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Volumn 35, Issue , 2015, Pages 96-106

Complexity in the tumour microenvironment: Cancer associated fibroblast gene expression patterns identify both common and unique features of tumour-stroma crosstalk across cancer types

Author keywords

Breast cancer; Cancer associated fibroblasts (CAF); Gene expression; Inter disease; Lung cancer; Prostate cancer

Indexed keywords

BREAST CANCER; CANCER ASSOCIATED FIBROBLAST; CANCER TISSUE; CARCINOGENESIS; CELL PROLIFERATION; CELL SURVIVAL; FIBROBLAST; GENE EXPRESSION; HUMAN; LUNG CANCER; MOLECULAR INTERACTION; PROSTATE CANCER; REVIEW; TUMOR MICROENVIRONMENT; ANIMAL; CELL COMMUNICATION; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; GENETICS; META ANALYSIS (TOPIC); METABOLISM; NEOPLASM; PATHOLOGY; SIGNAL TRANSDUCTION; STROMA CELL;

EID: 84948716649     PISSN: 1044579X     EISSN: 10963650     Source Type: Journal    
DOI: 10.1016/j.semcancer.2015.08.008     Document Type: Review
Times cited : (89)

References (127)
  • 1
    • 77955928161 scopus 로고    scopus 로고
    • Tumors as organs: complex tissues that interface with the entire organism
    • Egeblad M., Nakasone E.S., Werb Z. Tumors as organs: complex tissues that interface with the entire organism. Dev. Cell 2010, 18:884-901. 10.1016/j.devcel.2010.05.012.
    • (2010) Dev. Cell , vol.18 , pp. 884-901
    • Egeblad, M.1    Nakasone, E.S.2    Werb, Z.3
  • 2
    • 77952568396 scopus 로고    scopus 로고
    • Hallmarks of cancer: interactions with the tumor stroma
    • Pietras K., Ostman A. Hallmarks of cancer: interactions with the tumor stroma. Exp. Cell Res. 2010, 316:1324-1331. 10.1016/j.yexcr.2010.02.045.
    • (2010) Exp. Cell Res. , vol.316 , pp. 1324-1331
    • Pietras, K.1    Ostman, A.2
  • 3
    • 58149345546 scopus 로고    scopus 로고
    • Co-evolution of tumor cells and their microenvironment
    • Polyak K., Haviv I., Campbell I.G. Co-evolution of tumor cells and their microenvironment. Trends Genet. 2009, 25:30-38.
    • (2009) Trends Genet. , vol.25 , pp. 30-38
    • Polyak, K.1    Haviv, I.2    Campbell, I.G.3
  • 4
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: functions of cells recruited to the tumor microenvironment
    • Hanahan D., Coussens L.M. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 2012, 21:309-322. 10.1016/j.ccr.2012.02.022.
    • (2012) Cancer Cell , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 5
    • 84887444879 scopus 로고    scopus 로고
    • Microenvironmental regulation of tumor progression and metastasis
    • Quail D.F., Joyce J.A. Microenvironmental regulation of tumor progression and metastasis. Nat. Med. 2013, 19:1423-1437. 10.1038/nm.3394.
    • (2013) Nat. Med. , vol.19 , pp. 1423-1437
    • Quail, D.F.1    Joyce, J.A.2
  • 7
    • 84868640245 scopus 로고    scopus 로고
    • The tumor microenvironment controls drug sensitivity
    • Östman A. The tumor microenvironment controls drug sensitivity. Nat. Med. 2012, 18:1332-1334. 10.1038/nm.2938.
    • (2012) Nat. Med. , vol.18 , pp. 1332-1334
    • Östman, A.1
  • 8
    • 84923194150 scopus 로고    scopus 로고
    • Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis
    • Fong M.Y., Zhou W., Liu L., Alontaga A.Y., Chandra M., Ashby J., et al. Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis. Nat. Cell Biol. 2015, 17:183-194. 10.1038/ncb3094.
    • (2015) Nat. Cell Biol. , vol.17 , pp. 183-194
    • Fong, M.Y.1    Zhou, W.2    Liu, L.3    Alontaga, A.Y.4    Chandra, M.5    Ashby, J.6
  • 9
    • 84925446437 scopus 로고    scopus 로고
    • Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes
    • Webber J.P., Spary L.K., Sanders A.J., Chowdhury R., Jiang W.G., Steadman R., et al. Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes. Oncogene 2015, 34:290-302. 10.1038/onc.2013.560.
    • (2015) Oncogene , vol.34 , pp. 290-302
    • Webber, J.P.1    Spary, L.K.2    Sanders, A.J.3    Chowdhury, R.4    Jiang, W.G.5    Steadman, R.6
  • 10
    • 84929293007 scopus 로고    scopus 로고
    • Extracellular vesicles as modulators of the cancer microenvironment
    • Webber J., Yeung V., Clayton A. Extracellular vesicles as modulators of the cancer microenvironment. Semin. Cell Dev. Biol. 2015, 40:27-34. 10.1016/j.semcdb.2015.01.013.
    • (2015) Semin. Cell Dev. Biol. , vol.40 , pp. 27-34
    • Webber, J.1    Yeung, V.2    Clayton, A.3
  • 11
    • 84948571622 scopus 로고    scopus 로고
    • MicroRNAs as mediators and communicators between cancer cells and the tumor microenvironment
    • Kohlhapp F.J., Mitra A.K., Lengyel E., Peter M.E. MicroRNAs as mediators and communicators between cancer cells and the tumor microenvironment. Oncogene 2015, 10.1038/onc.2015.89.
    • (2015) Oncogene
    • Kohlhapp, F.J.1    Mitra, A.K.2    Lengyel, E.3    Peter, M.E.4
  • 12
    • 84905673351 scopus 로고    scopus 로고
    • The intercellular metabolic interplay between tumor and immune cells
    • Wang T., Liu G., Wang R. The intercellular metabolic interplay between tumor and immune cells. Front. Immunol. 2014, 5:358. 10.3389/fimmu.2014.00358.
    • (2014) Front. Immunol. , vol.5 , pp. 358
    • Wang, T.1    Liu, G.2    Wang, R.3
  • 13
    • 0035835829 scopus 로고    scopus 로고
    • Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation
    • Elenbaas B., Weinberg R.A. Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation. Exp. Cell Res. 2001, 264:169-184. 10.1006/excr.2000.5133.
    • (2001) Exp. Cell Res. , vol.264 , pp. 169-184
    • Elenbaas, B.1    Weinberg, R.A.2
  • 14
    • 33646384428 scopus 로고    scopus 로고
    • Fibroblasts in cancer
    • Kalluri R., Zeisberg M. Fibroblasts in cancer. Nat. Rev. Cancer 2006, 6:392-401. 10.1038/nrc1877.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 392-401
    • Kalluri, R.1    Zeisberg, M.2
  • 15
    • 9244227134 scopus 로고    scopus 로고
    • Stromal fibroblasts in cancer initiation and progression
    • Bhowmick N.A., Neilson E.G., Moses H.L. Stromal fibroblasts in cancer initiation and progression. Nature 2004, 432:332-337. 10.1038/nature03096.
    • (2004) Nature , vol.432 , pp. 332-337
    • Bhowmick, N.A.1    Neilson, E.G.2    Moses, H.L.3
  • 16
    • 33747859659 scopus 로고    scopus 로고
    • Stromal fibroblasts in cancer: a novel tumor-promoting cell type
    • Orimo A., Weinberg R.A. Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle 2006, 5:1597-1601.
    • (2006) Cell Cycle , vol.5 , pp. 1597-1601
    • Orimo, A.1    Weinberg, R.A.2
  • 17
    • 84884368877 scopus 로고    scopus 로고
    • Influence of tumour micro-environment heterogeneity on therapeutic response
    • Junttila M.R., de Sauvage F.J. Influence of tumour micro-environment heterogeneity on therapeutic response. Nature 2013, 501:346-354. 10.1038/nature12626.
