Activated RhoA binds to the Pleckstrin Homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation

Journal of Biological Chemistry

Volumn 285, Issue 27, 2010, Pages 21070-21081

  Chen, Zhe ^a   Medina, Frank ^a   Liu, Mu Ya ^a   Thomas, Celestine ^b   Sprang, Stephen R ^b   Sternweis, Paul C ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF MONTANA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOREGULATIONS; FREE STATE; GTPASES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; GUANOSINES; HYDROPHOBIC PATCH; IN-VIVO; PLECKSTRIN HOMOLOGY DOMAINS; POTENTIAL SITES; TERNARY COMPLEX; TRIPHOSPHATE;

NUCLEOTIDES; SIZE EXCLUSION CHROMATOGRAPHY;

CHEMICAL ACTIVATION;

GUANINE NUCLEOTIDE EXCHANGE FACTOR; PDZ PROTEIN; PLECKSTRIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ARTICLE; AUTOREGULATION; COMPLEX FORMATION; CONTROLLED STUDY; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REGULATORY MECHANISM;

BINDING SITES; CHROMATOGRAPHY, GEL; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; ESCHERICHIA COLI; GENETIC VECTORS; GTP PHOSPHOHYDROLASES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; HOMEOSTASIS; HUMANS; KINETICS; PEPTIDE FRAGMENTS; RHOA GTP-BINDING PROTEIN; THERMODYNAMICS;

EID: 77954238441     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.122549     Document Type: Article

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