메뉴 건너뛰기




Volumn 8, Issue , 2008, Pages

Vav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; ESTROGEN RECEPTOR ALPHA; GLUTATHIONE TRANSFERASE; LUCIFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; VAV PROTEIN; VAV3 PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; VAV3 PROTEIN, HUMAN;

EID: 45949098871     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-8-158     Document Type: Article
Times cited : (60)

References (41)
  • 1
    • 0033974061 scopus 로고    scopus 로고
    • Regulatory and signaling properties of the Vav family
    • 85310 10669724 10.1128/MCB.20.5.1461-1477.2000
    • Bustelo XR Regulatory and signaling properties of the Vav family Mol Cell Biol 2000, 20(5):1461-1477. 85310 10669724 10.1128/ MCB.20.5.1461-1477.2000
    • (2000) Mol Cell Biol , vol.20 , Issue.5 , pp. 1461-1477
    • Bustelo, X.R.1
  • 2
    • 0035473464 scopus 로고    scopus 로고
    • Vav proteins, adaptors and cell signaling
    • 10.1038/sj.onc.1204780 11607839
    • Bustelo XR Vav proteins, adaptors and cell signaling Oncogene 2001, 20(44):6372-6381. 10.1038/sj.onc.1204780 11607839
    • (2001) Oncogene , vol.20 , Issue.44 , pp. 6372-6381
    • Bustelo, X.R.1
  • 3
    • 0024433697 scopus 로고
    • vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells
    • 401160 2477241
    • Katzav S Martin-Zanca D Barbacid M vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells Embo J 1989, 8(8):2283-2290. 401160 2477241
    • (1989) Embo J , vol.8 , Issue.8 , pp. 2283-2290
    • Katzav, S.1    Martin-Zanca, D.2    Barbacid, M.3
  • 4
    • 0037160051 scopus 로고    scopus 로고
    • Structural determinants for the biological activity of Vav proteins
    • 10.1074/jbc.M208039200 12228230
    • Zugaza JL Lopez-Lago MA Caloca MJ Dosil M Movilla N Bustelo XR Structural determinants for the biological activity of Vav proteins J Biol Chem 2002, 277(47):45377-45392. 10.1074/jbc.M208039200 12228230
    • (2002) J Biol Chem , vol.277 , Issue.47 , pp. 45377-45392
    • Zugaza, J.L.1    Lopez-Lago, M.A.2    Caloca, M.J.3    Dosil, M.4    Movilla, N.5    Bustelo, X.R.6
  • 6
    • 0034269240 scopus 로고    scopus 로고
    • Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation
    • 10.1016/S0092-8674(00)00085-4 11007481
    • Aghazadeh B Lowry WE Huang XY Rosen MK Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation Cell 2000, 102(5):625-633. 10.1016/ S0092-8674(00)00085-4 11007481
    • (2000) Cell , vol.102 , Issue.5 , pp. 625-633
    • Aghazadeh, B.1    Lowry, W.E.2    Huang, X.Y.3    Rosen, M.K.4
  • 7
    • 0034751220 scopus 로고    scopus 로고
    • Estrogen receptor and breast cancer
    • 10.1006/scbi.2001.0389 11562176
    • Sommer S Fuqua SA Estrogen receptor and breast cancer Semin Cancer Biol 2001, 11(5):339-352. 10.1006/scbi.2001.0389 11562176
    • (2001) Semin Cancer Biol , vol.11 , Issue.5 , pp. 339-352
    • Sommer, S.1    Fuqua, S.A.2
  • 8
    • 32044466838 scopus 로고    scopus 로고
    • Exploiting the PI3K/AKT pathway for cancer drug discovery
    • 10.1038/nrd1902 16341064
    • Hennessy BT Smith DL Ram PT Lu Y Mills GB Exploiting the PI3K/AKT pathway for cancer drug discovery Nature reviews 2005, 4(12):988-1004. 10.1038/nrd1902 16341064
    • (2005) Nature Reviews , vol.4 , Issue.12 , pp. 988-1004
    • Hennessy, B.T.1    Smith, D.L.2    Ram, P.T.3    Lu, Y.4    Mills, G.B.5
  • 9
    • 26944443648 scopus 로고    scopus 로고