    • (2013) Nature , vol.501 , pp. 346-354
    • Junttila, M.R.1    de Sauvage, F.J.2
  • 18
    • 33846967113 scopus 로고    scopus 로고
    • Identification of fibroblast heterogeneity in the tumor microenvironment
    • Sugimoto H., Mundel T.M., Kieran M.W., Kalluri R. Identification of fibroblast heterogeneity in the tumor microenvironment. Cancer Biol. Ther. 2006, 5:1640-1646.
    • (2006) Cancer Biol. Ther. , vol.5 , pp. 1640-1646
    • Sugimoto, H.1    Mundel, T.M.2    Kieran, M.W.3    Kalluri, R.4
  • 19
    • 84881030156 scopus 로고    scopus 로고
    • Cancer associated fibroblasts-more than meets the eye
    • Madar S., Goldstein I., Rotter V. Cancer associated fibroblasts-more than meets the eye. Trends Mol. Med. 2013, 19:447-453. 10.1016/j.molmed.2013.05.004.
    • (2013) Trends Mol. Med. , vol.19 , pp. 447-453
    • Madar, S.1    Goldstein, I.2    Rotter, V.3
  • 20
    • 84901020848 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironment
    • Augsten M. Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironment. Front. Oncol. 2014, 4:62. 10.3389/fonc.2014.00062.
    • (2014) Front. Oncol. , vol.4 , pp. 62
    • Augsten, M.1
  • 21
    • 84942919712 scopus 로고    scopus 로고
    • Tumor-promoting desmoplasia is disrupted by depleting FAP-expressing stromal cells
    • Lo A., Wang L.-C.S., Scholler J., Monslow J., Avery D., Newick K., et al. Tumor-promoting desmoplasia is disrupted by depleting FAP-expressing stromal cells. Cancer Res. 2015, 10.1158/0008-5472.CAN-14-3041.
    • (2015) Cancer Res.
    • Lo, A.1    Wang, L.-C.S.2    Scholler, J.3    Monslow, J.4    Avery, D.5    Newick, K.6
  • 22
    • 84902469661 scopus 로고    scopus 로고
    • Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
    • Ozdemir B.C., Pentcheva-Hoang T., Carstens J.L., Zheng X., Wu C.-C., Simpson T.R., et al. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell 2014, 25:719-734. 10.1016/j.ccr.2014.04.005.
    • (2014) Cancer Cell , vol.25 , pp. 719-734
    • Ozdemir, B.C.1    Pentcheva-Hoang, T.2    Carstens, J.L.3    Zheng, X.4    Wu, C.-C.5    Simpson, T.R.6
  • 23
    • 84902435628 scopus 로고    scopus 로고
    • Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
    • Rhim A.D., Oberstein P.E., Thomas D.H., Mirek E.T., Palermo C.F., Sastra S.A., et al. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell 2014, 25:735-747. 10.1016/j.ccr.2014.04.021.
    • (2014) Cancer Cell , vol.25 , pp. 735-747
    • Rhim, A.D.1    Oberstein, P.E.2    Thomas, D.H.3    Mirek, E.T.4    Palermo, C.F.5    Sastra, S.A.6
  • 24
    • 84905103883 scopus 로고    scopus 로고
    • Fibroblast heterogeneity in the cancer wound
    • Öhlund D., Elyada E., Tuveson D. Fibroblast heterogeneity in the cancer wound. J. Exp. Med. 2014, 211:1503-1523. 10.1084/jem.20140692.
    • (2014) J. Exp. Med. , vol.211 , pp. 1503-1523
    • Öhlund, D.1    Elyada, E.2    Tuveson, D.3
  • 25
    • 84910130785 scopus 로고    scopus 로고
    • Importance of carcinoma-associated fibroblast-derived proteins in clinical oncology
    • Valcz G., Sipos F., Tulassay Z., Molnar B., Yagi Y. Importance of carcinoma-associated fibroblast-derived proteins in clinical oncology. J. Clin. Pathol. 2014, 67:1026-1031. 10.1136/jclinpath-2014-202561.
    • (2014) J. Clin. Pathol. , vol.67 , pp. 1026-1031
    • Valcz, G.1    Sipos, F.2    Tulassay, Z.3    Molnar, B.4    Yagi, Y.5
  • 26
    • 84897483751 scopus 로고    scopus 로고
    • Prognostic relevance of cancer-associated fibroblasts in human cancer
    • Paulsson J., Micke P. Prognostic relevance of cancer-associated fibroblasts in human cancer. Semin. Cancer Biol. 2014, 25:61-68. 10.1016/j.semcancer.2014.02.006.
    • (2014) Semin. Cancer Biol. , vol.25 , pp. 61-68
    • Paulsson, J.1    Micke, P.2
  • 28
    • 78349256721 scopus 로고    scopus 로고
    • The role of the microenvironment in mammary gland development and cancer
    • Polyak K., Kalluri R. The role of the microenvironment in mammary gland development and cancer. Cold Spring Harb. Perspect. Biol. 2010, 2:a003244. 10.1101/cshperspect.a003244.
    • (2010) Cold Spring Harb. Perspect. Biol. , vol.2 , pp. a003244
    • Polyak, K.1    Kalluri, R.2
  • 29
    • 3142512612 scopus 로고    scopus 로고
    • Molecular characterization of the tumor microenvironment in breast cancer
    • Allinen M., Beroukhim R., Cai L., Brennan C., Lahti-Domenici J., Huang H., et al. Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell 2004, 6:17-32. 10.1016/j.ccr.2004.06.010.
    • (2004) Cancer Cell , vol.6 , pp. 17-32
    • Allinen, M.1    Beroukhim, R.2    Cai, L.3    Brennan, C.4    Lahti-Domenici, J.5    Huang, H.6
  • 30
    • 84875945044 scopus 로고    scopus 로고
    • Biological characteristics and genetic heterogeneity between carcinoma-associated fibroblasts and their paired normal fibroblasts in human breast cancer
    • Peng Q., Zhao L., Hou Y., Sun Y., Wang L., Luo H., et al. Biological characteristics and genetic heterogeneity between carcinoma-associated fibroblasts and their paired normal fibroblasts in human breast cancer. PLoS One 2013, 8:e60321. 10.1371/journal.pone.0060321.
    • (2013) PLoS One , vol.8 , pp. e60321
    • Peng, Q.1    Zhao, L.2    Hou, Y.3    Sun, Y.4    Wang, L.5    Luo, H.6
  • 31
    • 0035495401 scopus 로고    scopus 로고
    • Putting tumours in context
    • Bissell M.J., Radisky D. Putting tumours in context. Nat. Rev. Cancer 2001, 1:46-54. 10.1038/35094059.
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 46-54
    • Bissell, M.J.1    Radisky, D.2
  • 32
    • 78650563018 scopus 로고    scopus 로고
    • Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
    • Kojima Y., Acar A., Eaton E.N., Mellody K.T., Scheel C., Ben-Porath I., et al. Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:20009-20014. 10.1073/pnas.1013805107.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 20009-20014
    • Kojima, Y.1    Acar, A.2    Eaton, E.N.3    Mellody, K.T.4    Scheel, C.5    Ben-Porath, I.6
  • 33
    • 64549145804 scopus 로고    scopus 로고
    • Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression
    • Spaeth E.L., Dembinski J.L., Sasser A.K., Watson K., Klopp A., Hall B., et al. Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression. PLoS One 2009, 4:e4992. 10.1371/journal.pone.0004992.
    • (2009) PLoS One , vol.4 , pp. e4992
    • Spaeth, E.L.1    Dembinski, J.L.2    Sasser, A.K.3    Watson, K.4    Klopp, A.5    Hall, B.6
  • 34
    • 35948945337 scopus 로고    scopus 로고
    • Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts
    • Zeisberg E.M., Potenta S., Xie L., Zeisberg M., Kalluri R. Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res. 2007, 67:10123-10128. 10.1158/0008-5472.CAN-07-3127.
    • (2007) Cancer Res. , vol.67 , pp. 10123-10128
    • Zeisberg, E.M.1    Potenta, S.2    Xie, L.3    Zeisberg, M.4    Kalluri, R.5
  • 35
    • 34547776969 scopus 로고    scopus 로고
    • Occurence of stromal myofibroblasts in the invasive ductal breast cancer tissue is an unfavourable prognostic factor
    • Surowiak P., Murawa D., Materna V., Maciejczyk A., Pudelko M., Ciesla S., et al. Occurence of stromal myofibroblasts in the invasive ductal breast cancer tissue is an unfavourable prognostic factor. Anticancer Res 2007, 27:2917-2924.
