-
1
-
-
0037032835
-
The protein kinase complement of the human genome
-
DOI 10.1126/science.1075762
-
Manning G, Whyte DB,Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science. 2002;298(5600):1912-1934. (Pubitemid 35425239)
-
(2002)
Science
, vol.298
, Issue.5600
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
2
-
-
58249090833
-
SmithCI. Phylogeny of Tec family kinases identification of a premetazoan origin of Btk, Bmx, Itk, Tec, Txk, and the Btk regulator SH3BP5
-
Ortutay C,Nore BF, Vihinen M, SmithCI. Phylogeny of Tec family kinases identification of a premetazoan origin of Btk, Bmx, Itk, Tec, Txk, and the Btk regulator SH3BP5. Adv Genet. 2008;64:51-80.
-
(2008)
Adv Genet.
, vol.64
, pp. 51-80
-
-
Ortutay, C.1
Nore, B.F.2
Vihinen, M.3
-
3
-
-
0034693799
-
Lin SF.The protein tyrosine kinase family of the human genome
-
Robinson DR,Wu YM, Lin SF.The protein tyrosine kinase family of the human genome. Oncogene. 2000;19(49):5548-5557.
-
(2000)
Oncogene.
, vol.19
, Issue.49
, pp. 5548-5557
-
-
Robinson, D.R.1
Wu, Y.M.2
-
4
-
-
0033190523
-
Tec family of protein-tyrosine kinases: An overview of their structure and function
-
DOI 10.1016/S1359-6101(99)00019-2, PII S1359610199000192
-
ManoH. Tec family of protein-tyrosine kinases: an overview of their structure and function.Cytokine Growth Factor Rev. 1999;10(3-4):267-280. (Pubitemid 30041404)
-
(1999)
Cytokine and Growth Factor Reviews
, vol.10
, Issue.3-4
, pp. 267-280
-
-
Mano, H.1
-
5
-
-
33947322053
-
Tec kinases in T cell and mast cell signaling
-
DOI 10.1016/S0065-2776(06)93004-1, PII S0065277606930041
-
Felices M, Falk M, Kosaka Y, Berg LJ. Tec kinases in T cell and mast cell signaling. Adv Immunol. 2007;93:145-184. (Pubitemid 46441430)
-
(2007)
Advances in Immunology
, vol.93
, pp. 145-184
-
-
Felices, M.1
Falk, M.2
Kosaka, Y.3
Berg, L.J.4
-
6
-
-
69149095639
-
The role of Tec family kinases in mononuclear phagocytes
-
Koprulu AD, Ellmeier W. The role of Tec family kinases in mononuclear phagocytes. Crit Rev Immunol. 2009;29(4):317-333.
-
(2009)
Crit Rev Immunol.
, vol.29
, Issue.4
, pp. 317-333
-
-
Koprulu, A.D.1
Ellmeier, W.2
-
7
-
-
2542461503
-
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk
-
Chamorro M, Czar MJ, Debnath J, et al. Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk. BMC Immunol. 2001;2:3.
-
(2001)
BMC Immunol.
