메뉴 건너뛰기




Volumn 15, Issue 15-16, 2010, Pages 610-621

Cell culture metabolomics: Applications and future directions

Author keywords

[No Author keywords available]

Indexed keywords

METHANOL; PHOSPHATE BUFFERED SALINE;

EID: 77955518663     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2010.06.012     Document Type: Review
Times cited : (188)

References (82)
  • 1
    • 0034959944 scopus 로고    scopus 로고
    • Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks
    • Fiehn O. Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks. Comp. Funct. Genomics 2001, 2:155-168.
    • (2001) Comp. Funct. Genomics , vol.2 , pp. 155-168
    • Fiehn, O.1
  • 2
    • 0032168794 scopus 로고    scopus 로고
    • Systematic functional analysis of the yeast genome
    • Oliver S.G., et al. Systematic functional analysis of the yeast genome. Trends Biotechnol. 1998, 16:373-378.
    • (1998) Trends Biotechnol. , vol.16 , pp. 373-378
    • Oliver, S.G.1
  • 3
    • 0032694577 scopus 로고    scopus 로고
    • 'Metabonomics' understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
    • Nicholson J.K., et al. 'Metabonomics' understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999, 29:1181-1189.
    • (1999) Xenobiotica , vol.29 , pp. 1181-1189
    • Nicholson, J.K.1
  • 4
    • 39149126712 scopus 로고    scopus 로고
    • Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts
    • Beckonert O., et al. Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts. Nat. Protoc. 2007, 2:2692-2703.
    • (2007) Nat. Protoc. , vol.2 , pp. 2692-2703
    • Beckonert, O.1
  • 5
    • 36448930569 scopus 로고    scopus 로고
    • 1H NMR metabonomics as a prognostic and diagnostic tool
    • 1H NMR metabonomics as a prognostic and diagnostic tool. Exp. Rev. Mol. Diagn. 2007, 7:761-773.
    • (2007) Exp. Rev. Mol. Diagn. , vol.7 , pp. 761-773
    • Ala-Korpela, M.1
  • 6
    • 3042823722 scopus 로고    scopus 로고
    • Metabolomic profiles of cancer cells
    • Griffin J.L., Shockcor J.P. Metabolomic profiles of cancer cells. Nat. Rev. Cancer 2004, 4:551-561.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 551-561
    • Griffin, J.L.1    Shockcor, J.P.2
  • 8
    • 60149091657 scopus 로고    scopus 로고
    • Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
    • Sreekumar A., et al. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature 2009, 457:910-914.
    • (2009) Nature , vol.457 , pp. 910-914
    • Sreekumar, A.1
  • 9
    • 70149096873 scopus 로고    scopus 로고
    • Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism
    • Clayton T.A., et al. Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:14728-14733.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 14728-14733
    • Clayton, T.A.1
  • 10
    • 50849141305 scopus 로고    scopus 로고
    • 1H NMR spectroscopy: early systemic signs of Alzheimer's disease
    • 1H NMR spectroscopy: early systemic signs of Alzheimer's disease. Biochem. Biophys. Res. Commun. 2008, 375:356-361.
    • (2008) Biochem. Biophys. Res. Commun. , vol.375 , pp. 356-361
    • Tukiainen, T.1
  • 11
    • 70349324702 scopus 로고    scopus 로고
    • High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism
    • Soininen P., et al. High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism. Analyst 2009, 134:1781-1785.
    • (2009) Analyst , vol.134 , pp. 1781-1785
    • Soininen, P.1
  • 12
    • 34249890793 scopus 로고    scopus 로고
    • Metabolomics as a complementary tool in cell culture
    • Khoo S.H.G., Al-Rubeai M. Metabolomics as a complementary tool in cell culture. Biotechnol. Appl. Biochem. 2007, 47:71-84.
