-
1
-
-
75849159205
-
Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression
-
Shimoda M, Mellody KT, Orimo A. Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression. Semin Cell Dev Biol 2010;21:19-25.
-
(2010)
Semin Cell Dev Biol
, vol.21
, pp. 19-25
-
-
Shimoda, M.1
Mellody, K.T.2
Orimo, A.3
-
2
-
-
84873713209
-
Microenvironment-mediated resistance to anticancer therapies
-
Olson OC, Joyce JA. Microenvironment-mediated resistance to anticancer therapies. Cell Res 2013;23:179-81.
-
(2012)
Cell Res
, vol.23
, pp. 179-181
-
-
Olson, O.C.1
Joyce, J.A.2
-
3
-
-
84861116448
-
Tumor microenvironment complexity: Emerging roles in cancer therapy
-
Swartz MA, Iida N, Roberts EW, et al. Tumor microenvironment complexity: emerging roles in cancer therapy. Cancer Res 2012;72:2473-80.
-
(2012)
Cancer Res
, vol.72
, pp. 2473-2480
-
-
Swartz, M.A.1
Iida, N.2
Roberts, E.W.3
-
4
-
-
84859073207
-
Recent developments in myofibroblast biology: Paradigms for connective tissue remodeling
-
Hinz B, Phan SH, Thannickal VJ, et al. Recent developments in myofibroblast biology: paradigms for connective tissue remodeling. Am J Pathol 2012;180:1340-55.
-
(2012)
Am J Pathol
, vol.180
, pp. 1340-1355
-
-
Hinz, B.1
Phan, S.H.2
Thannickal, V.J.3
-
5
-
-
84879603171
-
Exosomes in tumor microenvironment influence cancer progression and metastasis
-
Kahlert C, Kalluri R. Exosomes in tumor microenvironment influence cancer progression and metastasis. J Mol Med 2013;91:431-7.
-
(2012)
J Mol Med
, vol.91
, pp. 431-437
-
-
Kahlert, C.1
Kalluri, R.2
-
6
-
-
84871528926
-
MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer
-
Mitra AK, Zillhardt M, Hua Y, et al. MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer. Cancer Discov 2012;2:1100-8.
-
(2012)
Cancer Discov
, vol.2
, pp. 1100-1108
-
-
Mitra, A.K.1
Zillhardt, M.2
Hua, Y.3
-
7
-
-
53249130662
-
Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers
-
Sabbah M, Emami S, Redeuilh G, et al. Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers. Drug Resist Updat 2008;11:123-51.
-
(2008)
Drug Resist Updat
, vol.11
, pp. 123-151
-
-
Sabbah, M.1
Emami, S.2
Redeuilh, G.3
-
8
-
-
84910119035
-
Review of cancer - Associated fibroblasts and therapies that interfere with their activity
-
Takebe N, Ivy P, Timmer W, et al. Review of cancer - associated fibroblasts and therapies that interfere with their activity. Tum Microenvir and Ther 2013;1:19-36.
-
(2012)
Tum Microenvir and Ther
, vol.1
, pp. 19-36
-
-
Takebe, N.1
Ivy, P.2
Timmer, W.3
-
9
-
-
84875234222
-
Carcinoma-associated fibroblasts are a promising therapeutic target
-
Togo S, Polanska UM, Horimoto Y, et al. Carcinoma-associated fibroblasts are a promising therapeutic target. Cancers 2013;5:149-69.
-
(2012)
Cancers
, vol.5
, pp. 149-169
-
-
Togo, S.1
Polanska, U.M.2
Horimoto, Y.3
-
10
-
-
84875217448
-
Fibroblast-mediated drug resistance in cancer
-
Paraiso KH, Smalley KS. Fibroblast-mediated drug resistance in cancer. Biochem Pharmacol 2013;85:1033-41.
-
(2012)
Biochem Pharmacol
, vol.85
, pp. 1033-1041
-
-
Paraiso, K.H.1
Smalley, K.S.2
-
11
-
-
78651073833
-
The role of tumor stroma in cancer progression and prognosis: Emphasis on carcinoma-associated fibroblasts and non-small cell lung cancer
-
Bremnes RM, Dønnem T, Al-Saad S, et al. The role of tumor stroma in cancer progression and prognosis: emphasis on carcinoma-associated fibroblasts and non-small cell lung cancer. J Thorac Oncol 2011;6:209-17.
-
(2011)
J Thorac Oncol
, vol.6
, pp. 209-217
-
-
Bremnes, R.M.1
Dønnem, T.2
Al-Saad, S.3
-
12
-
-
75849116069
-
Molecular biology of cancer-associated fibroblasts: Can these cells be targeted in anti-cancer therapy?
-
Gonda TA, Varro A, Wang TC, et al. Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy? Semin Cell Dev Biol 2010;21:2-10.
-
(2010)
Semin Cell Dev Biol
, vol.21
, pp. 2-10
-
-
Gonda, T.A.1
Varro, A.2
Wang, T.C.3
-
13
-
-
0342264492
-
Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: Implications for tumorigenesis
-
Moinfar F, Man YG, Arnould L, et al. Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis. Cancer Res 2000;60:2562-6.
-
(2000)
Cancer Res
, vol.60
, pp. 2562-2566
-
-
Moinfar, F.1
Man, Y.G.2
Arnould, L.3
-
14
-
-
0036843937
-
Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas
-
Kurose K, Gilley K, Matsumoto S, et al. Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Nat Gen 2002;32:355-7.
-
(2002)
Nat Gen
, vol.32
, pp. 355-357
-
-
Kurose, K.1
Gilley, K.2
Matsumoto, S.3
-
15
-
-
37349101054
-
Breast-cancer stromal cells with TP53 mutations and nodal metastases
-
Patocs A, Zhang L, Xu Y, et al. Breast-cancer stromal cells with TP53 mutations and nodal metastases. N Engl J Med 2007;357:2543-51.
-
(2007)
N Engl J Med
, vol.357
, pp. 2543-2551
-
-
Patocs, A.1
Zhang, L.2
Xu, Y.3
-
16
-
-
0034566319
-
Presence of genetic alterations in microdissected stroma of human colon and breast cancers
-
Wernert N, Löcherbach C, Wellmann A, et al. Presence of genetic alterations in microdissected stroma of human colon and breast cancers. J Mol Med 2000;78: B30.
