Flux response of glycolysis and storage metabolism during rapid feast/famine conditions in Penicillium chrysogenum using dynamic 13C labeling

Biotechnology Journal

Volumn 9, Issue 3, 2014, Pages 372-385

  de Jonge, Lodewijk ^a,c   Buijs, Nicolaas A A ^a,d   Heijnen, Joseph J ^a   van Gulik, Walter M ^a   Abate, Alessandro ^b   Wahl, S Aljoscha ^a  

^a DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c CRUCELL HOLLAND BV   (Netherlands)

^d CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

Author keywords

Dynamic conditions; In vivo enzyme kinetics; P. chrysogenum; Systems biology

Indexed keywords

CULTIVATION; ENZYME KINETICS; FERMENTATION; FOOD SUPPLY; GLUCOSE; METABOLISM; METABOLITES; PHYSIOLOGY; PRODUCTIVITY;

DYNAMIC CONDITION; FLUX ANALYSIS; IN-VIVO; P. CHRYSOGENUM; SYSTEMS BIOLOGY;

ENZYME ACTIVITY;

ADENOSINE TRIPHOSPHATE; CARBON 13; GLUCOSE; GLYCOGEN; MANNITOL; PENICILLIN G; TREHALOSE; URIDINE TRIPHOSPHATE;

ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DEGRADATION; FUNGAL METABOLISM; FUNGUS CULTURE; GLUCOSE INTAKE; GLUCOSE TRANSPORT; GLYCOLYSIS; HUNGER; HYBRID; IN VIVO STUDY; ISOTOPE LABELING; METABOLITE; NONHUMAN; PENICILLIUM CHRYSOGENUM; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; STEADY STATE; STORAGE METABOLISM; SYNTHESIS; TURNOVER TIME;

PENICILLIUM CHRYSOGENUM;

13C FLUX ANALYSIS; DYNAMIC CONDITIONS; IN VIVO ENZYME KINETICS; P. CHRYSOGENUM; SYSTEMS BIOLOGY;

CARBON RADIOISOTOPES; CULTURE MEDIA; GLUCOSE; GLYCOLYSIS; PENICILLIN G; PENICILLIUM CHRYSOGENUM; SUBSTRATE SPECIFICITY;

EID: 84897666121     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201200260     Document Type: Article

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