-
1
-
-
57249084249
-
Neutrophils of centenarians show function levels similar to those of young adults
-
Alonso-Fernandez P, Puerto M, Mate I, Ribera JM, De la Fuente M (2008) Neutrophils of centenarians show function levels similar to those of young adults. J Am Geriatr Soc 56:2244-2251
-
(2008)
J am Geriatr Soc
, vol.56
, pp. 2244-2251
-
-
Alonso-Fernandez, P.1
Puerto, M.2
Mate, I.3
Ribera, J.M.4
De La Fuente, M.5
-
3
-
-
4043147336
-
Environmental enrichment improves cognition in aged Alzheimer’s transgenic mice despite stable beta-amyloid deposition
-
Arendash GW, Garcia MF, Costa DA, Cracchiolo JR, Wefes IM, Potter H (2004) Environmental enrichment improves cognition in aged Alzheimer’s transgenic mice despite stable beta-amyloid deposition. Neuroreport 15:1751-1754
-
(2004)
Neuroreport
, vol.15
, pp. 1751-1754
-
-
Arendash, G.W.1
Garcia, M.F.2
Costa, D.A.3
Cracchiolo, J.R.4
Wefes, I.M.5
Potter, H.6
-
6
-
-
77956110851
-
Environmental enrichment improves age-related immune system impairment. Long-term exposure since adulthood increases life span in mice
-
Arranz L, De Castro NM, Baeza I, Mate I, Viveros MP, De la Fuente M (2010a) Environmental enrichment improves age-related immune system impairment. Long-term exposure since adulthood increases life span in mice. Rejuvenation Res 13:415-428
-
(2010)
Rejuvenation Res
, vol.13
, pp. 415-428
-
-
Arranz, L.1
De Castro, N.M.2
Baeza, I.3
Mate, I.4
Viveros, M.P.5
De La Fuente, M.6
-
7
-
-
78649329478
-
Preserved ex vivo inflammatory status and cytokine responses in naturally long-lived mice
-
Arranz L, Lord JM, De la Fuente M (2010b) Preserved ex vivo inflammatory status and cytokine responses in naturally long-lived mice. Age (Dordr) 32:451-466
-
(2010)
Age (Dordr)
, vol.32
, pp. 451-466
-
-
Arranz, L.1
Lord, J.M.2
De La Fuente, M.3
-
8
-
-
77955863405
-
Preserved immune functions and controlled leukocyte oxidative stress in naturally long-lived mice: Possible role of nuclear factor kappa B
-
Arranz L, Caamano JH, Lord JM, De la Fuente M (2010c) Preserved immune functions and controlled leukocyte oxidative stress in naturally long-lived mice: possible role of nuclear factor kappa B. J Gerontol A Biol Sci Med Sci 65:941-950
-
(2010)
J Gerontol a Biol Sci Med Sci
, vol.65
, pp. 941-950
-
-
Arranz, L.1
Caamano, J.H.2
Lord, J.M.3
De La Fuente, M.4
-
9
-
-
77954956801
-
Differential expression of Toll-like receptor 2 and 4 on peritoneal leukocyte populations from long-lived and non-selected old female mice
-
Arranz L, De Castro NM, Baeza I, De la Fuente M (2010d) Differential expression of Toll-like receptor 2 and 4 on peritoneal leukocyte populations from long-lived and non-selected old female mice. Biogerontology 11:475-482
-
(2010)
Biogerontology
, vol.11
, pp. 475-482
-
-
Arranz, L.1
De Castro, N.M.2
Baeza, I.3
De La Fuente, M.4
-
11
-
-
23744505083
-
Age-related oxidative protein damages in central nervous system of rats: Modulatory role of grape seed extract
-
Balu M, Sangeetha P, Murali G, Panneerselvam C (2005) Age-related oxidative protein damages in central nervous system of rats: modulatory role of grape seed extract. Int J Dev Neuroscience 23:501-507
-
(2005)
Int J Dev Neuroscience
, vol.23
, pp. 501-507
-
-
Balu, M.1
Sangeetha, P.2
Murali, G.3
Panneerselvam, C.4
-
12
-
-
33749242959
-
The immune system and happiness
-
Barak Y (2006) The immune system and happiness. Autoimmun Rev 5:523-527
-
(2006)
Autoimmun Rev
, vol.5
, pp. 523-527
-
-
Barak, Y.1
-
13
-
-
0028169132
-
Oxygen free radicals and antioxidants: A review
-
Barber DA, Harris SR (1994) Oxygen free radicals and antioxidants: a review. Am Pharm 34:2635
-
(1994)
Am Pharm
, vol.34
, pp. 2635
-
-
Barber, D.A.1
Harris, S.R.2
-
14
-
-
0036596625
-
Endogenous oxidative stress: Relationship to aging, longevity and caloric restriction
-
Barja G (2002) Endogenous oxidative stress: relationship to aging, longevity and caloric restriction. Aging Res Rev 1:397-411
-
(2002)
Aging Res Rev
, vol.1
, pp. 397-411
-
-
Barja, G.1
-
15
-
-
0028323318
-
In vivo evaluation of brain iron in Alzheimer’s disease and normal subjects using MRI
-
Bartzokis G, Sultzer D, Mintz J, Holt LE, Marx P, Phelan CK, Marder SR (1994) In vivo evaluation of brain iron in Alzheimer’s disease and normal subjects using MRI. Biol Psychiatry 35:480-487