-
(2000)
J Mol Med
, vol.78
, pp. B30
-
-
Wernert, N.1
Löcherbach, C.2
Wellmann, A.3
-
17
-
-
70149088171
-
Clonal mutations in the cancer-associated fibroblasts: The case against genetic coevolution
-
Campbell I, Polyak K, Haviv I. Clonal mutations in the cancer-associated fibroblasts: the case against genetic coevolution. Cancer Res 2009;69: 6765-8.
-
(2009)
Cancer Res
, vol.69
, pp. 6765-6768
-
-
Campbell, I.1
Polyak, K.2
Haviv, I.3
-
18
-
-
77955029223
-
Breast carcinoma-associated fibroblasts rarely contain p53 mutations or chromosomal aberrations
-
Hosein AN, Wu M, Arcand SL, et al. Breast carcinoma-associated fibroblasts rarely contain p53 mutations or chromosomal aberrations. Cancer Res 2010;70:5770-7.
-
(2010)
Cancer Res
, vol.70
, pp. 5770-5777
-
-
Hosein, A.N.1
Wu, M.2
Arcand, S.L.3
-
19
-
-
42549152045
-
No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas
-
Qiu W, Hu M, Sridhar A, et al. No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas. Nat Gen 2008;40:650-5.
-
(2008)
Nat Gen
, vol.40
, pp. 650-655
-
-
Qiu, W.1
Hu, M.2
Sridhar, A.3
-
20
-
-
84865036227
-
Implication of tumor microenvironment in chemoresistance: Tumor-associated stromal cells protect tumor cells from cell death
-
Castells M, Thibault B, Delord JP, et al. Implication of tumor microenvironment in chemoresistance: tumor-associated stromal cells protect tumor cells from cell death. Int J Mol Sci 2012;13:9545-71.
-
(2012)
Int J Mol Sci
, vol.13
, pp. 9545-9571
-
-
Castells, M.1
Thibault, B.2
Delord, J.P.3
-
21
-
-
69249087671
-
Environment-mediated drug resistance: A major contributor to minimal residual disease
-
Meads MB, Gatenby RA, Dalton WS. Environment-mediated drug resistance: a major contributor to minimal residual disease. Nat Rev Cancer 2009;9:665-74.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 665-674
-
-
Meads, M.B.1
Gatenby, R.A.2
Dalton, W.S.3
-
22
-
-
0035328628
-
N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells
-
Li G, Satyamoorthy K, Herlyn M. N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells. Cancer Res 2001;61:3819-25.
-
(2001)
Cancer Res
, vol.61
, pp. 3819-3825
-
-
Li, G.1
Satyamoorthy, K.2
Herlyn, M.3
-
23
-
-
84885014865
-
Tumor-stromal interactions with direct cell contacts enhance motility of non-small cell lung cancer cells through the hedgehog signaling pathway
-
Choe C, Shin YS, Kim SH, et al. Tumor-stromal interactions with direct cell contacts enhance motility of non-small cell lung cancer cells through the hedgehog signaling pathway. Anticancer Res 2013;33:3715-23.
-
(2012)
Anticancer Res
, vol.33
, pp. 3715-3723
-
-
Choe, C.1
Shin, Y.S.2
Kim, S.H.3
-
24
-
-
77249117415
-
Pancreatic cancer stem cells and EMT in drug resistance and metastasis
-
Sarkar FH, Li Y, Wang Z, et al. Pancreatic cancer stem cells and EMT in drug resistance and metastasis. Minerva Chir 2009;64:489-500.
-
(2009)
Minerva Chir
, vol.64
, pp. 489-500
-
-
Sarkar, F.H.1
Li, Y.2
Wang, Z.3
-
25
-
-
84890227134
-
Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway
-
Wu Q, Wang R, Yang Q, et al. Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway. Oncotarget 2013;4:1999-2009.
-
(2012)
Oncotarget
, vol.4
, pp. 1999-2009
-
-
Wu, Q.1
Wang, R.2
Yang, Q.3
-
26
-
-
84873385587
-
Integrin signaling in cancer cell survival and chemoresistance
-
Aoudjit F, Vuori K. Integrin signaling in cancer cell survival and chemoresistance. Chemother Res Pract 2012;2012:283181.
-
(2012)
Chemother Res Pract
, vol.2012
, pp. 283181
-
-
Aoudjit, F.1
Vuori, K.2
-
27
-
-
67650451085
-
The multifaceted role of periostin in tumorigenesis
-
Ruan K, Bao S, Ouyang G. The multifaceted role of periostin in tumorigenesis. Cell Mol Life Sci 2009;66:2219-30.
-
(2009)
Cell Mol Life Sci
, vol.66
, pp. 2219-2230
-
-
Ruan, K.1
Bao, S.2
Ouyang, G.3
-
28
-
-
84868633053
-
Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B
-
Sun Y, Campisi J, Higano C, et al. Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. Nat Med 2012;18:1359-68.
-
(2012)
Nat Med
, vol.18
, pp. 1359-1368
-
-
Sun, Y.1
Campisi, J.2
Higano, C.3
-
29
-
-
77949534041
-
Combined anti-angiogenic therapy targeting PDGF and VEGF receptors lowers the interstitial fluid pressure in a murine experimental carcinoma
-
Klosowska-Wardega A, Hasumi Y, Burmakin M, et al. Combined anti-angiogenic therapy targeting PDGF and VEGF receptors lowers the interstitial fluid pressure in a murine experimental carcinoma. PLoS ONE 2009;4:e8149.
-
(2009)
PLoS ONE
, vol.4
, pp. e8149
-
-
Klosowska-Wardega, A.1
Hasumi, Y.2
Burmakin, M.3
-
30
-
-
11144354392
-
Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
-
Willett CG, Boucher Y, di Tomaso E, et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med 2004;10:145-7.
