Changes in substrate availability in Escherichia coli lead to rapid metabolite, flux and growth rate responses

Metabolic Engineering

Volumn 16, Issue 1, 2013, Pages 115-129

  Taymaz Nikerel, Hilal ^a   De Mey, Marjan ^b   Baart, Gino ^b   Maertens, Jo ^b   Heijnen, Joseph J ^a   van Gulik, Walter ^a  

^a DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

Growth rate; In vivo kinetics; Intracellular metabolites; Metabolic flux analysis; Stimulus response experiments

Indexed keywords

DIFFERENT SUBSTRATES; DILUTION RATE; EQUILIBRIUM REACTIONS; IN-VIVO; INTRACELLULAR METABOLITES; METABOLIC FLUX; METABOLIC FLUX ANALYSIS; METABOLOMES; OXYGEN UPTAKE; PROTEIN SYNTHESIS; PSEUDO STEADY STATE; PULSE EXPERIMENTS; PYRUVATES; RATE RESPONSE; STIMULUS RESPONSE; SUBSTRATE AVAILABILITIES;

BIOMOLECULES; DYNAMIC RESPONSE; ESCHERICHIA COLI; EXPERIMENTS; GLUCOSE; GROWTH RATE; METABOLISM; METABOLITES; REACTION RATES;

SUBSTRATES;

GLUCOSE; OXYGEN; PYRUVIC ACID; SUCCINIC ACID;

AEROBIC METABOLISM; ARTICLE; BACTERIAL GROWTH; BACTERIAL METABOLISM; BACTERIAL STRAIN; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; CROSS COUPLING REACTION; DILUTION; EQUILIBRIUM CONSTANT; ESCHERICHIA COLI; EXTRACELLULAR MATRIX; GLUCONEOGENESIS; GLYCOLYSIS; IN VIVO STUDY; INTRACELLULAR MEMBRANE; KINETICS; METABOLITE; METABOLOME; MOLECULAR DYNAMICS; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; STEADY STATE;

AEROBIOSIS; ESCHERICHIA COLI K12; GLUCONEOGENESIS; GLUCOSE; GLYCOLYSIS; METABOLOME; PYRUVIC ACID; SUCCINIC ACID; SWEETENING AGENTS;

EID: 84874566685     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2013.01.004     Document Type: Article

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