    • (2007) Anticancer Res , vol.27 , pp. 2917-2924
    • Surowiak, P.1    Murawa, D.2    Materna, V.3    Maciejczyk, A.4    Pudelko, M.5    Ciesla, S.6
  • 36
    • 28244447726 scopus 로고    scopus 로고
    • Tumor immunotherapy targeting fibroblast activation protein, a product expressed in tumor-associated fibroblasts
    • Lee J., Fassnacht M., Nair S., Boczkowski D., Gilboa E. Tumor immunotherapy targeting fibroblast activation protein, a product expressed in tumor-associated fibroblasts. Cancer Res. 2005, 65:11156-11163. 10.1158/0008-5472.CAN-05-2805.
    • (2005) Cancer Res. , vol.65 , pp. 11156-11163
    • Lee, J.1    Fassnacht, M.2    Nair, S.3    Boczkowski, D.4    Gilboa, E.5
  • 37
    • 0033579444 scopus 로고    scopus 로고
    • Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts
    • Park J.E., Lenter M.C., Zimmermann R.N., Garin-Chesa P., Old L.J., Rettig W.J. Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts. J. Biol. Chem. 1999, 274:36505-36512.
    • (1999) J. Biol. Chem. , vol.274 , pp. 36505-36512
    • Park, J.E.1    Lenter, M.C.2    Zimmermann, R.N.3    Garin-Chesa, P.4    Old, L.J.5    Rettig, W.J.6
  • 38
    • 67649975270 scopus 로고    scopus 로고
    • Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer
    • Paulsson J., Sjöblom T., Micke P., Pontén F., Landberg G., Heldin C.-H., et al. Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer. Am. J. Pathol. 2009, 175:334-341. 10.2353/ajpath.2009.081030.
    • (2009) Am. J. Pathol. , vol.175 , pp. 334-341
    • Paulsson, J.1    Sjöblom, T.2    Micke, P.3    Pontén, F.4    Landberg, G.5    Heldin, C.-H.6
  • 39
    • 0035915797 scopus 로고    scopus 로고
    • Stromal expression of fibroblast activation protein/seprase, a cell membrane serine proteinase and gelatinase, is associated with longer survival in patients with invasive ductal carcinoma of breast
    • Ariga N., Sato E., Ohuchi N., Nagura H., Ohtani H. Stromal expression of fibroblast activation protein/seprase, a cell membrane serine proteinase and gelatinase, is associated with longer survival in patients with invasive ductal carcinoma of breast. Int. J. Cancer 2001, 95:67-72.
    • (2001) Int. J. Cancer , vol.95 , pp. 67-72
    • Ariga, N.1    Sato, E.2    Ohuchi, N.3    Nagura, H.4    Ohtani, H.5
  • 40
    • 33845524970 scopus 로고    scopus 로고
    • Transforming growth factor-beta in cancer and metastasis
    • Jakowlew S.B. Transforming growth factor-beta in cancer and metastasis. Cancer Metastasis Rev. 2006, 25:435-457. 10.1007/s10555-006-9006-2.
    • (2006) Cancer Metastasis Rev. , vol.25 , pp. 435-457
    • Jakowlew, S.B.1
  • 42
    • 84860619381 scopus 로고    scopus 로고
    • Contribution of fibroblast and mast cell (afferent) and tumor (efferent) IL-6 effects within the tumor microenvironment
    • Hugo H.J., Lebret S., Tomaskovic-Crook E., Ahmed N., Blick T., Newgreen D.F., et al. Contribution of fibroblast and mast cell (afferent) and tumor (efferent) IL-6 effects within the tumor microenvironment. Cancer Microenviron. 2012, 10.1007/s12307-012-0098-7.
    • (2012) Cancer Microenviron.
    • Hugo, H.J.1    Lebret, S.2    Tomaskovic-Crook, E.3    Ahmed, N.4    Blick, T.5    Newgreen, D.F.6
  • 43
  • 44
    • 49749144117 scopus 로고    scopus 로고
    • Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy
    • Mercier I., Casimiro M.C., Wang C., Rosenberg A.L., Quong J., Minkeu A., et al. Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy. Cancer Biol. Ther. 2008, 7:1212-1225.
    • (2008) Cancer Biol. Ther. , vol.7 , pp. 1212-1225
    • Mercier, I.1    Casimiro, M.C.2    Wang, C.3    Rosenberg, A.L.4    Quong, J.5    Minkeu, A.6
  • 45
    • 77954165461 scopus 로고    scopus 로고
    • Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors
    • Martinez-Outschoorn U.E., Pavlides S., Whitaker-Menezes D., Daumer K.M., Milliman J.N., Chiavarina B., et al. Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors. Cell Cycle 2010, 9:2423-2433.
    • (2010) Cell Cycle , vol.9 , pp. 2423-2433
    • Martinez-Outschoorn, U.E.1    Pavlides, S.2    Whitaker-Menezes, D.3    Daumer, K.M.4    Milliman, J.N.5    Chiavarina, B.6
  • 46
    • 0028953271 scopus 로고
    • Reduction of caveolin and caveolae in oncogenically transformed cells
    • Koleske A.J., Baltimore D., Lisanti M.P. Reduction of caveolin and caveolae in oncogenically transformed cells. Proc. Natl. Acad. Sci. U.S.A. 1995, 92:1381-1385.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 1381-1385
    • Koleske, A.J.1    Baltimore, D.2    Lisanti, M.P.3
  • 47
    • 66549114050 scopus 로고    scopus 로고
    • An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers
    • Witkiewicz A.K., Dasgupta A., Sotgia F., Mercier I., Pestell R.G., Sabel M., et al. An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers. Am. J. Pathol. 2009, 174:2023-2034. 10.2353/ajpath.2009.080873.
    • (2009) Am. J. Pathol. , vol.174 , pp. 2023-2034
    • Witkiewicz, A.K.1    Dasgupta, A.2    Sotgia, F.3    Mercier, I.4    Pestell, R.G.5    Sabel, M.6
  • 48
    • 77953551959 scopus 로고    scopus 로고
    • The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts
    • Bonuccelli G., Whitaker-Menezes D., Castello-Cros R., Pavlides S., Pestell R.G., Fatatis A., et al. The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts. Cell Cycle 2010, 9:1960-1971.
    • (2010) Cell Cycle , vol.9 , pp. 1960-1971
    • Bonuccelli, G.1    Whitaker-Menezes, D.2    Castello-Cros, R.3    Pavlides, S.4    Pestell, R.G.5    Fatatis, A.6
  • 49
    • 84893678593 scopus 로고    scopus 로고
    • A review of stem cell translation and potential confounds by cancer stem cells
    • Bibber B., Sinha G., Lobba A.R.M., Greco S.J., Rameshwar P. A review of stem cell translation and potential confounds by cancer stem cells. Stem Cells Int. 2013, 2013:241048. 10.1155/2013/241048.
    • (2013) Stem Cells Int. , vol.2013 , pp. 241048
    • Bibber, B.1    Sinha, G.2    Lobba, A.R.M.3    Greco, S.J.4    Rameshwar, P.5
  • 50
    • 84861882582 scopus 로고    scopus 로고
    • CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells
    • Tsuyada A., Chow A., Wu J., Somlo G., Chu P., Loera S., et al. CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells. Cancer Res. 2012, 72:2768-2779. 10.1158/0008-5472.CAN-11-3567.
    • (2012) Cancer Res. , vol.72 , pp. 2768-2779
    • Tsuyada, A.1    Chow, A.2    Wu, J.3    Somlo, G.4    Chu, P.5    Loera, S.6
  • 51
    • 84922641173 scopus 로고    scopus 로고
    • Differential expression of cancer-associated fibroblast-related proteins according to molecular subtype and stromal histology in breast cancer
    • Park S.Y., Kim H.M., Koo J.S. Differential expression of cancer-associated fibroblast-related proteins according to molecular subtype and stromal histology in breast cancer. Breast Cancer Res. Treat. 2015, 149:727-741. 10.1007/s10549-015-3291-9.
