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Volumn 152, Issue , 2016, Pages 137-151

Advances and practices of bioprocess scale-up

Author keywords

Bioprocess engineering; Bioprocess monitoring; Fluid dynamics; Mathematical model; Microbial kinetics; Scale up

Indexed keywords

BIOLOGICAL MODEL; BIOREACTOR; KINETICS;

EID: 84948799348     PISSN: 07246145     EISSN: None     Source Type: Book Series    
DOI: 10.1007/10_2014_293     Document Type: Chapter
Times cited : (40)

References (73)
  • 1
    • 0038050543 scopus 로고    scopus 로고
    • Integration of physiology and fluid dynamics
    • Scheper T, Springer, Berlin
    • Schamalzriedt S et al (2003) Integration of physiology and fluid dynamics. In: Scheper T (ed) Advances in biochemical engineering/biotechnology. Springer, Berlin, pp 19-68
    • (2003) Advances in Biochemical Engineering/Biotechnology , pp. 19-68
    • Schamalzriedt, S.1
  • 2
    • 0027364350 scopus 로고
    • The auxiliary substrate concept—an approach for overcoming limits of microbial performances
    • Babel W, Brinkmann U, Müller R (1993) The auxiliary substrate concept—an approach for overcoming limits of microbial performances. Acta Biotechnol 13(3):211-242
    • (1993) Acta Biotechnol , vol.13 , Issue.3 , pp. 211-242
    • Babel, W.1    Brinkmann, U.2    Müller, R.3
  • 3
    • 77955852809 scopus 로고    scopus 로고
    • On-line infrared spectroscopy for bioprocess monitoring
    • Landgrebe D et al (2010) On-line infrared spectroscopy for bioprocess monitoring. Appl Microbiol Biotechnol 88(1):11-22
    • (2010) Appl Microbiol Biotechnol , vol.88 , Issue.1 , pp. 11-22
    • Landgrebe, D.1
  • 4
    • 2342499985 scopus 로고    scopus 로고
    • In situ bioprocess monitoring of Escherichia coli bioreactions using Raman spectroscopy
    • Lee HLT et al (2004) In situ bioprocess monitoring of Escherichia coli bioreactions using Raman spectroscopy. Vibrational Spectroscopy 35(1-2):131-137
    • (2004) Vibrational Spectroscopy , vol.35 , Issue.1-2 , pp. 131-137
    • Lee, H.1
  • 5
    • 84893505510 scopus 로고    scopus 로고
    • Optimization of polyhydroxyalkanoates fermentations with on-line capacitance measurement
    • Li L et al (2014) Optimization of polyhydroxyalkanoates fermentations with on-line capacitance measurement. Bioresour Technol 156:216-221
    • (2014) Bioresour Technol , vol.156 , pp. 216-221
    • Li, L.1
  • 6
    • 84901080397 scopus 로고    scopus 로고
    • Studies on the multi-scale problems of guanosine fermentation process
    • Zhang SL et al (2004) Studies on the multi-scale problems of guanosine fermentation process. Chin J Bioprocess Eng 2(3):23-29
    • (2004) Chin J Bioprocess Eng , vol.2 , Issue.3 , pp. 23-29
    • Zhang, S.L.1
  • 7
    • 37349099750 scopus 로고    scopus 로고
    • A predictive model for transcriptional control of physiology in a free living cell
    • Bonneau R et al (2007) A predictive model for transcriptional control of physiology in a free living cell. Cell 131(7):1354-1356
    • (2007) Cell , vol.131 , Issue.7 , pp. 1354-1356
    • Bonneau, R.1
  • 8
    • 34247612307 scopus 로고    scopus 로고
    • Multiple high-throughput analyses monitor the response of E. Coli to perturbations
    • Ishii N et al (2007) Multiple high-throughput analyses monitor the response of E. coli to perturbations. Science 316:593-597
    • (2007) Science , vol.316 , pp. 593-597
    • Ishii, N.1
  • 9
    • 3142783726 scopus 로고    scopus 로고
    • A multi-scale study of industrial fermentation processes and their optimization