    • (2007) Biotechnol. Appl. Biochem. , vol.47 , pp. 71-84
    • Khoo, S.H.G.1    Al-Rubeai, M.2
  • 13
    • 58149460015 scopus 로고    scopus 로고
    • Effective quenching processes for physiologically valid metabolite profiling of suspension cultured Mammalian cells
    • Sellick C.A., et al. Effective quenching processes for physiologically valid metabolite profiling of suspension cultured Mammalian cells. Anal. Chem. 2009, 81:174-183.
    • (2009) Anal. Chem. , vol.81 , pp. 174-183
    • Sellick, C.A.1
  • 14
    • 67349235296 scopus 로고    scopus 로고
    • A direct cell quenching method for cell-culture based metabolomics
    • Teng Q., et al. A direct cell quenching method for cell-culture based metabolomics. Metabolomics 2009, 5:199-208.
    • (2009) Metabolomics , vol.5 , pp. 199-208
    • Teng, Q.1
  • 15
    • 67249083144 scopus 로고    scopus 로고
    • Analytical approaches towards successful human cell metabolome studies by NMR spectroscopy
    • Duarte I.F., et al. Analytical approaches towards successful human cell metabolome studies by NMR spectroscopy. Anal. Chem. 2009, 81:5023-5032.
    • (2009) Anal. Chem. , vol.81 , pp. 5023-5032
    • Duarte, I.F.1
  • 16
    • 50349092706 scopus 로고    scopus 로고
    • Kinetic flux profiling for quantitation of cellular metabolic fluxes
    • Yuan J., et al. Kinetic flux profiling for quantitation of cellular metabolic fluxes. Nat. Protoc. 2008, 3:1328-1340.
    • (2008) Nat. Protoc. , vol.3 , pp. 1328-1340
    • Yuan, J.1
  • 17
    • 37549064772 scopus 로고    scopus 로고
    • Simultaneous extraction of several metabolites of energy metabolism and related substances in mammalian cells: optimization using experimental design
    • Ritter J.B., et al. Simultaneous extraction of several metabolites of energy metabolism and related substances in mammalian cells: optimization using experimental design. Anal. Biochem. 2007, 373:349-369.
    • (2007) Anal. Biochem. , vol.373 , pp. 349-369
    • Ritter, J.B.1
  • 18
    • 33847421719 scopus 로고    scopus 로고
    • Nature News: meet the human metabolome
    • Pearson H. Nature News: meet the human metabolome. Nature 2007, 446:8.
    • (2007) Nature , vol.446 , pp. 8
    • Pearson, H.1
  • 19
    • 34748839546 scopus 로고    scopus 로고
    • Proposed minimum reporting standards for data analysis in metabolomics
    • Goodacre R., et al. Proposed minimum reporting standards for data analysis in metabolomics. Metabolomics 2007, 3:231-241.
    • (2007) Metabolomics , vol.3 , pp. 231-241
    • Goodacre, R.1
  • 20
    • 70349466529 scopus 로고    scopus 로고
    • Population context determines cell-to-cell variability in endocytosis and virus infection
    • Snijder B., et al. Population context determines cell-to-cell variability in endocytosis and virus infection. Nature 2009, 461:520-523.
    • (2009) Nature , vol.461 , pp. 520-523
    • Snijder, B.1
  • 21
    • 68849116797 scopus 로고    scopus 로고
    • Development and performance of a gas chromatography-time-of-flight mass spectrometry analysis for large-scale nontargeted metabolomic studies of human serum
    • Begley P., et al. Development and performance of a gas chromatography-time-of-flight mass spectrometry analysis for large-scale nontargeted metabolomic studies of human serum. Anal. Chem. 2009, 81:7038-7046.
    • (2009) Anal. Chem. , vol.81 , pp. 7038-7046
    • Begley, P.1
  • 22
    • 61849100465 scopus 로고    scopus 로고
    • International NMR-based environmental metabolomics intercomparison exercise
    • Viant M.R., et al. International NMR-based environmental metabolomics intercomparison exercise. Environ. Sci. Technol. 2009, 43:219-225.