    • (2015) Breast Cancer Res. Treat. , vol.149 , pp. 727-741
    • Park, S.Y.1    Kim, H.M.2    Koo, J.S.3
  • 52
    • 77950099096 scopus 로고    scopus 로고
    • Heterogeneity of gene expression in stromal fibroblasts of human breast carcinomas and normal breast
    • Bauer M., Su G., Casper C., He R., Rehrauer W., Friedl A. Heterogeneity of gene expression in stromal fibroblasts of human breast carcinomas and normal breast. Oncogene 2010, 29:1732-1740. 10.1038/onc.2009.463.
    • (2010) Oncogene , vol.29 , pp. 1732-1740
    • Bauer, M.1    Su, G.2    Casper, C.3    He, R.4    Rehrauer, W.5    Friedl, A.6
  • 53
    • 13044295427 scopus 로고    scopus 로고
    • WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors
    • Pennica D., Swanson T.A., Welsh J.W., Roy M.A., Lawrence D.A., Lee J., et al. WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:14717-14722.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 14717-14722
    • Pennica, D.1    Swanson, T.A.2    Welsh, J.W.3    Roy, M.A.4    Lawrence, D.A.5    Lee, J.6
  • 54
    • 57749105327 scopus 로고    scopus 로고
    • Wnt1 expression induces short-range and long-range cell recruitments that modify mammary tumor development and are not induced by a cell-autonomous beta-catenin effector
    • Kim Y.C., Clark R.J., Ranheim E.A., Alexander C.M. Wnt1 expression induces short-range and long-range cell recruitments that modify mammary tumor development and are not induced by a cell-autonomous beta-catenin effector. Cancer Res. 2008, 68:10145-10153. 10.1158/0008-5472.CAN-08-2992.
    • (2008) Cancer Res. , vol.68 , pp. 10145-10153
    • Kim, Y.C.1    Clark, R.J.2    Ranheim, E.A.3    Alexander, C.M.4
  • 55
    • 43249121177 scopus 로고    scopus 로고
    • Stromal gene expression predicts clinical outcome in breast cancer
    • Finak G., Bertos N., Pepin F., Sadekova S., Souleimanova M., Zhao H., et al. Stromal gene expression predicts clinical outcome in breast cancer. Nat. Med. 2008, 14:518-527. 10.1038/nm1764.
    • (2008) Nat. Med. , vol.14 , pp. 518-527
    • Finak, G.1    Bertos, N.2    Pepin, F.3    Sadekova, S.4    Souleimanova, M.5    Zhao, H.6
  • 56
    • 58149334773 scopus 로고    scopus 로고
    • A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer
    • Farmer P., Bonnefoi H., Anderle P., Cameron D., Wirapati P., Wirapati P., et al. A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer. Nat. Med. 2009, 15:68-74. 10.1038/nm.1908.
    • (2009) Nat. Med. , vol.15 , pp. 68-74
    • Farmer, P.1    Bonnefoi, H.2    Anderle, P.3    Cameron, D.4    Wirapati, P.5    Wirapati, P.6
  • 58
    • 67549125238 scopus 로고    scopus 로고
    • Gene expression profiling of the tumor microenvironment during breast cancer progression
    • Ma X.-J., Dahiya S., Richardson E., Erlander M., Sgroi D.C. Gene expression profiling of the tumor microenvironment during breast cancer progression. Breast Cancer Res. 2009, 11:R7. 10.1186/bcr2222.
    • (2009) Breast Cancer Res. , vol.11 , pp. R7
    • Ma, X.-J.1    Dahiya, S.2    Richardson, E.3    Erlander, M.4    Sgroi, D.C.5
  • 59
    • 0035170731 scopus 로고    scopus 로고
    • Reactive stroma in prostate cancer progression
    • Tuxhorn J.A., Ayala G.E., Rowley D.R. Reactive stroma in prostate cancer progression. J. Urol. 2001, 166:2472-2483.
    • (2001) J. Urol. , vol.166 , pp. 2472-2483
    • Tuxhorn, J.A.1    Ayala, G.E.2    Rowley, D.R.3
  • 60
    • 0036718369 scopus 로고    scopus 로고
    • Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling
    • Tuxhorn J.A., Ayala G.E., Smith M.J., Smith V.C., Dang T.D., Rowley D.R. Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling. Clin. Cancer Res. 2002, 8:2912-2923.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 2912-2923
    • Tuxhorn, J.A.1    Ayala, G.E.2    Smith, M.J.3    Smith, V.C.4    Dang, T.D.5    Rowley, D.R.6
  • 61
    • 84887188959 scopus 로고    scopus 로고
    • Microenvironment and tumor cell plasticity: an easy way out
    • Taddei M.L., Giannoni E., Comito G., Chiarugi P. Microenvironment and tumor cell plasticity: an easy way out. Cancer Lett. 2013, 341:80-96. 10.1016/j.canlet.2013.01.042.
    • (2013) Cancer Lett. , vol.341 , pp. 80-96
    • Taddei, M.L.1    Giannoni, E.2    Comito, G.3    Chiarugi, P.4
  • 63
    • 84873952155 scopus 로고    scopus 로고
    • Expression changes in the stroma of prostate cancer predict subsequent relapse
    • Jia Z., Rahmatpanah F.B., Chen X., Lernhardt W., Wang Y., Xia X.-Q., et al. Expression changes in the stroma of prostate cancer predict subsequent relapse. PLoS One 2012, 7:e41371. 10.1371/journal.pone.0041371.
    • (2012) PLoS One , vol.7 , pp. e41371
    • Jia, Z.1    Rahmatpanah, F.B.2    Chen, X.3    Lernhardt, W.4    Wang, Y.5    Xia, X.-Q.6
  • 64
    • 0033215242 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium
    • Olumi A.F., Grossfeld G.D., Hayward S.W., Carroll P.R., Tlsty T.D., Cunha G.R. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res. 1999, 59:5002-5011.
    • (1999) Cancer Res. , vol.59 , pp. 5002-5011
    • Olumi, A.F.1    Grossfeld, G.D.2    Hayward, S.W.3    Carroll, P.R.4    Tlsty, T.D.5    Cunha, G.R.6
  • 65
    • 84867112200 scopus 로고    scopus 로고
    • Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay
    • Fiaschi T., Marini A., Giannoni E., Taddei M.L., Gandellini P., De Donatis A., et al. Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay. Cancer Res. 2012, 72:5130-5140. 10.1158/0008-5472.CAN-12-1949.
    • (2012) Cancer Res. , vol.72 , pp. 5130-5140
    • Fiaschi, T.1    Marini, A.2    Giannoni, E.3    Taddei, M.L.4    Gandellini, P.5    De Donatis, A.6
  • 66
    • 77956280130 scopus 로고    scopus 로고
    • Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness
    • Giannoni E., Bianchini F., Masieri L., Serni S., Torre E., Calorini L., et al. Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness. Cancer Res. 2010, 70:6945-6956. 10.1158/0008-5472.CAN-10-0785.
    • (2010) Cancer Res. , vol.70 , pp. 6945-6956
    • Giannoni, E.1    Bianchini, F.2    Masieri, L.3    Serni, S.4    Torre, E.5    Calorini, L.6
  • 67
    • 79957532451 scopus 로고    scopus 로고
    • Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness
    • Giannoni E., Bianchini F., Calorini L., Chiarugi P. Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness. Antioxid. Redox Signal. 2011, 14:2361-2371. 10.1089/ars.2010.3727.
    • (2011) Antioxid. Redox Signal. , vol.14 , pp. 2361-2371
    • Giannoni, E.1    Bianchini, F.2    Calorini, L.3    Chiarugi, P.4
  • 68
    • 84894039409 scopus 로고    scopus 로고
    • MiR-205 hinders the malignant interplay between prostate cancer cells and associated fibroblasts
    • Gandellini P., Giannoni E., Casamichele A., Taddei M.L., Callari M., Piovan C., et al. miR-205 hinders the malignant interplay between prostate cancer cells and associated fibroblasts. Antioxid. Redox Signal. 2014, 20:1045-1059. 10.1089/ars.2013.5292.
