Metabolomics for high-resolution monitoring of the cellular physiological state in cell culture engineering

Metabolic Engineering

Volumn 12, Issue 3, 2010, Pages 212-222

  Chrysanthopoulos, Panagiotis K ^a,c   Goudar, Chetan T ^b   Klapa, Maria I ^a,d  

^a INSTITUTE OF CHEMICAL ENGINEERING SCIENCES   (Greece)

^b BAYER CORPORATION   (United States)

^c UNIVERSITY OF PATRAS   (Greece)

^d UNIVERSITY OF MARYLAND   (United States)

Author keywords

Bioprocess development and optimization of mammalian cell cultures; Gas chromatography mass spectrometry (GC MS) metabolic profiling; High throughput molecular analysis; Perfusion system; Therapeutic protein production

Indexed keywords

BIOPROCESS DEVELOPMENT; BIOPROCESS DEVELOPMENT AND OPTIMIZATION OF MAMMALIAN CELL CULTURES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HIGH-THROUGHPUT; MAMMALIAN CELL CULTURE; METABOLIC PROFILING; MOLECULAR ANALYSIS; PERFUSION SYSTEM; THERAPEUTIC PROTEIN;

ANIMAL CELL CULTURE; BIOREACTORS; CELLS; GAS CHROMATOGRAPHY; GROWTH KINETICS; INFORMATION MANAGEMENT; MAMMALS; MASS SPECTROMETRY; METABOLISM; PRODUCTIVITY; PROTEINS; THROUGHPUT;

CELL CULTURE;

ANIMAL CELL; ARTICLE; BIOREACTOR; CELL AGING; CELL CULTURE; CELL GROWTH; CELL STRAIN BHK; MASS FRAGMENTOGRAPHY; METABOLOMICS; NONHUMAN; PRIORITY JOURNAL; SPECIES CULTIVATION; TISSUE ENGINEERING;

ANIMALS; BIOREACTORS; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; CELL PHYSIOLOGICAL PHENOMENA; CELL PROLIFERATION; CRICETINAE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; INFANT; LABORATORY TECHNIQUES AND PROCEDURES; METABOLOMICS; PERFUSION; RESEARCH;

CRICETINAE; MAMMALIA;

EID: 77950865891     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2009.11.001     Document Type: Article

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