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Volumn 83, Issue 13, 2011, Pages 5422-5430

Metabolomics profiling of cell culture media leading to the identification of riboflavin photosensitized degradation of tryptophan causing slow growth in cell culture

(6) Zang, Li a Frenkel, Ruth a Simeone, Jeffrey b Lanan, Maureen a Byers, Mark b Lyubarskaya, Yelena a

a Analytical Development (United States)

b Manufacturing Sciences Department (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOPHARMACEUTICAL INDUSTRY; BIOPHARMACEUTICALS; CELL CULTURE MEDIA; CELL CULTURE PROCESS; CONDENSATION PRODUCT; FLUORESCENT LIGHT; HIGH RESOLUTION MASS SPECTROMETRY; LIGHT EXPOSURE; LIGHT-INDUCED DEGRADATION; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; LOW GROWTH RATE; LUMICHROME; MAMMALIAN CELL CULTURE; MEDIA COMPONENTS; METABOLOMICS; MOLECULAR FORMULA; PHOTOSENSITIZED DEGRADATION; POOR PERFORMANCE; SLOW GROWTH; STRESS CONDITION; TEMPERATURE STRESS; TRYPTOPHAN OXIDATION; VIABLE CELLS;

AMINO ACIDS; ANIMAL CELL CULTURE; CYTOLOGY; DEGRADATION; GLUCOSE; LIQUID CHROMATOGRAPHY; MAMMALS; MASS SPECTROMETRY;

CELLS;

RIBOFLAVIN; TRYPTOPHAN;

ARTICLE; CELL CULTURE; CELL DIVISION; CHEMISTRY; CULTURE MEDIUM; LIQUID CHROMATOGRAPHY; METABOLISM; METABOLOMICS; PHOTOCHEMISTRY; PRINCIPAL COMPONENT ANALYSIS; TANDEM MASS SPECTROMETRY;

CELL DIVISION; CELLS, CULTURED; CHROMATOGRAPHY, LIQUID; CULTURE MEDIA; METABOLOMICS; PHOTOCHEMISTRY; PRINCIPAL COMPONENT ANALYSIS; RIBOFLAVIN; TANDEM MASS SPECTROMETRY; TRYPTOPHAN;

EID: 79960026499 PISSN: 00032700 EISSN: None Source Type: Journal
DOI: 10.1021/ac2009492 Document Type: Article

Times cited : (40)

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