    • (2014) Antioxid. Redox Signal. , vol.20 , pp. 1045-1059
    • Gandellini, P.1    Giannoni, E.2    Casamichele, A.3    Taddei, M.L.4    Callari, M.5    Piovan, C.6
  • 69
    • 65549115615 scopus 로고    scopus 로고
    • MiR-205 exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase Cepsilon
    • Gandellini P., Folini M., Longoni N., Pennati M., Binda M., Colecchia M., et al. miR-205 exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase Cepsilon. Cancer Res. 2009, 69:2287-2295. 10.1158/0008-5472.CAN-08-2894.
    • (2009) Cancer Res. , vol.69 , pp. 2287-2295
    • Gandellini, P.1    Folini, M.2    Longoni, N.3    Pennati, M.4    Binda, M.5    Colecchia, M.6
  • 70
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani S.A., Guo W., Liao M.-J., Eaton E.N., Ayyanan A., Zhou A.Y., et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008, 133:704-715. 10.1016/j.cell.2008.03.027.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.-J.3    Eaton, E.N.4    Ayyanan, A.5    Zhou, A.Y.6
  • 71
    • 77956904572 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts enhance the gland-forming capability of prostate cancer stem cells
    • Liao C.-P., Adisetiyo H., Liang M., Roy-Burman P. Cancer-associated fibroblasts enhance the gland-forming capability of prostate cancer stem cells. Cancer Res. 2010, 70:7294-7303. 10.1158/0008-5472.CAN-09-3982.
    • (2010) Cancer Res. , vol.70 , pp. 7294-7303
    • Liao, C.-P.1    Adisetiyo, H.2    Liang, M.3    Roy-Burman, P.4
  • 72
    • 84863289409 scopus 로고    scopus 로고
    • Integrated analysis reveals critical genomic regions in prostate tumor microenvironment associated with clinicopathologic phenotypes
    • Ashida S., Orloff M.S., Bebek G., Zhang L., Zheng P., Peehl D.M., et al. Integrated analysis reveals critical genomic regions in prostate tumor microenvironment associated with clinicopathologic phenotypes. Clin. Cancer Res. 2012, 18:1578-1587. 10.1158/1078-0432.CCR-11-2535.
    • (2012) Clin. Cancer Res. , vol.18 , pp. 1578-1587
    • Ashida, S.1    Orloff, M.S.2    Bebek, G.3    Zhang, L.4    Zheng, P.5    Peehl, D.M.6
  • 73
    • 79952536678 scopus 로고    scopus 로고
    • Differential inductive signaling of CD90 prostate cancer-associated fibroblasts compared to normal tissue stromal mesenchyme cells
    • Pascal L.E., Ai J., Vêncio R.Z.N., Vêncio E.F., Zhou Y., Page L.S., et al. Differential inductive signaling of CD90 prostate cancer-associated fibroblasts compared to normal tissue stromal mesenchyme cells. Cancer Microenviron. 2011, 4:51-59. 10.1007/s12307-010-0061-4.
    • (2011) Cancer Microenviron. , vol.4 , pp. 51-59
    • Pascal, L.E.1    Ai, J.2    Vêncio, R.Z.N.3    Vêncio, E.F.4    Zhou, Y.5    Page, L.S.6
  • 74
    • 79956215274 scopus 로고    scopus 로고
    • Identification of prognostic molecular features in the reactive stroma of human breast and prostate cancer
    • Planche A., Bacac M., Provero P., Fusco C., Delorenzi M., Stehle J.-C., et al. Identification of prognostic molecular features in the reactive stroma of human breast and prostate cancer. PLoS One 2011, 6:e18640. 10.1371/journal.pone.0018640.
    • (2011) PLoS One , vol.6 , pp. e18640
    • Planche, A.1    Bacac, M.2    Provero, P.3    Fusco, C.4    Delorenzi, M.5    Stehle, J.-C.6
  • 75
    • 84945542006 scopus 로고    scopus 로고
    • Integrated gene and miRNA expression analysis of prostate cancer associated fibroblasts supports a prominent role for interleukin-6 in fibroblast activation
    • in press
    • Doldi V., Callari M., Giannoni E., D'Aiuto F., Maffezzini M., Valdagni R., et al. Integrated gene and miRNA expression analysis of prostate cancer associated fibroblasts supports a prominent role for interleukin-6 in fibroblast activation. Oncotarget 2015, in press.
    • (2015) Oncotarget
    • Doldi, V.1    Callari, M.2    Giannoni, E.3    D'Aiuto, F.4    Maffezzini, M.5    Valdagni, R.6
  • 76
    • 38549116786 scopus 로고    scopus 로고
    • Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis
    • Dean J.P., Nelson P.S. Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis. Br. J. Cancer 2008, 98:245-249. 10.1038/sj.bjc.6604087.
    • (2008) Br. J. Cancer , vol.98 , pp. 245-249
    • Dean, J.P.1    Nelson, P.S.2
  • 77
    • 77958580732 scopus 로고    scopus 로고
    • The effects of aging on the molecular and cellular composition of the prostate microenvironment
    • Bianchi-Frias D., Vakar-Lopez F., Coleman I.M., Plymate S.R., Reed M.J., Nelson P.S. The effects of aging on the molecular and cellular composition of the prostate microenvironment. PLoS One 2010, 5. 10.1371/journal.pone.0012501.
    • (2010) PLoS One , vol.5
    • Bianchi-Frias, D.1    Vakar-Lopez, F.2    Coleman, I.M.3    Plymate, S.R.4    Reed, M.J.5    Nelson, P.S.6
  • 78
    • 31544479046 scopus 로고    scopus 로고
    • The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms
    • Bavik C., Coleman I., Dean J.P., Knudsen B., Plymate S., Nelson P.S. The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms. Cancer Res. 2006, 66:794-802. 10.1158/0008-5472.CAN-05-1716.
    • (2006) Cancer Res. , vol.66 , pp. 794-802
    • Bavik, C.1    Coleman, I.2    Dean, J.P.3    Knudsen, B.4    Plymate, S.5    Nelson, P.S.6
  • 79
    • 33750798741 scopus 로고    scopus 로고
    • The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis
    • Yang G., Rosen D.G., Zhang Z., Bast R.C., Mills G.B., Colacino J.A., et al. The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:16472-16477. 10.1073/pnas.0605752103.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 16472-16477
    • Yang, G.1    Rosen, D.G.2    Zhang, Z.3    Bast, R.C.4    Mills, G.B.5    Colacino, J.A.6
  • 80
    • 79960339381 scopus 로고    scopus 로고
    • Rb1 protects endothelial cells from hydrogen peroxide-induced cell senescence by modulating redox status
    • Liu D.-H., Chen Y.-M., Liu Y., Hao B.-S., Zhou B., Wu L., et al. Rb1 protects endothelial cells from hydrogen peroxide-induced cell senescence by modulating redox status. Biol. Pharm. Bull. 2011, 34:1072-1077.
    • (2011) Biol. Pharm. Bull. , vol.34 , pp. 1072-1077
    • Liu, D.-H.1    Chen, Y.-M.2    Liu, Y.3    Hao, B.-S.4    Zhou, B.5    Wu, L.6
  • 81
    • 18144371956 scopus 로고    scopus 로고
    • Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts
    • Waghray M., Cui Z., Horowitz J.C., Subramanian I.M., Martinez F.J., Toews G.B., et al. Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts. FASEB J. 2005, 19:854-856. 10.1096/fj.04-2882fje.
    • (2005) FASEB J. , vol.19 , pp. 854-856
    • Waghray, M.1    Cui, Z.2    Horowitz, J.C.3    Subramanian, I.M.4    Martinez, F.J.5    Toews, G.B.6
  • 82
    • 84911977766 scopus 로고    scopus 로고
    • Senescent stroma promotes prostate cancer progression: the role of miR-210
    • Taddei M.L., Cavallini L., Comito G., Giannoni E., Folini M., Marini A., et al. Senescent stroma promotes prostate cancer progression: the role of miR-210. Mol. Oncol. 2014, 8:1729-1746. 10.1016/j.molonc.2014.07.009.
