relA is required for actinomycin production in Streptomyces antibioticus

Journal of Bacteriology

Volumn 181, Issue 12, 1999, Pages 3824-3829

  Hoyt, Shannan ^a   Jones, George H ^a  

^a EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTINOMYCIN SYNTHETASE I; BACTERIAL ENZYME; BACTERIAL PROTEIN; DACTINOMYCIN; GUANOSINE 3' DIPHOSPHATE 5' DIPHOSPHATE; PHENOXAZINONE SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENE; BACTERIAL GENETICS; BACTERIUM MUTANT; CONTROLLED STUDY; GENE MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STREPTOMYCES ANTIBIOTICUS; STREPTOMYCES COELICOLOR;

STREPTOMYCES ANTIBIOTICUS;

EID: 0033053011     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.181.12.3824-3829.1999     Document Type: Article

References (22)

1. Bierman, R., R. Logan, K. O'Brien, E. T. Seno, R. N. Rao, R. Baltz, and B. E. Shoner. 1992. Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp. Gene 116:43-49.
2. Cashel, M., D. R. Gentry, V. J. Hernandez, and D. Vinella. 1996. The stringent response, p. 1458-1496. In F. C. Neidhardt, R. Curtiss III, J. L. Ingraham, E. C. C. Lin, K. B. Low, B. Magasanik, W. S. Reznikoff, M. Riley, M. Schaechter, and H. E. Umbarger (ed.), Escherichia coli and Salmonella: cellular and molecular biology, 2nd ed. ASM Press, Washington, D.C.
3. Chakraburrty, R., and M. J. Bibb. 1997. The ppGpp synthetase gene (relA) of Streptomyces coelicolor A3(2) plays a conditional role in antibiotic production and morphological differentiation. J. Bacteriol. 179:5854-5861.
4. Chakraburrty, R., J. White, E. Takano, and M. J. Bibb. 1996. Cloning, characterization and disruption of a (p)ppGpp synthetase gene (relA) of Streptomyces coelicolor A3(2). Mol. Microbiol. 19:357-358.
5. Choy, H. A., and G. H. Jones. 1981. Phenoxazinone synthase from Streptomyces antibioticus: purification of the large and small enzyme forms. Arch. Biochem. Biophys. 211:55-65.
6. Flett, F., V. Mersenias, and C. P. Smith. 1998. High efficiency intergenic conjugal transfer of plasmid DNA from Escherichia coli to methyl DNA-restricting streptomycetes. FEMS Microbiol. Lett. 155:223-229.
7. Gallo, M., and E. Katz. 1972. Regulation of secondary metabolite biosynthesis: catabolite repression of phenoxazinone synthase and actinomycin formation by glucose. J. Bacteriol. 109:659-667.
8. Harris, B. Z., D. Kaiser, and M. Singer. 1998. The guanosine nucleotide (p)ppGpp initiates development and A-factor production in Myxacoccus xanthus. Genes Dev. 12:1022-1035.
9. Hughes, J., and G. Mellows. 1978. Inhibition of isoleucyl-transfer ribonucleic acid synthetase in Escherichia coli by pseudomonic acid. Biochem. J. 176: 305-318.
10. Jones, G. H. 1993. Combined purification of actinomycin synthetase I and 3-hydroxyanthranilic acid 4-methyltransferase from Streptomyces antibioticus. J. Biol. Chem. 268:6831-6834.
11. Jones, G. H. 1994. Purification and properties of ATP-GTP 3′-pyrophosphotransferase (guanosine pentaphosphate synthetase) from Streptomyces antibioticus. J. Bacteriol. 176:1474-1481.
12. Jones, G. H. 1994. Activation of ATP:GTP 3′-pyrophosphotransferase (guanosine pentaphosphate synthetase) in Streptomyces antibioticus. J. Bacteriol. 176:1482-1487.
13. Jones, G. H., and M. J. Bibb. 1996. Guanosine pentaphosphate synthetase from Streptomyces antibioticus is also a polynucleotide phosphorylase. J. Bacteriol. 178:4281-4288.
14. Jones, G. H., and H. Weissbach. 1970. RNA metabolism in Streptomyces antibioticus: effect of 5-fluorouracil on the appearance of phenoxazinone synthetase. Arch. Biochem. Biophys. 136:558-573.
15. Jones, G. H., M. S. B. Paget, L. Chamberlin, and M. J. Buttner. 1997. Sigma-E is required for the production of the antibiotic actinomycin in Streptomyces antibioticus. Mol. Microbiol. 23:169-178.
16. Kelly, K. S., K. Ochi, and G. H. Jones. 1991. Pleiotropic effects of a relC mutation in Streptomyces antibioticus. J. Bacteriol. 173:2297-2300.
17. Martinez-Costa, O. H., P. Arias, N. M. Romero, V. Parro, R. P. Mellado, and F. Malpartida. 1996. A relA/spoT homologous gene from Streptomyces coelicolor A3(2) controls antibiotic biosynthetic genes. J. Biol. Chem. 271:10627-10634.
18. Ochi, K. 1986. Occurrence of the stringent response in Streptomyces spp. and its significance for the inhibition of morphological and physiological differentiation. J. Gen. Microbiol. 132:2621-2631.
19. Ochi, K. 1987. A rel mutation abolishes the enzyme induction needed for actinomycin synthesis by Streptomyces antibioticus. Agric. Biol. Chem. 51: 829-835.
20. Pedersen, F. S., and N. O. Kjeldgaard. 1977. Analysis of the relA gene product of Escherichia coli. Eur. J. Biochem. 76:91-97.
21. Strauch, E., E. Takano, H. A. Bayliss, and M. J. Bibb. 1991. The stringent response in Streptomyces coelicolor A3(2). Mol. Microbiol. 5:289-298.
22. Thompson, C. J., T. Kieser, J. M. Ward, and D. A. Hopwood. 1982. Physical analysis of antibiotic resistance genes from Streptomyces and their use in vector construction. Gene 20:51-62.