    • Zhang SL, Chu J, Zhuang Y (2004) A multi-scale study of industrial fermentation processes and their optimization. Adv Biochem Eng Biotechnol 87:97-150
    • (2004) Adv Biochem Eng Biotechnol , vol.87 , pp. 97-150
    • Zhang, S.L.1    Chu, J.2    Zhuang, Y.3
  • 10
    • 33846885651 scopus 로고    scopus 로고
    • Living with heterogeneities in bioreactors
    • Lara AR et al (2006) Living with heterogeneities in bioreactors. Mol Biotechnol 34 (3):355-381
    • (2006) Mol Biotechnol , vol.34 , Issue.3 , pp. 355-381
    • Lara, A.R.1
  • 11
    • 0035852880 scopus 로고    scopus 로고
    • Physiological responses to mixing in large scale bioreactors
    • Enfors S-O et al (2001) Physiological responses to mixing in large scale bioreactors. J Biotechnol 85(2):175-185
    • (2001) J Biotechnol , vol.85 , Issue.2 , pp. 175-185
    • Enfors, S.-O.1
  • 12
    • 0031891446 scopus 로고    scopus 로고
    • Substrate gradient formation in the large-scale bioreactor lowers cell yield and increases by-product formation
    • Bylund F et al (1998) Substrate gradient formation in the large-scale bioreactor lowers cell yield and increases by-product formation. Bioprocess Eng 18(3):171-180
    • (1998) Bioprocess Eng , vol.18 , Issue.3 , pp. 171-180
    • Bylund, F.1
  • 13
    • 77950627215 scopus 로고    scopus 로고
    • Scale-down simulators for metabolic analysis of large-scale bioprocesses
    • Neubauer P, Junne S (2010) Scale-down simulators for metabolic analysis of large-scale bioprocesses. Curr Opin Biotechnol 21(1):114-121
    • (2010) Curr Opin Biotechnol , vol.21 , Issue.1 , pp. 114-121
    • Neubauer, P.1    Junne, S.2
  • 14
    • 84861482967 scopus 로고    scopus 로고
    • Real-time fluid dynamics investigation and physiological response for erythromycin fermentation scale-up from 50 L to 132 m3 fermenter
    • Zou X et al (2012) Real-time fluid dynamics investigation and physiological response for erythromycin fermentation scale-up from 50 L to 132 m3 fermenter. Bioprocess Biosyst Eng 35(5):789-800
    • (2012) Bioprocess Biosyst Eng , vol.35 , Issue.5 , pp. 789-800
    • Zou, X.1
  • 15
    • 77952888809 scopus 로고    scopus 로고
    • Toward design-based engineering of industrial microbes
    • Tyo KEJ, Kocharin K, Nielsen J (2010) Toward design-based engineering of industrial microbes. Curr Opin Microbiol 13(3):255-262
    • (2010) Curr Opin Microbiol , vol.13 , Issue.3 , pp. 255-262
    • Tyo, K.1    Kocharin, K.2    Nielsen, J.3
  • 16
    • 84900827538 scopus 로고    scopus 로고
    • Kinetic models in industrial biotechnology—improving cell factory performance
    • Almquist J et al (2014) Kinetic models in industrial biotechnology—improving cell factory performance. Metab Eng 24:38-60
    • (2014) Metab Eng , vol.24 , pp. 38-60
    • Almquist, J.1
  • 17
    • 0035892272 scopus 로고    scopus 로고
    • CMA: Integration of fluid dynamics and microbial kinetics in modelling of large-scale fermentations
    • Vrabel P et al (2001) CMA: integration of fluid dynamics and microbial kinetics in modelling of large-scale fermentations. Chem Eng J 84(3):463-474
    • (2001) Chem Eng J , vol.84 , Issue.3 , pp. 463-474
    • Vrabel, P.1
  • 18
    • 3543021486 scopus 로고    scopus 로고
    • Dynamic behavior of microbial populations in stirred bioreactors simulated with euler-lagrange methods: Traveling along the lifelines of single cells
    • Lapin A, Müller D, Reuss M (2004) Dynamic behavior of microbial populations in stirred bioreactors simulated with euler-lagrange methods: traveling along the lifelines of single cells. Ind Eng Chem Res 43(16):4647-4656
    • (2004) Ind Eng Chem Res , vol.43 , Issue.16 , pp. 4647-4656
