Ngo A, Gannon MC. Regulation of hepatic glucose production and the role of gluconeogenesis in humans: is the rate of gluconeogenesis constant? Diabetes Metab Res Rev. 2008;24:438-458.
42. Rizza RA. Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes: implications for therapy. Diabetes. 2010;59: 2697-2707.
43. Krssak M, Brehm A, Bernroider E, et al. Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes. Diabetes. 2004;53: 3048-3056.
44. Magnusson I, Rothman DL, Katz LD, Shulman RG, Shulman GI. Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study. J Clin Invest. 1992;90:1323-1327.
45. Willms B, Ben-Ami P, Soling HD. Hepatic enzyme activities of glycolysisand gluconeogenesis in diabetes of man and laboratory animals. Horm Metab Res. 1970;2:135-141.
46. Clore JN, Stillman J, Sugerman H. Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes. Diabetes. 2000;49:969-974. CBP, CREB-binding protein; CRE, cAMP response element; CREB, CRE-binding protein; GS, glycogen synthase; shRNA, short hairpin RNA; WT, wild type.