-
(1994)
Biol Psychiatry
, vol.35
, pp. 480-487
-
-
Bartzokis, G.1
Sultzer, D.2
Mintz, J.3
Holt, L.E.4
Marx, P.5
Phelan, C.K.6
Marder, S.R.7
-
16
-
-
0345276530
-
Environmental enrichment lowers stress-responsive hormones in singly housed male and female rats
-
Belz EE, Kennell JS, Czambel RK, Rubin RT, Rhodes ME (2003) Environmental enrichment lowers stress-responsive hormones in singly housed male and female rats. Pharmacol Biochem Behav 76:481-486
-
(2003)
Pharmacol Biochem Behav
, vol.76
, pp. 481-486
-
-
Belz, E.E.1
Kennell, J.S.2
Czambel, R.K.3
Rubin, R.T.4
Rhodes, M.E.5
-
17
-
-
4544344733
-
Environmental enrichment in mice decreases anxiety, attenuates stress responses and enhances natural killer cell activity
-
Benaroya-Milshtein N, Hollander N, Apter A, Kukulansky T, Raz N, Wilf A, Yaniv I, Pick CG (2004) Environmental enrichment in mice decreases anxiety, attenuates stress responses and enhances natural killer cell activity. Eur J Neurosci 20:1341-1347
-
(2004)
Eur J Neurosci
, vol.20
, pp. 1341-1347
-
-
Benaroya-Milshtein, N.1
Hollander, N.2
Apter, A.3
Kukulansky, T.4
Raz, N.5
Wilf, A.6
Yaniv, I.7
Pick, C.G.8
-
18
-
-
33845186911
-
Physiology of psychoneuroimmunology: A personal view
-
Besedovsky HO, Del Rey A (2007) Physiology of psychoneuroimmunology: a personal view. Brain Behav Immun 21:34-44
-
(2007)
Brain Behav Immun
, vol.21
, pp. 34-44
-
-
Besedovsky, H.O.1
Del Rey, A.2
-
19
-
-
77950229880
-
Neural mechanisms of aging and cognitive decline
-
Bishop NA, Lu T, Yankner BA (2010) Neural mechanisms of aging and cognitive decline. Nature 464:529-535
-
(2010)
Nature
, vol.464
, pp. 529-535
-
-
Bishop, N.A.1
Lu, T.2
Yankner, B.A.3
-
20
-
-
0038133269
-
Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis
-
Brown J, Cooper-Kuhn CM, Kempermann G, Van Praag H, Winkler J, Gage FH, Kuhn HG (2003) Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis. Eur J Neurosci 17:2042-2046
-
(2003)
Eur J Neurosci
, vol.17
, pp. 2042-2046
-
-
Brown, J.1
Cooper-Kuhn, C.M.2
Kempermann, G.3
Van Praag, H.4
Winkler, J.5
Gage, F.H.6
Kuhn, H.G.7
-
21
-
-
13444283646
-
New neurons in the dentate gyrus are involved in the expression of enhanced long-term memory following environmental enrichment
-
Bruel-Jungerman E, Laroche S, Rampon C (2005) New neurons in the dentate gyrus are involved in the expression of enhanced long-term memory following environmental enrichment. Eur J Neurosci 21:513-521
-
(2005)
Eur J Neurosci
, vol.21
, pp. 513-521
-
-
Bruel-Jungerman, E.1
Laroche, S.2
Rampon, C.3
-
22
-
-
0036236006
-
The mitochondrial-lysosomal axis theory of aging: Accumulation of damaged mitrochondria as a result of imperfect autophagocytosis
-
Brunk UT, Terman A (2002) The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitrochondria as a result of imperfect autophagocytosis. Eur J Biochem 269:1996-2002
-
(2002)
Eur J Biochem
, vol.269
, pp. 1996-2002
-
-
Brunk, U.T.1
Terman, A.2
-
23
-
-
1842525777
-
Increased expression of heat shock proteins in rat brain during aging: Relationship with mitochondrial function and glutathione redox state
-
Calabrese V, Scapagnini G, Ravagna A, Colombrita C, Spadaro F, Butterfield DA, Guffrida Stella AM (2004) Increased expression of heat shock proteins in rat brain during aging: relationship with mitochondrial function and glutathione redox state. Mech Aging Dev 125:325-335
-
(2004)
Mech Aging Dev
, vol.125
, pp. 325-335
-
-
Calabrese, V.1
Scapagnini, G.2
Ravagna, A.3
Colombrita, C.4
Spadaro, F.5
Butterfield, D.A.6
Guffrida Stella, A.M.7
-
25
-
-
0018776894
-
Hydroperoxide metabolism in mammalian organs
-
Chance B, Sies H, Boveris A (1979) Hydroperoxide metabolism in mammalian organs. Physiol Rev 59:527-605
-
(1979)
Physiol Rev
, vol.59
, pp. 527-605
-
-
Chance, B.1
Sies, H.2
Boveris, A.3
-
26
-
-
0024325997
-
T2 values in the human brain: Comparison with quantitative assays of iron and ferritin
-
Chen JC, Hardy PA, Clauberg M, Joshi JG, Parravano J, Deck JH, Henkelman RM, Becker LE, Kucharczyk W (1989) T2 values in the human brain: comparison with quantitative assays of iron and ferritin. Radiology 173:521-526
-
(1989)
Radiology
, vol.173
, pp. 521-526
-
-
Chen, J.C.1