    • Lapin, A.1    Müller, D.2    Reuss, M.3
  • 19
    • 33646816768 scopus 로고    scopus 로고
    • Modeling the dynamics of E. Coli populations in the three-dimensional turbulent field of a stirred-tank bioreactor-A structured-segregated approach
    • Lapin A, Schmid J, Reuss M (2006) Modeling the dynamics of E. coli populations in the three-dimensional turbulent field of a stirred-tank bioreactor-A structured-segregated approach. Chem Eng Sci 61(14):4783-4797
    • (2006) Chem Eng Sci , vol.61 , Issue.14 , pp. 4783-4797
    • Lapin, A.1    Schmid, J.2    Reuss, M.3
  • 20
    • 84907855507 scopus 로고    scopus 로고
    • Prelude to rational scale-up of penicillin production: A scale-down study
    • Wang G et al (2014) Prelude to rational scale-up of penicillin production: a scale-down study. Appl Microbiol Biotechnol 98(6):2359-2369
    • (2014) Appl Microbiol Biotechnol , vol.98 , Issue.6 , pp. 2359-2369
    • Wang, G.1
  • 21
    • 0037323564 scopus 로고    scopus 로고
    • Complex systems
    • Ottino JM (2003) Complex systems. AIChE J 49(2):292-299
    • (2003) Aiche J , vol.49 , Issue.2 , pp. 292-299
    • Ottino, J.M.1
  • 22
    • 3142783726 scopus 로고    scopus 로고
    • A multi-scale study of industrial fermentation processes and their optimization
    • Springer, Berlin
    • Zhang SL, Chu J, Zhuang YP (2004) A multi-scale study of industrial fermentation processes and their optimization. In: Biomanufacturing. Springer, Berlin, pp 97-150
    • (2004) Biomanufacturing , pp. 97-150
    • Zhang, S.L.1    Chu, J.2    Zhuang, Y.P.3
  • 23
    • 0019905142 scopus 로고
    • Effect of cycling dissolved oxygen concentrations on product formation in penicillin fermentations
    • Vardar F, Lilly M (1982) Effect of cycling dissolved oxygen concentrations on product formation in penicillin fermentations. Eur J Appl Microbiol Biotechnol 14(4):203-211
    • (1982) Eur J Appl Microbiol Biotechnol , vol.14 , Issue.4 , pp. 203-211
    • Vardar, F.1    Lilly, M.2
  • 24
    • 81455131559 scopus 로고    scopus 로고
    • Industrial glucoamylase fed-batch benefits from oxygen limitation and high osmolarity
    • Pedersen L et al (2012) Industrial glucoamylase fed-batch benefits from oxygen limitation and high osmolarity. Biotechnol Bioeng 109(1):116-124
    • (2012) Biotechnol Bioeng , vol.109 , Issue.1 , pp. 116-124
    • Pedersen, L.1
  • 25
    • 79961182391 scopus 로고    scopus 로고
    • Simulation of dissolved CO2 gradients in a scale-down system: A metabolic and transcriptional study of recombinant Escherichia coli
    • 2 gradients in a scale-down system: a metabolic and transcriptional study of recombinant Escherichia coli. Biotechnol J 6 (8):959-967
    • (2011) Biotechnol J , vol.6 , Issue.8 , pp. 959-967
    • Baez, A.1
  • 26
    • 85007144117 scopus 로고    scopus 로고
    • Assessment of robustness against dissolved oxygen/substrate oscillations for C. Glutamicum DM1933 in two-compartment bioreactor
    • Käß F et al (2013) Assessment of robustness against dissolved oxygen/substrate oscillations for C. glutamicum DM1933 in two-compartment bioreactor. Bioprocess Biosyst Eng 1-12
    • (2013) Bioprocess Biosyst Eng , pp. 1-12
    • Käß, F.1
  • 27
    • 84874566685 scopus 로고    scopus 로고
    • Changes in substrate availability in Escherichia coli lead to rapid metabolite, flux and growth rate responses
    • Taymaz-Nikerel H et al (2013) Changes in substrate availability in Escherichia coli lead to rapid metabolite, flux and growth rate responses. Metabol Eng 16:115-129
    • (2013) Metabol Eng , vol.16 , pp. 115-129