, vol.2
, pp. 3
-
-
Chamorro, M.1
Czar, M.J.2
Debnath, J.3
-
8
-
-
0032961364
-
Rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases
-
Debnath J, Chamorro M, Czar MJ, et al. rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases.Mol Cell Biol. 1999;19(2):1498-1507. (Pubitemid 29046891)
-
(1999)
Molecular and Cellular Biology
, vol.19
, Issue.2
, pp. 1498-1507
-
-
Debnath, J.1
Chamorro, M.2
Czar, M.J.3
Schaeffer, E.M.4
Lenardo, M.J.5
Varmus, H.E.6
Schwartzberg, P.L.7
-
9
-
-
0030662106
-
Predominant expression of murine Bmx tyrosine kinase in the granulo- monocytic lineage
-
Weil D, Power MA, Smith SI, Li CL. Predominant expression of murine Bmx tyrosine kinase in the granulo-monocytic lineage. Blood. 1997;90(11):4332-4340. (Pubitemid 27508439)
-
(1997)
Blood
, vol.90
, Issue.11
, pp. 4332-4340
-
-
Weil, D.1
Power, M.-A.2
Smith, S.I.3
Li, C.L.4
-
10
-
-
0029791422
-
BMX tyrosine kinase gene is expressed in granulocytes and myeloid leukaemias
-
Kaukonen J, Lahtinen I, Laine S, Alitalo K, Palotie A. BMX tyrosine kinase gene is expressed in granulocytes andmyeloid leukaemias. Br J Haematol. 1996;94(3):455-460. (Pubitemid 26284066)
-
(1996)
British Journal of Haematology
, vol.94
, Issue.3
, pp. 455-460
-
-
Kaukonen, J.1
Lahtinen, I.2
Laine, S.3
Alitalo, K.4
Palotie, A.5
-
11
-
-
0030756590
-
Bmx tyrosine kinase is specifically expressed in the endocardium and the endothelium of large arteries
-
Ekman N, Lymboussaki A, Vastrik I, Sarvas K, Kaipainen A, Alitalo K. Bmx tyrosine kinase is specifically expressed in the endocardium and the endothelium of large arteries. Circulation. 1997;96(6):1729-1732. (Pubitemid 27400725)
-
(1997)
Circulation
, vol.96
, Issue.6
, pp. 1729-1732
-
-
Ekman, N.1
Lymboussaki, A.2
Vastrik, I.3
Sarvas, K.4
Kaipainen, A.5
Alitalo, K.6
-
12
-
-
41549110303
-
Expression of Etk/Bmx tyrosine kinase in intrahepatic cholangiocarcinoma
-
DOI 10.1002/jso.20983
-
Guo L, Guo Y, Xiao S. Expression of Etk/Bmx tyrosine kinase in intrahepatic cholangiocarcinoma. J Surg Oncol. 2008;97(5):428-432. (Pubitemid 351466386)
-
(2008)
Journal of Surgical Oncology
, vol.97
, Issue.5
, pp. 428-432
-
-
Guo, L.1
Guo, Y.2
Xiao, S.3
-
13
-
-
39049115413
-
Expression of tyrosine kinase Etk/Bmx and its relationship with AP-1- and NF-κB-associated proteins in hepatocellular carcinoma
-
DOI 10.1159/000113491
-
Guo L, Guo Y, Xiao S. Expression of tyrosine kinase Etk/Bmx and its relationship with AP-1- and NFkappaB- associated proteins in hepatocellular carcinoma. Oncology. 2007;72(5-6):410-416. (Pubitemid 351238157)
-
(2007)
Oncology
, vol.72
, Issue.5-6
, pp. 410-416
-
-
Guo, L.1
Guo, Y.2
Xiao, S.3
-
14
-
-
33748071774
-
Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse
-
DOI 10.1158/0008-5472.CAN-06-1364
-
Dai B, Kim O, Xie Y, et al. Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse. Cancer Res. 2006;66(16):8058-8064. (Pubitemid 44299171)
-
(2006)
Cancer Research
, vol.66
, Issue.16
, pp. 8058-8064
-
-
Dai, B.1
Kim, O.2
Xie, Y.3
Guo, Z.4
Xu, K.5
Wang, B.6
Kong, X.7
Melamed, J.8
Chen, H.9
Bieberich, C.J.10
Borowsky, A.D.11
Kung, H.-J.12
Wei, G.13
Ostrowski, M.C.14
Brodie, A.15
Qiu, Y.16
-
15
-
-
0035800799
-
Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells
-
Bagheri-Yarmand R,Mandal M, Taludker AH, et al. Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells. J Biol Chem. 2001;276(31):29403-29409.
-
(2001)
J Biol Chem.