Hardy, P.A.2
Clauberg, M.3
Joshi, J.G.4
Parravano, J.5
Deck, J.H.6
Henkelman, R.M.7
Becker, L.E.8
Kucharczyk, W.9
-
27
-
-
0031935568
-
Sex differences in brain aging: A quantitative magnetic resonance imaging study
-
Coffey CE, Lucke JF, Saxton JA, Ratcliff G, Unitas LJ, Billig B, Bryan RN (1998) Sex differences in brain aging: a quantitative magnetic resonance imaging study. Arch Neurol 55:169-179
-
(1998)
Arch Neurol
, vol.55
, pp. 169-179
-
-
Coffey, C.E.1
Lucke, J.F.2
Saxton, J.A.3
Ratcliff, G.4
Unitas, L.J.5
Billig, B.6
Bryan, R.N.7
-
29
-
-
80255127361
-
Neurogenesis, cellular plasticity and cognition: The impact of stem cells in the adult and aging brain
-
Couillard-Despres S, Iglseder B, Aigner L (2011) Neurogenesis, cellular plasticity and cognition: the impact of stem cells in the adult and aging brain. Gerontology 57:559-564
-
(2011)
Gerontology
, vol.57
, pp. 559-564
-
-
Couillard-Despres, S.1
Iglseder, B.2
Aigner, L.3
-
30
-
-
57149096659
-
Role of neuroimmunomodulation in aging
-
De la Fuente M (2008) Role of neuroimmunomodulation in aging. Neuroimmunomodulation 15:213-223
-
(2008)
Neuroimmunomodulation
, vol.15
, pp. 213-223
-
-
De La Fuente, M.1
-
31
-
-
70449431387
-
An update of the oxidation-inflammation theory of aging: The involvement of the immune systemin oxi-inflamm-aging
-
De la Fuente M, Miquel J (2009) An update of the oxidation-inflammation theory of aging: the involvement of the immune systemin oxi-inflamm-aging. Curr Pharm Des 15:3003-3026
-
(2009)
Curr Pharm Des
, vol.15
, pp. 3003-3026
-
-
De La Fuente, M.1
Miquel, J.2
-
32
-
-
16344376370
-
Inflamm-aging and lifelong antigenic load as major determinants of aging rate and longevity
-
De Martinis M, Franceschi C, Monti D, Ginaldi L (2005) Inflamm-aging and lifelong antigenic load as major determinants of aging rate and longevity. FEBS Lett 579:2035-2039
-
(2005)
FEBS Lett
, vol.579
, pp. 2035-2039
-
-
De Martinis, M.1
Franceschi, C.2
Monti, D.3
Ginaldi, L.4
-
34
-
-
34447324973
-
Immunological biomarkers of aging in man: Changes in both innate and adaptive immunity are associated with health and longevity
-
De la Rosa O, Pawelec G, Peralbo E, Wikby A, Mariani E, Mocchegiani E, Tarazona R, Solana R (2006) Immunological biomarkers of aging in man: changes in both innate and adaptive immunity are associated with health and longevity. Biogerontology 7:471-481
-
(2006)
Biogerontology
, vol.7
, pp. 471-481
-
-
De La Rosa, O.1
Pawelec, G.2
Peralbo, E.3
Wikby, A.4
Mariani, E.5
Mocchegiani, E.6
Tarazona, R.7
Solana, R.8
-
35
-
-
0030693927
-
T2-weighted MRI studies of mouse lemurs: A primate model of brain aging
-
Dhenain M, Michot JL, Volk A, Picq JL, Boiler F (1997) T2-weighted MRI studies of mouse lemurs: a primate model of brain aging. Neurobiol Aging 18:517-521
-
(1997)
Neurobiol Aging
, vol.18
, pp. 517-521
-
-
Dhenain, M.1
Michot, J.L.2
Volk, A.3
Picq, J.L.4
Boiler, F.5
-
36
-
-
28244472080
-
Growth hormone administration to aged animals reduces disulfideglutathione levels in hippocampus
-
Donahue AN, Aschner M, Lash LH, Syversen T, Sonntag WE (2006) Growth hormone administration to aged animals reduces disulfideglutathione levels in hippocampus. Mech Aging Dev 127:57-63
-
(2006)
Mech Aging Dev
, vol.127
, pp. 57-63
-
-
Donahue, A.N.1
Aschner, M.2
Lash, L.H.3
Syversen, T.4
Sonntag, W.E.5
-
37
-
-
0022529733
-
MRI of brain iron
-
Drayer B, Burger P, Darwin R, Riederer S, Herfkens R, Johnson GA (1986) MRI of brain iron. AJR Am J Roentgenol 147:103-110
-
(1986)
AJR am J Roentgenol
, vol.147
, pp. 103-110
-
-
Drayer, B.1
Burger, P.2
Darwin, R.3
Riederer, S.4
Herfkens, R.5
Johnson, G.A.6
-
38
-
-
0036977353
-
Aging-related changes in the thiol/disulfide redox state: Implications for the use of thiol antioxidants
-
Droge W (2002) Aging-related changes in the thiol/disulfide redox state: implications for the use of thiol antioxidants. Exp Gerontol 37:1333-1345
-
(2002)
Exp Gerontol
, vol.37
, pp. 1333-1345
-
-
Droge, W.1
-
39
-
-
34249104544
-
Oxidative stress and aberrant signaling in aging and cognitive decline
-
Droge W, Schipper HM (2007) Oxidative stress and aberrant signaling in aging and cognitive decline. Aging Cell 6:361-370
-
(2007)
Aging Cell
, vol.6
, pp. 361-370
-
-
Droge, W.1