    • Taymaz-Nikerel, H.1
  • 28
    • 79961188551 scopus 로고    scopus 로고
    • Scale-down of penicillin production in Penicillium chrysogenum
    • de Jonge LP et al (2011) Scale-down of penicillin production in Penicillium chrysogenum. Biotechnol J 6(8):944-958
    • (2011) Biotechnol J , vol.6 , Issue.8 , pp. 944-958
    • De Jonge, L.P.1
  • 29
    • 84892396971 scopus 로고    scopus 로고
    • Process inhomogeneity leads to rapid side product turnover in cultivation of Corynebacterium glutamicum
    • Käß F et al (2014) Process inhomogeneity leads to rapid side product turnover in cultivation of Corynebacterium glutamicum. Microb Cell Fact 13(1):1-11
    • (2014) Microb Cell Fact , vol.13 , Issue.1 , pp. 1-11
    • Käß, F.1
  • 30
    • 85047677968 scopus 로고    scopus 로고
    • Substrate gradients in bioreactors: Origin and consequences
    • Larsson G et al (1996) Substrate gradients in bioreactors: origin and consequences. Bioprocess Eng 14(6):281-289
    • (1996) Bioprocess Eng , vol.14 , Issue.6 , pp. 281-289
    • Larsson, G.1
  • 31
    • 84862167117 scopus 로고    scopus 로고
    • Scale-up of microbial processes: Impacts, tools and open questions
    • Takors R (2012) Scale-up of microbial processes: impacts, tools and open questions. J Biotechnol 160(1-2):3-9
    • (2012) J Biotechnol , vol.160 , Issue.1-2 , pp. 3-9
    • Takors, R.1
  • 32
    • 79961189026 scopus 로고    scopus 로고
    • An industrial perspective on bioreactor scale-down: What we can learn from combined large-scale bioprocess and model fluid studies
    • Noorman H (2011) An industrial perspective on bioreactor scale-down: what we can learn from combined large-scale bioprocess and model fluid studies. Biotechnol J 6(8):934-943
    • (2011) Biotechnol J , vol.6 , Issue.8 , pp. 934-943
    • Noorman, H.1
  • 33
    • 84897666121 scopus 로고    scopus 로고
    • Flux response of glycolysis and storage metabolism during rapid feast/ famine conditions in Penicillium chrysogenum using dynamic 13C labeling
    • 13C labeling. Biotechnol J 9 (3):372-385
    • (2014) Biotechnol J , vol.9 , Issue.3 , pp. 372-385
    • De Jonge, L.1
  • 34
    • 7444260253 scopus 로고    scopus 로고
    • Correlation between key enzyme activities in the inosine synthetic pathway and inosine production
    • Chu J et al (2005) Correlation between key enzyme activities in the inosine synthetic pathway and inosine production. Process Biochem 40(2):891-894
    • (2005) Process Biochem , vol.40 , Issue.2 , pp. 891-894
    • Chu, J.1
  • 35
    • 23444448779 scopus 로고    scopus 로고
    • Enhancement of inosine production by Bacillus subtilis through suppression of carbon overflow by sodium citrate
    • Chen SX et al (2005) Enhancement of inosine production by Bacillus subtilis through suppression of carbon overflow by sodium citrate. Biotechnol Lett 27(10):689-692
    • (2005) Biotechnol Lett , vol.27 , Issue.10 , pp. 689-692
    • Chen, S.X.1
  • 36
    • 36348976352 scopus 로고    scopus 로고
    • Systems biology of antibiotic production by microorganisms
    • Rokem JS, Lantz AE, Nielsen J (2007) Systems biology of antibiotic production by microorganisms. Nat Prod Rep 24(6):1262-1287
    • (2007) Nat Prod Rep , vol.24 , Issue.6 , pp. 1262-1287
    • Rokem, J.S.1    Lantz, A.E.2    Nielsen, J.3
  • 37
    • 0029278153 scopus 로고
    • Metabolic flux distributions in Penicillium chrysogenum during fed-batch cultivations
    • Jorgensen H et al (1995) Metabolic flux distributions in Penicillium chrysogenum during fed-batch cultivations. Biotechnol Bioeng 46(2):117-131
    • (1995) Biotechnol Bioeng , vol.46 , Issue.2 , pp. 117-131