-
(2004)
Nat Med
, vol.10
, pp. 145-147
-
-
Willett, C.G.1
Boucher, Y.2
Di Tomaso, E.3
-
31
-
-
84872785096
-
Tumor stroma as targets for cancer therapy
-
Zhang J, Liu J. Tumor stroma as targets for cancer therapy. Pharmacol Ther 2013;137:200-15.
-
(2012)
Pharmacol Ther
, vol.137
, pp. 200-215
-
-
Zhang, J.1
Liu, J.2
-
32
-
-
0348012943
-
The fibroblast: Sentinel cell and local immune modulator in tumor tissue
-
Silzle T, Randolph GJ, Kreutz M, et al. The fibroblast: sentinel cell and local immune modulator in tumor tissue. Int J Cancer 2004;108:173-80.
-
(2004)
Int J Cancer
, vol.108
, pp. 173-180
-
-
Silzle, T.1
Randolph, G.J.2
Kreutz, M.3
-
33
-
-
84900402318
-
Cancer-associated fibroblasts and M2-polarized macrophages synergize during prostate carcinoma progression
-
Comito G, Giannoni E, Segura CP, et al. Cancer-associated fibroblasts and M2-polarized macrophages synergize during prostate carcinoma progression. Oncogene 2014;33:2423-31.
-
(2014)
Oncogene
, vol.33
, pp. 2423-2431
-
-
Comito, G.1
Giannoni, E.2
Segura, C.P.3
-
34
-
-
84876424760
-
Macrophage regulation of tumor responses to anticancer therapies
-
De Palma M, Lewis CE. Macrophage regulation of tumor responses to anticancer therapies. Cancer Cell 2013;23:277-86.
-
(2012)
Cancer Cell
, vol.23
, pp. 277-286
-
-
De Palma, M.1
Lewis, C.E.2
-
35
-
-
84884368877
-
Influence of tumour micro-environment heterogeneity on therapeutic response
-
Junttila MR, de Sauvage FJ. Influence of tumour micro-environment heterogeneity on therapeutic response. Nature 2013;501:346-54.
-
(2012)
Nature
, vol.501
, pp. 346-354
-
-
Junttila, M.R.1
De Sauvage, F.J.2
-
36
-
-
82955189189
-
Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer
-
Shree T, Olson OC, Elie BT, et al. Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer. Genes Dev 2011;25:2465-79.
-
(2011)
Genes Dev
, vol.25
, pp. 2465-2479
-
-
Shree, T.1
Olson, O.C.2
Elie, B.T.3
-
37
-
-
84863116741
-
Fibroblast activation protein: A potential therapeutic target in cancer
-
Liu R, Li H, Liu L, et al. Fibroblast activation protein: a potential therapeutic target in cancer. Cancer Biol Ther 2012;13:123-9.
-
(2012)
Cancer Biol Ther
, vol.13
, pp. 123-129
-
-
Liu, R.1
Li, H.2
Liu, L.3
-
38
-
-
80455158257
-
Expression and role of fibroblast activation protein-alpha in microinvasive breast carcinoma
-
Hua X, Yu L, Huang X, et al. Expression and role of fibroblast activation protein-alpha in microinvasive breast carcinoma. Diagn Pathol 2011;6:111.
-
(2011)
Diagn Pathol
, vol.6
, pp. 111
-
-
Hua, X.1
Yu, L.2
Huang, X.3
-
39
-
-
84882724223
-
Clinical implications of fibroblast activation protein-A in non-small cell lung cancer after curative resection: A new predictor for prognosis
-
Liao Y, Ni Y, He R, et al. Clinical implications of fibroblast activation protein-a in non-small cell lung cancer after curative resection: a new predictor for prognosis. J Cancer Res Clin Oncol 2013;139:1523-8.
-
(2012)
J Cancer Res Clin Oncol
, vol.139
, pp. 1523-1528
-
-
Liao, Y.1
Ni, Y.2
He, R.3
-
40
-
-
84877137104
-
High intratumoral expression of fibroblast activation protein (FAP) in colon cancer is associated with poorer patient prognosis
-
Wikberg ML, Edin S, Lundberg IV, et al. High intratumoral expression of fibroblast activation protein (FAP) in colon cancer is associated with poorer patient prognosis. Tumor Biol 2013;34:1013-20.
-
(2012)
Tumor Biol
, vol.34
, pp. 1013-1020
-
-
Wikberg, M.L.1
Edin, S.2
Lundberg, I.V.3
-
41
-
-
0036790060
-
Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy
-
Pietras K, Rubin K, Sjöblom T, et al. Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy. Cancer Res 2002;62:5476-84.
-
(2002)
Cancer Res
, vol.62
, pp. 5476-5484
-
-
Pietras, K.1
Rubin, K.2
Sjöblom, T.3
-
42
-
-
84867979311
-
PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker
-
Yuzawa S, Kano MR, Einama T, et al. PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker. Med Onc 2012;29:2824-30.
-
(2012)
Med Onc
, vol.29
, pp. 2824-2830
-
-
Yuzawa, S.1
Kano, M.R.2
Einama, T.3
-
43
-
-
67649975270
-
Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer
-
Paulsson J, Sjöblom T, Micke P, et al. Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer. Am J Pathol 2009;175:334-41.
-
(2009)
Am J Pathol
, vol.175
, pp. 334-341
-
-
Paulsson, J.1
Sjöblom, T.2
Micke, P.3
-
44
-
-
58149106094
-
Prognostic impact of platelet-derived growth factors in non-small cell lung cancer tumor and stromal cells
-
Donnem T, Al-Saad S, Al-Shibli K, et al. Prognostic impact of platelet-derived growth factors in non-small cell lung cancer tumor and stromal cells. J Thorac Oncol 2008;3:963-70.
-
(2008)
J Thorac Oncol
, vol.3
, pp. 963-970
-
-
Donnem, T.1
Al-Saad, S.2
Al-Shibli, K.3
-
45
-
-
84890445450
-
Podoplanin expression in cancer-associated fibroblasts enhances tumor progression of invasive ductal carcinoma of the pancreas
-
Shindo K, Aishima S, Ohuchida K, et al. Podoplanin expression in cancer-associated fibroblasts enhances tumor progression of invasive ductal carcinoma of the pancreas. Mol Cancer 2013;12:168.