Schipper, H.M.2
-
40
-
-
0025417859
-
A neuroendocrine-immune theory of aging
-
Fabris N (1990) A neuroendocrine-immune theory of aging. Int J Neurosci 51:373-375
-
(1990)
Int J Neurosci
, vol.51
, pp. 373-375
-
-
Fabris, N.1
-
41
-
-
0028294612
-
Impairment of mitochondrial oxidative phosphorylation in the brain of aged mice
-
Ferrandiz ML, Martinez M, De Juan E, Diez A, Bustos G, Miquel J (1994) Impairment of mitochondrial oxidative phosphorylation in the brain of aged mice. Brain Res 644:335-338
-
(1994)
Brain Res
, vol.644
, pp. 335-338
-
-
Ferrandiz, M.L.1
Martinez, M.2
De Juan, E.3
Diez, A.4
Bustos, G.5
Miquel, J.6
-
42
-
-
34248523169
-
Recovery of learning and memory is associated with chromatin remodelling
-
Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai LH (2007) Recovery of learning and memory is associated with chromatin remodelling. Nature 447:178-182
-
(2007)
Nature
, vol.447
, pp. 178-182
-
-
Fischer, A.1
Sananbenesi, F.2
Wang, X.3
Dobbin, M.4
Tsai, L.H.5
-
44
-
-
43249096157
-
Effects of environmental enrichment on exploration, anxiety, and memory in female TgCRND8 Alzheimer mice
-
Gortz N, Lewejohann L, Tomm M, Ambree O, Keyvani K, Paulus W, Sachser N (2008) Effects of environmental enrichment on exploration, anxiety, and memory in female TgCRND8 Alzheimer mice. Behav Brain Res 191:43-48
-
(2008)
Behav Brain Res
, vol.191
, pp. 43-48
-
-
Gortz, N.1
Lewejohann, L.2
Tomm, M.3
Ambree, O.4
Keyvani, K.5
Paulus, W.6
Sachser, N.7
-
45
-
-
0037393466
-
An impairment of phagocytic function is linked to a shorter life span in two strains of prematurely aging mice
-
Guayerbas N, De la Fuente M (2003) An impairment of phagocytic function is linked to a shorter life span in two strains of prematurely aging mice. Dev Comp Immunol 27:339-350
-
(2003)
Dev Comp Immunol
, vol.27
, pp. 339-350
-
-
Guayerbas, N.1
De La Fuente, M.2
-
46
-
-
0037151259
-
Relation of behaviour and macrophage function to life span in a murine model of premature immunosenescence
-
Guayerbas N, Catalan M, Victor VM, Miquel J, De la Fuente M (2002a) Relation of behaviour and macrophage function to life span in a murine model of premature immunosenescence. Behav Brain Res 134(1-2):41-48
-
(2002)
Behav Brain Res
, vol.134
, Issue.1-2
, pp. 41-48
-
-
Guayerbas, N.1
Catalan, M.2
Victor, V.M.3
Miquel, J.4
De La Fuente, M.5
-
47
-
-
0037012047
-
Leukocyte function and life span in a murine model of premature immunosenescence
-
Guayerbas N, Puerto M, Victor VM, Miquel J, De la Fuente M (2002b) Leukocyte function and life span in a murine model of premature immunosenescence. Exp Gerontol 37(2-3):249-256
-
(2002)
Exp Gerontol
, vol.37
, Issue.2-3
, pp. 249-256
-
-
Guayerbas, N.1
Puerto, M.2
Victor, V.M.3
Miquel, J.4
De La Fuente, M.5
-
48
-
-
0035964315
-
Does oxidative damage to DNA increase with age?
-
Hamilton ML, Van Remmen H, Drake JA, Yang H, Guo ZM, Kewitt K, Walter CA, Richardson A (2001) Does oxidative damage to DNA increase with age? Proc Natl Acad Sci U S A 98:10469-10474
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 10469-10474
-
-
Hamilton, M.L.1
Van Remmen, H.2
Drake, J.A.3
Yang, H.4
Guo, Z.M.5
Kewitt, K.6
Walter, C.A.7
Richardson, A.8
-
49
-
-
0037470542
-
Aging and genome maintenance: Lessons from the mouse?
-
Hasty P, Campisi J, Hoeijmakers J, van Steeg H, Vijg J (2003) Aging and genome maintenance: lessons from the mouse? Science 299(5611):1355-1359
-
(2003)
Science
, vol.299
, Issue.5611
, pp. 1355-1359
-
-
Hasty, P.1
Campisi, J.2
Hoeijmakers, J.3
Van Steeg, H.4
Vijg, J.5
-
51
-
-
0042023711
-
Alzheimer disease in the US population: Prevalence estimates using the 2000 census
-
Hebert LE, Scherr PA, Bienias JL, Bennett DA, Evans DA (2003) Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol 60:1119-1122
-
(2003)
Arch Neurol
, vol.60
, pp. 1119-1122
-
-
Hebert, L.E.1
Scherr, P.A.2
Bienias, J.L.3
Bennett, D.A.4
Evans, D.A.5
-
52
-
-
0842324563
-
Infection as a cause of age-related morbidity and mortality
-
High KP (2004) Infection as a cause of age-related morbidity and mortality. Aging Res Rev 3:1-14
-
(2004)
Aging Res Rev
, vol.3
, pp. 1-14
-
-
High, K.P.1
-
53
-
-
1242292288
-
Could a deficiency in growth hormone signaling be beneficial to the aging brain?