    • Jorgensen, H.1
  • 38
    • 84948764590 scopus 로고    scopus 로고
    • Study on chaos of the erythromycin fermentation process
    • Zhao J et al (2002) Study on chaos of the erythromycin fermentation process. Chin J Antibiot 27(12):717-719
    • (2002) Chin J Antibiot , vol.27 , Issue.12 , pp. 717-719
    • Zhao, J.1
  • 39
    • 0035075387 scopus 로고    scopus 로고
    • Revisiting the stringent response, ppGpp and starvation signaling
    • Chatterji D, Kumar Ojha A (2001) Revisiting the stringent response, ppGpp and starvation signaling. Curr Opin Microbiol 4(2):160-165
    • (2001) Curr Opin Microbiol , vol.4 , Issue.2 , pp. 160-165
    • Chatterji, D.1    Kumar Ojha, A.2
  • 40
    • 0031791740 scopus 로고    scopus 로고
    • Actinorhodin and undecylprodigiosin production in wild-type and relA mutant strains of Streptomyces coelicolor A3 (2) grown in continuous culture
    • Kang SG et al (1998) Actinorhodin and undecylprodigiosin production in wild-type and relA mutant strains of Streptomyces coelicolor A3 (2) grown in continuous culture. FEMS Microbiol Lett 168(2):221-226
    • (1998) FEMS Microbiol Lett , vol.168 , Issue.2 , pp. 221-226
    • Kang, S.G.1
  • 41
    • 0033053011 scopus 로고    scopus 로고
    • Rela is required for actinomycin production in Streptomyces antibioticus
    • Hoyt S, Jones GH (1999) rela is required for actinomycin production in Streptomyces antibioticus. J Bacteriol 181(12):3824-3829
    • (1999) J Bacteriol , vol.181 , Issue.12 , pp. 3824-3829
    • Hoyt, S.1    Jones, G.H.2
  • 42
    • 0032718712 scopus 로고    scopus 로고
    • Transcription Regulation of the Colicin Kcka Gene Reveals Induction of Colicin Synthesis by Differential Responses to Environmental Signals
    • Kuhar I, Žgur-Bertok D (1999) Transcription Regulation of the Colicin Kcka Gene Reveals Induction of Colicin Synthesis by Differential Responses to Environmental Signals. J Bacteriol 181(23):7373-7380
    • (1999) J Bacteriol , vol.181 , Issue.23 , pp. 7373-7380
    • Kuhar, I.1    Žgur-Bertok, D.2
  • 43
    • 33745553265 scopus 로고    scopus 로고
    • Multi-scale methodology: A key to deciphering systems biology
    • Ye X et al (2005) Multi-scale methodology: a key to deciphering systems biology. Front Biosci 10:961-965
    • (2005) Front Biosci , vol.10 , pp. 961-965
    • Ye, X.1
  • 44
    • 70349770725 scopus 로고    scopus 로고
    • Industrial bioprocess control and optimization in the context of systems biotechnology
    • Wang Y et al (2009) Industrial bioprocess control and optimization in the context of systems biotechnology. Biotechnol Adv 27(6):989-995
    • (2009) Biotechnol Adv , vol.27 , Issue.6 , pp. 989-995
    • Wang, Y.1
  • 45
    • 82955232424 scopus 로고    scopus 로고
    • Review of computational fluid dynamics applications in biotechnology processes
    • Sharma C, Malhotra D, Rathore AS (2011) Review of computational fluid dynamics applications in biotechnology processes. Biotechnol Prog 27(6):1497-1510
    • (2011) Biotechnol Prog , vol.27 , Issue.6 , pp. 1497-1510
    • Sharma, C.1    Malhotra, D.2    Rathore, A.S.3
  • 46
    • 38849099107 scopus 로고    scopus 로고
    • Computational investigation of fluid dynamics in a recently developed centrifugal impeller bioreactor
    • Xia JY et al (2008) Computational investigation of fluid dynamics in a recently developed centrifugal impeller bioreactor. Biochem Eng J 38(3):406-413
    • (2008) Biochem Eng J , vol.38 , Issue.3 , pp. 406-413
    • Xia, J.Y.1
  • 47
    • 58349110978 scopus 로고    scopus 로고
