Computational investigation of fluid dynamics in a recently developed centrifugal impeller bioreactor

Biochemical Engineering Journal

Volumn 38, Issue 3, 2008, Pages 406-413

  Xia, Jian Ye ^a   Wang, Si Jing ^a   Zhang, Si Liang ^a   Zhong, Jian Jiang ^b  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Centrifugal impeller; CFD; Circulation time distribution; Fluid circulation; Shear force; Velocity profile

Indexed keywords

BIOLOGICAL SYSTEMS; CENTRIFUGES; COMPUTATIONAL FLUID DYNAMICS; IMPELLERS; SHEAR STRESS;

CENTRIFUGAL IMPELLERS; CIRCULATION TIME DISTRIBUTION; FLUID CIRCULATION; SHEAR FORCE; VELOCITY PROFILE;

BIOREACTORS;

ARTICLE; BIOREACTOR; CENTRIFUGAL IMPELLER BIOREACTOR; COMPUTATIONAL FLUID DYNAMICS; PRIORITY JOURNAL; PROCESS DESIGN; QUANTITATIVE ANALYSIS; SCALE UP; SHEAR FLOW; SHEAR STRESS; SIMULATION;

EID: 38849099107     PISSN: 1369703X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bej.2007.08.006     Document Type: Article

References (24)

1. Wang S.J., and Zhong J.J. Bioreactor engineering. In: Yang S.-T. (Ed). Bioprocessing for Value-Added Products from Renewable Resources: New Technologies and Applications (2006), Elsevier 131-161
2. Reuss M., Schmalzriedt S., and Jenne M. Application of computational fluid dynamics (CFD) to modeling stirred tank bioreactors. In: Schügerl K., and Bellgardt K.H. (Eds). Bioreaction Engineering (2000), Springer, New York 207-246
3. Jaworski Z., Dyster K.N., and Nienow A.W. The effect of size, location and pumping direction of pitched blade turbine impellers on flow patterns: LDA measurements and CFD predictions. Trans. Inst. Chem. Eng. A 79 (2001) 887-893
4. Micale G., Brucato A., Grisafi F., and Ciofalo M. Prediction of flow fields in a dual-impeller stirred vessel. AIChE J. 45 (1999) 2133-2148
5. Begley C.M., and Kleis S.J. The fluid dynamic and shear environment in the NASA/JSC rotating-wall perfused-vessel bioreactor. Biotechnol. Bioeng. 70 (2000) 32-40
6. Unger D.R., Muzzio F.J., Aunins J.G., and Singhvi R. Computational and experimental investigation of flow and fluid mixing in the roller bottle bioreactor. Biotechnol. Bioeng. 70 (2000) 117-130
7. Sucosky P., Osorio D.F., Brown J.B., and Neitzel G.P. Fluid mechanics of a spinner-flask bioreactor. Biotechnol. Bioeng. 85 (2004) 34-46
8. Williams K.A., Saini A., and Wick T.M. Computational fluid dynamics modeling of steady-state momentum and mass transport in a bioreactor for cartilage tissue engineering. Biotechnol. Prog. 18 (2002) 951-963
9. Metodiev B., Lilova K., Karamanev D., and Lilov L. Computational fluid dynamics (CFD) simulation of velocity and concentration profiles in the vicinity of immobilized Acidithiobacillus ferrooxidans cells. Biochem. Eng. J. 29 (2006) 182-190
10. Wang S.J., and Zhong J.J. A novel centrifugal impeller bioreactor. I. Fluid circulation, mixing, and liquid velocity profiles. Biotechnol. Bioeng. 51 (1996) 511-519
11. Wang S.J., and Zhong J.J. A novel centrifugal impeller bioreactor. II. Oxygen transfer and power consumption. Biotechnol. Bioeng. 51 (1996) 520-527
12. Zhang Z.Y., and Zhong J.J. Scale-up of centrifugal impeller bioreactor for hyperproduction of ginseng saponin and polysaccharide by high-density cultivation of Panax notoginseng cells. Biotechnol. Prog. 20 (2004) 1076-1081
13. Prakash G., and Srivastava A.K. Azadirachtin production in stirred tank reactors by Azadirachta indica suspension culture. Process Biochem. 42 (2007) 93-97
14. Mao X.B., and Zhong J.J. Hyperproduction of cordycepin by two-stage dissolved oxygen control in submerged cultivation of medicinal mushroom Cordyceps militaris in bioreactors. Biotechnol. Prog. 20 (2004) 1408-1413
15. Fluent online help document, ver6.1, Fluent Inc., February, 2003.
16. J.C. Middleton, Measurement of circulation within large mixing vessels, Third European Conference on Mixing, Paper A, York, UK, 1979, pp. 15-36.
17. Roberts R.M., Gray M.R., Thompson B., and Kresta S.M. The effect of impeller and tank geometry on circulation time distributions in stirred tanks. Trans. Inst. Chem. Eng. 73A (1995) 78-86
18. R. Schmitz, Circulation time studies in newtonian and nonnewtonian fluids in stirred tanks, Ph.D. Thesis, University of Birmingham, UK, 1996.
19. van Barneveld J., Smit W., Oosterhuis N.M.G., and Pragt H.J. Measuring the liquid circulation time in a large gas-liquid contactor by means of a radio pill. Ind. Eng. Chem. Res. 26 (1987) 2185-2195
20. Tatterson G.B. Fluid Mixing and Gas Dispersion in Agitated Tanks (1991), McGraw-Hill Inc., New York pp. 208
21. Khopkar A.R., Kasat G.R., Pandit A.B., and Ranade V.V. CFD simulation of mixing in tall gas-liquid stirred vessel: role of local flowpatterns. Chem. Eng. Sci. 61 (2006) 2921-2929
22. Davidson K.M., Sushil S., Eggleton C.D., and Marten M.R. Using computational fluid dynamics software to estimate circulation time distributions in bioreactors. Biotechnol. Prog. 19 (2003) 1480-1486
23. Enfors S.O., Jahic M., Rozkov A., Xu B., Hecker M., Jurgen B., Kruger E., Schweder T., Hamer G., O'Beirne D., Noisommit-Rizzi N., Reuss M., Boone L., Hewitt C., McFarlane C., Nienow A., Kovacs T., Tragardh C., Fuchs L., Revstedt J., Friberg P.C., Hjertager B., Blomsten G., Skogman H., Hjort S., Hoeks F., Lin H.Y., Neubauer P., van der Lans R., Luyben K., Vrabel P., and Manelius A. Physiological responses to mixing in large scale bioreactors. J. Biotechnol. 85 (2001) 175-185
24. Justen P., Paul G.C., Nienow A.W., and Thomas C.R. Dependence of mycelial morphology on impeller type and agitation intensity. Biotechnol. Bioeng. 52 (1996) 672-684