Neutrophil elastase and proteinase-3 trigger G proteinbiased signaling through proteinase-activated receptor-1 (PAR1)

Journal of Biological Chemistry

Volumn 288, Issue 46, 2013, Pages 32979-32990

  Mihara, Koichiro ^a   Ramachandran, Rithwik ^a,b   Renaux, Bernard ^a   Saifeddine, Mahmoud ^a   Hollenberg, Morley D ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b NONE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM SIGNALING; MITOGEN-ACTIVATED PROTEIN KINASE ACTIVATION; NEUTROPHIL INFILTRATION; PERTUSSIS TOXIN; PROTEINASE-ACTIVATED RECEPTOR; SYNTHETIC PEPTIDE; TETHERED LIGAND; TISSUE FUNCTION;

ANTIBODIES; CHEMICAL ACTIVATION; ENDOTHELIAL CELLS; ENZYMES; SIGNAL TRANSDUCTION; SIGNALING;

LIGANDS;

G PROTEIN COUPLED RECEPTOR; LEUKOCYTE ELASTASE; MYELOBLASTIN; PROTEINASE ACTIVATED RECEPTOR 1;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRESS; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME REGULATION; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

BIASED SIGNALING; CALCIUM SIGNALING; ENDOTHELIAL CELL; G PROTEIN-COUPLED RECEPTORS (GPCR); INTRACELLULAR TRAFFICKING; MAP KINASES (MAPKS); NEUTROPHIL; PROTEINASE-ACTIVATED RECEPTOR; THROMBIN;

CELL LINE, TUMOR; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GTP-BINDING PROTEIN ALPHA SUBUNITS; HEK293 CELLS; HUMANS; LEUKOCYTE ELASTASE; MAP KINASE SIGNALING SYSTEM; MYELOBLASTIN; RECEPTOR, PAR-1; THROMBIN;

EID: 84887852110     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.483123     Document Type: Article

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