    • (2014) Mol. Oncol. , vol.8 , pp. 1729-1746
    • Taddei, M.L.1    Cavallini, L.2    Comito, G.3    Giannoni, E.4    Folini, M.5    Marini, A.6
  • 83
    • 84938751873 scopus 로고    scopus 로고
    • MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
    • Laberge R.-M., Sun Y., Orjalo A.V., Patil C.K., Freund A., Zhou L., et al. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nat. Cell Biol. 2015, 17:1049-1061. 10.1038/ncb3195.
    • (2015) Nat. Cell Biol. , vol.17 , pp. 1049-1061
    • Laberge, R.-M.1    Sun, Y.2    Orjalo, A.V.3    Patil, C.K.4    Freund, A.5    Zhou, L.6
  • 84
    • 78651073833 scopus 로고    scopus 로고
    • The role of tumor stroma in cancer progression and prognosis: emphasis on carcinoma-associated fibroblasts and non-small cell lung cancer
    • Bremnes R.M., Dønnem T., Al-Saad S., Al-Shibli K., Andersen S., Sirera R., et al. The role of tumor stroma in cancer progression and prognosis: emphasis on carcinoma-associated fibroblasts and non-small cell lung cancer. J. Thorac. Oncol. 2011, 6:209-217. 10.1097/JTO.0b013e3181f8a1bd.
    • (2011) J. Thorac. Oncol. , vol.6 , pp. 209-217
    • Bremnes, R.M.1    Dønnem, T.2    Al-Saad, S.3    Al-Shibli, K.4    Andersen, S.5    Sirera, R.6
  • 85
    • 84878168372 scopus 로고    scopus 로고
    • Human lung cancer-associated fibroblasts enhance motility of non-small cell lung cancer cells in co-culture
    • Kim S.-H., Choe C., Shin Y.-S., Jeon M.-J., Choi S.-J., Lee J., et al. Human lung cancer-associated fibroblasts enhance motility of non-small cell lung cancer cells in co-culture. Anticancer Res. 2013, 33:2001-2009.
    • (2013) Anticancer Res. , vol.33 , pp. 2001-2009
    • Kim, S.-H.1    Choe, C.2    Shin, Y.-S.3    Jeon, M.-J.4    Choi, S.-J.5    Lee, J.6
  • 86
    • 79955562722 scopus 로고    scopus 로고
    • Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer
    • Navab R., Strumpf D., Bandarchi B., Zhu C.-Q., Pintilie M., Ramnarine V.R., et al. Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:7160-7165. 10.1073/pnas.1014506108.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 7160-7165
    • Navab, R.1    Strumpf, D.2    Bandarchi, B.3    Zhu, C.-Q.4    Pintilie, M.5    Ramnarine, V.R.6
  • 88
    • 0347383870 scopus 로고    scopus 로고
    • Gene expression profiling of normal human pulmonary fibroblasts following coculture with non-small-cell lung cancer cells reveals alterations related to matrix degradation, angiogenesis, cell growth and survival
    • Fromigué O., Louis K., Dayem M., Milanini J., Pages G., Tartare-Deckert S., et al. Gene expression profiling of normal human pulmonary fibroblasts following coculture with non-small-cell lung cancer cells reveals alterations related to matrix degradation, angiogenesis, cell growth and survival. Oncogene 2003, 22:8487-8497. 10.1038/sj.onc.1206918.
    • (2003) Oncogene , vol.22 , pp. 8487-8497
    • Fromigué, O.1    Louis, K.2    Dayem, M.3    Milanini, J.4    Pages, G.5    Tartare-Deckert, S.6
  • 89
    • 84869219069 scopus 로고    scopus 로고
    • Cross-species functional analysis of cancer-associated fibroblasts identifies a critical role for CLCF1 and IL-6 in non-small cell lung cancer in vivo
    • Vicent S., Sayles L.C., Vaka D., Khatri P., Gevaert O., Chen R., et al. Cross-species functional analysis of cancer-associated fibroblasts identifies a critical role for CLCF1 and IL-6 in non-small cell lung cancer in vivo. Cancer Res. 2012, 72:5744-5756. 10.1158/0008-5472.CAN-12-1097.
    • (2012) Cancer Res. , vol.72 , pp. 5744-5756
    • Vicent, S.1    Sayles, L.C.2    Vaka, D.3    Khatri, P.4    Gevaert, O.5    Chen, R.6
  • 90
    • 79956093785 scopus 로고    scopus 로고
    • Interaction between neoplastic cells and cancer-associated fibroblasts through the CXCL12/CXCR4 axis: role in non-small cell lung cancer tumor proliferation
    • Wald O., Izhar U., Amir G., Kirshberg S., Shlomai Z., Zamir G., et al. Interaction between neoplastic cells and cancer-associated fibroblasts through the CXCL12/CXCR4 axis: role in non-small cell lung cancer tumor proliferation. J. Thorac. Cardiovasc. Surg. 2011, 141:1503-1512. 10.1016/j.jtcvs.2010.11.056.
    • (2011) J. Thorac. Cardiovasc. Surg. , vol.141 , pp. 1503-1512
    • Wald, O.1    Izhar, U.2    Amir, G.3    Kirshberg, S.4    Shlomai, Z.5    Zamir, G.6
  • 91
    • 84942886878 scopus 로고    scopus 로고
    • Microenvironment modulated metastatic CD133+/CXCR4+/EpCAM- lung cancer initiating cells sustain tumor dissemination and correlate with poor prognosis
    • in review
    • Bertolini G., D'Amico L., Moro M., Landoni E., Perego P., Miceli R., et al. Microenvironment modulated metastatic CD133+/CXCR4+/EpCAM- lung cancer initiating cells sustain tumor dissemination and correlate with poor prognosis. Cancer Res. 2015, in review.
    • (2015) Cancer Res.
    • Bertolini, G.1    D'Amico, L.2    Moro, M.3    Landoni, E.4    Perego, P.5    Miceli, R.6
  • 92
    • 84897058262 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling
    • Chen W.-J., Ho C.-C., Chang Y.-L., Chen H.-Y., Lin C.-A., Ling T.-Y., et al. Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling. Nat. Commun. 2014, 5:3472. 10.1038/ncomms4472.
    • (2014) Nat. Commun. , vol.5 , pp. 3472
    • Chen, W.-J.1    Ho, C.-C.2    Chang, Y.-L.3    Chen, H.-Y.4    Lin, C.-A.5    Ling, T.-Y.6
  • 95
    • 78649742699 scopus 로고    scopus 로고
    • Human lung parenchyma but not proximal bronchi produces fibroblasts with enhanced TGF-beta signaling and alpha-SMA expression
    • Pechkovsky D.V., Hackett T.L., An S.S., Shaheen F., Murray L.A., Knight D.A. Human lung parenchyma but not proximal bronchi produces fibroblasts with enhanced TGF-beta signaling and alpha-SMA expression. Am. J. Respir. Cell Mol. Biol. 2010, 43:641-651. 10.1165/rcmb.2009-0318OC.
    • (2010) Am. J. Respir. Cell Mol. Biol. , vol.43 , pp. 641-651
    • Pechkovsky, D.V.1    Hackett, T.L.2    An, S.S.3    Shaheen, F.4    Murray, L.A.5    Knight, D.A.6
  • 96
    • 84883155635 scopus 로고    scopus 로고
    • Qualitative rather than quantitative changes are hallmarks of fibroblasts in bleomycin-induced pulmonary fibrosis
    • Tsukui T., Ueha S., Abe J., Hashimoto S., Shichino S., Shimaoka T., et al. Qualitative rather than quantitative changes are hallmarks of fibroblasts in bleomycin-induced pulmonary fibrosis. Am. J. Pathol. 2013, 183:758-773. 10.1016/j.ajpath.2013.06.005.