, vol.276
, Issue.31
, pp. 29403-29409
-
-
Bagheri-Yarmand, R.1
Mandal, M.2
Taludker, A.H.3
-
16
-
-
0029954686
-
A tyrosine kinase profile of prostate carcinoma
-
DOI 10.1073/pnas.93.12.5958
-
Robinson D,He F, PretlowT,KungHJ. A tyrosine kinase profile of prostate carcinoma. ProcNatl Acad Sci U S A. 1996;93(12):5958-5962. (Pubitemid 26190784)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.12
, pp. 5958-5962
-
-
Robinson, D.1
He, F.2
Pretlow, T.3
Kung, H.-J.4
-
17
-
-
0033532146
-
Reconstitution of Btk signaling by the atypical tec family tyrosine kinases Bmx and Txk
-
TomlinsonMG, Kurosaki T, Berson AE, Fujii GH, Johnston JA, Bolen JB. Reconstitution of Btk signaling by the atypical tec family tyrosine kinases Bmx and Txk. J Biol Chem. 1999;274(19):13577-13585.
-
(1999)
J Biol Chem.
, vol.274
, Issue.19
, pp. 13577-13585
-
-
Tomlinson, M.G.1
Kurosaki, T.2
Berson, A.E.3
Fujii, G.H.4
Johnston, J.A.5
Bolen, J.B.6
-
18
-
-
0034606219
-
Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk
-
Ellmeier W, Jung S, Sunshine MJ, et al. Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk. J ExpMed. 2000;192(11):1611-1624.
-
(2000)
J Exp Med.
, vol.192
, Issue.11
, pp. 1611-1624
-
-
Ellmeier, W.1
Jung, S.2
Sunshine, M.J.3
-
19
-
-
0027944227
-
BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2
-
Tamagnone L, Lahtinen I, Mustonen T, et al. BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2. Oncogene. 1994;9(12):3683-3688.
-
(1994)
Oncogene.
, vol.9
, Issue.12
, pp. 3683-3688
-
-
Tamagnone, L.1
Lahtinen, I.2
Mustonen, T.3
-
20
-
-
33750973379
-
BTKbase: The mutation database for X-linked agammaglobulinemia
-
DOI 10.1002/humu.20410
-
Valiaho J, Smith CI, Vihinen M. BTKbase: themutation database for X-linked agammaglobulinemia. HumMutat. 2006;27(12):1209-1217. (Pubitemid 44749723)
-
(2006)
Human Mutation
, vol.27
, Issue.12
, pp. 1209-1217
-
-
Valiaho, J.1
Smith, C.I.E.2
Vihinen, M.3
-
21
-
-
0034954684
-
Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium
-
DOI 10.1128/MCB.21.14.4647-4655.2001
-
Rajantie I, Ekman N, Iljin K, et al. Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium. Mol Cell Biol. 2001;21(14):4647-4655. (Pubitemid 32588247)
-
(2001)
Molecular and Cellular Biology
, vol.21
, Issue.14
, pp. 4647-4655
-
-
Rajantie, I.1
Ekman, N.2
Iljin, K.3
Arighi, E.4
Gunji, Y.5
Kaukonen, J.6
Palotie, A.7
Dewerchin, M.8
Carmeliet, P.9
Alitalo, K.10
-
22
-
-
33748292990
-
Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis
-
DOI 10.1172/JCI28123
-
He Y, Luo Y, Tang S, et al. Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis. J Clin Invest. 2006;116(9):2344-2355. (Pubitemid 44330133)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.9
, pp. 2344-2355
-
-
He, Y.1
Luo, Y.2
Tang, S.3
Rajantie, I.4
Salven, P.5
Heil, M.6
Zhang, R.7
Luo, D.8
Li, X.9
Chi, H.10
Yu, J.11
Carmeliet, P.12
Schaper, W.13
Sinusas, A.J.14
Sessa, W.C.15
Alitalo, K.16
Min, W.17
-
23
-
-
0347065353
-
Etk/Bmx Transactivates Vascular Endothelial Growth Factor 2 and Recruits Phosphatidylinositol 3-Kinase to Mediate the Tumor Necrosis Factor-induced Angiogenic Pathway
-
DOI 10.1074/jbc.M310678200
-
Zhang R, Xu Y, Ekman N, et al. Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits phosphatidylinositol 3-kinase to mediate the tumor necrosis factor-induced angiogenic pathway. J Biol Chem. 2003;278(51):51267-51276. (Pubitemid 38020364)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.51
, pp. 51267-51276
-
-
Zhang, R.1
Xu, Y.2
Ekman, N.3
Wu, Z.4
Wu, J.5
Alitalo, K.6
Min, W.7
-
24
-
-
84860488038
-
Suppression of Etk/Bmx Protects against ischemic brain injury
-
Chen KY, Wu CC, Chang CF, et al. Suppression of Etk/Bmx Protects against ischemic brain injury. Cell Transplant. 2011.
