Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner

Journal of Cell Biology

Volumn 163, Issue 2, 2003, Pages 315-326

  Debnath, Jayanta ^a,b   Walker, Stephanie J ^a   Brugge, Joan S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Akt PKB; Cell size; Mammary acini; MTOR; Proliferation

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; DNA; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; RAPAMYCIN; RETROVIRUS VECTOR;

ACINAR CELL; ARTICLE; BREAST; CELL CYCLE; CELL LINE; CELL PROLIFERATION; DNA CONTENT; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; VIRUS INFECTION;

ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BREAST; CELL DIVISION; CELL LINE; CELL LINE, TRANSFORMED; CELL POLARITY; CELL SIZE; CELL SURVIVAL; CYCLIN D1; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; EPITHELIAL CELLS; HUMANS; MORPHOGENESIS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RETROVIRIDAE; SIROLIMUS;

MAMMALIA; MINK CELL FOCUS-FORMING VIRUS; UNIDENTIFIED RETROVIRUS;

EID: 0242266916     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200304159     Document Type: Article

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