Human lung parenchyma but not proximal bronchi produces fibroblasts with enhanced TGF-β signaling and α-SMA expression

American Journal of Respiratory Cell and Molecular Biology

Volumn 43, Issue 6, 2010, Pages 641-651

  Pechkovsky, Dmitri V ^a,b   Hackett, Tillie L ^a   An, Steven S ^c   Shaheen, Furquan ^a   Murray, Lynne A ^d   Knight, Darryl A ^a,b  

^a ST PAUL S HOSPITAL   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^d MEDIMMUNE   (United States)

Author keywords

Bronchus; Fibroblasts; Lung; Myofibroblasts; TGF

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; GELATINASE A; GELATINASE B; SMAD1 PROTEIN; SMAD3 PROTEIN; SMAD5 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1;

ADOLESCENT; ADULT; AGED; ARTICLE; BRONCHUS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG PARENCHYMA; MALE; MESENCHYME CELL; OUTCOME ASSESSMENT; PRESCHOOL CHILD; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TISSUE REPAIR;

ACTINS; ADOLESCENT; ADULT; AGED; BRONCHI; CHILD, PRESCHOOL; DEMOGRAPHY; DIPEPTIDES; FEMALE; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; YOUNG ADULT;

EID: 78649742699     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2009-0318OC     Document Type: Article

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