    • Fluid dynamics investigation of variant impeller combinations by simulation and fermentation experiment
    • Xia JY et al (2009) Fluid dynamics investigation of variant impeller combinations by simulation and fermentation experiment. Biochem Eng J 43(3):252-260
    • (2009) Biochem Eng J , vol.43 , Issue.3 , pp. 252-260
    • Xia, J.Y.1
  • 48
    • 84864539322 scopus 로고    scopus 로고
    • A novel impeller configuration to improve fungal physiology performance and energy conservation for cephalosporin C production
    • Yang YM et al (2012) A novel impeller configuration to improve fungal physiology performance and energy conservation for cephalosporin C production. J Biotechnol 161 (3):250-256
    • (2012) J Biotechnol , vol.161 , Issue.3 , pp. 250-256
    • Yang, Y.M.1
  • 49
    • 34548497149 scopus 로고    scopus 로고
    • The scale up of microbial batch and fed-batch fermentation processes
    • Hewitt CJ, Nienow AW (2007) The scale up of microbial batch and fed-batch fermentation processes. Adv Appl Microbiol 62:105-135
    • (2007) Adv Appl Microbiol , vol.62 , pp. 105-135
    • Hewitt, C.J.1    Nienow, A.W.2
  • 50
    • 3242789580 scopus 로고    scopus 로고
    • Scale-up methodologies for Escherichia coli and yeast fermentation processes
    • Junker BH (2004) Scale-up methodologies for Escherichia coli and yeast fermentation processes. J Biosci Bioeng 97(6):347-364
    • (2004) J Biosci Bioeng , vol.97 , Issue.6 , pp. 347-364
    • Junker, B.H.1
  • 51
    • 84877063612 scopus 로고    scopus 로고
    • Consistent development of bioprocesses from microliter cultures to the industrial scale
    • Neubauer P et al (2013) Consistent development of bioprocesses from microliter cultures to the industrial scale. Engineering in Life Sciences 13(3):224-238
    • (2013) Engineering in Life Sciences , vol.13 , Issue.3 , pp. 224-238
    • Neubauer, P.1
  • 52
    • 0022070398 scopus 로고
    • Scale-down and optimization studies of the gluconic acid fermentation by Gluconobacter oxydans
    • Oosterhuis NMG et al (1985) Scale-down and optimization studies of the gluconic acid fermentation by Gluconobacter oxydans. Biotechnol Bioeng 27(5):711-720
    • (1985) Biotechnol Bioeng , vol.27 , Issue.5 , pp. 711-720
    • Oosterhuis, N.1
  • 53
    • 0023384454 scopus 로고
    • Regime analysis and scale-down: Tools to investigate the performance of bioreactors
    • Sweere APJ, Luyben KCAM, Kossen NWF (1987) Regime analysis and scale-down: tools to investigate the performance of bioreactors. Enzyme Microb Technol 9(7):386-398
    • (1987) Enzyme Microb Technol , vol.9 , Issue.7 , pp. 386-398
    • Sweere, A.1    Luyben, K.2    Kossen, N.3
  • 54
    • 33645580745 scopus 로고    scopus 로고
    • Transcriptional and metabolic response of recombinant Escherichia coli to spatial dissolved oxygen tension gradients simulated in a scale-down system
    • Lara AR et al (2006) Transcriptional and metabolic response of recombinant Escherichia coli to spatial dissolved oxygen tension gradients simulated in a scale-down system. Biotechnol Bioeng 93(2):372-385
    • (2006) Biotechnol Bioeng , vol.93 , Issue.2 , pp. 372-385
    • Lara, A.R.1
  • 55
    • 84881109863 scopus 로고    scopus 로고
    • Investigation of the physiological response to oxygen limited process conditions of Pichia pastoris Mut+ strain using a two-compartment scale-down system
    • Lorantfy B, Jazini M, Herwig C (2013) Investigation of the physiological response to oxygen limited process conditions of Pichia pastoris Mut+ strain using a two-compartment scale-down system. J Biosci Bioeng 116(3):371-379