    • (2009) Environ. Sci. Technol. , vol.43 , pp. 219-225
    • Viant, M.R.1
  • 23
    • 64249158872 scopus 로고    scopus 로고
    • Metabolic profiling of drug responses in acute myeloid leukaemia cell lines
    • Tiziani S., et al. Metabolic profiling of drug responses in acute myeloid leukaemia cell lines. PLoS One 2009, 4:e4251.
    • (2009) PLoS One , vol.4
    • Tiziani, S.1
  • 24
    • 17844383964 scopus 로고    scopus 로고
    • Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements
    • Ramanathan A., et al. Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:5992-5997.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 5992-5997
    • Ramanathan, A.1
  • 25
    • 42049085016 scopus 로고    scopus 로고
    • Metabolic and morphological differences between rapidly proliferating cancerous and normal breast epithelial cells
    • Meadows A.L., et al. Metabolic and morphological differences between rapidly proliferating cancerous and normal breast epithelial cells. Biotechnol. Prog. 2008, 24:334-341.
    • (2008) Biotechnol. Prog. , vol.24 , pp. 334-341
    • Meadows, A.L.1
  • 26
    • 4544278657 scopus 로고    scopus 로고
    • Hormone sensitivity is reflected in the phospholipid profiles of breast cancer cell lines
    • Sterin M., et al. Hormone sensitivity is reflected in the phospholipid profiles of breast cancer cell lines. Breast Cancer Res. Treat. 2004, 87:1-11.
    • (2004) Breast Cancer Res. Treat. , vol.87 , pp. 1-11
    • Sterin, M.1
  • 27
    • 53849135245 scopus 로고    scopus 로고
    • 1H NMR of whole cells and cellular extracts
    • 1H NMR of whole cells and cellular extracts. NMR Biomed. 2008, 21:809-819.
    • (2008) NMR Biomed. , vol.21 , pp. 809-819
    • Gottschalk, M.1
  • 28
    • 0027633559 scopus 로고
    • 31P NMR spectroscopy
    • 31P NMR spectroscopy. NMR Biomed. 1993, 6:254-263.
    • (1993) NMR Biomed. , vol.6 , pp. 254-263
    • Shedd, S.F.1
  • 29
    • 67349149379 scopus 로고    scopus 로고
    • Changes of the metabolism of the colon cancer cell line SW-480 under serum-free and serum-reduced growth conditions
    • Hartmann M., et al. Changes of the metabolism of the colon cancer cell line SW-480 under serum-free and serum-reduced growth conditions. In Vitro Cell. Dev. Biol. Anim. 2008, 44:458-463.
    • (2008) In Vitro Cell. Dev. Biol. Anim. , vol.44 , pp. 458-463
    • Hartmann, M.1
  • 30
    • 0036792396 scopus 로고    scopus 로고
    • Spectral profiles of cultured neuronal and glial cells derived from HRMAS (1)H NMR spectroscopy
    • Griffin J.L., et al. Spectral profiles of cultured neuronal and glial cells derived from HRMAS (1)H NMR spectroscopy. NMR Biomed. 2002, 15:375-384.
    • (2002) NMR Biomed. , vol.15 , pp. 375-384
    • Griffin, J.L.1
  • 31
    • 64049085457 scopus 로고    scopus 로고
    • 1H-NMR measured changes of the metabolite profile as mesenchymal stem cells differentiate to targeted fat cells in vitro: implications for non-invasive monitoring of stem cell differentiation in vivo
    • 1H-NMR measured changes of the metabolite profile as mesenchymal stem cells differentiate to targeted fat cells in vitro: implications for non-invasive monitoring of stem cell differentiation in vivo. J. Tissue Eng. Regen. Med. 2008, 2:482-490.
    • (2008) J. Tissue Eng. Regen. Med. , vol.2 , pp. 482-490
    • Shi, C.1
  • 32
    • 36248980949 scopus 로고    scopus 로고
    • 1H MRS identifies specific metabolite profiles associated with MYCN-amplified and non-amplified tumour subtypes of neuroblastoma cell lines
    • Peet A.C., et al. 1H MRS identifies specific metabolite profiles associated with MYCN-amplified and non-amplified tumour subtypes of neuroblastoma cell lines. NMR Biomed. 2007, 20:692-700.
