Real-time fluid dynamics investigation and physiological response for erythromycin fermentation scale-up from 50 L to 132 m 3 fermenter

Bioprocess and Biosystems Engineering

Volumn 35, Issue 5, 2012, Pages 789-800

  Zou, Xiang ^a,b   Xia, Jian Ye ^a   Chu, Ju ^a   Zhuang, Ying Ping ^a   Zhang, Si Liang ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SOUTHWEST UNIVERSITY   (China)

Author keywords

Erythromycin biosynthesis; Fermentation; Fluid mechanics; Non Newtonian fluids; Physiological response; Scale up

Indexed keywords

COMPUTATIONAL FLUID DYNAMICS MODELING; DIFFERENT SCALE; ERYTHROMYCIN FERMENTATION; FERMENTATION PROCESS; MAXIMAL CONSISTENCY; NON-NEWTONIAN FLUIDS; OXYGEN TRANSFER RATE; OXYGEN UPTAKE RATES; PHYSIOLOGICAL RESPONSE; SCALE-UP;

ANTIBIOTICS; BIOCHEMISTRY; BIOSYNTHESIS; COMPUTATIONAL FLUID DYNAMICS; FERMENTATION; FERMENTERS; FLOW MEASUREMENT; FLUID MECHANICS; NON NEWTONIAN LIQUIDS; PHYSIOLOGY; RHEOLOGY; VISCOUS FLOW;

PHYSIOLOGICAL MODELS;

ERYTHROMYCIN;

ACTINOBACTERIA; ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BACILLUS PUMILUS; BIOMASS FERMENTATION; BIOREACTOR; BIOREACTOR DESIGN; CELL FUNCTION; CELL GROWTH; CELL METABOLISM; CHEMICAL PARAMETERS; CIRCULATION TIME DISTRIBUTION; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; DRUG DETERMINATION; DRUG SCREENING; ENERGY DISSIPATION FUNCTION; FLOW KINETICS; HYDRODYNAMICS; IMPELLER; LOCAL OXYGEN MASS TRANSFER COEFFICIENT; MICROBIAL BIOMASS; MIXING TIME; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN TRANSFER RATE; OXYGEN UPTAKE RATE; PHYSICAL PARAMETERS; PRIORITY JOURNAL; REAL TIME COMPUTATIONAL FLUID DYNAMICS; SCALE UP; SHEAR STRESS; STREPTOMYCES ERYTHRAEUS;

BIOREACTORS; ERYTHROMYCIN; HYDRODYNAMICS; MODELS, BIOLOGICAL; SACCHAROPOLYSPORA;

EID: 84861482967     PISSN: 16157591     EISSN: 16157605     Source Type: Journal    
DOI: 10.1007/s00449-011-0659-z     Document Type: Article

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