-
Kinney-Forshee BA, Kinney NE, Steger RW, Bartke A (2004) Could a deficiency in growth hormone signaling be beneficial to the aging brain? Physiol Behav 80:589-594
-
(2004)
Physiol Behav
, vol.80
, pp. 589-594
-
-
Kinney-Forshee, B.A.1
Kinney, N.E.2
Steger, R.W.3
Bartke, A.4
-
54
-
-
3343012188
-
Dominance hieraechy influences adult neurogenesis in the dentate gyrus
-
Kozorovitskiy Y, Gould E (2004) Dominance hieraechy influences adult neurogenesis in the dentate gyrus. J Neurosci 24:6755-6759
-
(2004)
J Neurosci
, vol.24
, pp. 6755-6759
-
-
Kozorovitskiy, Y.1
Gould, E.2
-
55
-
-
20044377403
-
Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice
-
Lazarov O, Robinson J, Tang YP, Hairston IS, Korade-Mirnics Z, Lee VM, Hersh LB, Sapolsky RM, Mimics K, Sisodia SS (2005) Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell 120:701-713
-
(2005)
Cell
, vol.120
, pp. 701-713
-
-
Lazarov, O.1
Robinson, J.2
Tang, Y.P.3
Hairston, I.S.4
Korade-Mirnics, Z.5
Lee, V.M.6
Hersh, L.B.7
Sapolsky, R.M.8
Mimics, K.9
Sisodia, S.S.10
-
56
-
-
33750347347
-
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
-
Lin MT, Beal MF (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443:787-795
-
(2006)
Nature
, vol.443
, pp. 787-795
-
-
Lin, M.T.1
Beal, M.F.2
-
57
-
-
0037470488
-
Evolutionary medicine: From dwarf model to healthy centenarians?
-
Longo VD, Finch CE (2003) Evolutionary medicine: from dwarf model to healthy centenarians? Science 299:1342-1346
-
(2003)
Science
, vol.299
, pp. 1342-1346
-
-
Longo, V.D.1
Finch, C.E.2
-
58
-
-
3042631024
-
Gene regulation and DNA damage in the aging human brain
-
Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, Yankner BA (2004) Gene regulation and DNA damage in the aging human brain. Nature 429:883-891
-
(2004)
Nature
, vol.429
, pp. 883-891
-
-
Lu, T.1
Pan, Y.2
Kao, S.Y.3
Li, C.4
Kohane, I.5
Chan, J.6
Yankner, B.A.7
-
59
-
-
67349157695
-
Effects of stress throughout the lifespan on the brain, behaviour and cognition
-
Lupien SJ, McEwen BS, Gunnar MR, Heim C (2009) Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nature Rev Neurosci 10:434-445
-
(2009)
Nature Rev Neurosci
, vol.10
, pp. 434-445
-
-
Lupien, S.J.1
Mc ewen, B.S.2
Gunnar, M.R.3
Heim, C.4
-
60
-
-
77956986751
-
Skin and brain age together: The role of hormones in the aging process
-
Makrantonaki E, Schonknecht P, Hossini AM, Kaiser E, Katsouli MM, Adjaye J, Schroder J, Zouboulis CC (2010) Skin and brain age together: the role of hormones in the aging process. Exp Gerontol 45:801-813
-
(2010)
Exp Gerontol
, vol.45
, pp. 801-813
-
-
Makrantonaki, E.1
Schonknecht, P.2
Hossini, A.M.3
Kaiser, E.4
Katsouli, M.M.5
Adjaye, J.6
Schroder, J.7
Zouboulis, C.C.8
-
62
-
-
0030915855
-
Oxidative stress hypothesis in Alzheimer’s disease
-
Markesbery WR (1997) Oxidative stress hypothesis in Alzheimer’s disease. Free Radic Biol Med 23:134-147
-
(1997)
Free Radic Biol Med
, vol.23
, pp. 134-147
-
-
Markesbery, W.R.1
-
64
-
-
0035978954
-
Suppression of brain aging and neurodegenerative disorders by dietary restriction and environmental enrichment: Molecular mechanisms
-
Mattson MP, Duan W, Lee J, Guo Z (2001) Suppression of brain aging and neurodegenerative disorders by dietary restriction and environmental enrichment: molecular mechanisms. Mech Aging Dev 122:757-778
-
(2001)
Mech Aging Dev
, vol.122
, pp. 757-778
-
-
Mattson, M.P.1
Duan, W.2
Lee, J.3
Guo, Z.4
-
65
-
-
33745684603
-
Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment
-
Meshi D, Drew MR, Saxe M, Ansorge MS, David D, Santarelli L, Malapani C, Moore H, Hen R (2006) Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment. Nat Neurosci 9:729-731
-
(2006)
Nat Neurosci
, vol.9
, pp. 729-731
-
-
Meshi, D.1
Drew, M.R.2
Saxe, M.3
Ansorge, M.S.4
David, D.5
Santarelli, L.6
Malapani, C.7
Moore, H.8
Hen, R.9
-
67
-
-
34548801253
-
Aging, plasticity and environmental enrichment: Structural changes and neurotransmitter dynamics in several areas of the brain
-
Mora F, Segovia G, del Arco A (2007) Aging, plasticity and environmental enrichment: structural changes and neurotransmitter dynamics in several areas of the brain. Brain Res Rev 55:78-88
-
(2007)