    • The mechanisms and managements of hormone-therapy resistance in breast and prostate cancers
    • 10.1677/erc.1.01026 16172190
    • Rau KM Kang HY Cha TL Miller SA Hung MC The mechanisms and managements of hormone-therapy resistance in breast and prostate cancers Endocrine-related cancer 2005, 12(3):511-532. 10.1677/erc.1.01026 16172190
    • (2005) Endocrine-related Cancer , vol.12 , Issue.3 , pp. 511-532
    • Rau, K.M.1    Kang, H.Y.2    Cha, T.L.3    Miller, S.A.4    Hung, M.C.5
  • 10
    • 0035021516 scopus 로고    scopus 로고
    • Gene amplification and expression of the steroid receptor coactivator SRC3 (AIB1) in sporadic breast and endometrial carcinomas
    • 10.1055/s-2001-14938 11355743
    • Glaeser M Floetotto T Hanstein B Beckmann MW Niederacher D Gene amplification and expression of the steroid receptor coactivator SRC3 (AIB1) in sporadic breast and endometrial carcinomas Horm Metab Res 2001, 33(3):121-126. 10.1055/s-2001-14938 11355743
    • (2001) Horm Metab Res , vol.33 , Issue.3 , pp. 121-126
    • Glaeser, M.1    Floetotto, T.2    Hanstein, B.3    Beckmann, M.W.4    Niederacher, D.5
  • 11
    • 0037399647 scopus 로고    scopus 로고
    • Nuclear receptors: Integration of multiple signalling pathways through phosphorylation
    • 10.1016/S0898-6568(02)00115-8 12618210
    • Rochette-Egly C Nuclear receptors: Integration of multiple signalling pathways through phosphorylation Cell Signal 2003, 15(4):355-366. 10.1016/S0898-6568(02)00115-8 12618210
    • (2003) Cell Signal , vol.15 , Issue.4 , pp. 355-366
    • Rochette-Egly, C.1
  • 12
    • 0035168724 scopus 로고    scopus 로고
    • The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy
    • 10.1016/S0093-7754(01)90290-8 11706404
    • Mills GB Lu Y Fang X Wang H Eder A Mao M Swaby R Cheng KW Stokoe D Siminovitch K Jaffe R Gray J The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy Semin Oncol 2001, 28(5 Suppl 16):125-141. 10.1016/S0093-7754(01)90290-8 11706404
    • (2001) Semin Oncol , vol.28 , Issue.5 SUPPL. 16 , pp. 125-141
    • Mills, G.B.1    Lu, Y.2    Fang, X.3    Wang, H.4    Eder, A.5    Mao, M.6    Swaby, R.7    Cheng, K.W.8    Stokoe, D.9    Siminovitch, K.10    Jaffe, R.11    Gray, J.12
  • 15
    • 0036633164 scopus 로고    scopus 로고
    • Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells
    • 12479367
    • Clark AS West K Streicher S Dennis PA Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells Mol Cancer Ther 2002, 1(9):707-717. 12479367
    • (2002) Mol Cancer Ther , vol.1 , Issue.9 , pp. 707-717
    • Clark, A.S.1    West, K.2    Streicher, S.3    Dennis, P.A.4
  • 16
    • 0036488531 scopus 로고    scopus 로고
    • Endocrine-responsive breast cancer and strategies for combating resistance
    • 10.1038/nrc721 12635173
    • Ali S Coombes RC Endocrine-responsive breast cancer and strategies for combating resistance Nat Rev Cancer 2002, 2(2):101-112. 10.1038/nrc721 12635173
    • (2002) Nat Rev Cancer , vol.2 , Issue.2 , pp. 101-112
    • Ali, S.1    Coombes, R.C.2
  • 17
    • 13244273515 scopus 로고    scopus 로고
    • AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner
    • 15671247
    • Felekkis KN Narsimhan RP Near R Castro AF Zheng Y Quilliam LA Lerner A AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner Mol Cancer Res 2005, 3(1):32-41. 15671247
    • (2005) Mol Cancer Res , vol.3 , Issue.1 , pp. 32-41
    • Felekkis, K.N.1    Narsimhan, R.P.2    Near, R.3    Castro, A.F.4    Zheng, Y.5    Quilliam, L.A.6    Lerner, A.7
