Liquid chromatography-high-resolution mass spectrometry-based cell metabolomics: Experimental design, recommendations, and applications

TrAC - Trends in Analytical Chemistry

Volumn 75, Issue , 2016, Pages 118-128

  Madji Hounoum, Blandine ^a   Blasco, Hélène ^a,b   Emond, Patrick ^a   Mavel, Sylvie ^a  

^a CHRU de Tours   (France)

^b UNIVERSITY HOSPITAL OF TOURS   (France)

Author keywords

Cellular extract; Extraction; LC MS; Quenching; Sample pretreatment; Workflow

Indexed keywords

CELLS; CHROMATOGRAPHY; CYTOLOGY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; QUENCHING; SPECTROMETRY;

CELLULAR EXTRACTS; CELLULAR METABOLITES; HIGH RESOLUTION MASS SPECTROMETRY; LC-MS; LIQUID CHROMATOGRAPHY-HIGH RESOLUTION MASS SPECTROMETRIES; SAMPLE PRETREATMENT; SMALL BIOLOGICAL MOLECULE; WORKFLOW;

EXTRACTION;

ANALYTIC METHOD; CELL CULTURE; CELL FUNCTION; CELL METABOLISM; EXPERIMENTAL DESIGN; EXTRACTION; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEASUREMENT ACCURACY; METABOLISM; METABOLITE; METABOLOMICS; METHODOLOGY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SAMPLING; SENSITIVITY AND SPECIFICITY;

EID: 84947930354     PISSN: 01659936     EISSN: 18793142     Source Type: Journal    
DOI: 10.1016/j.trac.2015.08.003     Document Type: Review

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