Brain Res Rev
, vol.55
, pp. 78-88
-
-
Mora, F.1
Segovia, G.2
Del Arco, A.3
-
68
-
-
0030698871
-
Life and death of neurons in the aging brain
-
Morrison JH, Hof PR (1997) Life and death of neurons in the aging brain. Science 278:412-419
-
(1997)
Science
, vol.278
, pp. 412-419
-
-
Morrison, J.H.1
Hof, P.R.2
-
69
-
-
34447316414
-
Trends in oxidative aging theories
-
Muller FL, Lustgarten MS, Jang Y, Richardson A, Van Remmen H (2007) Trends in oxidative aging theories. Free Radic Biol Med 43:477-503
-
(2007)
Free Radic Biol Med
, vol.43
, pp. 477-503
-
-
Muller, F.L.1
Lustgarten, M.S.2
Jang, Y.3
Richardson, A.4
Van Remmen, H.5
-
70
-
-
0026687990
-
Age-related differences in volumes of subcortical nuclei, brain matter, and cerebrospinal fluid in healthy men as measured with magnetic resonance imaging
-
Murphy DG, DeCarli C, Schapiro MB, Rapoport SI, Horwitz B (1992) Age-related differences in volumes of subcortical nuclei, brain matter, and cerebrospinal fluid in healthy men as measured with magnetic resonance imaging. Arch Neurol 49:839-845
-
(1992)
Arch Neurol
, vol.49
, pp. 839-845
-
-
Murphy, D.G.1
Decarli, C.2
Schapiro, M.B.3
Rapoport, S.I.4
Horwitz, B.5
-
71
-
-
6344289360
-
Rat brain and liver mitochondria develop oxidative stress and lose enzymatic activities on aging
-
Navarro A, Boveris A (2004) Rat brain and liver mitochondria develop oxidative stress and lose enzymatic activities on aging. Am J Physiol Regul Integr Comp Physiol 287:R1244-R1249
-
(2004)
Am J Physiol Regul Integr Comp Physiol
, vol.287
-
-
Navarro, A.1
Boveris, A.2
-
72
-
-
0033564083
-
Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory
-
Nilsson M, Perfilieva E, Johansson U, Orwar O, Eriksson PS (1999) Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory. J Neurobiol 39:569-578
-
(1999)
J Neurobiol
, vol.39
, pp. 569-578
-
-
Nilsson, M.1
Perfilieva, E.2
Johansson, U.3
Orwar, O.4
Eriksson, P.S.5
-
73
-
-
33747613561
-
Enriched environments, experience-dependent plasticity and disorders of nervous system
-
Nithianantharajan J, Hannan AJ (2006) Enriched environments, experience-dependent plasticity and disorders of nervous system. Nat Rev Neurosci 7:697-709
-
(2006)
Nat Rev Neurosci
, vol.7
, pp. 697-709
-
-
Nithianantharajan, J.1
Hannan, A.J.2
-
74
-
-
56749156405
-
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
-
Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA (2008) SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell 135:907-918
-
(2008)
Cell
, vol.135
, pp. 907-918
-
-
Oberdoerffer, P.1
Michan, S.2
Mc vay, M.3
Mostoslavsky, R.4
Vann, J.5
Park, S.K.6
Hartlerode, A.7
Stegmuller, J.8
Hafner, A.9
Loerch, P.10
Wright, S.M.11
Mills, K.D.12
Bonni, A.13
Yankner, B.A.14
Scully, R.15
Prolla, T.A.16
Alt, F.W.17
Sinclair, D.A.18
-
75
-
-
50849104569
-
Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island
-
O’Hagan HM, Mohammad HP, Baylin SB (2008) Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island. PLoS Genet 4:e1000155
-
(2008)
PLoS Genet
, vol.4
-
-
O’hagan, H.M.1
Mohammad, H.P.2
Baylin, S.B.3
-
76
-
-
0036584494
-
T cells and aging, January 2002 update
-
Pawelec G, Barnett Y, Forsey R, Frasca D, Globerson A, McLeod J, Caruso C, Franceschi C, Fulop T, Gupta S, Mariani E, Mocchegiani E, Solana R (2002) T cells and aging, January 2002 update. Front Biosci 7:d1056-d1183
-
(2002)
Front Biosci
, vol.7
-
-
Pawelec, G.1
Barnett, Y.2
Forsey, R.3
Frasca, D.4
Globerson, A.5
Mc leod, J.6
Caruso, C.7
Franceschi, C.8
Fulop, T.9
Gupta, S.10
Mariani, E.11
Mocchegiani, E.12
Solana, R.13
-
78
-
-
33646699107
-
Proteomics analyses of specific protein oxidation and protein expression in aged rat brain and its modulation by L-acetylcarnitine: Insights into the mechanisms of action of this proposed therapeutic agent for CNS disorders associated with oxidative stress
-
Poon HF, Calabrese V, Calvani M, Butterfield DA (2006) Proteomics analyses of specific protein oxidation and protein expression in aged rat brain and its modulation by L-acetylcarnitine: insights into the mechanisms of action of this proposed therapeutic agent for CNS disorders associated with oxidative stress. Antioxid Redox Signal 8:381-394