  • 19
    • 34047127470 scopus 로고    scopus 로고
    • Mice expressing myrAKT1 in the mammary gland develop carcinogen-induced ER-positive mammary tumors that mimic human breast cancer
    • 10.1093/carcin/bgl190 17050554
    • Blanco-Aparicio C Perez-Gallego L Pequeno B Leal JF Renner O Carnero A Mice expressing myrAKT1 in the mammary gland develop carcinogen-induced ER-positive mammary tumors that mimic human breast cancer Carcinogenesis 2007, 28(3):584-594. 10.1093/carcin/bgl190 17050554
    • (2007) Carcinogenesis , vol.28 , Issue.3 , pp. 584-594
    • Blanco-Aparicio, C.1    Perez-Gallego, L.2    Pequeno, B.3    Leal, J.F.4    Renner, O.5    Carnero, A.6
  • 20
    • 33846416534 scopus 로고    scopus 로고
    • Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice
    • 10.1158/0008-5472.CAN-06-3782 17210696
    • Maroulakou IG Oemler W Naber SP Tsichlis PN Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice Cancer research 2007, 67(1):167-177. 10.1158/0008-5472.CAN-06-3782 17210696
    • (2007) Cancer Research , vol.67 , Issue.1 , pp. 167-177
    • Maroulakou, I.G.1    Oemler, W.2    Naber, S.P.3    Tsichlis, P.N.4
  • 21
    • 34250619620 scopus 로고    scopus 로고
    • Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR
    • 1876599 17525794
    • Vadlamudi RK Kumar R Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR Nuclear receptor signaling 2007, 5:e004. 1876599 17525794
    • (2007) Nuclear Receptor Signaling , vol.5
    • Vadlamudi, R.K.1    Kumar, R.2
  • 22
    • 32944482642 scopus 로고    scopus 로고
    • Novel mechanisms of resistance to endocrine therapy: Genomic and nongenomic considerations
    • 10.1158/1078-0432.CCR-05-2110 16467116
    • Gururaj AE Rayala SK Vadlamudi RK Kumar R Novel mechanisms of resistance to endocrine therapy: Genomic and nongenomic considerations Clin Cancer Res 2006, 12(3 Pt 2):1001s-1007s. 10.1158/1078-0432.CCR-05-2110 16467116
    • (2006) Clin Cancer Res , vol.12 , Issue.3 PART 2
    • Gururaj, A.E.1    Rayala, S.K.2    Vadlamudi, R.K.3    Kumar, R.4
  • 23
    • 33847221047 scopus 로고    scopus 로고
    • Phosphorylation of MNAR promotes estrogen activation of phosphatidylinositol 3-kinase
    • 1820473 17194752 10.1128/MCB.01732-06
    • Greger JG Fursov N Cooch N McLarney S Freedman LP Edwards DP Cheskis BJ Phosphorylation of MNAR promotes estrogen activation of phosphatidylinositol 3-kinase Mol Cell Biol 2007, 27(5):1904-1913. 1820473 17194752 10.1128/MCB.01732-06
    • (2007) Mol Cell Biol , vol.27 , Issue.5 , pp. 1904-1913
    • Greger, J.G.1    Fursov, N.2    Cooch, N.3    McLarney, S.4    Freedman, L.P.5    Edwards, D.P.6    Cheskis, B.J.7
  • 24
  • 25
    • 33749345249 scopus 로고    scopus 로고
    • Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer
    • 10.1210/me.2006-0048
    • Dong ZY Liu Y Lu S Wang A Lee K Wang LH Revelo M Lu S Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer Mol Endo 2006, 20:2315-2325. 10.1210/ me.2006-0048
    • (2006) Mol Endo , vol.20 , pp. 2315-2325
    • Dong, Z.Y.1    Liu, Y.2    Lu, S.3    Wang, A.4    Lee, K.5    Wang, L.H.6    Revelo, M.7    Lu, S.8
  • 26
    • 45949101412 scopus 로고    scopus 로고
    • Vav3, a Rho GTPase Guanine Nucleotide Exchange Factor, Increases During Progression to Androgen Independence in Prostate Cancer Cells and Potentiates Androgen Receptor Transcriptional Activity
    • December 29 16384856
