Transforming growth factor-β1 and α-smooth muscle actin in stromal fibroblasts are associated with a poor prognosis in patients with clinical stage I-IIIA nonsmall cell lung cancer after curative resection

Tumor Biology

Volumn 35, Issue 7, 2014, Pages 6707-6713

  Chen, Yongbing ^a   Zou, Li ^a   Zhang, Yongsheng ^a   Chen, Yuanyuan ^a   Xing, Pengfei ^a   Yang, Wentao ^a   Li, Feng ^a   Ji, Xiaoqing ^a   Liu, Fengjv ^b   Lu, Xueguan ^a  

^a SOOCHOW UNIVERSITY   (China)

^b MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

Author keywords

Lung cancer; Prognosis; Stromal fibroblasts; Transforming growth factor 1; Smooth muscle actin

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANTINEOPLASTIC AGENT; TRANSFORMING GROWTH FACTOR BETA1;

ADENOSQUAMOUS CARCINOMA; ADULT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER CELL; CANCER PATIENT; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CANCER TISSUE; CONTROLLED STUDY; FEMALE; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARGE CELL CARCINOMA; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; LUNG RESECTION; LUNG SQUAMOUS CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROMA CELL; VERY ELDERLY;

ACTINS; ADULT; AGED; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; FIBROBLASTS; GENETIC ASSOCIATION STUDIES; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; NEOPLASM STAGING; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84905040388     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-014-1908-y     Document Type: Article

References (28)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62:10-29.
2. Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127:2893-917.
3. Haithcock BE, Stinchcombe TE, Socinski MA. Treatment of surgically resectable non-small-cell lung cancer in elderly patients. Clin Lung Cancer. 2009;10:405-9.
4. Williams BA, Sugimura H, Endo C, et al. Predicting postrecurrence survival among completely resected non small cell lung cancer patients. Ann Thorac Surg. 2006;81:1021-7. (Pubitemid 43247679)
5. Kim MP, Chen Y, Bekele BN, et al. Activating enhancer-binding protein-2β nucleolar localization predicts poor survival after stage I non-small cell lung cancer resection. Ann Thorac Surg. 2011;92:1044-50.
6. Konopa K. Do we have markers to select patients for adjuvant therapies of non-small-cell lung cancer? Ann Oncol. 2010;7:199-202.
7. Cirri P, Chiarugi P. Cancer-associated-fibroblasts and tumor cells: a diabolic liaison driving cancer progression. Cancer Metastasis Rev. 2012;31:195-208.
8. Polyak K, Haviv I, Campbell IG. Co-evolution of tumor cells and their microenvironment. Trends Genet. 2009;25:30-8.
9. Tomasek JJ, Gabbiani G, Hinz B, et al. Myofibroblasts and mechanoregulation of connective tissue remodeling. Nat Rev Mol Cell Biol. 2002;3:349-63. (Pubitemid 34619269)
10. Cirri P, Chiarugi P. Cancer associated fibroblasts: the dark side of coin. Am J Cancer Res. 2011;1:482-97.
11. Mantoni TS, Lunardi SL, AI-Assar O, et al. Pancreatic stellate cells radioprotect pancreatic cancer cells through β1-integrin signaling. Cancer Res. 2011;71:3453-8.
12. Xu Z, Wang S, Wu M, et al. TGF-β1 and HGF protein secretion by esophageal squamous epithelial cells and stromal fibroblasts in oesophageal carcinogenesis. Oncol Lett. 2013;6:401-6.
13. Desmouliere A, Geinoz A, Gabbiani F, et al. Transforming growth factor-β1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol. 1993;122:103-11. (Pubitemid 23188802)
14. Hazelbag S, Gorter A, Kenter GG, et al. Transforming growth factor-β1 induces tumor stroma and reduces tumor infiltrate in cervical cancer. Hum Pathol. 2002;33:1193-9. (Pubitemid 36020069)
15. Hawinkels LJAC, Paauwe M, Verspage HW, et al. Interaction with colon cancer cells hyperactivates TGF-β signaling in cancer-associated fibroblasts. Oncogene. 2012. doi:10.1038/onc.2012.536.
16. Peng Y, Li Z, Li Z. GRP78 secreted by tumor cells stimulates differentiation of bone marrow mesenchymal stem cells to cancer-associated fibroblasts. Biochem Biophys Res Commun. 2013;440:558-63.
17. Liu C, Wu JF. Expression of TGF-β1, HIF-1α, VEGF and their clinical significance of gastric cancer. J Clin Exp Pathol. 2013;29:733-6.
18. Fuyuhiro Y, Yashiro M, Noda S, et al. Myofibroblasts are associated with the progression of scirrhous gastric carcinoma. Exp Ther Med. 2010;1:547-51.
19. Zhi K, Shen X, Zhang H, et al. Cancer-associated fibroblasts are positively correlated with metastasis potential of human gastric cancers. J Exp Clin Cancer Res. 2010;29:66-74.
20. Yamashita M, Ogawa T, Zhang X, et al. Role of stromal myofibroblasts in invasive breast cancer: stromal expression of alpha-smooth muscle actin correlates with worse clinical outcome. Breast Cancer. 2012;19:170-6.
21. Valach J, Fik Z, Strnad H, et al. Smooth muscle actin-expressing stromal fibroblasts in head and neck squamous cell carcinoma: Increased expression of galectin-1 and induction of poor prognosis factors. Int J Cancer. 2012;131:2499-508.
22. Tsamandas AC, Kardamakis D, Ravazoula P, et al. The potential role of TGFbeta1, TGFbeta2 and TGFbeta3 protein expression in colorectal carcinomas. Correlation with classic histopathologic factors and patient survival. Strahlenther Onkol. 2004;180:201-8. (Pubitemid 38461544)
23. Vagenas K, Spyropoulos C, Gavala V, et al. TGFbeta1, TGFbeta2, and TGFbeta3 protein expression in gastric carcinomas: correlation with prognostics factors and patient survival. J Surg Res. 2007;139:182-8. (Pubitemid 46551168)
24. Soufla G, Sifakis S, Porichis F, et al. Prognostic value of tgfb1 protein in endometrioid adenocarcinoma. Eur J Clin Investig. 2013;43:79-90.
25. Kojima Y, Acar A, Eaton EN, et al. Autocrine TGF-beta and stromal cell-derived factor (SDF-1) signaling derives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci USA. 2010;107:20009-14.
26. Fuyuhiro Y, Yashiro M, Noda S, et al. Upregulation of cancer-associated myofibroblasts by TGF-β from scirrhous gastric carcinoma cells. Br J Cancer. 2011;105:996-1001.
27. Brenmoehl J, Miller SN, Hofmann C, et al. Transforming growth factor-beta 1 induces intestinal myofibroblast differentiation and modulates their migration. World J Gastroenterol. 2009;15:1431-42.
28. Rosenthal E, McCrory A, Talbert M, et al. Elevated expression of TGF-β1 in head and neck cancer-associated fibroblasts. Mol Carcinogen. 2004;40:116-21. (Pubitemid 38736537)