-
(2011)
Cell Transplant.
-
-
Chen, K.Y.1
Wu, C.C.2
Chang, C.F.3
-
25
-
-
58149385416
-
Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy
-
Mitchell-Jordan SA, Holopainen T, Ren S, et al. Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy. Circ Res. 2008;103(12):1359-1362.
-
(2008)
Circ Res.
, vol.103
, Issue.12
, pp. 1359-1362
-
-
Mitchell-Jordan, S.A.1
Holopainen, T.2
Ren, S.3
-
26
-
-
78149281188
-
Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation
-
BryM, Kivela R, Holopainen T, et al. Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation. Circulation. 2010;122(17):1725- 1733.
-
(2010)
Circulation.
, vol.122
, Issue.17
, pp. 1725-1733
-
-
Brym Kivela, R.1
Holopainen, T.2
-
27
-
-
43049140184
-
Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways
-
Semaan N, Alsaleh G, Gottenberg JE, Wachsmann D, Sibilia J. Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways. J Immunol. 2008;180(5):3485-3491.
-
(2008)
J Immunol.
, vol.180
, Issue.5
, pp. 3485-3491
-
-
Semaan, N.1
Alsaleh, G.2
Gottenberg, J.E.3
Wachsmann, D.4
Sibilia, J.5
-
28
-
-
43049096082
-
Bmx regulates LPS-induced IL-6 and VEGF production viamRNA stability in rheumatoid synovial fibroblasts
-
Palmer CD, Mutch BE, Page TH, Horwood NJ, Foxwell BM. Bmx regulates LPS-induced IL-6 and VEGF production viamRNA stability in rheumatoid synovial fibroblasts. Biochem Biophys Res Commun. 2008;370(4):599-602.
-
(2008)
Biochem Biophys Res Commun.
, vol.370
, Issue.4
, pp. 599-602
-
-
Palmer, C.D.1
Mutch, B.E.2
Page, T.H.3
Horwood, N.J.4
Foxwell, B.M.5
-
29
-
-
41349109980
-
Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFκB activity
-
DOI 10.1182/blood-2007-07-102343
-
Palmer CD, Mutch BE, Workman S, McDaid JP, Horwood NJ, Foxwell BM. Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFkapp}B activity. Blood. 2008;111(4):1781-1788. (Pubitemid 351451482)
-
(2008)
Blood
, vol.111
, Issue.4
, pp. 1781-1788
-
-
Palmer, C.D.1
Mutch, B.E.2
Workman, S.3
McDaid, J.P.4
Horwood, N.J.5
Foxwell, B.M.J.6
-
30
-
-
23444437819
-
Design of a genome-wide siRNA library using an artificial neural network
-
DOI 10.1038/nbt1118
-
Huesken D, Lange J, Mickanin C, et al. Design of a genome-wide siRNA library using an artificial neural network. Nat Biotechnol. 2005;23(8):995-1001. (Pubitemid 41114034)
-
(2005)
Nature Biotechnology
, vol.23
, Issue.8
, pp. 995-1001
-
-
Huesken, D.1
Lange, J.2
Mickanin, C.3
Weiler, J.4
Asselbergs, F.5
Warner, J.6
Meloon, B.7
Engel, S.8
Rosenberg, A.9
Cohen, D.10
Labow, M.11
Reinhardt, M.12
Natt, F.13
Hall, J.14
-
31
-
-
33749537857
-
Genome-wide functional analysis of human cell-cycle regulators
-
DOI 10.1073/pnas.0604320103
-
Mukherji M, Bell R, Supekova L, et al. Genome-wide functional analysis of human cell-cycle regulators. Proc Natl Acad Sci U S A. 2006;103(40):14819- 14824. (Pubitemid 44527812)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.40
, pp. 14819-14824
-
-
Mukherji, M.1
Bell, R.2
Supekova, L.3
Wang, Y.4
Orth, A.P.5
Batalov, S.6
Miraglia, L.7
Huesken, D.8
Lange, J.9
Martin, C.10
Sahasrabudhe, S.11
Reinhardt, M.12
Natt, F.13
Hall, J.14
Mickanin, C.15
Labow, M.16
Chanda, S.K.17
Cho, C.Y.18
Schultz, P.G.19
-
32
-
-
43549122365
-
Wholegenomefunctional analysis identifiesnovelcomponents required formitotic spindle integrity in human cells
-
RinesDR,Gomez-FerreriaMA,ZhouY, et al.Wholegenomefunctional analysis identifiesnovelcomponents required formitotic spindle integrity in human cells. Genome Biol. 2008;9(2):R44.
