Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus

Journal of Neuroscience

Volumn 25, Issue 5, 2005, Pages 1089-1094

  Sairanen, Mikko ^a   Lucas, Guilherme ^b   Ernfors, Patrik ^b   Castrén, Maija ^a   Castrén, Eero ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

BDNF; Fluoxetine; Imipramine; Neurogenesis; Neurotrophins; Progenitor; trkB; TUC 4

Indexed keywords

ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; BROXURIDINE; DNA NUCLEOTIDYLEXOTRANSFERASE; FLUOXETINE; IMIPRAMINE; URIDINE TRIPHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DENTATE GYRUS; HIPPOCAMPUS; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; SURVIVAL TIME; TRANSGENIC MOUSE; TURNOVER TIME; WILD TYPE;

ANIMALS; ANTIDEPRESSIVE AGENTS; APOPTOSIS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL DIVISION; DENTATE GYRUS; FEMALE; FLUOXETINE; HETEROZYGOTE; IMIPRAMINE; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; MICE, KNOCKOUT; MICE, TRANSGENIC; NEURONS; RECEPTOR, TRKB; SIGNAL TRANSDUCTION;

EID: 13944257674     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3741-04.2005     Document Type: Article

References (30)

1. Altar CA (1999) Neurotrophins and depression. Trends Pharmacol Sci 20:59-61.
2. Barde Y-A (1989) Trophic factors and neuronal survival. Neuron 2:1525-1534.
3. Barnabe-Heider F, Miller FD (2003) Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways. J Neurosci 23:5149-5160.
4. Castrén E (2004) Neurotrophic effects of antidepressant drugs. Curr Opin Pharmacol 4:58-64.
5. Chen B, Dowlatshahi D, MacQueen GM, Wang JF, Young LT (2001) Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biol Psychiatry 50:260-265.
6. Chen G, Rajkowska G, Du F, Seraji-Bozorgzad N, Manji HK (2000) Enhancement of hippocampal neurogenesis by lithium. J Neurochem 75:1729-1734.
7. Cohen-Cory S (2002) The developing synapse: construction and modulation of synaptic structures and circuits. Science 298:770-776.
8. Czeh B, Michaelis T, Watanabe T, Frahm J, de Biurrun G, van Kampen M, Bartolomucci A, Fuchs E (2001) Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proc Natl Acad Sci USA 98:12796-12801.
9. Duman RS, Heninger GR, Nestler EJ (1997) A molecular and cellular theory of depression. Arch Gen Psychiatry 54:597-606.
10. Ernfors P, Lee KF, Jaenisch R (1994) Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature 368:147-150.
11. Gould E (1999) Serotonin and hippocampal neurogenesis. Neuropsychopharmacology 21:46S-51S.
12. Huang EJ, Reichardt LF (2001) Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24:677-736.
13. Kempermann G, Kuhn HG, Gage FH (1997) More hippocampal neurons in adult mice living in an enriched environment. Nature 386:493-495.
14. Kulkarni VA, Jha S, Vaidya VA (2002) Depletion of norepinephrine decreases the proliferation, but does not influence the survival and differentiation, of granule cell progenitors in the adult rat hippocampus. Eur J Neurosci 16:2008-2012.
15. Lee J, Duan W, Mattson MP (2002) Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J Neurochem 82:1367-1375.
16. Levi-Montakini R (1987) The nerve growth factor: thirty-five years later. EMBO J 6:1145-1154.
17. Malberg JE, Eisch AJ, Nestler EJ, Duman RS (2000) Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 20:9104-9110.
18. McEwen BS (1999) Stress and hippocampal plasticity. Annu Rev Neurosci 22:105-122.
19. Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM (2002) Neurobiology of depression. Neuron 34:13-25.
20. Nibuya M, Morinobu S, Duman RS (1995) Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci 15:7539-7547.
21. Poo MM (2001) Neurotrophins as synaptic modulators. Nat Rev Neurosci 2:24-32.
22. Quinn CC, Gray GE, Hockfield S (1999) A family of proteins implicated in axon guidance and outgrowth. J Neurobiol 41:158-164.
23. Russo-Neustadt AA, Beard RC, Huang YM, Cotman CW (2000) Physical activity and antidepressant treatment potentiate the expression of specific brain-derived neurotrophic factor transcripts in the rat hippocampus. Neuroscience 101:305-312.
24. Saarelainen T, Lukkarinen JA, Koponen S, Gröhn OH, Jolkkonen J, Koponen E, Haapasalo A, Alhonen L, Wong G, Koistinaho J, Kauppinen RA, Castrén E (2000) Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons show increased susceptibility to cortical injury after focal cerebral ischemia. Mol Cell Neurosci 16:87-96.
25. Saarelainen T, Hendolin P, Lucas G, Koponen E, Sairanen M, MacDonald E, Agerman K, Haapasalo A, Nawa H, Aloyz R, Ernfors P, Castrén E (2003) Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects. J Neurosci 23:349-357.
26. Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C, Hen R (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301:805-809.
27. Shirayama Y, Chen AC, Nakagawa S, Russell DS, Duman RS (2002) Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J Neurosci 22:3251-3261.
28. Siuciak JA, Lewis DR, Wiegand SJ, Lindsay RM (1997) Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacol Biochem Behav 56:131-137.
29. Thoenen H (1995) Neurotrophins and neuronal plasticity. Science 270:593-598.
30. van Praag H, Schinder AF, Christie BR, Toni N, Palmer TD, Gage FH (2002) Functional neurogenesis in the adult hippocampus. Nature 415:1030-1034.