-
(2012)
Mol Cancer
, vol.12
, pp. 168
-
-
Shindo, K.1
Aishima, S.2
Ohuchida, K.3
-
46
-
-
84863802475
-
Prognostic impact of cancer-associated stromal cells in patients with stage i lung adenocarcinoma
-
Ito M, Ishii G, Nagai K, et al. Prognostic impact of cancer-associated stromal cells in patients with stage I lung adenocarcinoma. Chest 2012;142:151-8.
-
(2012)
Chest
, vol.142
, pp. 151-158
-
-
Ito, M.1
Ishii, G.2
Nagai, K.3
-
47
-
-
67649221971
-
Podoplanin expression identified in stromal fibroblasts as a favorable prognostic marker in patients with colorectal carcinoma
-
Yamanashi T, Nakanishi Y, Fujii G, et al. Podoplanin expression identified in stromal fibroblasts as a favorable prognostic marker in patients with colorectal carcinoma. Oncology 2009;77:53-62.
-
(2009)
Oncology
, vol.77
, pp. 53-62
-
-
Yamanashi, T.1
Nakanishi, Y.2
Fujii, G.3
-
48
-
-
84876479033
-
Podoplanin expressing cancer associated fibroblasts are associated with unfavourable prognosis in adenocarcinoma of the esophagus
-
Schoppmann SF, Jesch B, Riegler MF, et al. Podoplanin expressing cancer associated fibroblasts are associated with unfavourable prognosis in adenocarcinoma of the esophagus. Clin Exp Metastasis 2013;30:441-6.
-
(2012)
Clin Exp Metastasis
, vol.30
, pp. 441-446
-
-
Schoppmann, S.F.1
Jesch, B.2
Riegler, M.F.3
-
49
-
-
33846916208
-
Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma
-
Infante JR, Matsubayashi H, Sato N, et al. Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma. J Clin Oncol 2007;25:319-25.
-
(2007)
J Clin Oncol
, vol.25
, pp. 319-325
-
-
Infante, J.R.1
Matsubayashi, H.2
Sato, N.3
-
50
-
-
0141482120
-
Enhanced expression of SPARC/osteonectin in the tumor-associated stroma of non-small cell lung cancer is correlated with markers of hypoxia/acidity and with poor prognosis of patients
-
Koukourakis MI, Giatromanolaki A, Brekken RA, et al. Enhanced expression of SPARC/osteonectin in the tumor-associated stroma of non-small cell lung cancer is correlated with markers of hypoxia/acidity and with poor prognosis of patients. Cancer Res 2003;63:5376-80.
-
(2003)
Cancer Res
, vol.63
, pp. 5376-5380
-
-
Koukourakis, M.I.1
Giatromanolaki, A.2
Brekken, R.A.3
-
51
-
-
33745465488
-
Hepatocyte growth factor and the Met system as a mediator of tumor-stromal interactions
-
Matsumoto K, Nakamura T. Hepatocyte growth factor and the Met system as a mediator of tumor-stromal interactions. Int J Cancer 2006;119:477-83.
-
(2006)
Int J Cancer
, vol.119
, pp. 477-483
-
-
Matsumoto, K.1
Nakamura, T.2
-
52
-
-
0035067626
-
C-MET expression in myofibroblasts: Role in autocrine activation and prognostic significance in lung adenocarcinoma
-
Tokunou M, Niki T, Eguchi K, et al. c-MET expression in myofibroblasts: role in autocrine activation and prognostic significance in lung adenocarcinoma. Am J Pathol 2001;158:1451-63.
-
(2001)
Am J Pathol
, vol.158
, pp. 1451-1463
-
-
Tokunou, M.1
Niki, T.2
Eguchi, K.3
-
53
-
-
84897556892
-
TGF-beta in CAF-mediated tumor growth and metastasis
-
Calon A, Tauriello DV, Batlle E. TGF-beta in CAF-mediated tumor growth and metastasis. Semin Cancer Biol 2014;25:15-22.
-
(2014)
Semin Cancer Biol
, vol.25
, pp. 15-22
-
-
Calon, A.1
Tauriello, D.V.2
Batlle, E.3
-
55
-
-
0029740157
-
Transforming growth factor beta 1 expression in human colorectal tumours: An independent prognostic marker in a subgroup of poor prognosis patients
-
Robson H, Anderson E, James RD, et al. Transforming growth factor beta 1 expression in human colorectal tumours: an independent prognostic marker in a subgroup of poor prognosis patients. Br J Cancer 1996;74:753-8.
-
(1996)
Br J Cancer
, vol.74
, pp. 753-758
-
-
Robson, H.1
Anderson, E.2
James, R.D.3
-
56
-
-
84925287388
-
TGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancer. Oncogene Published Online First: 16 Dec 2013
-
Busch S, Acar A, Magnusson Y, et al. TGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancer. Oncogene Published Online First: 16 Dec 2013. doi: 10.1038/onc.2013.527
-
Doi: 10.1038/onc.2013.527
-
-
Busch, S.1
Acar, A.2
Magnusson, Y.3
-
57
-
-
84870462491
-
Cancer-associated fibroblasts as targets for immunotherapy
-
Kakarla S, Song XT, Gottschalk S. Cancer-associated fibroblasts as targets for immunotherapy. Immunotherapy 2012;4:1129-38.
-
(2012)
Immunotherapy
, vol.4
, pp. 1129-1138
-
-
Kakarla, S.1
Song, X.T.2
Gottschalk, S.3
-
58
-
-
66349135076
-
The TGF-β paradox in human cancer: An update
-
Tian M, Schiemann WP. The TGF-β paradox in human cancer: an update. Future Oncol 2009;5:259-71.
-
(2009)
Future Oncol
, vol.5
, pp. 259-271
-
-
Tian, M.1
Schiemann, W.P.2
-
59
-
-
84857640591
-
Cancer associated fibroblasts: The dark side of the coin
-
Cirri P, Chiarugi P. Cancer associated fibroblasts: the dark side of the coin. Am J Cancer Res 2011;1:482-97.