-
(2008)
Genome Biol.
, vol.9
, Issue.2
-
-
Rines, D.R.1
Gomez-Ferreria, M.A.2
Zhou, Y.3
-
33
-
-
79956223769
-
The tyrosine kinase BMX is an essential mediator of inflammatory arthritis in a kinase-independent manner
-
Gottar-Guillier M, Dodeller F, Huesken D, et al. The tyrosine kinase BMX is an essential mediator of inflammatory arthritis in a kinase-independent manner. J Immunol. 2011;186(10): 6014-6023.
-
(2011)
J Immunol.
, vol.186
, Issue.10
, pp. 6014-6023
-
-
Gottar-Guillier, M.1
Dodeller, F.2
Huesken, D.3
-
34
-
-
0030606310
-
Organ-specific disease provoked by systemic autoimmunity
-
DOI 10.1016/S0092-8674(00)81989-3
-
Kouskoff V, Korganow AS, Duchatelle V, Degott C, Benoist C,Mathis D. Organ-specific disease provoked by systemic autoimmunity. Cell. 1996;87(5):811-822. (Pubitemid 26404281)
-
(1996)
Cell
, vol.87
, Issue.5
, pp. 811-822
-
-
Kouskoff, V.1
Korganow, A.-S.2
Duchatelle, V.3
Degott, C.4
Benoist, C.5
Mathis, D.6
-
35
-
-
0036645277
-
Critical roles for interleukin 1 and tumor necrosis factor α in antibody-induced arthritis
-
DOI 10.1084/jem.20020439
-
Ji H, Pettit A,Ohmura K, et al. Critical roles for interleukin 1 and tumor necrosis factor at in antibodyinduced arthritis. J ExpMed. 2002;196(1):77-85. (Pubitemid 34747313)
-
(2002)
Journal of Experimental Medicine
, vol.196
, Issue.1
, pp. 77-85
-
-
Ji, H.1
Pettit, A.2
Ohmura, K.3
Ortiz-Lopez, A.4
Duchatelle, V.5
Degott, C.6
Gravallese, E.7
Mathis, D.8
Benoist, C.9
-
37
-
-
0000915343
-
The production of arthritis in rabbits by an immunological reaction to fibrin
-
Dumonde DC, Glynn LE. The production of arthritis in rabbits by an immunological reaction to fibrin. Br J Exp Pathol. 1962;43:373-383.
-
(1962)
Br J Exp Pathol.