    • Lyons LS Burnstein KL Vav3, a Rho GTPase Guanine Nucleotide Exchange Factor, Increases During Progression to Androgen Independence in Prostate Cancer Cells and Potentiates Androgen Receptor Transcriptional Activity Mol Endocrinol 2005. December 29 16384856
    • (2005) Mol Endocrinol
    • Lyons, L.S.1    Burnstein, K.L.2
  • 27
    • 0033303702 scopus 로고    scopus 로고
    • Melecular mechanisms of androgen-independent growth of human prostate cancer LNCaP-AI cells
    • 10.1210/en.140.11.5054 10537131
    • Lu S Tsai SY Tsai MJ Melecular mechanisms of androgen-independent growth of human prostate cancer LNCaP-AI cells Endocrinology 1999, 140:5054-5059. 10.1210/en.140.11.5054 10537131
    • (1999) Endocrinology , vol.140 , pp. 5054-5059
    • Lu, S.1    Tsai, S.Y.2    Tsai, M.J.3
  • 28
    • 4344669438 scopus 로고    scopus 로고
    • E protein silencing by the leukemogenic AML1-ETO fusion protein
    • 10.1126/science.1097937 15333839
    • Zhang J Kalkum M Yamamura S Chait BT Roeder RG E protein silencing by the leukemogenic AML1-ETO fusion protein Science 2004, 305(5688):1286-1289. 10.1126/science.1097937 15333839
    • (2004) Science , vol.305 , Issue.5688 , pp. 1286-1289
    • Zhang, J.1    Kalkum, M.2    Yamamura, S.3    Chait, B.T.4    Roeder, R.G.5
  • 29
    • 0036211850 scopus 로고    scopus 로고
    • The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2
    • 10.1016/S1097-2765(02)00468-9 11931768
    • Zhang J Kalkum M Chait BT Roeder RG The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2 Mol Cell 2002, 9(3):611-623. 10.1016/S1097-2765(02)00468-9 11931768
    • (2002) Mol Cell , vol.9 , Issue.3 , pp. 611-623
    • Zhang, J.1    Kalkum, M.2    Chait, B.T.3    Roeder, R.G.4
  • 30
    • 0037894847 scopus 로고    scopus 로고
    • Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav
    • 85351 10669745 10.1128/MCB.20.5.1678-1691.2000
    • Lopez-Lago M Lee H Cruz C Movilla N Bustelo XR Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav Mol Cell Biol 2000, 20(5):1678- 1691. 85351 10669745 10.1128/ MCB.20.5.1678-1691.2000
    • (2000) Mol Cell Biol , vol.20 , Issue.5 , pp. 1678-1691
    • Lopez-Lago, M.1    Lee, H.2    Cruz, C.3    Movilla, N.4    Bustelo, X.R.5
  • 31
    • 0033120030 scopus 로고    scopus 로고
    • Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1
    • 10.1016/S1097-2765(00)80479-7 10230404
    • Tremblay A Tremblay GB Labrie F Giguere V Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1 Mol Cell 1999, 3(4):513-519. 10.1016/S1097-2765(00)80479-7 10230404
    • (1999) Mol Cell , vol.3 , Issue.4 , pp. 513-519
    • Tremblay, A.1    Tremblay, G.B.2    Labrie, F.3    Giguere, V.4
  • 32
    • 0033545848 scopus 로고    scopus 로고
    • From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells
    • 10318905 10.1073/pnas.96.10.5458
    • Yeh S Lin HK Kang HY Thin TH Lin MF Chang C From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells Proceedings of the National Academy of Sciences of the United States of America 1999, 96:5458-5463. 21881 10318905 10.1073/pnas.96.10.5458
    • (1999) Proceedings of the National Academy of Sciences of the United States of America , vol.96 , pp. 5458-5463
    • Yeh, S.1    Lin, H.K.2    Kang, H.Y.3    Thin, T.H.4    Lin, M.F.5    Chang, C.6
  • 33
    • 0034461581 scopus 로고    scopus 로고
    • Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation
    • 102179 11094073 10.1128/MCB.20.24.9212-9224.2000