-
(2011)
Am J Cancer Res
, vol.1
, pp. 482-497
-
-
Cirri, P.1
Chiarugi, P.2
-
60
-
-
59449090107
-
TGF-beta-induced epithelial to mesenchymal transition
-
Xu J, Lamouille S, Derynck R. TGF-beta-induced epithelial to mesenchymal transition. Cell Res 2009;19:156-72.
-
(2009)
Cell Res
, vol.19
, pp. 156-172
-
-
Xu, J.1
Lamouille, S.2
Derynck, R.3
-
61
-
-
15744372725
-
Role of transforming growth factor Beta in human cancer
-
Elliott RL, Blobe GC. Role of transforming growth factor Beta in human cancer. J Clin Oncol 2005;23:2078-93.
-
(2005)
J Clin Oncol
, vol.23
, pp. 2078-2093
-
-
Elliott, R.L.1
Blobe, G.C.2
-
62
-
-
0035890359
-
Transforming growth factor-beta1 increases survival of human melanoma through stroma remodeling
-
Berking C, Takemoto R, Schaider H, et al. Transforming growth factor-beta1 increases survival of human melanoma through stroma remodeling. Cancer Res 2001;61:8306-16.
-
(2001)
Cancer Res
, vol.61
, pp. 8306-8316
-
-
Berking, C.1
Takemoto, R.2
Schaider, H.3
-
63
-
-
78650563018
-
Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
-
Kojima Y, Acar A, Eaton EN, et al. Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci USA 2010;107:20009-14.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 20009-20014
-
-
Kojima, Y.1
Acar, A.2
Eaton, E.N.3
-
64
-
-
33947310596
-
Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis
-
Kryczek I, Wei S, Keller E, et al. Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis. Am J Physiol Cell Physiol 2007;292:987-95.
-
(2007)
Am J Physiol Cell Physiol
, vol.292
, pp. 987-995
-
-
Kryczek, I.1
Wei, S.2
Keller, E.3
-
65
-
-
84897566294
-
Phase i study of GC1008 (Fresolimumab): A human anti-transforming growth factor-beta (TGFβ) monoclonal antibody in patients with advanced malignant melanoma or renal cell carcinoma
-
Morris JC, Tan AR, Olencki TE, et al. Phase i study of GC1008 (Fresolimumab): a human anti-transforming growth factor-beta (TGFβ) monoclonal antibody in patients with advanced malignant melanoma or renal cell carcinoma. PLoS ONE 2014;9:e90353.
-
(2014)
PLoS ONE
, vol.9
, pp. e90353
-
-
Morris, J.C.1
Tan, A.R.2
Olencki, T.E.3
-
66
-
-
84865787544
-
Molecular pathways: Targeting the TGF-β pathway for cancer therapy
-
Smith AL, Robin TP, Ford HL. Molecular pathways: targeting the TGF-β pathway for cancer therapy. Clin Cancer Res 2012;18:4514-21.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 4514-4521
-
-
Smith, A.L.1
Robin, T.P.2
Ford, H.L.3
-
67
-
-
67651091694
-
Phase II trial of Belagenpumatucel-L, a TGF-beta2 antisense gene modified allogeneic tumor vaccine in advanced non small cell lung cancer (NSCLC) patients
-
Nemunaitis J, Nemunaitis M, Senzer N, et al. Phase II trial of Belagenpumatucel-L, a TGF-beta2 antisense gene modified allogeneic tumor vaccine in advanced non small cell lung cancer (NSCLC) patients. Cancer Gene Ther 2009;16:620-4.
-
(2009)
Cancer Gene Ther
, vol.16
, pp. 620-624
-
-
Nemunaitis, J.1
Nemunaitis, M.2
Senzer, N.3
-
68
-
-
84897450600
-
Transforming growth factor-β as a therapeutic target in hepatocellular carcinoma
-
Giannelli G, Villa E, Lahn M. Transforming growth factor-β as a therapeutic target in hepatocellular carcinoma. Cancer Res 2014;74:1890-94.
-
(2014)
Cancer Res
, vol.74
, pp. 1890-1894
-
-
Giannelli, G.1
Villa, E.2
Lahn, M.3
-
69
-
-
3543002277
-
VEGF-null cells require PDGFR alpha signaling-mediated stromal fibroblast recruitment for tumorigenesis
-
Dong J, Grunstein J, Tejada M, et al. VEGF-null cells require PDGFR alpha signaling-mediated stromal fibroblast recruitment for tumorigenesis. EMBO J 2004;23:2800-10.
-
(2004)
EMBO J
, vol.23
, pp. 2800-2810
-
-
Dong, J.1
Grunstein, J.2
Tejada, M.3
-
70
-
-
57849106330
-
PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment
-
Crawford Y, Kasman I, Yu L, et al. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell 2009;15:21-34.
-
(2009)
Cancer Cell
, vol.15
, pp. 21-34
-
-
Crawford, Y.1
Kasman, I.2
Yu, L.3
-
71
-
-
84860485278
-
Targeting the cancer-stroma interaction: A potential approach for pancreatic cancer treatment
-
Li X, Ma Q, Xu Q, et al. Targeting the cancer-stroma interaction: a potential approach for pancreatic cancer treatment. Curr Pharm Des 2012;18:2404-15.
-
(2012)
Curr Pharm des
, vol.18
, pp. 2404-2415
-
-
Li, X.1
Ma, Q.2
Xu, Q.3
-
72
-
-
0037007037
-
A role for survivin in chemoresistance of endothelial cells mediated by VEGF
-
Tran J, Master Z, Yu JL, et al. A role for survivin in chemoresistance of endothelial cells mediated by VEGF. Proc Natl Acad Sci USA 2002;99:4349-54.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 4349-4354
-
-
Tran, J.1
Master, Z.2
Yu, J.L.3
-
73
-
-
84910134993
-
Vascular endothelial growth factor modulates cisplatin sensitivity in human ovarian carcinoma cells
-
Hu G, Ryan S, Zhu Y, et al. Vascular endothelial growth factor modulates cisplatin sensitivity in human ovarian carcinoma cells. Cancer Ther 2003;1:31-7.