    • (2013) J Biosci Bioeng , vol.116 , Issue.3 , pp. 371-379
    • Lorantfy, B.1    Jazini, M.2    Herwig, C.3
  • 56
    • 33747803380 scopus 로고    scopus 로고
    • Generating short-term kinetic responses of primary metabolism of Penicillium chrysogenum through glucose perturbation in the bioscope mini reactor
    • Nasution U et al (2006) Generating short-term kinetic responses of primary metabolism of Penicillium chrysogenum through glucose perturbation in the bioscope mini reactor. Metab Eng 8(5):395-405
    • (2006) Metab Eng , vol.8 , Issue.5 , pp. 395-405
    • Nasution, U.1
  • 57
    • 84888312711 scopus 로고    scopus 로고
    • Scale-down studies for assessing the impact of different stress parameters on growth and product quality during animal cell culture
    • Nienow AW et al (2013) Scale-down studies for assessing the impact of different stress parameters on growth and product quality during animal cell culture. Chem Eng Res Des 91 (11):2265-2274
    • (2013) Chem Eng Res Des , vol.91 , Issue.11 , pp. 2265-2274
    • Nienow, A.W.1
  • 58
    • 7044232898 scopus 로고    scopus 로고
    • Heterogeneous conditions in dissolved oxygen affect N-glycosylation but not productivity of a monoclonal antibody in hybridoma cultures
    • Serrato JA et al (2004) Heterogeneous conditions in dissolved oxygen affect N-glycosylation but not productivity of a monoclonal antibody in hybridoma cultures. Biotechnol Bioeng 88 (2):176-188
    • (2004) Biotechnol Bioeng , vol.88 , Issue.2 , pp. 176-188
    • Serrato, J.A.1
  • 59
    • 0141942554 scopus 로고    scopus 로고
    • Design of a tubular loop bioreactor for scaleup and scale-down of fermentation processes
    • Papagianni M, Mattey M, Kristiansen B (2003) Design of a tubular loop bioreactor for scaleup and scale-down of fermentation processes. Biotechnol Prog 19(5):1498-1504
    • (2003) Biotechnol Prog , vol.19 , Issue.5 , pp. 1498-1504
    • Papagianni, M.1    Mattey, M.2    Kristiansen, B.3
  • 60
    • 77953510736 scopus 로고    scopus 로고
    • Design and characterization of a onecompartment scale-down system for simulating dissolved oxygen tension gradients
    • León-Rodríguez AD, Galindo E, Ramírez OT (2010) Design and characterization of a onecompartment scale-down system for simulating dissolved oxygen tension gradients. J Chem Technol Biotechnol 85(7):950-956
    • (2010) J Chem Technol Biotechnol , vol.85 , Issue.7 , pp. 950-956
    • León-Rodríguez, A.D.1    Galindo, E.2    Ramírez, O.T.3
  • 61
    • 79961180656 scopus 로고    scopus 로고
    • A two-compartment bioreactor system made of commercial parts for bioprocess scale-down studies: Impact of oscillations on Bacillus subtilis fed-batch cultivations
    • Junne S et al (2011) A two-compartment bioreactor system made of commercial parts for bioprocess scale-down studies: impact of oscillations on Bacillus subtilis fed-batch cultivations. Biotechnol J 6(8):1009-1017
    • (2011) Biotechnol J , vol.6 , Issue.8 , pp. 1009-1017
    • Junne, S.1
  • 62
    • 14244251570 scopus 로고    scopus 로고
    • Culture of Escherichia coli under dissolved oxygen gradients simulated in a two-compartment scale-down system: Metabolic response and production of recombinant protein
    • Sandoval-Basurto EA et al (2005) Culture of Escherichia coli under dissolved oxygen gradients simulated in a two-compartment scale-down system: metabolic response and production of recombinant protein. Biotechnol Bioeng 89(4):453-463
    • (2005) Biotechnol Bioeng , vol.89 , Issue.4 , pp. 453-463
    • Sandoval-Basurto, E.A.1
  • 64
    • 84862777177 scopus 로고    scopus 로고