, vol.43
, pp. 373-383
-
-
Dumonde, D.C.1
Glynn, L.E.2
-
38
-
-
0021352139
-
Flare-up of antigen-induced arthritis in mice after challenge with intravenous antigen: Studies on the characteristics of and mechanisms involved in the reaction
-
Lens JW, van den BergWB, van de Putte LB. Flare-up of antigen-induced arthritis in mice after challenge with intravenous antigen: studies on the characteristics of and mechanisms involved in the reaction. Clin Exp Immunol. 1984;55(2):287-294. (Pubitemid 14223465)
-
(1984)
Clinical and Experimental Immunology
, vol.55
, Issue.2
, pp. 287-294
-
-
Lens, J.W.1
Van Den Berg, W.B.2
Van De Putte, L.B.A.3
-
39
-
-
1842534326
-
The role of tyrosine kinase Etk/Bmx in EGF-induced apoptosis of MDA-MB-468 breast cancer cells
-
DOI 10.1038/sj.onc.1207308
-
Chen KY, Huang LM, Kung HJ, Ann DK, Shih HM. The role of tyrosine kinase Etk/Bmx in EGFinduced apoptosis of MDA-MB-468 breast cancer cells. Oncogene. 2004;23(10):1854-1862. (Pubitemid 38445411)
-
(2004)
Oncogene
, vol.23
, Issue.10
, pp. 1854-1862
-
-
Chen, K.-Y.1
Huang, L.-M.2
Kung, H.-J.3
Ann, D.K.4
Shih, H.-M.5
-
40
-
-
31644442039
-
Expression of Etk/Bmx tyrosine kinase in the tumorigenicity of nasopharyngeal epithelium and its relation with EB virus infection and the apoptosis-related protein Bcl-2
-
DOI 10.1016/j.canlet.2005.02.028, PII S0304383505001941
-
Guo L,Guo Y, Xiao S. Expression of Etk/Bmx tyrosine kinase in the tumorigenicity of nasopharyngeal epithelium and its relation with EB virus infection and the apoptosis-related protein Bcl-2. Cancer Lett. 2006;232(2):255-261. (Pubitemid 43170975)
-
(2006)
Cancer Letters
, vol.232
, Issue.2
, pp. 255-261
-
-
Guo, L.1
Guo, Y.2
Xiao, S.3
-
41
-
-
79952358749
-
Tyrosine kinase ETK/BMX is up-regulated in bladder cancer and predicts poor prognosis in patients with cystectomy
-
Guo S, Sun F, Guo Z, et al. Tyrosine kinase ETK/BMX is up-regulated in bladder cancer and predicts poor prognosis in patients with cystectomy. PLoS One. 2011;6(3):e17778.
-
(2011)
PLoS One.
, vol.6
, Issue.3
-
-
Guo, S.1
Sun, F.2
Guo, Z.3
-
42
-
-
28044459831
-
Human single-domain neutralizing intrabodies directed against Etk kinase: A novel approach to impair cellular transformation
-
DOI 10.1158/1535-7163.MCT-05-0174
-
Paz K, Brennan LA, IacolinaM,Doody J,Hadari YR, Zhu Z.Human single-domain neutralizing intrabodies directed against Etk kinase: a novel approach to impair cellular transformation. Mol Cancer Ther. 2005;4(11):1801-1809. (Pubitemid 41685315)
-
(2005)
Molecular Cancer Therapeutics
, vol.4
, Issue.11
, pp. 1801-1809
-
-
Paz, K.1
Brennan, L.A.2
Iacolina, M.3
Doody, J.4
Hadari, Y.R.5
Zhu, Z.6
-
43
-
-
79953757100
-
Nonreceptor tyrosine kinase BMX maintains selfrenewal and tumorigenic potential of glioblastoma stem cells by activating STAT3
-
Guryanova OA, Wu Q, Cheng L, et al. Nonreceptor tyrosine kinase BMX maintains selfrenewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. Cancer Cell. 2011;19(4):498-511.
-
(2011)
Cancer Cell.
, vol.19
, Issue.4
, pp. 498-511
-
-
Guryanova, O.A.1
Wu, Q.2
Cheng, L.3
-
44
-
-
69849099673
-
Biology of glioma cancer stem cells
-
Park DM, Rich JN. Biology of glioma cancer stem cells.Mol Cells. 2009;28(1):7-12.
-
(2009)
Mol Cells.
, vol.28
, Issue.1
, pp. 7-12
-
-
Park, D.M.1
Rich, J.N.2
-
45
-
-
67649939163
-
The increasing complexity of the cancer stem cell paradigm
-
Rosen JM, Jordan CT. The increasing complexity of the cancer stem cell paradigm. Science. 2009;324(5935):1670-1673.
-
(2009)
Science.
, vol.324
, Issue.5935
, pp. 1670-1673
-
-
Rosen, J.M.1
Jordan, C.T.2
-
46
-
-
70350525582
-
STAT3 regulation of glioblastoma pathogenesis
-
de la Iglesia N, Puram SV, Bonni A. STAT3 regulation of glioblastoma pathogenesis. Curr Mol Med. 2009;9(5):580-590.