    • (2007) NMR Biomed. , vol.20 , pp. 692-700
    • Peet, A.C.1
  • 33
    • 34249780124 scopus 로고    scopus 로고
    • N-(4-iodophenyl)-N'-(2-chloroethyl)urea as a microtubule disrupter: in vitro and in vivo profiling of antitumoral activity on CT-26 murine colon carcinoma cell line cultured and grafted to mice
    • Borel M., et al. N-(4-iodophenyl)-N'-(2-chloroethyl)urea as a microtubule disrupter: in vitro and in vivo profiling of antitumoral activity on CT-26 murine colon carcinoma cell line cultured and grafted to mice. Br. J. Cancer 2007, 96:1684-1691.
    • (2007) Br. J. Cancer , vol.96 , pp. 1684-1691
    • Borel, M.1
  • 34
    • 0037308636 scopus 로고    scopus 로고
    • Quantitative HRMAS proton total correlation spectroscopy applied to cultured melanoma cells treated by chloroethyl nitrosourea: demonstration of phospholipid metabolism alterations
    • Morvan D., et al. Quantitative HRMAS proton total correlation spectroscopy applied to cultured melanoma cells treated by chloroethyl nitrosourea: demonstration of phospholipid metabolism alterations. Magn. Reson. Med. 2003, 49:241-248.
    • (2003) Magn. Reson. Med. , vol.49 , pp. 241-248
    • Morvan, D.1
  • 35
    • 77954457415 scopus 로고    scopus 로고
    • Towards quantitative metabolomics of mammalian cells - development of a metabolite extraction protocol
    • 10.1016/j.ab.2010.04.031.
    • Dietmair S., et al. Towards quantitative metabolomics of mammalian cells - development of a metabolite extraction protocol. Anal. Biochem. 2010, 10.1016/j.ab.2010.04.031.
    • (2010) Anal. Biochem.
    • Dietmair, S.1
  • 36
    • 33846000626 scopus 로고    scopus 로고
    • Mass spectrometry-based metabolomics
    • Dettmer K., et al. Mass spectrometry-based metabolomics. Mass Spectrom. Rev. 2007, 26:51-78.
    • (2007) Mass Spectrom. Rev. , vol.26 , pp. 51-78
    • Dettmer, K.1
  • 37
    • 0142138236 scopus 로고    scopus 로고
    • Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterisation of xenobiotic toxicity and disease diagnosis
    • Griffin J.L. Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterisation of xenobiotic toxicity and disease diagnosis. Curr. Opin. Chem. Biol. 2003, 7:648-654.
    • (2003) Curr. Opin. Chem. Biol. , vol.7 , pp. 648-654
    • Griffin, J.L.1
  • 38
    • 84889428786 scopus 로고    scopus 로고
    • Wiley, R.G. Shulman, D.L. Rothman (Eds.)
    • Metabolomics by In Vivo NMR 2005, Wiley. R.G. Shulman, D.L. Rothman (Eds.).
    • (2005) Metabolomics by In Vivo NMR
  • 39
    • 0037717089 scopus 로고    scopus 로고
    • A fast method for the measurement of diffusion coefficients: one-dimensional DOSY
    • Thrippleton M.J., et al. A fast method for the measurement of diffusion coefficients: one-dimensional DOSY. Magn. Reson. Chem. 2003, 41:441-447.
    • (2003) Magn. Reson. Chem. , vol.41 , pp. 441-447
    • Thrippleton, M.J.1
  • 41
    • 63449109252 scopus 로고    scopus 로고
    • Reversible interactions with para-hydrogen enhance NMR sensitivity by polarization transfer
    • Adams R.W., et al. Reversible interactions with para-hydrogen enhance NMR sensitivity by polarization transfer. Science 2009, 323:1708-1711.