    • (2013) Am. J. Pathol. , vol.183 , pp. 758-773
    • Tsukui, T.1    Ueha, S.2    Abe, J.3    Hashimoto, S.4    Shichino, S.5    Shimaoka, T.6
  • 97
    • 59149104024 scopus 로고    scopus 로고
    • Senescent stromal-derived osteopontin promotes preneoplastic cell growth
    • Pazolli E., Luo X., Brehm S., Carbery K., Chung J.-J., Prior J.L., et al. Senescent stromal-derived osteopontin promotes preneoplastic cell growth. Cancer Res. 2009, 69:1230-1239. 10.1158/0008-5472.CAN-08-2970.
    • (2009) Cancer Res. , vol.69 , pp. 1230-1239
    • Pazolli, E.1    Luo, X.2    Brehm, S.3    Carbery, K.4    Chung, J.-J.5    Prior, J.L.6
  • 98
    • 5144220875 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 status in stromal fibroblasts, not in tumor cells, is a significant prognostic factor in non-small-cell lung cancer
    • Ishikawa S., Takenaka K., Yanagihara K., Miyahara R., Kawano Y., Otake Y., et al. Matrix metalloproteinase-2 status in stromal fibroblasts, not in tumor cells, is a significant prognostic factor in non-small-cell lung cancer. Clin. Cancer Res. 2004, 10:6579-6585. 10.1158/1078-0432.CCR-04-0272.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 6579-6585
    • Ishikawa, S.1    Takenaka, K.2    Yanagihara, K.3    Miyahara, R.4    Kawano, Y.5    Otake, Y.6
  • 99
    • 84905040388 scopus 로고    scopus 로고
    • Transforming growth factor-β1 and α-smooth muscle actin in stromal fibroblasts are associated with a poor prognosis in patients with clinical stage I-IIIA nonsmall cell lung cancer after curative resection
    • Chen Y., Zou L., Zhang Y., Chen Y., Xing P., Yang W., et al. Transforming growth factor-β1 and α-smooth muscle actin in stromal fibroblasts are associated with a poor prognosis in patients with clinical stage I-IIIA nonsmall cell lung cancer after curative resection. Tumour Biol. 2014, 35:6707-6713. 10.1007/s13277-014-1908-y.
    • (2014) Tumour Biol. , vol.35 , pp. 6707-6713
    • Chen, Y.1    Zou, L.2    Zhang, Y.3    Chen, Y.4    Xing, P.5    Yang, W.6
  • 100
    • 67649198500 scopus 로고    scopus 로고
    • Prognostic significance of carbonic anhydrase IX expression by cancer-associated fibroblasts in lung adenocarcinoma
    • Nakao M., Ishii G., Nagai K., Kawase A., Kenmotsu H., Kon-No H., et al. Prognostic significance of carbonic anhydrase IX expression by cancer-associated fibroblasts in lung adenocarcinoma. Cancer 2009, 115:2732-2743. 10.1002/cncr.24303.
    • (2009) Cancer , vol.115 , pp. 2732-2743
    • Nakao, M.1    Ishii, G.2    Nagai, K.3    Kawase, A.4    Kenmotsu, H.5    Kon-No, H.6
  • 101
    • 84863802475 scopus 로고    scopus 로고
    • Prognostic impact of cancer-associated stromal cells in patients with stage I lung adenocarcinoma
    • Ito M., Ishii G., Nagai K., Maeda R., Nakano Y., Ochiai A. Prognostic impact of cancer-associated stromal cells in patients with stage I lung adenocarcinoma. Chest 2012, 142:151-158. 10.1378/chest. 11-2458.
    • (2012) Chest , vol.142 , pp. 151-158
    • Ito, M.1    Ishii, G.2    Nagai, K.3    Maeda, R.4    Nakano, Y.5    Ochiai, A.6
  • 102
    • 84931564429 scopus 로고    scopus 로고
    • Podoplanin-expressing cancer-associated fibroblasts lead and enhance the local invasion of cancer cells in lung adenocarcinoma
    • Neri S., Ishii G., Hashimoto H., Kuwata T., Nagai K., Date H., et al. Podoplanin-expressing cancer-associated fibroblasts lead and enhance the local invasion of cancer cells in lung adenocarcinoma. Int. J. Cancer 2015, 10.1002/ijc.29464.
    • (2015) Int. J. Cancer
    • Neri, S.1    Ishii, G.2    Hashimoto, H.3    Kuwata, T.4    Nagai, K.5    Date, H.6
  • 103
    • 19344363035 scopus 로고    scopus 로고
    • Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds
    • Chang H.Y., Sneddon J.B., Alizadeh A.A., Sood R., West R.B., Montgomery K., et al. Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds. PLoS Biol. 2004, 2:E7. 10.1371/journal.pbio.0020007.
    • (2004) PLoS Biol. , vol.2 , pp. E7
    • Chang, H.Y.1    Sneddon, J.B.2    Alizadeh, A.A.3    Sood, R.4    West, R.B.5    Montgomery, K.6
  • 105
    • 38849141696 scopus 로고    scopus 로고
    • Cancer-associated stromal fibroblasts promote pancreatic tumor progression
    • Hwang R.F., Moore T., Arumugam T., Ramachandran V., Amos K.D., Rivera A., et al. Cancer-associated stromal fibroblasts promote pancreatic tumor progression. Cancer Res. 2008, 68:918-926. 10.1158/0008-5472.CAN-07-5714.
    • (2008) Cancer Res. , vol.68 , pp. 918-926
    • Hwang, R.F.1    Moore, T.2    Arumugam, T.3    Ramachandran, V.4    Amos, K.D.5    Rivera, A.6
  • 106
    • 80051525374 scopus 로고    scopus 로고
    • Interleukin 1α sustains the expression of inflammatory factors in human pancreatic cancer microenvironment by targeting cancer-associated fibroblasts
    • Tjomsland V., Spångeus A., Välilä J., Sandström P., Borch K., Druid H., et al. Interleukin 1α sustains the expression of inflammatory factors in human pancreatic cancer microenvironment by targeting cancer-associated fibroblasts. Neoplasia 2011, 13:664-675.
    • (2011) Neoplasia , vol.13 , pp. 664-675
    • Tjomsland, V.1    Spångeus, A.2    Välilä, J.3    Sandström, P.4    Borch, K.5    Druid, H.6
  • 107
    • 77949719411 scopus 로고    scopus 로고
    • Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts
    • Walter K., Omura N., Hong S.-M., Griffith M., Vincent A., Borges M., et al. Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts. Clin. Cancer Res. 2010, 16:1781-1789. 10.1158/1078-0432.CCR-09-1913.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 1781-1789
    • Walter, K.1    Omura, N.2    Hong, S.-M.3    Griffith, M.4    Vincent, A.5    Borges, M.6
  • 108
    • 80052470635 scopus 로고    scopus 로고
    • Tumor engraftment in nude mice and enrichment in stroma-related gene pathways predict poor survival and resistance to gemcitabine in patients with pancreatic cancer
    • Garrido-Laguna I., Uson M., Rajeshkumar N.V., Tan A.C., de Oliveira E., Karikari C., et al. Tumor engraftment in nude mice and enrichment in stroma-related gene pathways predict poor survival and resistance to gemcitabine in patients with pancreatic cancer. Clin. Cancer Res. 2011, 17:5793-5800. 10.1158/1078-0432.CCR-11-0341.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 5793-5800
    • Garrido-Laguna, I.1    Uson, M.2    Rajeshkumar, N.V.3    Tan, A.C.4    de Oliveira, E.5    Karikari, C.6
  • 109
    • 76349096670 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner
    • Erez N., Truitt M., Olson P., Arron S.T., Hanahan D. Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner. Cancer Cell 2010, 17:135-147. 10.1016/j.ccr.2009.12.041.
    • (2010) Cancer Cell , vol.17 , pp. 135-147
    • Erez, N.1    Truitt, M.2    Olson, P.3    Arron, S.T.4    Hanahan, D.5
  • 110
    • 84908505808 scopus 로고    scopus 로고
    • Differences between CAFs and their paired NCF from adjacent colonic mucosa reveal functional heterogeneity of CAFs, providing prognostic information
    • Berdiel-Acer M., Sanz-Pamplona R., Calon A., Cuadras D., Berenguer A., Sanjuan X., et al. Differences between CAFs and their paired NCF from adjacent colonic mucosa reveal functional heterogeneity of CAFs, providing prognostic information. Mol. Oncol. 2014, 8:1290-1305. 10.1016/j.molonc.2014.04.006.