-
(2003)
Cancer Ther
, vol.1
, pp. 31-37
-
-
Hu, G.1
Ryan, S.2
Zhu, Y.3
-
74
-
-
80051676156
-
Increased VEGFR-2 gene copy is associated with chemoresistance and shorter survival in patients with non-small-cell lung carcinoma who receive adjuvant chemotherapy
-
Yang F, Tang X, Riquelme E, et al. Increased VEGFR-2 gene copy is associated with chemoresistance and shorter survival in patients with non-small-cell lung carcinoma who receive adjuvant chemotherapy. Cancer Res 2011;71:5512-21.
-
(2011)
Cancer Res
, vol.71
, pp. 5512-5521
-
-
Yang, F.1
Tang, X.2
Riquelme, E.3
-
75
-
-
2442621619
-
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
-
Ferrara N, Hillan KJ, Gerber HP, et al. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Disc 2004;3:391-400.
-
(2004)
Nat Rev Drug Disc
, vol.3
, pp. 391-400
-
-
Ferrara, N.1
Hillan, K.J.2
Gerber, H.P.3
-
77
-
-
84864886635
-
Phase i study of pazopanib in combination with paclitaxel and carboplatin given every 21 days in patients with advanced solid tumors
-
Burris HA, Dowlati A, Moss RA, et al. Phase I study of pazopanib in combination with paclitaxel and carboplatin given every 21 days in patients with advanced solid tumors. Mol Cancer Ther 2012;11:1820-8.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 1820-1828
-
-
Burris, H.A.1
Dowlati, A.2
Moss, R.A.3
-
79
-
-
33846440150
-
Food and Drug Administration drug approval summary: Sunitinib malate for the treatment of gastrointestinal stromal tumor and advanced renal cell carcinoma
-
Rock EP, Goodman V, Jiang JX, et al. Food and Drug Administration drug approval summary: Sunitinib malate for the treatment of gastrointestinal stromal tumor and advanced renal cell carcinoma. Oncologist 2007;12:107-13.
-
(2007)
Oncologist
, vol.12
, pp. 107-113
-
-
Rock, E.P.1
Goodman, V.2
Jiang, J.X.3
-
80
-
-
84865129850
-
Phase 1b dose-finding study of motesanib with docetaxel or paclitaxel in patients with metastatic breast cancer
-
De Boer RH, Kotasek D, White S, et al. Phase 1b dose-finding study of motesanib with docetaxel or paclitaxel in patients with metastatic breast cancer. Breast Cancer Res Treat 2012;135:241-52.
-
(2012)
Breast Cancer Res Treat
, vol.135
, pp. 241-252
-
-
De Boer, R.H.1
Kotasek, D.2
White, S.3
-
81
-
-
84865095318
-
International, randomized, placebo-controlled, double-blind phase III study of motesanib plus carboplatin/ paclitaxel in patients with advanced nonsquamous non-small-cell lung cancer: MONET1
-
Scagliotti GV, Vynnychenko I, Park K, et al. International, randomized, placebo-controlled, double-blind phase III study of motesanib plus carboplatin/ paclitaxel in patients with advanced nonsquamous non-small-cell lung cancer: MONET1. J Clin Oncol 2012;30:2829-36.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2829-2836
-
-
Scagliotti, G.V.1
Vynnychenko, I.2
Park, K.3
-
82
-
-
79953196070
-
Motesanib, or open-label bevacizumab, in combination with paclitaxel, as first-line treatment for HER2-negative locally recurrent or metastatic breast cancer: A phase 2, randomised, double-blind, placebo-controlled study
-
Martin M, Roche H, Pinter T, et al. Motesanib, or open-label bevacizumab, in combination with paclitaxel, as first-line treatment for HER2-negative locally recurrent or metastatic breast cancer: a phase 2, randomised, double-blind, placebo-controlled study. Lancet Oncol 2011;12:369-76.
-
(2011)
Lancet Oncol
, vol.12
, pp. 369-376
-
-
Martin, M.1
Roche, H.2
Pinter, T.3
-
83
-
-
55749088393
-
Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
-
Wilhelm SM, Adnane L, Newell P, et al. Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther 2008;7:3129-40.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3129-3140
-
-
Wilhelm, S.M.1
Adnane, L.2
Newell, P.3
-
84
-
-
50449087162
-
Hepatocyte growth factor and Met in tumor biology and therapeutic approach with NK4
-
Matsumoto K, Nakamura T, Sakai K, et al. Hepatocyte growth factor and Met in tumor biology and therapeutic approach with NK4. Proteomics 2008;8:3360-70.
-
(2008)
Proteomics
, vol.8
, pp. 3360-3370
-
-
Matsumoto, K.1
Nakamura, T.2
Sakai, K.3
-
85
-
-
77954635026
-
Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion
-
Grugan KD, Miller CG, Yao Y, et al. Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion. Proc Nat Acad Sci USA 2010;107:11026-31.
-
(2010)
Proc Nat Acad Sci USA
, vol.107
, pp. 11026-11031
-
-
Grugan, K.D.1
Miller, C.G.2
Yao, Y.3
-
86
-
-
84872174511
-
HGF-MET cascade a key target for inhibiting cancer metastasis: The impact of NK4 discovery on cancer biology and therapeutics
-
Mizuno S, Nakamura T. HGF-MET Cascade, a Key Target for Inhibiting Cancer Metastasis: The Impact of NK4 Discovery on Cancer Biology and Therapeutics. Int J Mol Sci 2013;14:888-919.
-
(2012)
Int J Mol Sci
, vol.14
, pp. 888-919
-
-
Mizuno, S.1
Nakamura, T.2
-
87
-
-
0032537813
-
Scatter factor protects epithelial and carcinoma cells against apoptosis induced by DNA-damaging agents
-
Fan S, Wang JA, Yuan RQ, et al. Scatter factor protects epithelial and carcinoma cells against apoptosis induced by DNA-damaging agents. Oncogene 1998;17:131-41.
-
(1998)
Oncogene
, vol.17
, pp. 131-141
-
-
Fan, S.1
Wang, J.A.2
Yuan, R.Q.3
-
88
-
-
84864285794
-
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
-
Straussman R, Morikawa T, Shee K, et al. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature 2012;487:500-4.