    • (2009) Science , vol.323 , pp. 1708-1711
    • Adams, R.W.1
  • 42
    • 41049100247 scopus 로고    scopus 로고
    • Extending the breadth of metabolite profiling by gas chromatography coupled to mass spectrometry
    • Fiehn O. Extending the breadth of metabolite profiling by gas chromatography coupled to mass spectrometry. Trends Analyt. Chem. 2008, 27:261-269.
    • (2008) Trends Analyt. Chem. , vol.27 , pp. 261-269
    • Fiehn, O.1
  • 43
    • 69449084658 scopus 로고    scopus 로고
    • Liquid chromatography-mass spectrometry in metabolite profiling
    • Juo C.-G., et al. Liquid chromatography-mass spectrometry in metabolite profiling. Biofactors 2008, 34:159-169.
    • (2008) Biofactors , vol.34 , pp. 159-169
    • Juo, C.-G.1
  • 44
    • 8444223860 scopus 로고    scopus 로고
    • High-field asymmetric waveform ion mobility spectrometry: a new tool for mass spectrometry
    • Guevremont R. High-field asymmetric waveform ion mobility spectrometry: a new tool for mass spectrometry. J. Chromatogr. A 2004, 1058:3-19.
    • (2004) J. Chromatogr. A , vol.1058 , pp. 3-19
    • Guevremont, R.1
  • 45
    • 67649834742 scopus 로고    scopus 로고
    • Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics
    • Brown M., et al. Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics. Analyst 2009, 134:1322-1332.
    • (2009) Analyst , vol.134 , pp. 1322-1332
    • Brown, M.1
  • 46
    • 68549085318 scopus 로고    scopus 로고
    • 13C stable isotope-resolved metabolomics (SIRM)
    • 13C stable isotope-resolved metabolomics (SIRM). Mol. Cancer 2009, 8:41.
    • (2009) Mol. Cancer , vol.8 , pp. 41
    • Fan, T.W.1
  • 47
    • 60849139445 scopus 로고    scopus 로고
    • Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS)
    • Chan E.C., et al. Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS). J. Proteome Res. 2009, 8:352-361.
    • (2009) J. Proteome Res. , vol.8 , pp. 352-361
    • Chan, E.C.1
  • 48
    • 36048945250 scopus 로고    scopus 로고
    • Comparative metabolomics of breast cancer
    • Yang C., et al. Comparative metabolomics of breast cancer. Pac. Symp. Biocomput. 2007, 2007:181-192.
    • (2007) Pac. Symp. Biocomput. , vol.2007 , pp. 181-192
    • Yang, C.1
  • 49
    • 44849097091 scopus 로고    scopus 로고
    • Central carbon metabolism in the progression of mammary carcinoma
    • Richardson A.D., et al. Central carbon metabolism in the progression of mammary carcinoma. Breast Cancer Res. Treat. 2008, 110:297-307.
    • (2008) Breast Cancer Res. Treat. , vol.110 , pp. 297-307
    • Richardson, A.D.1
  • 50
    • 38949185267 scopus 로고    scopus 로고
    • Profiling of central metabolism in human cancer cells by 2D NMR, GC-MS analysis and isotopomer modelling
    • Yang C., et al. Profiling of central metabolism in human cancer cells by 2D NMR, GC-MS analysis and isotopomer modelling. Metabolomics 2008, 4:13-29.
    • (2008) Metabolomics , vol.4 , pp. 13-29
    • Yang, C.1
  • 51
    • 62549096290 scopus 로고    scopus 로고
    • Time-dependent effects of imatinib in human leukaemia cells: a kinetic NMR-profiling study
    • Klawitter J., et al. Time-dependent effects of imatinib in human leukaemia cells: a kinetic NMR-profiling study. Br. J. Cancer 2009, 100:923-931.
    • (2009) Br. J. Cancer , vol.100 , pp. 923-931
    • Klawitter, J.1
  • 53
    • 0027333165 scopus 로고
    • 13C NMR isotopomer and computer-simulation studies of the non-oxidative pentose phosphate pathway of human erythrocytes
    • Berthon H.A., et al. 13C NMR isotopomer and computer-simulation studies of the non-oxidative pentose phosphate pathway of human erythrocytes. Biochem. J. 1993, 296:379-387.