-
(2006)
Antioxid Redox Signal
, vol.8
, pp. 381-394
-
-
Poon, H.F.1
Calabrese, V.2
Calvani, M.3
Butterfield, D.A.4
-
79
-
-
22144481264
-
Modulation of neuropeptide Y and norepinephrine on several leucocyte functions in adult, old and very old mice
-
Puerto M, Guayerbas N, Alvarez P, De la Fuente M (2005) Modulation of neuropeptide Y and norepinephrine on several leucocyte functions in adult, old and very old mice. J Neuroimmunol 165(1-2):33-40
-
(2005)
J Neuroimmunol
, vol.165
, Issue.1-2
, pp. 33-40
-
-
Puerto, M.1
Guayerbas, N.2
Alvarez, P.3
De La Fuente, M.4
-
80
-
-
40149089557
-
Increased molecular damage and heterogeneity as the basis of aging
-
Rattan SI (2008) Increased molecular damage and heterogeneity as the basis of aging. Biol Chem 389:267-272
-
(2008)
Biol Chem
, vol.389
, pp. 267-272
-
-
Rattan, S.I.1
-
81
-
-
77953182378
-
Targeting the age-related occurrence, removal, and accumulation of molecular damage by hormesis
-
Rattan SI (2010) Targeting the age-related occurrence, removal, and accumulation of molecular damage by hormesis. Ann N Y Acad Sci 1197:28-32
-
(2010)
Ann N Y Acad Sci
, vol.1197
, pp. 28-32
-
-
Rattan, S.I.1
-
82
-
-
0035191204
-
Environmental enrichment in BALB/c mice: Effects in classical tests of anxiety and exposure to a predatory odor
-
Roy V, Belzung C, Delarue C, Chapillon P (2001) Environmental enrichment in BALB/c mice: effects in classical tests of anxiety and exposure to a predatory odor. Physiol Behav 74:313-320
-
(2001)
Physiol Behav
, vol.74
, pp. 313-320
-
-
Roy, V.1
Belzung, C.2
Delarue, C.3
Chapillon, P.4
-
83
-
-
13944257674
-
Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation and survival in the adult dentate gyrus
-
Sairanen M, Lucas G, Ernfors P, Castren M (2005) Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation and survival in the adult dentate gyrus. J Neurosci 25:1089-1094
-
(2005)
J Neurosci
, vol.25
, pp. 1089-1094
-
-
Sairanen, M.1
Lucas, G.2
Ernfors, P.3
Castren, M.4
-
85
-
-
0027449943
-
Age distribution and iron dependency of the T2 relaxation time in the globus pallidus and putamen
-
Schenker C, Meier D, Wichmann W, Boesiger P, Valavanis A (1993) Age distribution and iron dependency of the T2 relaxation time in the globus pallidus and putamen. Neuroradiology 35:119-124
-
(1993)
Neuroradiology
, vol.35
, pp. 119-124
-
-
Schenker, C.1
Meier, D.2
Wichmann, W.3
Boesiger, P.4
Valavanis, A.5
-
86
-
-
3042658542
-
Brain iron deposition and the free radical-mitochondrial theory of aging
-
Schipper HM (2004) Brain iron deposition and the free radical-mitochondrial theory of aging. Aging Res Rev 3:265-301
-
(2004)
Aging Res Rev
, vol.3
, pp. 265-301
-
-
Schipper, H.M.1
-
87
-
-
33744503719
-
Environmental enrichment promotes neurogenesis and changes the extracellular concentrations of glutamate and GABA in the hippocampus of aged rats
-
Segovia G, Yague AG, Garda-Verdugo JM, Mora F (2006) Environmental enrichment promotes neurogenesis and changes the extracellular concentrations of glutamate and GABA in the hippocampus of aged rats. Brain Res Bull 70:8-14
-
(2006)
Brain Res Bull
, vol.70
, pp. 8-14
-
-
Segovia, G.1
Yague, A.G.2
Garda-Verdugo, J.M.3
Mora, F.4
-
88
-
-
67651249565
-
Environmental enrichment, prefrontal cortex, stress, and aging of the brain
-
Segovia G, Arco AD, Mora F (2009) Environmental enrichment, prefrontal cortex, stress, and aging of the brain. J Neural Transm 116:1007-1016
-
(2009)
J Neural Transm
, vol.116
, pp. 1007-1016
-
-
Segovia, G.1
Arco, A.D.2
Mora, F.3
-
89
-
-
27644596252
-
Aging affects oxidative state in hippocampus, hypothalamus and adrenal glands of Wistar rats
-
Sigueira IR, Fochesatto C, Lucena da Silva Torres I, Dalmaz C, Netto CA (2005) Aging affects oxidative state in hippocampus, hypothalamus and adrenal glands of Wistar rats. Life Sci78:271-278
-
(2005)
Life Sci
, vol.78
, pp. 271-278
-
-
Sigueira, I.R.1
Fochesatto, C.2
Da Silva, L.3
Torres, I.4
Dalmaz, C.5
Netto, C.A.6
-
90
-
-
79151485351
-
Beneficial effects of folic acid on enhancement of memory and antioxidant status in aged rat brain
-