-
(2009)
Curr Mol Med.
, vol.9
, Issue.5
, pp. 580-590
-
-
De La Iglesia, N.1
Puram, S.V.2
Bonni, A.3
-
47
-
-
0030697510
-
The Bmx tyrosine kinase induces activation of the stat signaling pathway, which is specifically inhibited by protein kinase Cδ
-
Saharinen P, Ekman N, Sarvas K, Parker P, Alitalo K, Silvennoinen O. The Bmx tyrosine kinase induces activation of the Stat signaling pathway, which is specifically inhibited by protein kinase Cdelta. Blood. 1997;90(11):4341-4353. (Pubitemid 27508440)
-
(1997)
Blood
, vol.90
, Issue.11
, pp. 4341-4353
-
-
Saharinen, P.1
Ekman, N.2
Sarvas, K.3
Parker, P.4
Alitalo, K.5
Silvennoinen, O.6
-
48
-
-
0034002476
-
Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation
-
Tsai YT, Su YH, Fang SS, et al. Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation.Mol Cell Biol. 2000;20(6):2043-2054.
-
(2000)
Mol Cell Biol.
, vol.20
, Issue.6
, pp. 2043-2054
-
-
Tsai, Y.T.1
Su, Y.H.2
Fang, S.S.3
-
49
-
-
0035901090
-
Inflammation and cancer: Back to Virchow?
-
DOI 10.1016/S0140-6736(00)04046-0
-
Balkwill F, Mantovani A. Inflammation and cancer: back to Virchowč Lancet. 2001;357(9255):539-545. (Pubitemid 32173595)
-
(2001)
Lancet
, vol.357
, Issue.9255
, pp. 539-545
-
-
Balkwill, F.1
Mantovani, A.2
-
50
-
-
68449087605
-
Inflammation, microenvironment, and the immune system in cancer progression
-
Keibel A, Singh V, Sharma MC. Inflammation, microenvironment, and the immune system in cancer progression. Curr PharmDes. 2009;15(17):1949-1955.
-
(2009)
Curr PharmDes.
, vol.15
, Issue.17
, pp. 1949-1955
-
-
Keibel, A.1
Singh, V.2
Sharma, M.C.3
-
51
-
-
0345447618
-
Function of bruton's tyrosine kinase during b cell development is partially independent of its catalytic activity
-
Middendorp S, Dingjan GM, Maas A, Dahlenborg K, Hendriks RW. Function of Bruton's tyrosine kinase during B cell development is partially independent of its catalytic activity. J Immunol. 2003;171(11):5988-5996. (Pubitemid 37467217)
-
(2003)
Journal of Immunology
, vol.171
, Issue.11
, pp. 5988-5996
-
-
Middendorp, S.1
Dingjan, G.M.2
Maas, A.3
Dahlenborg, K.4
Hendriks, R.W.5
-
52
-
-
80054117850
-
X-ray crystal structure of bonemarrow kinase in the x chromosome: A Tec family kinase
-
Muckelbauer J, Sack JS, Ahmed N, et al. X-ray crystal structure of bonemarrow kinase in the x chromosome: a Tec family kinase. Chem Biol Drug Des. 2011;78(5):739-748.
-
(2011)
Chem Biol Drug Des.
, vol.78
, Issue.5
, pp. 739-748
-
-
Muckelbauer, J.1
Sack, J.S.2
Ahmed, N.3
-
53
-
-
33846899405
-
Molecular recognition of protein kinase binding pockets for design of potent and selective kinase inhibitors
-
DOI 10.1021/jm0608107
-
Liao JJ. Molecular recognition of protein kinase binding pockets for design of potent and selective kinase inhibitors. JMed Chem. 2007;50(3):409-424. (Pubitemid 46239775)
-
(2007)
Journal of Medicinal Chemistry
, vol.50
, Issue.3
, pp. 409-424
-
-
Liao, J.J.-L.1
-
54
-
-
78650433517
-
Specific Btk inhibition suppresses B cell- and myeloid cellmediated arthritis
-
Di Paolo JA, Huang T, Balazs M, et al. Specific Btk inhibition suppresses B cell- and myeloid cellmediated arthritis. Nat Chem Biol. 2011;7(1):41-50.