    • (1993) Biochem. J. , vol.296 , pp. 379-387
    • Berthon, H.A.1
  • 54
    • 66149148316 scopus 로고    scopus 로고
    • Quantitative phosphorus metabolomics using nanoflow liquid chromatography-tandem mass spectrometry and culture-derived comprehensive global internal standards
    • Uehara T., et al. Quantitative phosphorus metabolomics using nanoflow liquid chromatography-tandem mass spectrometry and culture-derived comprehensive global internal standards. Anal. Chem. 2009, 81:3836-3842.
    • (2009) Anal. Chem. , vol.81 , pp. 3836-3842
    • Uehara, T.1
  • 55
    • 57449119288 scopus 로고    scopus 로고
    • Reversed-phase LC/MS method for polyphosphoinositide analysis: changes in molecular species levels during epidermal growth factor activation in A431 cells
    • Ogiso H., Taguchi R. Reversed-phase LC/MS method for polyphosphoinositide analysis: changes in molecular species levels during epidermal growth factor activation in A431 cells. Anal. Chem. 2008, 80:9226-9232.
    • (2008) Anal. Chem. , vol.80 , pp. 9226-9232
    • Ogiso, H.1    Taguchi, R.2
  • 56
    • 58149456670 scopus 로고    scopus 로고
    • Live-single-cell metabolomics of tryptophan and histidine metabolites in a rat basophil leeukemia cell
    • Mizuno H., et al. Live-single-cell metabolomics of tryptophan and histidine metabolites in a rat basophil leeukemia cell. Anal. Sci. 2008, 24:1525-1527.
    • (2008) Anal. Sci. , vol.24 , pp. 1525-1527
    • Mizuno, H.1
  • 57
    • 34249662620 scopus 로고    scopus 로고
    • In vitro 1H NMR studies of RD human cell infection with Echovirus 11
    • Akhtar S.N., et al. In vitro 1H NMR studies of RD human cell infection with Echovirus 11. NMR Biomed. 2007, 20:422-428.
    • (2007) NMR Biomed. , vol.20 , pp. 422-428
    • Akhtar, S.N.1
  • 58
    • 42049085016 scopus 로고    scopus 로고
    • Metabolic and morphological difference between rapidly proliferating cancerous and normal breast epithelial cells
    • Meadows A.L., et al. Metabolic and morphological difference between rapidly proliferating cancerous and normal breast epithelial cells. Biotechnol. Prog. 2008, 24:334-341.
    • (2008) Biotechnol. Prog. , vol.24 , pp. 334-341
    • Meadows, A.L.1
  • 59
    • 4544278657 scopus 로고    scopus 로고
    • Hormone sensitivity is reflected in the phospholipid profiles of breast cancer cell line
    • Sterin M., et al. Hormone sensitivity is reflected in the phospholipid profiles of breast cancer cell line. Breast Cancer Res. Treat. 2004, 87:1-11.
    • (2004) Breast Cancer Res. Treat. , vol.87 , pp. 1-11
    • Sterin, M.1
  • 60
    • 68549108035 scopus 로고    scopus 로고
    • NMR metabolomic analysis of caco-2 cell differentiation
    • Lee I.J., et al. NMR metabolomic analysis of caco-2 cell differentiation. J. Proteome Res. 2009, 8:4104-4108.
    • (2009) J. Proteome Res. , vol.8 , pp. 4104-4108
    • Lee, I.J.1
  • 61
    • 33847369007 scopus 로고    scopus 로고
    • Chemometrics in metabonomics
    • Trygg J., et al. Chemometrics in metabonomics. J. Proteome Res. 2007, 6:469-479.
    • (2007) J. Proteome Res. , vol.6 , pp. 469-479
    • Trygg, J.1
  • 62
    • 55949092929 scopus 로고    scopus 로고
    • Human metabolic phenotyping and metabolome wide association studies
    • Holmes E., Nicholson J.K. Human metabolic phenotyping and metabolome wide association studies. Ernst Schering Found. Symp. Proc. 2007, 4:227-249.