Singh R, Kanwar SS, Sood PK, Nehru B (2011) Beneficial effects of folic acid on enhancement of memory and antioxidant status in aged rat brain. Cell Mol Neurobiol 31:83-91
-
(2011)
Cell Mol Neurobiol
, vol.31
, pp. 83-91
-
-
Singh, R.1
Kanwar, S.S.2
Sood, P.K.3
Nehru, B.4
-
91
-
-
0033772434
-
Evaluating the function of hippocampal subregions with high-resolution MRI in Alzheimer’s disease and aging
-
Small SA, Nava AS, Perera GM, Delapaz R, Stern Y (2000) Evaluating the function of hippocampal subregions with high-resolution MRI in Alzheimer’s disease and aging. Microsc Res Tech 51:101-108
-
(2000)
Microsc Res Tech
, vol.51
, pp. 101-108
-
-
Small, S.A.1
Nava, A.S.2
Perera, G.M.3
Delapaz, R.4
Stern, Y.5
-
92
-
-
34547749000
-
Inflammatory processes in the aging mouse brain: Participation of dendritic cells and T-cells
-
Stichel CC, Luebbert H (2007) Inflammatory processes in the aging mouse brain: participation of dendritic cells and T-cells. Neurobiol Aging 28:1507-1521
-
(2007)
Neurobiol Aging
, vol.28
, pp. 1507-1521
-
-
Stichel, C.C.1
Luebbert, H.2
-
93
-
-
34249684293
-
Adult neurogenesis in the hippocampus of long-lived mice during aging
-
Sun LY, Bartke A (2007) Adult neurogenesis in the hippocampus of long-lived mice during aging. J Gerontol A Biol Sci Med Sci 62:117-125
-
(2007)
J Gerontol a Biol Sci Med Sci
, vol.62
, pp. 117-125
-
-
Sun, L.Y.1
Bartke, A.2
-
94
-
-
0027283807
-
The dementias: Correlation of clinical features, pathophysiology, and neuroradiology
-
Tien RD, Felsberg GJ, Ferris NJ, Osumi AK (1993) The dementias: correlation of clinical features, pathophysiology, and neuroradiology. AJR Am J Roentgenol 161:245-255
-
(1993)
AJR am J Roentgenol
, vol.161
, pp. 245-255
-
-
Tien, R.D.1
Felsberg, G.J.2
Ferris, N.J.3
Osumi, A.K.4
-
95
-
-
0043037254
-
Neuronal aging from an intraneuronal perspective: Roles of endoplasmic reticulum and mitochondria
-
Toescu EC, Verkhratsky A (2003) Neuronal aging from an intraneuronal perspective: roles of endoplasmic reticulum and mitochondria. Cell Calcium 34:311-323
-
(2003)
Cell Calcium
, vol.34
, pp. 311-323
-
-
Toescu, E.C.1
Verkhratsky, A.2
-
97
-
-
0142151379
-
Mitochondrial theory of aging: Importance to explain why females live longer than males
-
Vina J, Sastre J, Pallardo F, Borras C (2003) Mitochondrial theory of aging: importance to explain why females live longer than males. Antioxid Redox Signal 5:549-556
-
(2003)
Antioxid Redox Signal
, vol.5
, pp. 549-556
-
-
Vina, J.1
Sastre, J.2
Pallardo, F.3
Borras, C.4
-
98
-
-
41749116202
-
Glial cell dysregulation: A new perspective on Alzheimer disease
-
von Bernhardi R (2007) Glial cell dysregulation: a new perspective on Alzheimer disease. Neuro-tox Res 12:215-232
-
(2007)
Neuro-Tox Res
, vol.12
, pp. 215-232
-
-
Von Bernhardi, R.1
-
99
-
-
78349252337
-
Brain aging in the oldest-old
-
von Gunten A, Ebbing K, Imhof A, Giannakopoulos P, Kovari E (2010) Brain aging in the oldest-old. Curr Gerontol Geriatr Res pii: 358-531
-
(2010)
Curr Gerontol Geriatr Res Pii
, pp. 358-531
-
-
Von Gunten, A.1
Ebbing, K.2
Imhof, A.3
Giannakopoulos, P.4
Kovari, E.5
-
101
-
-
0025213974
-
Cell-mediated immunity as a predictor of morbidity and mortality in subjects over 60
-
Wayne SL, Rhyne RL, Garry PJ, Goodwin JS (1990) Cell-mediated immunity as a predictor of morbidity and mortality in subjects over 60. J Gerontol 45:M45-48
-
(1990)
J Gerontol
, vol.45
-
-
Wayne, S.L.1
Rhyne, R.L.2
Garry, P.J.3
Goodwin, J.S.4
-
102
-
-
34249691621
-
Influence of aging and enriched environment on motor activity and emotional responses in mice
-
Zambrana Z, Marco EM, Arranz L, De Castro NM, Viveros MP, De la Fuente M (2007) Influence of aging and enriched environment on motor activity and emotional responses in mice. Ann N Y Acad Sci 1100:543-552
-
(2007)
Ann N Y Acad Sci
, vol.1100
, pp. 543-552
-
-
Zambrana, Z.1
Marco, E.M.2
Arranz, L.3
De Castro, N.M.4
Viveros, M.P.5
De La Fuente, M.6
-
103
-
-
33744525840
-
Age-related change in glutathione and glutathione related enzymes in rat brain
-
Zhu Y, Carvey PM, Ling Z (2006) Age-related change in glutathione and glutathione related enzymes in rat brain. Brain Res 1090:35-44
-
(2006)
Brain Res
, vol.1090
, pp. 35-44
-
-
Zhu, Y.1
Carvey, P.M.2
Ling, Z.3
|