Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR 2)

Journal of Biological Chemistry

Volumn 286, Issue 28, 2011, Pages 24638-24648

  Ramachandran, Rithwik ^a   Mihara, Koichiro ^a   Chung, Hyunjae ^a   Renaux, Bernard ^a   Lau, Chang S ^b   Muruve, Daniel A ^a   DeFea, Kathryn A ^b   Bouvier, Michel ^c   Hollenberg, Morley D ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARRESTINS; CALCIUM SIGNALING; CELL SIGNALING; ELASTASE; ENZYME ACTIVATION; G PROTEIN COUPLED RECEPTORS; HUMAN NEUTROPHIL; N-TERMINALS; SIGNAL PATHWAYS; SYNTHETIC PEPTIDE; TETHERED LIGAND;

CHEMICAL ACTIVATION; ENZYMES; PATHOLOGY;

SIGNALING;

BETA ARRESTIN; CALCIUM ION; CATHEPSIN G; ELASTASE; G PROTEIN COUPLED RECEPTOR; LEUKOCYTE ELASTASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYELOBLASTIN; PROTEINASE ACTIVATED RECEPTOR 2; SYNTHETIC PEPTIDE; TRYPSIN;

AMINO ACID SEQUENCE; ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME RELEASE; HUMAN; HUMAN CELL; INFLAMMATION; INTERNALIZATION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FAMILY; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ANIMALS; ARRESTINS; CALCIUM SIGNALING; CATHEPSIN G; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HEK293 CELLS; HUMANS; INFLAMMATION; LEUKOCYTE ELASTASE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYELOBLASTIN; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTOR, PAR-2;

EID: 79960114650     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.201988     Document Type: Article

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