    • (2007) Ernst Schering Found. Symp. Proc. , vol.4 , pp. 227-249
    • Holmes, E.1    Nicholson, J.K.2
  • 63
    • 19644385170 scopus 로고    scopus 로고
    • Mass spectrometry in metabolome analysis
    • Villas-Bôas S.G., et al. Mass spectrometry in metabolome analysis. Mass Spectrom. Rev. 2005, 24:613-646.
    • (2005) Mass Spectrom. Rev. , vol.24 , pp. 613-646
    • Villas-Bôas, S.G.1
  • 64
    • 41049096359 scopus 로고    scopus 로고
    • Quantitative metabolomics using NMR
    • Wishart D.S. Quantitative metabolomics using NMR. Trends Analyt. Chem. 2008, 27:228-237.
    • (2008) Trends Analyt. Chem. , vol.27 , pp. 228-237
    • Wishart, D.S.1
  • 65
    • 0030853518 scopus 로고    scopus 로고
    • A new method for absolute quantitation of MRS metabolites
    • Barantin L., et al. A new method for absolute quantitation of MRS metabolites. Magn. Reson. Med. 1997, 38:179-182.
    • (1997) Magn. Reson. Med. , vol.38 , pp. 179-182
    • Barantin, L.1
  • 66
    • 77950944945 scopus 로고    scopus 로고
    • 1H-NMR reveals differences between chronic lymphocytic leukaemia molecular subgroups
    • 1H-NMR reveals differences between chronic lymphocytic leukaemia molecular subgroups. Leukemia 2010, 24:788-797.
    • (2010) Leukemia , vol.24 , pp. 788-797
    • MacIntyre, D.A.1
  • 67
    • 38849104440 scopus 로고    scopus 로고
    • UPLC-ESI-TOFMS based metabolomics and gene expression dynamics inspector self-organizing metabolomics maps as tools for understanding the cellular response to ionizing radiation
    • Patterson A.D., et al. UPLC-ESI-TOFMS based metabolomics and gene expression dynamics inspector self-organizing metabolomics maps as tools for understanding the cellular response to ionizing radiation. Anal. Chem. 2008, 80:665-674.
    • (2008) Anal. Chem. , vol.80 , pp. 665-674
    • Patterson, A.D.1
  • 68
    • 72249122347 scopus 로고    scopus 로고
    • NMR metabolomic analysis of samples using fuzzy K-means clustering
    • Cuperlovic-Culf M., et al. NMR metabolomic analysis of samples using fuzzy K-means clustering. Magn. Reson. Chem. 2009, 47(Suppl. 1):S96-S104.
    • (2009) Magn. Reson. Chem. , vol.47 , Issue.SUPPL. 1
    • Cuperlovic-Culf, M.1
  • 70
    • 16244422362 scopus 로고    scopus 로고
    • Determination of tumour marker genes from gene expression data
    • Cuperlovic-Culf M., et al. Determination of tumour marker genes from gene expression data. Drug Discov. Today 2005, 10:429-437.
    • (2005) Drug Discov. Today , vol.10 , pp. 429-437
    • Cuperlovic-Culf, M.1
  • 71
    • 0035965476 scopus 로고    scopus 로고
    • PLS-regression: a basic tool of chemometrics
    • Wold S., et al. PLS-regression: a basic tool of chemometrics. Chemom. Intell. Lab. Syst. 2001, 58:109-130.
    • (2001) Chemom. Intell. Lab. Syst. , vol.58 , pp. 109-130
    • Wold, S.1
  • 72
    • 0036083139 scopus 로고    scopus 로고
    • Orthogonal projections to latent structures (O-PLS)
    • Trygg J., Wold S. Orthogonal projections to latent structures (O-PLS). J. Chemometr. 2002, 16:119-128.
