Enhancement of inosine production by Bacillus subtilis through suppression of carbon overflow by sodium citrate

Biotechnology Letters

Volumn 27, Issue 10, 2005, Pages 689-692

  Chen, Shuangxi ^a,b   Chu, Ju ^a   Zhuang, Yingping ^a   Zhang, Siliang ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HENAN UNIVERSITY   (China)

Author keywords

Bacillus subtilis; Carbon overflow; Inosine; Sodium citrate

Indexed keywords

BIOTECHNOLOGY; CARBON; ENZYMES; SYNTHESIS (CHEMICAL);

ACETATE POOLS; INOSINE; PHOSPHOENOLPYRUVATE (PEP); PYRUVATE KINASE;

SODIUM COMPOUNDS;

6 PHOSPHOFRUCTOKINASE; ACETIC ACID DERIVATIVE; CARBOXYLIC ACID; CITRATE SODIUM; CITRATE SYNTHASE; CITRIC ACID; GLUCOKINASE; GLUCOSE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; INOSINE; PHOSPHOENOLPYRUVATE; PYRUVATE KINASE; PYRUVIC ACID;

ARTICLE; BACILLUS SUBTILIS; BIOSYNTHESIS; COMPARATIVE STUDY; DRUG EFFECT; ENZYMOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; TIME;

ACETATES; BACILLUS SUBTILIS; CARBOXYLIC ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRATE (SI)-SYNTHASE; CITRATES; GLUCOKINASE; GLUCOSE; GLUCOSEPHOSPHATE DEHYDROGENASE; INOSINE; PHOSPHOENOLPYRUVATE; PHOSPHOFRUCTOKINASES; PYRUVATE KINASE; PYRUVIC ACID; TIME FACTORS;

BACILLUS SUBTILIS;

EID: 23444448779     PISSN: 01415492     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10529-005-4686-1     Document Type: Article

References (12)

1. AM Alves GJ Euverink MJ Bibb L Dijkhuizen 1997 Identification of ATP-dependent phosphofructokinase as a regulatory step in the glycolytic pathway of the Actinomycete streptomyces coelicolor A3 (2) Appl. Environ. Microbiol 63 956 961
2. A Boiteux M Markus T Plesser B Hess M Malcovati 1983 Interaction of pyruvate kinase from Escherichia coli with fructose 1,6-biphosphate and calcium ions Biochem. J 211 631 640
3. SH Fisher B Mangasanik 1984 Synthesis of oxaloacetate in Bacillus subtilis mutants lacking the 2-ketoglutarate dehydrogenase enzymatic complex J. Bacteriol 158 55 62
4. P Fortnagel E Freese 1968 Analysis of sporulation mutants II. Mutants blocked in the citric acid cycle J. Bacteriol 95 1434 1438
5. A Goel J Lee MM Domach MM Ataai 1995 Suppressed acid formation by cofeeding glucose and citrate in Bacilluscultures: emergence of pyruvate kinase as a potential metabolic engineering site Biotechnol. Prog 11 380 386
6. A Goel J Lee MM Domach MM Ataai 1999 Metabolic fluxes, pool and enzyme measurements suggest a tighter coupling of energetics and biosynthetic reactions associated with reduced pyruvate kinase flux Biotechnol. Bioeng 64 129 134
7. R Horne W Anderson R Nordlie 1970 Glucose dehydrogenase activity of yeast glucose-6-phosphate dehydrogenase. Inhibition by adenosine 5′- triphosphate and other nucleoside 5′-triphosphates and diphosphate Biochemistry 9 610 615
8. M Malcovati G Valentini 1982 AMP and fructose 6-phophate activated pyruvate kinase from E. coli Meth. Enzymol 90 170 179
9. T Palme K Tiisma A Kahru R Vilu 1990 Glucose-limited fed-batch cultivation of Escherichia coli with computer-con-trolled fixed growth rate Biotechnol. Bioeng 35 312 319
10. E Postma WA Scheffers JP van Dijken 1988 Adaptation of the kinetics of glucose transport to environmental conditions in the yeast Candida utilis CBS 621 continuous-culture study J. Gen. Microbiol 134 1109 1116
11. PW Postma JW Lengeler GR Jacobson 1993 Phosphoenolpyruvate: carbohydrate phosphotransferase systems of bacteria Microbiol. Rev 57 543 594
12. K Willecke AB Pardee 1971 Inducible transport of citrate in Gram-positive bacteria, B.subtilis J. Biol. Chem 246 1032 1040