-
(2011)
Nat Chem Biol.
, vol.7
, Issue.1
, pp. 41-50
-
-
Di Paolo, J.A.1
Huang, T.2
Balazs, M.3
-
56
-
-
55249109749
-
Clinical stage EGF rinhibitors irreversibly alkylate bmxkinase
-
HurW,VelentzaA,Kim S, et al.Clinical stageEGFRinhibitors irreversibly alkylateBmxkinase.Bioorg Med Chem Lett. 2008;18(22):5916-5919.
-
(2008)
Bioorg Med Chem Lett.
, vol.18
, Issue.22
, pp. 5916-5919
-
-
Hur, W.1
Velentza, A.2
Kim, S.3
-
57
-
-
79953314480
-
The resurgence of covalent drugs
-
Singh J, Petter RC, Baillie TA, Whitty A. The resurgence of covalent drugs. Nat Rev Drug Discov. 2011;10(4):307-317.
-
(2011)
Nat Rev Drug Discov.
, vol.10
, Issue.4
, pp. 307-317
-
-
Singh, J.1
Petter, R.C.2
Baillie, T.A.3
Whitty, A.4
-
58
-
-
78951491063
-
The Btk inhibitor PCI-32765 induces durable responses with minimal toxicity in patients with relapsed/refractory B-cellmalignancies: Results from a phase i study
-
Fowler N, Sharman JP, Smith SM, et al. The Btk inhibitor, PCI-32765, induces durable responses with minimal toxicity in patients with relapsed/refractory B-cellmalignancies: results from a phase I study. ASH AnnualMeeting Abstracts 2010;116(21):964.
-
(2010)
ASH AnnualMeeting Abstracts
, vol.116
, Issue.21
, pp. 964
-
-
Fowler, N.1
Sharman, J.P.2
Smith, S.M.3
-
59
-
-
84860478464
-
The Bruton's tyrosine kinase (Btk) inhibitor PCI-32765 modulates chronic active BCR signaling and induces tumor regression in relapsed/refractory ABCDLBCL
-
Staudt LM,Dunleavy K, Buggy JJ, et al.TheBruton's tyrosine kinase (Btk) inhibitor PCI-32765 modulates chronic active BCR signaling and induces tumor regression in relapsed/refractory ABCDLBCL. ASH AnnualMeeting Abstracts 2011;118(21):2716.
-
(2011)
ASH AnnualMeeting Abstracts
, vol.118
, Issue.21
, pp. 2716
-
-
Staudt, L.M.1
Dunleavy, K.2
Buggy, J.J.3
-
60
-
-
84860430028
-
The Bruton's tyrosine kinase inhibitor PCI-32765 is highly active as single-agent therapy in previously-treatedmantle cell lymphoma (MCL): Preliminary results of a phase II trial
-
Wang L, Martin P, Blum KA, et al. The Bruton's tyrosine kinase inhibitor PCI-32765 is highly active as single-agent therapy in previously-treatedmantle cell lymphoma (MCL): preliminary results of a phase II trial. ASH AnnualMeeting Abstracts 2011;118(21):442.
-
(2011)
ASH AnnualMeeting Abstracts
, vol.118
, Issue.21
, pp. 442
-
-
Wang, L.1
Martin, P.2
Blum, K.A.3
-
61
-
-
77955625479
-
The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
-
Honigberg LA, Smith AM, SirisawadM, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A 2010;107(29):13075-13080.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.29
, pp. 13075-13080
-
-
Honigberg, L.A.1
Smith, A.M.2
Sirisawad, M.3
-
62
-
-
77953631133
-
Strategies for discovering and derisking covalent, irreversible enzyme inhibitors
-
Johnson DS,Weerapana E, Cravatt BF. Strategies for discovering and derisking covalent, irreversible enzyme inhibitors. FutureMed Chem. 2010;2(6):949-964.
-
(2010)
Future Med Chem.
, vol.2
, Issue.6
, pp. 949-964
-
-
Johnson, D.S.1
Weerapana, E.2
Cravatt, B.F.3
|