-
(2012)
Nature
, vol.487
, pp. 500-504
-
-
Straussman, R.1
Morikawa, T.2
Shee, K.3
-
89
-
-
70350721786
-
Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors
-
Wang W, Li Q, Yamada T, et al. Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors. Clin Cancer Res 2009;15:6630-8.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6630-6638
-
-
Wang, W.1
Li, Q.2
Yamada, T.3
-
90
-
-
84861733799
-
MET: A promising anticancer therapeutic target
-
Peters S, Adjei AA. MET: a promising anticancer therapeutic target. Nat Rev Clin Oncol 2012;9:314-26.
-
(2012)
Nat Rev Clin Oncol
, vol.9
, pp. 314-326
-
-
Peters, S.1
Adjei, A.A.2
-
91
-
-
80051991655
-
A phase II study of the efficacy and safety of AMG 102 in patients with metastatic renal cell carcinoma
-
Schöffski P, Garcia JA, Stadler WM, et al. A phase II study of the efficacy and safety of AMG 102 in patients with metastatic renal cell carcinoma. BJU Int 2011;108:679-86.
-
(2011)
BJU Int
, vol.108
, pp. 679-686
-
-
Schöffski, P.1
Garcia, J.A.2
Stadler, W.M.3
-
92
-
-
84871962904
-
Targeted MET inhibition in castration-resistant prostate cancer: A randomized phase II study and biomarker analysis with rilotumumab plus mitoxantrone and prednisone
-
Ryan CJ, Rosenthal M, Ng S, et al. Targeted MET inhibition in castration-resistant prostate cancer: a randomized phase II study and biomarker analysis with rilotumumab plus mitoxantrone and prednisone. Clin Cancer Res 2013;19:215-24.
-
(2012)
Clin Cancer Res
, vol.19
, pp. 215-224
-
-
Ryan, C.J.1
Rosenthal, M.2
Ng, S.3
-
93
-
-
84883176380
-
Treatment rationale and study design for a randomized, double-blind, placebo-controlled phase II study evaluating onartuzumab (MetMAb) in combination with bevacizumab plus mFOLFOX-6 in patients with previously untreated metastatic colorectal cancer
-
Bendell JC, Ervin TJ, Gallinson D, et al. Treatment rationale and study design for a randomized, double-blind, placebo-controlled phase II study evaluating onartuzumab (MetMAb) in combination with bevacizumab plus mFOLFOX-6 in patients with previously untreated metastatic colorectal cancer. Clin Colorectal Cancer 2013;12:218-22.
-
(2012)
Clin Colorectal Cancer
, vol.12
, pp. 218-222
-
-
Bendell, J.C.1
Ervin, T.J.2
Gallinson, D.3
-
94
-
-
84890108571
-
Randomized phase II trial of onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer
-
Spigel DR, Ervin TJ, Ramlau RA, et al. Randomized phase II trial of onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer. J Clin Oncol 2013;31:4105-14.
-
(2012)
J Clin Oncol
, vol.31
, pp. 4105-4114
-
-
Spigel, D.R.1
Ervin, T.J.2
Ramlau, R.A.3
-
95
-
-
84896514016
-
Phase i dose-escalation study of onartuzumab as a single agent and in combination with bevacizumab in patients with advanced solid malignancies
-
Salgia R, Patel P, Bothos J, et al. Phase I dose-escalation study of onartuzumab as a single agent and in combination with bevacizumab in patients with advanced solid malignancies. Clin Cancer Res 2014;20:1666-75.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 1666-1675
-
-
Salgia, R.1
Patel, P.2
Bothos, J.3
-
96
-
-
83355166909
-
Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth
-
Yakes FM, Chen J, Tan J, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther 2011;10:2298-308.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 2298-2308
-
-
Yakes, F.M.1
Chen, J.2
Tan, J.3
-
97
-
-
84874787799
-
Cabozantinib in patients with advanced prostate cancer: Results of a phase II randomized discontinuation trial
-
Smith DC, Smith MR, Sweeney C, et al. Cabozantinib in patients with advanced prostate cancer: results of a phase II randomized discontinuation trial. J Clin Oncol 2013;31:412-19.
-
(2012)
J Clin Oncol
, vol.31
, pp. 412-419
-
-
Smith, D.C.1
Smith, M.R.2
Sweeney, C.3
-
99
-
-
84879071011
-
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
-
Shaw AT, Kim DW, Nakagawa K, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med 2013;368:2385-94.
-
(2012)
N Engl J Med
, vol.368
, pp. 2385-2394
-
-
Shaw, A.T.1
Kim, D.W.2
Nakagawa, K.3
-
100
-
-
84555190809
-
MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib
-
Lennerz JK, Kwak FL, Ackerman A, et al. MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. J Clin Oncol 2011;29:4803-10.
-
(2011)
J Clin Oncol
, vol.29
, pp. 4803-4810
-
-
Lennerz, J.K.1
Kwak, F.L.2
Ackerman, A.3
-
101
-
-
77953458271
-
ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity
-
Munshi N, Jeay S, Li Y, et al. ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity. Mol Cancer Ther 2010;9:1544-53.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 1544-1553
-
-
Munshi, N.1
Jeay, S.2
Li, Y.3
-
102
-
-
84871721240
-
Tivantinib for second-line treatment of advanced hepatocellular carcinoma: A randomised, placebo-controlled phase 2 study
-
Santoro A, Rimassa L, Borbath I, et al. Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study. Lancet Oncol 2013;14:55-63.
-
(2012)
Lancet Oncol
, vol.14
, pp. 55-63
-
-
Santoro, A.1
Rimassa, L.2
Borbath, I.3
-
103
-
-
84896404764
-
A phase II trial of a selective c-Met inhibitor tivantinib (ARQ 197) monotherapy as a second- or third-line therapy in the patients with metastatic gastric cancer
-
Kang YK, Muro K, Ryu MH, et al. A phase II trial of a selective c-Met inhibitor tivantinib (ARQ 197) monotherapy as a second- or third-line therapy in the patients with metastatic gastric cancer. Invest New Drugs 2014;32:355-61.