    • (2002) J. Chemometr. , vol.16 , pp. 119-128
    • Trygg, J.1    Wold, S.2
  • 73
    • 63649146110 scopus 로고    scopus 로고
    • Metabolic characterization of a hyper-productive state in an antibody producing NS0 myeloma cell line
    • Khoo S.H.G., Al-Rubeai M. Metabolic characterization of a hyper-productive state in an antibody producing NS0 myeloma cell line. Metab. Eng. 2009, 11:199-211.
    • (2009) Metab. Eng. , vol.11 , pp. 199-211
    • Khoo, S.H.G.1    Al-Rubeai, M.2
  • 74
    • 37849024323 scopus 로고    scopus 로고
    • A novel in vitro metabolomics approach for neurotoxicity testing, proof of principle for methyl mercury chloride and caffeine
    • Van Vliet E., et al. A novel in vitro metabolomics approach for neurotoxicity testing, proof of principle for methyl mercury chloride and caffeine. Neurotoxicology 2007, 29:1-12.
    • (2007) Neurotoxicology , vol.29 , pp. 1-12
    • Van Vliet, E.1
  • 75
    • 33747608188 scopus 로고    scopus 로고
    • Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers
    • Ippolito J.E., et al. Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:12505-12510.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 12505-12510
    • Ippolito, J.E.1
  • 76
    • 33750516719 scopus 로고    scopus 로고
    • NMR-based metabolic profiling of human hepatoma cells in relation to cell growth by culture media analysis
    • Miccheli A.T., et al. NMR-based metabolic profiling of human hepatoma cells in relation to cell growth by culture media analysis. Biochim. Biophys. Acta 2006, 1760:1723-1731.
    • (2006) Biochim. Biophys. Acta , vol.1760 , pp. 1723-1731
    • Miccheli, A.T.1
  • 77
    • 44449113808 scopus 로고    scopus 로고
    • Identification of metabolic fluxes in hepatic cells from transient 13C labelling experiments
    • Hofmann U., et al. Identification of metabolic fluxes in hepatic cells from transient 13C labelling experiments. Biotechnol. Bioeng. 2008, 100:344-354.
    • (2008) Biotechnol. Bioeng. , vol.100 , pp. 344-354
    • Hofmann, U.1
  • 78
    • 0037085584 scopus 로고    scopus 로고
    • Metabolic profiling of cell growth and death in cancer: applications in drug discovery
    • Boros L.G., et al. Metabolic profiling of cell growth and death in cancer: applications in drug discovery. Drug Discov. Today 2002, 7:364-372.
    • (2002) Drug Discov. Today , vol.7 , pp. 364-372
    • Boros, L.G.1
  • 79
    • 58149263489 scopus 로고    scopus 로고
    • Metabolomics and fluxomics approaches
    • Cascante M., Martin S. Metabolomics and fluxomics approaches. Essays Biochem. 2008, 45:67-81.
    • (2008) Essays Biochem. , vol.45 , pp. 67-81
    • Cascante, M.1    Martin, S.2
  • 80
    • 13344285960 scopus 로고    scopus 로고
    • Use of metabolic pathway flux information in targeted cancer drug design
    • Boros L.G., et al. Use of metabolic pathway flux information in targeted cancer drug design. Drug Disc. Today: Ther. Strategies 2004, 1:435-443.
    • (2004) Drug Disc. Today: Ther. Strategies , vol.1 , pp. 435-443
    • Boros, L.G.1
  • 81
    • 33846088138 scopus 로고    scopus 로고
    • HMDB: the Human Metabolome Database
    • Database issue
    • Wishart D.S., et al. HMDB: the Human Metabolome Database. Nucleic Acids Res. 2007, 35(Database issue):D521-D526.
    • (2007) Nucleic Acids Res. , vol.35
    • Wishart, D.S.1
  • 82
    • 53249144283 scopus 로고    scopus 로고
    • PRIMe: a Web site that assembles tools for metabolomics and transcriptomics
    • Akiyama K., et al. PRIMe: a Web site that assembles tools for metabolomics and transcriptomics. Silico Biol. 2008, 8:0027.
    • (2008) Silico Biol. , vol.8 , pp. 0027
    • Akiyama, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.