    • (2014) Mol. Oncol. , vol.8 , pp. 1290-1305
    • Berdiel-Acer, M.1    Sanz-Pamplona, R.2    Calon, A.3    Cuadras, D.4    Berenguer, A.5    Sanjuan, X.6
  • 111
    • 84887119057 scopus 로고    scopus 로고
    • Functional heterogeneity of cancer-associated fibroblasts from human colon tumors shows specific prognostic gene expression signature
    • Herrera M., Islam A.B.M.M.K., Herrera A., Martín P., García V., Silva J., et al. Functional heterogeneity of cancer-associated fibroblasts from human colon tumors shows specific prognostic gene expression signature. Clin. Cancer Res. 2013, 19:5914-5926. 10.1158/1078-0432.CCR-13-0694.
    • (2013) Clin. Cancer Res. , vol.19 , pp. 5914-5926
    • Herrera, M.1    Islam, A.B.M.M.K.2    Herrera, A.3    Martín, P.4    García, V.5    Silva, J.6
  • 114
    • 79651469459 scopus 로고    scopus 로고
    • Fibroblast gene expression profile reflects the stage of tumour progression in oral squamous cell carcinoma
    • Lim K.P., Cirillo N., Hassona Y., Wei W., Thurlow J.K., Cheong S.C., et al. Fibroblast gene expression profile reflects the stage of tumour progression in oral squamous cell carcinoma. J. Pathol. 2011, 223:459-469. 10.1002/path.2841.
    • (2011) J. Pathol. , vol.223 , pp. 459-469
    • Lim, K.P.1    Cirillo, N.2    Hassona, Y.3    Wei, W.4    Thurlow, J.K.5    Cheong, S.C.6
  • 115
    • 67449164585 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 2-positive fibroblasts provide a suitable microenvironment for tumor development and progression in esophageal carcinoma
    • Zhang C., Fu L., Fu J., Hu L., Yang H., Rong T.-H., et al. Fibroblast growth factor receptor 2-positive fibroblasts provide a suitable microenvironment for tumor development and progression in esophageal carcinoma. Clin. Cancer Res. 2009, 15:4017-4027. 10.1158/1078-0432.CCR-08-2824.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 4017-4027
    • Zhang, C.1    Fu, L.2    Fu, J.3    Hu, L.4    Yang, H.5    Rong, T.-H.6
  • 116
    • 84923292396 scopus 로고    scopus 로고
    • Cancer associated fibroblasts in hematological malignancies
    • Raffaghello L., Vacca A., Pistoia V., Ribatti D. Cancer associated fibroblasts in hematological malignancies. Oncotarget 2015, 6:2589-2603.
    • (2015) Oncotarget , vol.6 , pp. 2589-2603
    • Raffaghello, L.1    Vacca, A.2    Pistoia, V.3    Ribatti, D.4
  • 117
    • 84942457204 scopus 로고    scopus 로고
    • Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts
    • Paggetti J., Haderk F., Seiffert M., Janji B., Distler U., Ammerlaan W., et al. Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts. Blood 2015, 10.1182/blood-2014-12-618025.
    • (2015) Blood
    • Paggetti, J.1    Haderk, F.2    Seiffert, M.3    Janji, B.4    Distler, U.5    Ammerlaan, W.6
  • 118
    • 46249088370 scopus 로고    scopus 로고
    • Lumi: a pipeline for processing Illumina microarray
    • Du P., Kibbe W.A., Lin S.M. Lumi: a pipeline for processing Illumina microarray. Bioinforma 2008, 24:1547-1548.
    • (2008) Bioinforma , vol.24 , pp. 1547-1548
    • Du, P.1    Kibbe, W.A.2    Lin, S.M.3
  • 119
    • 0142121516 scopus 로고    scopus 로고
    • Exploration, normalization, and summaries of high density oligonucleotide array probe level data
    • Irizarry R.A., Hobbs B., Collin F., Beazer-Barclay Y.D., Antonellis K.J., Scherf U., et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostat 2003, 4:249-264.
    • (2003) Biostat , vol.4 , pp. 249-264
    • Irizarry, R.A.1    Hobbs, B.2    Collin, F.3    Beazer-Barclay, Y.D.4    Antonellis, K.J.5    Scherf, U.6
  • 120
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical bayes methods for assessing differential expression in microarray experiments
    • Smyth G.K. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol. 2004, 3:Article3.
    • (2004) Stat. Appl. Genet. Mol. Biol. , vol.3
    • Smyth, G.K.1
  • 122
    • 38949202980 scopus 로고    scopus 로고
    • Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome
    • Bergamaschi A., Tagliabue E., Sørlie T., Naume B., Triulzi T., Orlandi R., et al. Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome. J. Pathol. 2008, 214:357-367. 10.1002/path.2278.
    • (2008) J. Pathol. , vol.214 , pp. 357-367
    • Bergamaschi, A.1    Tagliabue, E.2    Sørlie, T.3    Naume, B.4    Triulzi, T.5    Orlandi, R.6
  • 123
    • 84874165459 scopus 로고    scopus 로고
    • Neoplastic and stromal cells contribute to an extracellular matrix gene expression profile defining a breast cancer subtype likely to progress
    • Triulzi T., Casalini P., Sandri M., Ratti M., Carcangiu M.L., Colombo M.P., et al. Neoplastic and stromal cells contribute to an extracellular matrix gene expression profile defining a breast cancer subtype likely to progress. PLoS One 2013, 8:e56761. 10.1371/journal.pone.0056761.
    • (2013) PLoS One , vol.8 , pp. e56761
    • Triulzi, T.1    Casalini, P.2    Sandri, M.3    Ratti, M.4    Carcangiu, M.L.5    Colombo, M.P.6
  • 124
    • 84929156364 scopus 로고    scopus 로고
    • Therapeutic combinations of immune-modulating antibodies in melanoma and beyond
    • Cohen J., Sznol M. Therapeutic combinations of immune-modulating antibodies in melanoma and beyond. Semin. Oncol. 2015, 42:488-494. 10.1053/j.seminoncol.2015.02.014.
    • (2015) Semin. Oncol. , vol.42 , pp. 488-494
    • Cohen, J.1    Sznol, M.2
  • 125
    • 84929145540 scopus 로고    scopus 로고
    • Immune checkpoint inhibitors in melanoma provide the cornerstones for curative therapies
    • Eggermont A.M.M., Maio M., Robert C. Immune checkpoint inhibitors in melanoma provide the cornerstones for curative therapies. Semin. Oncol. 2015, 42:429-435. 10.1053/j.seminoncol.2015.02.010.
    • (2015) Semin. Oncol. , vol.42 , pp. 429-435
    • Eggermont, A.M.M.1    Maio, M.2    Robert, C.3
  • 126
    • 84929208731 scopus 로고    scopus 로고
    • Immunologic checkpoint blockade in lung cancer
    • Reck M., Paz-Ares L. Immunologic checkpoint blockade in lung cancer. Semin. Oncol. 2015, 42:402-417. 10.1053/j.seminoncol.2015.02.013.
    • (2015) Semin. Oncol. , vol.42 , pp. 402-417
    • Reck, M.1    Paz-Ares, L.2
  • 127
    • 84885045558 scopus 로고    scopus 로고
    • Understanding the impact of 2D and 3D fibroblast cultures on in vitro breast cancer models
    • Sung K.E., Su X., Berthier E., Pehlke C., Friedl A., Beebe D.J. Understanding the impact of 2D and 3D fibroblast cultures on in vitro breast cancer models. PLoS One 2013, 8:e76373. 10.1371/journal.pone.0076373.
    • (2013) PLoS One , vol.8 , pp. e76373
    • Sung, K.E.1    Su, X.2    Berthier, E.3    Pehlke, C.4    Friedl, A.5    Beebe, D.J.6


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