    • Zeng L Sachdev P Yan L Chan JL Trenkle T McClelland M Welsh J Wang LH Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation Mol Cell Biol 2000, 20(24):9212-9224. 102179 11094073 10.1128/MCB.20.24.9212-9224.2000
    • (2000) Mol Cell Biol , vol.20 , Issue.24 , pp. 9212-9224
    • Zeng, L.1    Sachdev, P.2    Yan, L.3    Chan, J.L.4    Trenkle, T.5    McClelland, M.6    Welsh, J.7    Wang, L.H.8
  • 34
    • 0037124081 scopus 로고    scopus 로고
    • Distinct role of phosphatidylinositol 3-kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes
    • 10.1074/jbc.M111575200 11884391
    • Sachdev P Zeng L Wang LH Distinct role of phosphatidylinositol 3-kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes J Biol Chem 2002, 277(20):17638-17648. 10.1074/jbc.M111575200 11884391
    • (2002) J Biol Chem , vol.277 , Issue.20 , pp. 17638-17648
    • Sachdev, P.1    Zeng, L.2    Wang, L.H.3
  • 36
    • 0032696592 scopus 로고    scopus 로고
    • Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins
    • 84867 10523675
    • Movilla N Bustelo XR Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins Mol Cell Biol 1999, 19(11):7870-7885. 84867 10523675
    • (1999) Mol Cell Biol , vol.19 , Issue.11 , pp. 7870-7885
    • Movilla, N.1    Bustelo, X.R.2
  • 37
    • 0032518944 scopus 로고    scopus 로고
    • The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways
    • 1170401 9430642 10.1093/emboj/17.2.507
    • Voegel JJ Heine MJ Tini M Vivat V Chambon P Gronemeyer H The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways Embo J 1998, 17(2):507-519. 1170401 9430642 10.1093/emboj/17.2.507
    • (1998) Embo J , vol.17 , Issue.2 , pp. 507-519
    • Voegel, J.J.1    Heine, M.J.2    Tini, M.3    Vivat, V.4    Chambon, P.5    Gronemeyer, H.6
  • 38
    • 0034615669 scopus 로고    scopus 로고
    • The SRC family of nuclear receptor coactivators
    • 10.1016/S0378-1119(00)00024-X 10713439
    • Leo C Chen JD The SRC family of nuclear receptor coactivators Gene 2000, 245(1):1-11. 10.1016/S0378-1119(00)00024-X 10713439
    • (2000) Gene , vol.245 , Issue.1 , pp. 1-11
    • Leo, C.1    Chen, J.D.2
  • 39
    • 0037986269 scopus 로고    scopus 로고
    • Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac
    • 10.1074/jbc.M207555200 12454019
    • Tamas P Solti Z Bauer P Illes A Sipeki S Bauer A Farago A Downward J Buday L Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac J Biol Chem 2003, 278(7):5163-5171. 10.1074/jbc.M207555200 12454019
    • (2003) J Biol Chem , vol.278 , Issue.7 , pp. 5163-5171
    • Tamas, P.1    Solti, Z.2    Bauer, P.3    Illes, A.4    Sipeki, S.5    Bauer, A.6    Farago, A.7    Downward, J.8    Buday, L.9
  • 40
    • 33847023585 scopus 로고    scopus 로고
    • Long-term treatment with tamoxifen facilitates translocation of estrogen receptor alpha out of the nucleus and enhances its interaction with EGFR in MCF-7 breast cancer cells
    • 10.1158/0008-5472.CAN-06-1020 17283173
    • Fan P Wang J Santen RJ Yue W Long-term treatment with tamoxifen facilitates translocation of estrogen receptor alpha out of the nucleus and enhances its interaction with EGFR in MCF-7 breast cancer cells Cancer research 2007, 67(3):1352-1360. 10.1158/0008-5472.CAN-06-1020 17283173
    • (2007) Cancer Research , vol.67 , Issue.3 , pp. 1352-1360
    • Fan, P.1    Wang, J.2    Santen, R.J.3    Yue, W.4
  • 41


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.