Interaction between neoplastic cells and cancer-associated fibroblasts through the CXCL12/CXCR4 axis: Role in non-small cell lung cancer tumor proliferation

Journal of Thoracic and Cardiovascular Surgery

Volumn 141, Issue 6, 2011, Pages 1503-1512

  Wald, Ori ^a   Izhar, Uzi ^a   Amir, Gail ^a   Kirshberg, Sophie ^a   Shlomai, Zippora ^a   Zamir, Gideon ^a   Peled, Amnon ^a   Shapira, Oz M ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; STROMAL CELL DERIVED FACTOR 1;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CANCER STAGING; CELL INTERACTION; CELL PROLIFERATION; CYTOKINE PRODUCTION; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMOKINE CCL20; CHEMOKINE CXCL12; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION MEDIATORS; LUNG NEOPLASMS; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASM STAGING; PHOSPHORYLATION; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION; TIME FACTORS; TISSUE ARRAY ANALYSIS; TUMOR MICROENVIRONMENT;

EID: 79956093785     PISSN: 00225223     EISSN: 1097685X     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2010.11.056     Document Type: Article

References (29)

1. D.A. Arenberg, M.P. Keane, B. DiGiovine, S.L. Kunkel, S.R. Strom, and M.D. Burdick Macrophage infiltration in human non-small-cell lung cancer: the role of CC chemokines Cancer Immunol Immunother 49 2000 63 70 (Pubitemid 30431641)
2. I. Perrot, D. Blanchard, N. Freymond, S. Isaac, B. Guibert, and Y. Pachéco Dendritic cells infiltrating human non-small cell lung cancer are blocked at immature stage J Immunol 178 2007 2763 2769 (Pubitemid 46333153)
3. + T cells accumulate in lung adenocarcinoma J Immunol 177 2006 6983 6990 (Pubitemid 44715064)
4. A. Zlotnik, and O. Yoshie Chemokines: a new classification system and their role in immunity Immunity 12 2000 121 127 (Pubitemid 30398626)
5. A. Mantovani, P. Allavena, S. Sozzani, A. Vecchi, M. Locati, and A. Sica Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors Semin Cancer Biol 14 2004 155 160 (Pubitemid 38586740)
6. A. Mantovani Chemokines in neoplastic progression Semin Cancer Biol 14 2004 147 148
7. K. Beider, M. Abraham, M. Begin, H. Wald, I.D. Weiss, and O. Wald Interaction between CXCR4 and CCL20 pathways regulates tumor growth PLoS One 4 4 2009 e5125
8. J.A. Burger, and T.J. Kipps CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment Blood 107 2006 1761 1767 (Pubitemid 43289351)
9. L. Su, J. Zhang, H. Xu, Y. Wang, Y. Chu, and R. Liu Differential expression of CXCR4 is associated with the metastatic potential of human non-small cell lung cancer cells Clin Cancer Res 11 2005 8273 8280 (Pubitemid 41746937)
10. P.L. Wagner, E. Hyjek, M.F. Vazquez, D. Meherally, Y.F. Liu, and P.A. Chadwick CXCL12 and CXCR4 in adenocarcinoma of the lung: association with metastasis and survival J Thorac Cardiovasc Surg 137 2009 615 621
11. R.J. Phillips, M.D. Burdick, M. Lutz, J.A. Belperio, M.P. Keane, and R.M. Strieter The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases Am J Respir Crit Care Med 167 2003 1676 1686 (Pubitemid 36760683)
12. P.J. Roberts, and C.J. Der Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer Oncogene 26 2007 3291 3310 (Pubitemid 46763022)
13. Y.C. Huang, Y.C. Hsiao, Y.J. Chen, Y.Y. Wei, T.H. Lai, and C.H. Tang Stromal cell-derived factor-1 enhances motility and integrin up-regulation through CXCR4, ERK and NF-κB-dependent pathway in human lung cancer cells Biochem Pharmacol 74 2007 1702 1712
14. R.K. Ganju, S.A. Brubaker, J. Meyer, P. Dutt, Y. Yang, and S. Qin The alpha-chemokine, stromal cell-derived factor-1alpha, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways J Biol Chem 273 1998 23169 23175 (Pubitemid 28417500)
15. S. Barbero, R. Bonavia, A. Bajetto, C. Porcile, P. Pirani, and J.L. Ravetti Stromal cell-derived factor 1alpha stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt Cancer Res 63 2003 1969 1974 (Pubitemid 36460865)
16. X. Shen, A. Artinyan, D. Jackson, R.M. Thomas, A.M. Lowy, and J. Kim Chemokine receptor CXCR4 enhances proliferation in pancreatic cancer cells through AKT and ERK dependent pathways Pancreas 39 2010 81 87
17. A. Orimo, P.B. Gupta, D.C. Sgroi, F. Arenzana-Seisdedos, T. Delaunay, and R. Naeem Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion Cell 121 2005 335 348 (Pubitemid 40692295)
18. A. Orimo, and R.A. Weinberg Stromal fibroblasts in cancer: a novel tumor-promoting cell type Cell Cycle 5 2006 1597 1601 (Pubitemid 44285243)
19. L. Karra, A. Shushan, A. Ben-Meir, N. Rojansky, B.Y. Klein, and D. Shveiky Changes related to phosphatidylinositol 3-kinase/Akt signaling in leiomyomas: possible involvement of glycogen synthase kinase 3alpha and cyclin D2 in the pathophysiology Fertil Steril 93 2009 2646 2651
20. F. Economidou, K.M. Antoniou, G. Soufla, I. Lasithiotaki, K. Karagiannis, and R. Lymbouridou Role of VEGF-stromal cell-derived factor-1alpha/CXCL12 axis in pleural effusion of lung cancer J Recept Signal Transduct Res 30 2010 154 160
21. J.P. Spano, F. Andre, L. Morat, L. Sabatier, B. Besse, and C. Combadiere Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome Ann Oncol 15 2004 613 617 (Pubitemid 38559598)
22. I.K. Na, C. Scheibenbogen, C. Adam, A. Stroux, P. Ghadjar, and E. Thiel Nuclear expression of CXCR4 in tumor cells of non-small cell lung cancer is correlated with lymph node metastasis Hum Pathol 39 2008 1751 1755
23. A. Müller, B. Homey, H. Soto, N. Ge, D. Catron, and M.E. Buchanan Involvement of chemokine receptors in breast cancer metastasis Nature 410 2001 50 56 (Pubitemid 32225831)
24. J.A. Burger, and A. Peled CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers Leukemia 23 2009 43 52
25. I. Takanami Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis Int J Cancer 105 2003 186 189 (Pubitemid 36505319)
26. W. Lee, Z. Jiang, J. Liu, P.M. Haverty, Y. Guan, and J. Stinson The mutation spectrum revealed by paired genome sequences from a lung cancer patient Nature 465 2010 473 477
27. M. Darash-Yahana, E. Pikarsky, R. Abramovitch, E. Zeira, B. Pal, and R. Karplus Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis FASEB J 18 2004 1240 1242 (Pubitemid 39561563)
28. C.H. Tang, T.W. Tan, W.M. Fu, and R.S. Yang Involvement of matrix metalloproteinase-9 in stromal cell-derived factor-1/CXCR4 pathway of lung cancer metastasis Carcinogenesis 29 2008 35 43
29. + regulatory T cells J Immunol 182 2009 2795 2807