Human metabolic profiles are stably controlled by genetic and environmental variation

Molecular Systems Biology

Volumn 7, Issue , 2011, Pages

  Nicholson, George ^a   Rantalainen, Mattias ^a   Maher, Anthony D ^b,i   Li, Jia V ^b   Malmodin, Daniel ^c   Ahmadi, Kourosh R ^d   Faber, Johan H ^c   Hallgrímsdóttir, Ingileif B ^a   Barrett, Amy ^e   Toft, Henrik ^c   Krestyaninova, Maria ^f   Viksna, Juris ^g   Neogi, Sudeshna Guha ^h   Dumas, Marc Emmanuel ^b   Sarkans, Ugis ^f   Silverman, Bernard W ^a,j   Donnelly, Peter ^a,j   Nicholson, Jeremy K ^b   Allen, Maxine ^e   Zondervan, Krina T ^j   Lindon, John C ^b   Spector, Tim D ^d   McCarthy, Mark I ^e,j   Holmes, Elaine ^b   Baunsgaard, Dorrit ^c   Holmes, Chris C ^a   more..

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c NOVO NORDISK A S   (Denmark)

^d ST THOMAS HOSPITAL   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^g UNIVERSITY OF LATVIA   (Latvia)

^h ADDENBROOKE S HOSPITAL   (United Kingdom)

ⁱ DEPARTMENT OF PRIMARY INDUSTRIES   (Australia)

^j UNIVERSITY OF OXFORD   (United Kingdom)

more..

Author keywords

1H nuclear magnetic resonance spectroscopy; biomarker; metabolome wide association study; top down systems biology; variance decomposition

Indexed keywords

ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HEREDITY; HUMAN; HUMAN EXPERIMENT; LONGITUDINAL STUDY; MALE; MATHEMATICAL PARAMETERS; METABOLITE; METABOLOME; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SEMEN ANALYSIS; URINALYSIS; AGED; ALGORITHM; BLOOD; CAUCASIAN; DIZYGOTIC TWINS; GENETIC DATABASE; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; METHODOLOGY; MIDDLE AGED; MONOZYGOTIC TWINS; NUCLEAR MAGNETIC RESONANCE; SAMPLE SIZE; STATISTICAL MODEL; SYSTEMS BIOLOGY; URINE;

BIOLOGICAL MARKER;

AGED; ALGORITHMS; BIOLOGICAL MARKERS; DATABASES, GENETIC; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC VARIATION; HUMANS; METABOLOME; MIDDLE AGED; MODELS, STATISTICAL; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; RESEARCH DESIGN; SAMPLE SIZE; SYSTEMS BIOLOGY; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC;

EID: 80052400897     PISSN: None     EISSN: 17444292     Source Type: Journal    
DOI: 10.1038/msb.2011.57     Document Type: Article

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