    • Hydrodynamic and kinetic study of cellulase production by Trichoderma reesei with pellet morphology
    • Yu L et al (2012) Hydrodynamic and kinetic study of cellulase production by Trichoderma reesei with pellet morphology. Biotechnol Bioeng 109(7):1755-1768
    • (2012) Biotechnol Bioeng , vol.109 , Issue.7 , pp. 1755-1768
    • Yu, L.1
  • 65
    • 84862643799 scopus 로고    scopus 로고
    • A model for cellulase production from Trichoderma reesei in an airlift reactor
    • Bannari R et al (2012) A model for cellulase production from Trichoderma reesei in an airlift reactor. Biotechnol Bioeng 109(8):2025-2038
    • (2012) Biotechnol Bioeng , vol.109 , Issue.8 , pp. 2025-2038
    • Bannari, R.1
  • 66
    • 0000311643 scopus 로고
    • Measurements and computational fluid dynamics simulation of Saccharomyces cerevisiae production in a 30 m3 stirred tank reactor
    • Helsingùr, Denmark
    • Noorman H et al (1993) Measurements and computational fluid dynamics simulation of Saccharomyces cerevisiae production in a 30 m3 stirred tank reactor. In: Proceedings of International Symposium on Bioreactor Performance, Helsingùr, Denmark
    • (1993) Proceedings of International Symposium on Bioreactor Performance
    • Noorman, H.1
  • 68
    • 84866487983 scopus 로고    scopus 로고
    • CFD modelling of two-phase stirred bioreaction systems by segregated solution of the Euler-Euler model
    • Elqotbi M et al (2013) CFD modelling of two-phase stirred bioreaction systems by segregated solution of the Euler-Euler model. Comput Chem Eng 48:113-120
    • (2013) Comput Chem Eng , vol.48 , pp. 113-120
    • Elqotbi, M.1
  • 69
    • 84889686639 scopus 로고    scopus 로고
    • A coupled population balance model and CFD approach for the simulation of mixing issues in lab-scale and industrial bioreactors
    • Morchain J, Gabelle J-C, Cockx A (2014) A coupled population balance model and CFD approach for the simulation of mixing issues in lab-scale and industrial bioreactors. AIChE J 60(1):27-40
    • (2014) Aiche J , vol.60 , Issue.1 , pp. 27-40
    • Morchain, J.1    Gabelle, J.-C.2    Cockx, A.3
  • 70
    • 82055163042 scopus 로고    scopus 로고
    • Multi-scale spatio-temporal modeling: Lifelines of microorganisms in bioreactors and tracking molecules in cells
    • Wittmann C, Krull R (eds), Springer, Berlin
    • Lapin A, Klann M, Reuss M (2010) Multi-scale spatio-temporal modeling: lifelines of microorganisms in bioreactors and tracking molecules in cells. In: Wittmann C, Krull R (eds) Biosystems engineering II. Springer, Berlin, pp 23-43
    • (2010) Biosystems Engineering II , pp. 23-43
    • Lapin, A.1    Klann, M.2    Reuss, M.3
  • 71
    • 84862166539 scopus 로고    scopus 로고
    • A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level
    • Grünberger A et al (2012) A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level. Lab Chip 12:2060-2068
    • (2012) Lab Chip , vol.12 , pp. 2060-2068
    • Grünberger, A.1
  • 72
    • 27644509570 scopus 로고    scopus 로고
    • Optimization and scale up of industrial fermentation processes
    • Schmidt FR (2005) Optimization and scale up of industrial fermentation processes. Appl Microbiol Biotechnol 68:425-435
    • (2005) Appl Microbiol Biotechnol , vol.68 , pp. 425-435
    • Schmidt, F.R.1
  • 73
    • 0031885663 scopus 로고    scopus 로고
    • Shake flask to fermentor: What have we learned?
    • Humphrey A (1998) Shake flask to fermentor: what have we learned? Biotechnol Prog 14:3-7
    • (1998) Biotechnol Prog , vol.14 , pp. 3-7
    • Humphrey, A.1


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