-
(2014)
Invest New Drugs
, vol.32
, pp. 355-361
-
-
Kang, Y.K.1
Muro, K.2
Ryu, M.H.3
-
104
-
-
80051974548
-
Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer
-
Sequist LV, von Pawel J, Garmey EG, et al. Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer. J Clin Oncol 2011;29:3307-15.
-
(2011)
J Clin Oncol
, vol.29
, pp. 3307-3315
-
-
Sequist, L.V.1
Von Pawel, J.2
Garmey, E.G.3
-
105
-
-
84879110331
-
A Phase 1 dose-escalation study of the safety and pharmacokinetics of once-daily oral foretinib, a multi-kinase inhibitor, in patients with solid tumors
-
Shapiro GI, McCallum S, Adams LM, et al. A Phase 1 dose-escalation study of the safety and pharmacokinetics of once-daily oral foretinib, a multi-kinase inhibitor, in patients with solid tumors. Invest New Drugs 2013;31:742-50.
-
(2012)
Invest New Drugs
, vol.31
, pp. 742-750
-
-
Shapiro, G.I.1
McCallum, S.2
Adams, L.M.3
-
106
-
-
84875035582
-
Phase II study evaluating 2 dosing schedules of oral foretinib (GSK1363089), cMET/VEGFR2 inhibitor, in patients with metastatic gastric cancer
-
Shah MA, Wainberg ZA, Catenacci DV, et al. Phase II study evaluating 2 dosing schedules of oral foretinib (GSK1363089), cMET/VEGFR2 inhibitor, in patients with metastatic gastric cancer. PLoS One 2013;8:e54014.
-
(2012)
PLoS One
, vol.8
, pp. e54014
-
-
Shah, M.A.1
Wainberg, Z.A.2
Catenacci, D.V.3
-
108
-
-
74549203484
-
IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients
-
Rajski M, Zanetti-Dällenbach R, Vogel B, et al. IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients. BMC Med 2010;8:1.
-
(2010)
BMC Med
, vol.8
, pp. 1
-
-
Rajski, M.1
Zanetti-Dällenbach, R.2
Vogel, B.3
-
109
-
-
79951579534
-
Insulin-like growth factor 1 mediates 5-fluorouracil chemoresistance in esophageal carcinoma cells through increasing survivin stability
-
Juan HC, Tsai HT, Chang PH, et al. Insulin-like growth factor 1 mediates 5-fluorouracil chemoresistance in esophageal carcinoma cells through increasing survivin stability. Apoptosis 2011;16:174-83.
-
(2011)
Apoptosis
, vol.16
, pp. 174-183
-
-
Juan, H.C.1
Tsai, H.T.2
Chang, P.H.3
-
110
-
-
84856287736
-
A humanized anti-IGF-1R monoclonal antibody (R1507) and/or metformin enhance gemcitabine-induced apoptosis in pancreatic cancer cells
-
Kawanami T, Takiguchi S, Ikeda N, et al. A humanized anti-IGF-1R monoclonal antibody (R1507) and/or metformin enhance gemcitabine-induced apoptosis in pancreatic cancer cells. Oncol Rep 2012;27:867-72.
-
(2012)
Oncol Rep
, vol.27
, pp. 867-872
-
-
Kawanami, T.1
Takiguchi, S.2
Ikeda, N.3
-
111
-
-
84897058262
-
Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signaling
-
Chen WJ, Ho CC, Chang YL, et al. Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signaling. Nat Commun 2014;5:3472.
-
(2014)
Nat Commun
, vol.5
, pp. 3472
-
-
Chen, W.J.1
Ho, C.C.2
Chang, Y.L.3
-
112
-
-
77951233373
-
Cancer associated fibroblasts (CAFs) in tumor microenvironment
-
Xing F, Saidou J, Watabe K. Cancer associated fibroblasts (CAFs) in tumor microenvironment. Front Biosci 2010;15:166-79.
-
(2010)
Front Biosci
, vol.15
, pp. 166-179
-
-
Xing, F.1
Saidou, J.2
Watabe, K.3
-
113
-
-
84856934228
-
Rationale behind targeting fibroblast activation protein-expressing carcinoma-associated fibroblasts as a novel chemotherapeutic strategy
-
Brennen WN, Isaacs JT, Denmeade SR. Rationale behind targeting fibroblast activation protein-expressing carcinoma-associated fibroblasts as a novel chemotherapeutic strategy. Mol Cancer Ther 2012;11:257-66.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 257-266
-
-
Brennen, W.N.1
Isaacs, J.T.2
Denmeade, S.R.3
-
114
-
-
33745837774
-
Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake
-
Loeffler M, Krüger JA, Niethammer AG, et al. Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake. J Clin Invest 2006;116:1955-62.
-
(2006)
J Clin Invest
, vol.116
, pp. 1955-1962
-
-
Loeffler, M.1
Krüger, J.A.2
Niethammer, A.G.3
-
115
-
-
79960478878
-
Evaluation of the tumor targeting of a FAPa-based doxorubicin prodrug
-
Huang S, Fang R, Xu J, et al. Evaluation of the tumor targeting of a FAPa-based doxorubicin prodrug. J Drug Target 2011;19:487-96.
-
(2011)
J Drug Target
, vol.19
, pp. 487-496
-
-
Huang, S.1
Fang, R.2
Xu, J.3
-
116
-
-
84869203157
-
Radioimmunotherapy of fibroblast activation protein positive tumors by rapidly internalizing antibodies
-
Fischer E, Chaitanya K, Wüest T, et al. Radioimmunotherapy of fibroblast activation protein positive tumors by rapidly internalizing antibodies. Clin Cancer Res 2012;18:6208-18.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 6208-6218
-
-
Fischer, E.1
Chaitanya, K.2
Wüest, T.3
-
117
-
-
84880626610
-
Short hairpin RNA targeting of fibroblast activation protein inhibits tumor growth and improves the tumor microenvironment in a mouse model
-
Cai F, Li Z, Wang C, et al. Short hairpin RNA targeting of fibroblast activation protein inhibits tumor growth and improves the tumor microenvironment in a mouse model. BMB Rep 2013;46:252-7.
-
(2012)
BMB Rep
, vol.46
, pp. 252-257
-
-
Cai, F.1
Li, Z.2
Wang, C.3
|